Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. I. Acute infection. Academic Article uri icon

abstract

  • The present study describes the replication of Theiler's virus in cloned cerebrovascular endothelial cells (CVE) isolated from strains of mice that are either susceptible or resistant to Theiler's virus-induced demyelination (TVID). CVE isolated from all strains of mice were equally permissive to Theiler's virus infection. Interferon-gamma and tumor necrosis factor-alpha were found to inhibit the replication of Theiler's virus in CVE. A correlation between susceptibility to demyelination and the ability of Theiler's virus to induce MHC Class I on CVE was demonstrated.

author list (cited authors)

  • Welsh, C. J., Sapatino, B. V., Rosenbaum, B. A., & Smith, R.

complete list of authors

  • Welsh, CJ||Sapatino, BV||Rosenbaum, BA||Smith, R

publication date

  • January 1, 1995 11:11 AM