Consensus Measures of Diet for Genomewide Association Studies of GeneNutrient Interactions in Health and Disease Academic Article uri icon

abstract

  • Genenutrient interactions influence risk for initiation and progression of some common chronic diseases. Genomewide association studies (GWAS) permit comprehensive identification of genetic variation that interacts with dietary components to confer risk or protective phenotypes. Data pooling is essential to achieve statistical power to identify and confirm genediet associations. Therefore GWAS require replication in multiple populations, but such approaches are often hindered by lack of consistency in quantifying dietary exposures and nutritional status among studies, including choice of measures and methodologies. The PhenX (consensus measures for Phenotypes and eXposures) was initiated to enhance crossstudy analyses of GWAS and largescale genomic research through definition standardization of disease phenotypes, risk factors, and environmental exposures. The PhenX "Nutrition and Dietary Supplements" Working Group finalized measures and protocols to be recommended to the research community will be available in the PhenX Toolkit (http://www.phenx.org). This will enable comparability and replication of GWAS studies to investigate genenutrient interactions.

published proceedings

  • The FASEB Journal

author list (cited authors)

  • Stover, P. J., Ordovas, J. M., McCalla, A., Hammond, J., Maiese, D., Wagner, D., Hamilton, C. M., & Ramos, E.

citation count

  • 0

complete list of authors

  • Stover, Patick J||Ordovas, Jose M||McCalla, Anne‐Lyne||Hammond, Jane||Maiese, Debbie||Wagner, Diane||Hamilton, Carol M||Ramos, Erin

publication date

  • April 2009

publisher