Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. I. Acute infection. Academic Article

abstract

• The present study describes the replication of Theiler's virus in cloned cerebrovascular endothelial cells (CVE) isolated from strains of mice that are either susceptible or resistant to Theiler's virus-induced demyelination (TVID). CVE isolated from all strains of mice were equally permissive to Theiler's virus infection. Interferon-gamma and tumor necrosis factor-alpha were found to inhibit the replication of Theiler's virus in CVE. A correlation between susceptibility to demyelination and the ability of Theiler's virus to induce MHC Class I on CVE was demonstrated.

authors

• Smith, Roger
• Welsh, Christabel Jane

published proceedings

• J Neuroimmunol

author list (cited authors)

• Welsh, C. J., Sapatino, B. V., Rosenbaum, B. A., & Smith, R.

citation count

• 21

complete list of authors

• Welsh, CJ||Sapatino, BV||Rosenbaum, BA||Smith, R

publication date

• November 1995

publisher

• Elsevier  Publisher

published in

• JOURNAL OF NEUROIMMUNOLOGY  Journal

keywords

• Acute Disease
• Animals
• Brain
• Clone Cells
• Endothelium, Vascular
• Histocompatibility Antigens Class I
• Histocompatibility Antigens Class II
• Interferon-gamma
• Mice
• Mice, Inbred BALB C
• Mice, Inbred CBA
• Poliomyelitis
• T-Lymphocytes
• Theilovirus
• Tumor Necrosis Factor-alpha

PubMed Central ID

• 7499499

Digital Object Identifier (DOI)

• 10.1016/0165-5728(95)00093-2

start page

• 119

end page

• 125

volume

• 62

issue

• 2

URL

• http://dx.doi.org/10.1016/0165-5728(95)00093-2