HR job title
- Professor
- Contact Info
Stover, Patrick Professor
Positions
- Professor, Nutrition, College of Agriculture and Life Sciences
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- Teaching
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Overview
Publications
selected publications
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academic article
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Tiani, K. A., & Stover, P. J.
(2024).
DTYMK is an essential gene in mice and heterozygosity does not cause neural tube defects. Archives of Biochemistry and Biophysics.
755, 109991-109991.
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Stover, P. J., Field, M. S., Andermann, M. L., Bailey, R. L., Batterham, R. L., Cauffman, E., ... Angelin, B. o.
(2023).
Neurobiology of eating behavior, nutrition, and health. Journal of Internal Medicine.
294(5), 582-604.
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Stover, P. J., Field, M. S., Brawley, H. N., Angelin, B., Iversen, P. O., & Frhbeck, G.
(2022).
Nutrition and stem cell integrity in aging. Journal of Internal Medicine.
292(4), 587-603.
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Bae, S., Kamynina, E., Guetterman, H. M., Farinola, A. F., Caudill, M. A., Berry, R. J., Cassano, P. A., & Stover, P. J.
(2021).
Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults. 10(10), CD012649.
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Miura, N., Matsumoto, H., Cynober, L., Stover, P. J., Elango, R., Kadowaki, M., Bier, D. M., & Smriga, M.
(2021).
Subchronic Tolerance Trials of Graded Oral Supplementation with Phenylalanine or Serine in Healthy Adults. Nutrients.
13(6), 1976-1976.
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Gheller, B. J., Blum, J. E., Lim, E. W., Handzlik, M. K., Hannah Fong, E. H., Ko, A. C., ... Thalacker-Mercer, A. E.
(2021).
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function. Molecular Metabolism.
43, 101106-101106.
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Stover, P. J., & King, J. C.
(2020).
More Nutrition Precision, Better Decisions for the Health of Our Nation. 150(12), 3058-3060.
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Maruvada, P., Stover, P. J., Mason, J. B., Bailey, R. L., Davis, C. D., Field, M. S., ... Zappal, G.
(2020).
Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop. AMERICAN JOURNAL OF CLINICAL NUTRITION.
112(5), 1390-1403.
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Stover, P. J., Garza, C., Durga, J., & Field, M. S.
(2020).
Emerging Concepts in Nutrient Needs. 150(Suppl 1), 2593S-2601S.
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Fleischhacker, S. E., Woteki, C. E., Coates, P. M., Hubbard, V. S., Flaherty, G. E., Glickman, D. R., ... Mozaffarian, D.
(2020).
Strengthening national nutrition research: rationale and options for a new coordinated federal research effort and authority. 112(3), 721-769.
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Chakraborty, J., & Stover, P. J.
(2020).
Deoxyuracil in DNA in health and disease. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE.
23(4), 247-252.
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Lachenauer, E. R., Stabler, S. P., Field, M. S., & Stover, P. J.
(2020).
p53 Disruption Increases Uracil Accumulation in DNA of Murine Embryonic Fibroblasts and Leads to Folic Acid-Nonresponsive Neural Tube Defects in Mice. 150(7), 1705-1712.
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Johnston, B. C., Zeraatkar, D., Han, M. A., Vernooij, R., Valli, C., El Dib, R., ... Guyatt, G. H.
(2019).
Unprocessed Red Meat and Processed Meat Consumption: Dietary Guideline Recommendations From the Nutritional Recommendations (NutriRECS) Consortium. Annals of Internal Medicine.
171(10), 756-764.
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Balling, R., & Stover, P. J.
(2019).
Addressing the Increased Expectations of Nutrition. Annual Review of Nutrition.
39(1), v-vi.
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Tiani, K. A., Stover, P. J., & Field, M. S.
(2019).
The Role of Brain Barriers in Maintaining Brain Vitamin Levels. Annual Review of Nutrition.
39(1), 147-173.
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James, W., Johnson, R. J., Speakman, J. R., Wallace, D. C., Frhbeck, G., Iversen, P. O., & Stover, P. J.
(2019).
Nutrition and its role in human evolution. Journal of Internal Medicine.
285(5), 533-549.
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Chon, J., Field, M. S., & Stover, P. J.
(2019).
Deoxyuracil in DNA and disease: Genomic signal or managed situation?. DNA Repair.
77, 36-44.
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Misselbeck, K., Marchetti, L., Priami, C., Stover, P. J., & Field, M. S.
(2019).
The 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolism. Scientific Reports.
9(1), 4322.
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Rudolph, A., Nusser, S., Stover, P., Mohapatra, P., Wilhelm, R., & Dorhout, P.
(2019).
Lincoln's Biodefense Strategy: Protecting the Agricultural Base. Health Security.
17(1), 80-81.
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Garza, C., Stover, P. J., Ohlhorst, S. D., Field, M. S., Steinbrook, R., Rowe, S., Woteki, C., & Campbell, E.
(2019).
Best practices in nutrition science to earn and keep the public's trust. 109(1), 225-243.
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Alonzo, J. R., Venkataraman, C., Field, M. S., & Stover, P. J.
(2018).
The mitochondrial inner membrane protein MPV17 prevents uracil accumulation in mitochondrial DNA. 293(52), 20285-20294.
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Lan, X. u., Field, M. S., & Stover, P. J.
(2018).
Cell cycle regulation of folate-mediated one-carbon metabolism. Wiley Interdisciplinary Reviews: Systems Biology and Medicine.
10(6), e1426.
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Stover, P. J., James, W., Krook, A., & Garza, C.
(2018).
Emerging concepts on the role of epigenetics in the relationships between nutrition and health. Journal of Internal Medicine.
284(1), 37-49.
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Field, M. S., Lan, X. u., Stover, D. M., & Stover, P. J.
(2018).
Dietary Uridine Decreases Tumorigenesis in the ApcMin/+ Model of Intestinal Cancer. 2(5), nzy013-2005005.
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Dixit, R., Nettem, S., Madan, S. S., Soe, H., Abas, A. B., Vance, L. D., & Stover, P. J.
(2018).
Folate supplementation in people with sickle cell disease. Cochrane Database of Systematic Reviews.
3(3), CD011130.
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Field, M. S., & Stover, P. J.
(2018).
Safety of folic acid. Annals of the New York Academy of Sciences.
1414(1), 59-71.
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Zwart, S. R., Gibson, C. R., Gregory, J. F., Mader, T. H., Stover, P. J., Zeisel, S. H., & Smith, S. M.
(2017).
Astronaut ophthalmic syndrome. The FASEB Journal.
31(9), 3746-3756.
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Hootman, K. C., Trezzi, J., Kraemer, L., Burwell, L. S., Dong, X., Guertin, K. A., ... Cassano, P. A.
(2017).
Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults. Proceedings of the National Academy of Sciences of the United States of America.
114(21), E4233-E4240.
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Palmer, A. M., Kamynina, E., Field, M. S., & Stover, P. J.
(2017).
Folate rescues vitamin B12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability. Proceedings of the National Academy of Sciences of the United States of America.
114(20), E4095-E4102.
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Bae, S., Kamynina, E., Farinola, A. F., Caudill, M. A., Stover, P. J., Cassano, P. A., Berry, R., & PeaRosas, J. P.
(2017).
Provision of folic acid for reducing arsenic toxicity in arsenicexposed children and adults. 2017(5),
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Misselbeck, K., Marchetti, L., Field, M. S., Scotti, M., Priami, C., & Stover, P. J.
(2017).
A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis. Scientific Reports.
7(1), 797.
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Bae, S., Chon, J., Field, M. S., & Stover, P. J.
(2017).
Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells. Journal of Nutrition.
147(4), 499-505.
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Stover, P. J., & Mehta, S.
(2017).
Editorial overview: Food biotechnology. Current Opinion in Biotechnology.
44, v-vi.
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Stover, P. J., Durga, J., & Field, M. S.
(2017).
Folate nutrition and blood-brain barrier dysfunction. Current Opinion in Biotechnology.
44, 146-152.
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Kamynina, E., Lachenauer, E. R., DiRisio, A. C., Liebenthal, R. P., Field, M. S., & Stover, P. J.
(2017).
Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis. Proceedings of the National Academy of Sciences of the United States of America.
114(12), E2319-E2326.
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Chon, J., Stover, P. J., & Field, M. S.
(2017).
Targeting nuclear thymidylate biosynthesis. Molecular Aspects of Medicine.
53, 48-56.
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Kamynina, E., & Stover, P. J.
(2017).
The Roles of SUMO in Metabolic Regulation. Advances in Experimental Medicine and Biology.
963, 143-168.
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Stover, P. J., Berry, R. J., & Field, M. S.
(2016).
Time to Think About Nutrient Needs in Chronic Disease. JAMA Internal Medicine.
176(10), 1451-1452.
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Field, M. S., Kamynina, E., & Stover, P. J.
(2016).
MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability. Biochimie.
126, 27-30.
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Dixit, R., Nettem, S., Madan, S. S., Soe, H., Abas, A., Vance, L. D., & Stover, P. J.
(2016).
Folate supplementation in people with sickle cell disease. Cochrane Database of Systematic Reviews.
2(2), CD011130.
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Finkelstein, J. L., Layden, A. J., & Stover, P. J.
(2015).
Vitamin B-12 and Perinatal Health. 6(5), 552-563.
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MacFarlane, A. J., Behan, N. A., Field, M. S., Williams, A., Stover, P. J., & Yauk, C. L.
(2015).
Dietary folic acid protects against genotoxicity in the red blood cells of mice. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
779, 105-111.
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Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., Mills, J. L., ... Raiten, D. J.
(2015).
Biomarkers of Nutrition for Development-Folate Review. Journal of Nutrition.
145(7), 1636S-1680S.
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Nesheim, M., Stover, P. J., & Oria, M.
(2015).
Food systems: Healthy diet sustains the environment too. Nature.
522(7556), 287-287.
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Stover, P. J., MacFarlane, A. J., & Field, M. S.
(2015).
Bringing clarity to the role of MTHFR variants in neural tube defect prevention. AMERICAN JOURNAL OF CLINICAL NUTRITION.
101(6), 1111-1112.
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Awuah, E., Field, M., & Stover, P.
(2015).
Effects of disrupted serine hydroxymethyltransferase 1 (Shmt1) gene expression on motor function and myelin degeneration in vitamin B12 deficient mice. 29(S1),
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Martiniova, L., Field, M. S., Finkelstein, J. L., Perry, C. A., & Stover, P. J.
(2015).
Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects. AMERICAN JOURNAL OF CLINICAL NUTRITION.
101(4), 860-869.
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Field, M. S., Kamynina, E., Watkins, D., Rosenblatt, D. S., & Stover, P. J.
(2015).
Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis. Proceedings of the National Academy of Sciences of the United States of America.
112(2), 400-405.
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Stover, P. J., & Field, M. S.
(2015).
Vitamin B-6. Advances in Nutrition.
6(1), 132-133.
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Field, M. S., Kamynina, E., Agunloye, O. C., Liebenthal, R. P., Lamarre, S. G., Brosnan, M. E., Brosnan, J. T., & Stover, P. J.
(2014).
Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency. Journal of Biological Chemistry.
289(43), 29642-29650.
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Ohlhorst, S. D., Russell, R., Bier, D., Klurfeld, D. M., Li, Z., Mein, J. R., ... Konopka, E.
(2014).
Erratum. AMERICAN JOURNAL OF CLINICAL NUTRITION.
100(3), 988-988.
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MacFarlane, A. J., McEntee, M. F., & Stover, P. J.
(2014).
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity. Journal of Nutrition.
144(4), 419-424.
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Field, M., & Stover, P.
(2014).
Dietary uridine supplementation decreases tumor number in Apc(Min/+) mice (829.11). The FASEB Journal.
28(S1),
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Ohlhorst, S. D., Russell, R., Bier, D., Klurfeld, D. M., Li, Z., Mein, J. R., ... Konopka, E.
(2013).
Nutrition research to affect food and a healthy lifespan. Advances in Nutrition.
4(5), 579-584.
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Ohlhorst, S. D., Russell, R., Bier, D., Klurfeld, D. M., Li, Z., Mein, J. R., ... Konopka, E.
(2013).
Nutrition research to affect food and a healthy life span. 143(8), 1349-1354.
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Ohlhorst, S. D., Russell, R., Bier, D., Klurfeld, D. M., Li, Z., Mein, J. R., ... Konopka, E.
(2013).
Nutrition research to affect food and a healthy life span. 98(2), 620-625.
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Ash, J. A., Jiang, X., Malysheva, O. V., Fiorenza, C. G., Bisogni, A. J., Levitsky, D. A., ... Strupp, B. J.
(2013).
Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice. NEUROTOXICOLOGY AND TERATOLOGY.
38, 79-91.
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Abarinov, E. V., Beaudin, A. E., Field, M. S., Perry, C. A., Allen, R. H., Stabler, S. P., & Stover, P. J.
(2013).
Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice. Journal of Nutrition.
143(7), 1028-1035.
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Scotti, M., Stella, L., Shearer, E. J., & Stover, P. J.
(2013).
Modeling cellular compartmentation in one-carbon metabolism. Wiley Interdisciplinary Reviews: Systems Biology and Medicine.
5(3), 343-365.
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Field, M. S., Shields, K. S., Abarinov, E. V., Malysheva, O. V., Allen, R. H., Stabler, S. P., ... Caudill, M. A.
(2013).
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration. Journal of Nutrition.
143(1), 41-45.
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Stover, P. J., & Weiss, R. S.
(2012).
Sensitizing cancer cells: is it really all about U?. Cancer Cell.
22(1), 3-4.
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Wernimont, S. M., Clark, A. G., Stover, P. J., Wells, M. T., Litonjua, A. A., Weiss, S. T., ... Cassano, P. A.
(2012).
Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. Journal of Nutrition.
142(7), 1272-1279.
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Swayne, B. G., Behan, N. A., Williams, A., Stover, P. J., Yauk, C. L., & MacFarlane, A. J.
(2012).
Supplemental dietary folic acid has no effect on chromosome damage in erythrocyte progenitor cells of mice. Journal of Nutrition.
142(5), 813-817.
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Beaudin, A. E., Perry, C. A., Stabler, S. P., Allen, R. H., & Stover, P. J.
(2012).
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. AMERICAN JOURNAL OF CLINICAL NUTRITION.
95(4), 882-891.
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Anderson, D. D., Woeller, C. F., Chiang, E., Shane, B., & Stover, P. J.
(2012).
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis. 287(10), 7051-7062.
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Beaudin, A. E., Abarinov, E. V., Malysheva, O., Perry, C. A., Caudill, M., & Stover, P. J.
(2012).
Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. 95(1), 109-114.
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MacFarlane, A. J., Anderson, D. D., Flodby, P., Perry, C. A., Allen, R. H., Stabler, S. P., & Stover, P. J.
(2011).
Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA. Journal of Biological Chemistry.
286(51), 44015-44022.
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Field, M. S., Anderson, D. D., & Stover, P. J.
(2011).
Mthfs is an Essential Gene in Mice and a Component of the Purinosome. Frontiers in Genetics.
2(JUNE), 36.
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Wernimont, S. M., Clark, A. G., Stover, P. J., Wells, M. T., Litonjua, A. A., Weiss, S. T., ... Cassano, P. A.
(2011).
Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. BMC Medical Genetics.
12(1), 150.
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Stover, P. J., & Field, M. S.
(2011).
Trafficking of intracellular folates. Advances in Nutrition.
2(4), 325-331.
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Beaudin, A. E., Abarinov, E. V., Noden, D. M., Perry, C. A., Chu, S., Stabler, S. P., Allen, R. H., & Stover, P. J.
(2011).
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. 93(4), 789-798.
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Macfarlane, A. J., Perry, C. A., McEntee, M. F., Lin, D. M., & Stover, P. J.
(2011).
Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk. Cancer Research.
71(6), 2098-2107.
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MacFarlane, A. J., Perry, C. A., McEntee, M. F., Lin, D. M., & Stover, P. J.
(2011).
Mthfd1 is a modifier of chemically induced intestinal carcinogenesis. Carcinogenesis.
32(3), 427-433.
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Wernimont, S. M., Raiszadeh, F., Stover, P. J., Rimm, E. B., Hunter, D. J., Tang, W., & Cassano, P. A.
(2011).
Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans. 141(2), 255-260.
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Stover, P. J.
(2011).
Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies. Journal of Nutrigenetics and Nutrigenomics.
4(5), 293-305.
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Ching, Y., Munroe, R. J., Moran, J. L., Barker, A. K., Mauceli, E., Fennell, T., ... Schimenti, J. C.
(2010).
High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5. BMC Genetics.
11(1), 106.
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Stover, P. J., Harlan, W. R., Hammond, J. A., Hendershot, T., & Hamilton, C. M.
(2010).
PhenX: a toolkit for interdisciplinary genetics research. Current Opinion in Lipidology.
21(2), 136-140.
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Bentley, A. R., Raiszadeh, F., Stover, P. J., Hunter, D. J., Hankinson, S. E., & Cassano, P. A.
(2010).
No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study. European Journal of Clinical Nutrition.
64(1), 108-110.
-
Stover, P. J.
(2010).
Vitamin B12 and older adults. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE.
13(1), 24-27.
-
Stover, P. J.
(2009).
One-carbon metabolism-genome interactions in folate-associated pathologies. 139(12), 2402-2405.
-
Fox, J. T., Shin, W. K., Caudill, M. A., & Stover, P. J.
(2009).
A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair. Journal of Biological Chemistry.
284(45), 31097-31108.
-
Fox, J. T., & Stover, P. J.
(2009).
Mechanism of the internal ribosome entry site-mediated translation of serine hydroxymethyltransferase 1. Journal of Biological Chemistry.
284(45), 31085-31096.
-
Anderson, D. D., & Stover, P. J.
(2009).
SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis. PLoS ONE.
4(6), e5839-e5839.
-
Stover, P. J., Ordovas, J. M., McCalla, A., Hammond, J., Maiese, D., Wagner, D., Hamilton, C. M., & Ramos, E.
(2009).
Consensus Measures of Diet for Genomewide Association Studies of GeneNutrient Interactions in Health and Disease. 23(S1), lb520-lb520.
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Beaudin, A. E., & Stover, P. J.
(2009).
Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. 85(4), 274-284.
-
MacFarlane, A. J., Perry, C. A., Girnary, H. H., Gao, D., Allen, R. H., Stabler, S. P., Shane, B., & Stover, P. J.
(2009).
Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. Journal of Biological Chemistry.
284(3), 1533-1539.
-
Field, M. S., Anguera, M. C., Page, R., & Stover, P. J.
(2009).
5,10-Methenyltetrahydrofolate synthetase activity is increased in tumors and modifies the efficacy of antipurine LY309887. Archives of Biochemistry and Biophysics.
481(2), 145-150.
-
Fox, J. T., & Stover, P. J.
(2008).
Folate-mediated one-carbon metabolism. Vitamins and Hormones: Advances in Research and Applications.
79, 1-44.
-
MacFarlane, A. J., Liu, X., Perry, C. A., Flodby, P., Allen, R. H., Stabler, S. P., & Stover, P. J.
(2008).
Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. Journal of Biological Chemistry.
283(38), 25846-25853.
-
Stover, P. J., & Caudill, M. A.
(2008).
Genetic and epigenetic contributions to human nutrition and health: managing genome-diet interactions. Journal of the American Dietetic Association.
108(9), 1480-1487.
-
Stover, P. J., & MacFarlane, A. J.
(2008).
Mouse models to elucidate mechanisms of folate-related cancer pathologies. Nutrition Reviews.
66 Suppl 1(Suppl 1), S54-S58.
-
Stover, P.
(2008).
Discussion: Folate and vitamin B
12 metabolism: Overview and interaction with riboflavin, vitamin B6 , and polymorphisms. Food and Nutrition Bulletin. 29(2 SUPPL.),
-
MacFarlane, A. J., & Stover, P. J.
(2007).
Convergence of Genetic, Nutritional and Inflammatory Factors in Gastrointestinal Cancers. Nutrition Reviews.
65(SUPPL.3), S157-S166.
-
Woeller, C. F., Fox, J. T., Perry, C., & Stover, P. J.
(2007).
A ferritin-responsive internal ribosome entry site regulates folate metabolism. 282(41), 29927-29935.
-
Beaudin, A. E., & Stover, P. J.
(2007).
Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression. Birth Defects Research Part C: Embryo Today Reviews.
81(3), 183-203.
-
Woeller, C. F., Anderson, D. D., Szebenyi, D., & Stover, P. J.
(2007).
Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway. Journal of Biological Chemistry.
282(24), 17623-17631.
-
Perry, C., Yu, S., Chen, J., Matharu, K. S., & Stover, P. J.
(2007).
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells. Archives of Biochemistry and Biophysics.
462(1), 21-27.
-
Stover, P. J.
(2007).
Human nutrition and genetic variation. Food and Nutrition Bulletin.
28(1 SUPPL. 1),
-
Stover, P. J.
(2007).
Human nutrition and genetic variation. Food and Nutrition Bulletin.
28(1 Suppl International), S101-S115.
-
Field, M. S., Szebenyi, D., Perry, C. A., & Stover, P. J.
(2007).
Inhibition of 5,10-methenyltetrahydrofolate synthetase. Archives of Biochemistry and Biophysics.
458(2), 194-201.
-
Anderson, D. D., Woeller, C. F., & Stover, P. J.
(2007).
Small ubiquitin-like modifier-1 (SUMO-1) modification of thymidylate synthase and dihydrofolate reductase. Clinical Chemistry and Laboratory Medicine.
45(12), 1760-1763.
-
Anguera, M. C., & Stover, P. J.
(2006).
Methenyltetrahydrofolate synthetase is a high-affinity catecholamine-binding protein. Archives of Biochemistry and Biophysics.
455(2), 175-187.
-
Anguera, M. C., Field, M. S., Perry, C., Ghandour, H., Chiang, E., Selhub, J., Shane, B., & Stover, P. J.
(2006).
Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. 281(27), 18335-18342.
-
Stover, P. J., & Garza, C.
(2006).
Nutrition and developmental biology--implications for public health. Nutrition Reviews.
64(5 Pt 2), S60-S71.
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Field, M. S., Szebenyi, D., & Stover, P. J.
(2006).
Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma. Journal of Biological Chemistry.
281(7), 4215-4221.
-
Stover, P. J.
(2006).
Influence of human genetic variation on nutritional requirements. AMERICAN JOURNAL OF CLINICAL NUTRITION.
83(2), 436S-442S.
-
Lim, U., Peng, K., Shane, B., Stover, P. J., Litonjua, A. A., Weiss, S. T., ... Cassano, P. A.
(2005).
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. 135(8), 1989-1994.
-
Perry, C., Sastry, R., Nasrallah, I. M., & Stover, P. J.
(2005).
Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication. Journal of Biological Chemistry.
280(1), 396-400.
-
Anguera, M. C., Liu, X., & Stover, P. J.
(2004).
Cloning, expression, and purification of 5,10-methenyltetrahydrofolate synthetase from Mus musculus. Protein Expression and Purification.
35(2), 276-283.
-
Stover, P. J.
(2004).
Nutritional genomics. Physiological Genomics.
16(2), 161-165.
-
Stover, P. J.
(2003).
New paradigms for nutrient control of genome translation. Nutrition Reviews.
61(12), 427-431.
-
Anguera, M. C., Suh, J. R., Ghandour, H., Nasrallah, I. M., Selhub, J., & Stover, P. J.
(2003).
Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. Journal of Biological Chemistry.
278(32), 29856-29862.
-
Zanetti, K. A., & Stover, P. J.
(2003).
Pyridoxal phosphate inhibits dynamic subunit interchange among serine hydroxymethyltransferase tetramers. Journal of Biological Chemistry.
278(12), 10142-10149.
-
Herbig, K., Chiang, E., Lee, L., Hills, J., Shane, B., & Stover, P. J.
(2002).
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. Journal of Biological Chemistry.
277(41), 38381-38389.
-
Herbig, A. K., & Stover, P. J.
(2002).
Nutrition and developmental biology. Annales Nestle.
60(1), 1-11.
-
Allen, L. H., Bentley, M. E., Donovan, S. M., Ney, D. M., & Stover, P. J.
(2002).
Securing the future of nutritional sciences through integrative graduate education. Journal of Nutrition.
132(4), 779-784.
-
Hirschberger, L. L., Daval, S., Stover, P. J., & Stipanuk, M. H.
(2001).
Murine cysteine dioxygenase gene: structural organization, tissue-specific expression and promoter identification. Gene.
277(1-2), 153-161.
-
Zhao, R., Chen, Y., Tan, W., Waly, M., Sharma, A., Stover, P., ... Deth, R. C.
(2001).
Relationship between dopamine-stimulated phospholipid methylation and the single-carbon folate pathway. Journal of Neurochemistry.
78(4), 788-796.
-
Suh, J. R., Herbig, A. K., & Stover, P. J.
(2001).
New perspectives on folate catabolism. Annual Review of Nutrition.
21(1), 255-282.
-
Oppenheim, E. W., Adelman, C., Liu, X., & Stover, P. J.
(2001).
Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis. Journal of Biological Chemistry.
276(23), 19855-19861.
-
Liu, X., Szebenyi, D. M., Anguera, M. C., Thiel, D. J., & Stover, P. J.
(2001).
Lack of catalytic activity of a murine mRNA cytoplasmic serine hydroxymethyltransferase splice variant: evidence against alternative splicing as a regulatory mechanism. Biochemistry.
40(16), 4932-4939.
-
Suh, J. R., Oppenheim, E. W., Girgis, S., & Stover, P. J.
(2000).
Purification and properties of a folate-catabolizing enzyme. Journal of Biological Chemistry.
275(45), 35646-35655.
-
Szebenyi, D. M., Liu, X., Kriksunov, I. A., Stover, P. J., & Thiel, D. J.
(2000).
Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers. Biochemistry.
39(44), 13313-13323.
-
Liu, X., Reig, B., Nasrallah, I. M., & Stover, P. J.
(2000).
Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein. Biochemistry.
39(38), 11523-11531.
-
Liu, X., Reig, B., Nasrallah, I. M., & Stover, P. J.
(2000).
Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein. Biochemistry.
39(38), 11523-11531.
-
Oppenheim, E. W., Nasrallah, I. M., Mastri, M. G., & Stover, P. J.
(2000).
Mimosine is a cell-specific antagonist of folate metabolism. Journal of Biological Chemistry.
275(25), 19268-19274.
-
Girgis, S., Nasrallah, I. M., Suh, J. R., Oppenheim, E., Zanetti, K. A., Mastri, M. G., & Stover, P. J.
(1998).
Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene. Gene.
210(2), 315-324.
-
Nasrallah, I. M., Girgis, S., & Stover, P. J.
(1997).
Structural comparison of the human mitochondrial and cytoplasmic serine hydroxymethyltransferase genes. The FASEB Journal.
11(9), A1377-A1377.
-
Girgis, S., Suh, J. R., Jolivet, J., & Stover, P. J.
(1997).
5-Formyltetrahydrofolate regulates homocysteine remethylation in human neuroblastoma. Journal of Biological Chemistry.
272(8), 4729-4734.
-
Stover, P. J., Chen, L. H., Suh, J. R., Stover, D. M., Keyomarsi, K., & Shane, B.
(1997).
Molecular cloning, characterization, and regulation of the human mitochondrial serine hydroxymethyltransferase gene. Journal of Biological Chemistry.
272(3), 1842-1848.
-
Elsea, S. H., Juyal, R. C., Jiralerspong, S., Finucane, B. M., Pandolfo, M., Greenberg, F., ... Patel, P. I.
(1995).
Haploinsufficiency of cytosolic serine hydroxymethyltransferase in the Smith-Magenis syndrome. American Journal of Human Genetics.
57(6), 1342-1350.
-
Maras, B., Stover, P., Valiante, S., Barra, D., & Schirch, V.
(1994).
Primary structure and tetrahydropteroylglutamate binding site of rabbit liver cytosolic 5,10-methenyltetrahydrofolate synthetase. Journal of Biological Chemistry.
269(28), 18429-18433.
-
Stover, P., Kruschwitz, H., Schirch, V., & Wright, H. T.
(1993).
Diffraction grade crystals of Escherichia coli serine hydroxymethyltransferase. Journal of Molecular Biology.
230(3), 1094-1096.
-
Stover, P., & Schirch, V.
(1993).
The metabolic role of leucovorin. 18(3), 102-106.
-
Stover, P., Zamora, M., Shostak, K., Gautam-Basak, M., & Schirch, V.
(1992).
Escherichia coli serine hydroxymethyltransferase. The role of histidine 228 in determining reaction specificity. Journal of Biological Chemistry.
267(25), 17679-17687.
-
Stover, P., & Schirch, V.
(1992).
Synthesis of (6S)-5-formyltetrahydropteroyl-polyglutamates and interconversion to other reduced pteroylpolyglutamate derivatives. Analytical Biochemistry.
202(1), 82-88.
-
Stover, P., & Schirch, V.
(1992).
Enzymatic mechanism for the hydrolysis of 5,10-methenyltetrahydropteroylglutamate to 5-formyltetrahydropteroylglutamate by serine hydroxymethyltransferase. Biochemistry.
31(7), 2155-2164.
-
Stover, P., & Schirch, V.
(1992).
Evidence for the accumulation of a stable intermediate in the nonenzymatic hydrolysis of 5,10-methenyltetrahydropteroylglutamate to 5-formyltetrahydropteroylglutamate. Biochemistry.
31(7), 2148-2155.
-
Stover, P., & Schirch, V.
(1991).
5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase. Journal of Biological Chemistry.
266(3), 1543-1550.
-
Stover, P., & Schirch, V.
(1990).
Serine hydroxymethyltransferase catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate. Journal of Biological Chemistry.
265(24), 14227-14233.
-
Tiani, K. A., & Stover, P. J.
(2024).
DTYMK is an essential gene in mice and heterozygosity does not cause neural tube defects. Archives of Biochemistry and Biophysics.
755, 109991-109991.
-
book
-
Field, M. S., Kamynina, E., Chon, J., & Stover, P. J.
(2018).
Nuclear Folate Metabolism. Ed. 38.
Annual Reviews.
-
Field, M. S., Kamynina, E., Chon, J., & Stover, P. J.
(2018).
Nuclear Folate Metabolism. Ed. 38.
Annual Reviews.
-
chapter
-
Balling, R., & Stover, P. J.
(2021).
Celebrating 40 Years of the Annual Review of Nutrition. Annual Review of Nutrition.
ANNUAL REVIEW OF NUTRITION, VOL 41, 2021.
(pp. v-vi).
Annual Reviews.
-
MacFarlane, A. J., & Stover, P. J.
(2017).
Gastrointestinal Disorders: Overview. International Encyclopedia of Public Health.
(pp. 223-232).
Elsevier.
-
Stover, P. J.
(2012).
Folic acid. Modern Nutrition in Health and Disease: Eleventh Edition.
(pp. 358-368).
-
Stover, P. J., & Gu, Z.
(2012).
Genetic variation: Effect on nutrient utilization and metabolism. Modern Nutrition in Health and Disease: Eleventh Edition.
(pp. 523-533).
-
Stover, P. J.
(2011).
Folate, Vitamin B12, and Vitamin B6. Nutrition in Epigenetics.
(pp. 209-223).
Wiley.
-
Stover, P. J., Twigt, J. M., Laven, J., Steegers-Theunissen, R., Gorman, E. B., Finnell, R. H., ... Rozen, R.
(2010).
Vitamins in the prevention of human diseases. Herrmann, W., & Obeid, R. (Eds.),
Vitamins in the Prevention of Human Diseases.
(pp. 91-186).
DE GRUYTER.
-
Anderson, D. D., & Stover, P. J.
(2009).
The Roles of SUMO in Metabolic Regulation. SUMO REGULATION OF CELLULAR PROCESSES.
(pp. 137-149).
Springer Nature.
-
MacFarlane, A. J., & Stover, P. J.
(2008).
Gastrointestinal Disorders: Overview. International Encyclopedia of Public Health.
(pp. 9-19).
Elsevier.
-
Herbig, A. K., Girgis, S., & Stover, P. J.
(2002).
Effects of Cellular Glycine on Cell Proliferation. Chemistry and Biology of Pteridines and Folates.
(pp. 491-494).
Springer Nature.
-
Anguera, M. C., & Stover, P. J.
(2002).
Rapid Purification of the T-Protein of the Glycine Cleavage System from Rabbit Liver. Chemistry and Biology of Pteridines and Folates.
(pp. 485-489).
Springer Nature.
-
Field, M. S., Stover, P. J., & Kisliuk, R.
Thymidylate Synthesis. Encyclopedia of Life Sciences.
(pp. 1-7).
Wiley.
-
Balling, R., & Stover, P. J.
(2021).
Celebrating 40 Years of the Annual Review of Nutrition. Annual Review of Nutrition.
ANNUAL REVIEW OF NUTRITION, VOL 41, 2021.
(pp. v-vi).
Annual Reviews.
-
conference paper
-
Cynober, L., Bier, D. M., Stover, P., Kadowaki, M., Morris, S. M., Elango, R., & Smriga, M.
(2020).
Proposals for Upper Limits of Safe Intake for Methionine, Histidine, and Lysine in Healthy Humans. Journal of Nutrition.
2606S-2608S.
-
Lachenauer, E. R., Stabler, S. P., Field, M. S., & Stover, P. J.
(2019).
p53 Disruption Increases Uracil Accumulation in DNA and Leads to Folic Acid Nonresponsive Neural Tube Defects in Mice. Birth Defects Research.
503-503.
-
Lachenauer, E. R., Kamynina, E., Kraemer, L., Dirisio, A. C., Stabler, S. P., Brosnan, M. E., ... Stover, P. J.
(2018).
Arsenic Exposure Alters Folate Metabolism Causing Genomic Instability and Neural Tube Defects in a Dose-Dependent Manner. Birth Defects Research.
760-760.
-
Brannon, P. M., Stover, P. J., & Taylor, C. L.
(2017).
Integrating themes, evidence gaps, and research needs identified by workshop on iron screening and supplementation in iron-replete pregnant women and young children. AMERICAN JOURNAL OF CLINICAL NUTRITION.
1703S-1712S.
-
Chon, J., Gondokusumo, J. C., Field, M. S., & Stover, P. J.
(2017).
De novo Thymidylate Biosynthesis and dUTPase Interact in DNA Synthesis. The FASEB Journal.
-
Stover, P., Ohlhorst, S., Field, M., & Garza, C.
(2017).
BEST PRACTICES FROM THE ASN COMMITTEE ON PUBLIC TRUST. ANNALS OF NUTRITION AND METABOLISM.
142-142.
-
Chon, J., Field, M., Gondokusumo, J., & Stover, P.
(2016).
Identifying the role of genomic uracil in folate deficiency. The FASEB Journal.
-
DiRisio, A., Kamynina, E., Field, M. S., & Stover, P. J.
(2016).
The Effects of Folate Deficiency and Arsenic Exposure on Thymidylate Synthesis in Serine Hydroxymethyltransferase 1-Deficient Mouse Embryonic Fibroblasts. The FASEB Journal.
-
Chon, J., Field, M., Gondokusumo, J., & Stover, P.
(2016).
Identifying the role of genomic uracil in folate deficiency. The FASEB Journal.
-
DiRisio, A., Kamynina, E., & Stover, P.
(2015).
The Role of Serine Hydroxymethyltransferase and Methylene-Tetrahydrofolate Dehydrogenase in Genome Stability. The FASEB Journal.
-
Romagnolo, D. F., Dashwood, R., Stover, P. J., Waterland, R. A., & Ziegler, T. R.
(2012).
Nutritional regulation of epigenetic changes. Advances in Nutrition.
749-750.
-
Yetley, E. A., Pfeiffer, C. M., Phinney, K. W., Fazili, Z., Lacher, D. A., Bailey, R. L., ... Picciano, M. F.
(2011).
Biomarkers of folate status in NHANES: a roundtable summary. AMERICAN JOURNAL OF CLINICAL NUTRITION.
303S-312S.
-
Yetley, E. A., Pfeiffer, C. M., Phinney, K. W., Bailey, R. L., Blackmore, S., Bock, J. L., ... Picciano, M. F.
(2011).
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. AMERICAN JOURNAL OF CLINICAL NUTRITION.
313S-321S.
-
Stover, P. J.
(2004).
Physiology of folate and vitamin B
12 in health and disease. Nutrition Reviews.
-
Garza, C., & Stover, P.
(2003).
General introduction: the role of science in identifying common ground in the debate on genetic modification of foods. Trends in Food Science and Technology.
182-190.
-
Stover, P. J., & Garza, C.
(2002).
Molecular and genetic considerations for long-term nutrition interventions. Asia Pacific Journal of Clinical Nutrition.
S129-S136.
-
Stover, P. J., & Garza, C.
(2002).
Bringing individuality to public health recommendations. Journal of Nutrition.
-
Stover, P., Kruschwitz, H., & Schirch, V.
(1993).
Evidence that 5-formyltetrahydropteroylglutamate has a metabolic role in one-carbon metabolism. Advances in Experimental Medicine and Biology.
679-685.
-
Shane, B., Garrow, T., Brenner, A., Chen, L., Choi, Y. J., Hsu, J. C., & Stover, P.
(1993).
Folylpoly-gamma-glutamate synthetase. Advances in Experimental Medicine and Biology.
629-634.
-
Stover, P., Huang, T., Schirch, V., Maras, B., Valiante, S., & Barra, D.
(1993).
Purification and properties of rabbit liver 5,10-methenyltetrahydrofolate synthetase. Advances in Experimental Medicine and Biology.
723-726.
-
Cynober, L., Bier, D. M., Stover, P., Kadowaki, M., Morris, S. M., Elango, R., & Smriga, M.
(2020).
Proposals for Upper Limits of Safe Intake for Methionine, Histidine, and Lysine in Healthy Humans. Journal of Nutrition.
2606S-2608S.
-
institutional repository document
-
Blank, H. M., Hammer, S. E., Boatright, L., Roberts, C., Heyden, K. E., Nagarajan, A., ... Polymenis, M.
(2024).
Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice
-
Blank, H. M., Hammer, S. E., Boatright, L., Roberts, C., Heyden, K. E., Nagarajan, A., ... Polymenis, M.
(2024).
Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- GENE491 Hnr-research Instructor
- NUTR491 Hnr-research Instructor
Background
education and training
- Ph.D. in Biochemistry & Molecular Biophysics, Virginia Commonwealth University - (Richmond, Virginia, United States) 1990
- B.S. in Chemistry, Saint Joseph's University - (Philadelphia, Pennsylvania, United States) 1986
awards and honors
- W.O. Atwater Memorial Lecturer, conferred by United States Department of Agriculture - (Washington D.C., District of Columbia, United States), 2023
- Members/Foreign Associates, conferred by National Academy of Sciences - (Washington D.C., District of Columbia, United States), 2016
- Osborne and Mendel Award, conferred by American Society for Nutrition - (Bethesda, Maryland, United States), 2014
Contact
first name
- Patrick
has last name
- Stover
mailing address
-
Texas A&M AgriLife Research
Vice Chancellor of Agriculture - Management
2147 TAMUS
College Station, TX 77843-2147
USA
Other
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- patrick.stover@tamu.edu