Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies. Academic Article

abstract

• Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability and chromatin methylation, and result from nutritional deficiencies and common gene variants. The mechanisms underlying folate-associated pathologies and developmental anomalies have yet to be established. This review focuses on the relationships among folate-mediated 1-carbon metabolism, chromatin methylation and human disease, and the role of gene-nutrient interactions in modifying epigenetic processes.

authors

• Stover, Patrick

published proceedings

• J Nutrigenet Nutrigenomics

altmetric score

• 0.5

author list (cited authors)

• Stover, P. J.

citation count

• 82

complete list of authors

• Stover, Patrick J

publication date

• January 2011

publisher

• Karger Publishers  Publisher

published in

• Journal of Nutrigenetics and Nutrigenomics  Journal

keywords

• Alleles
• Animals
• Carbon
• Chromatin
• DNA Methylation
• Dna Modification Methylases
• Epigenomics
• Folic Acid
• Genetic Variation
• Homocysteine
• Humans
• Mitochondria
• Models, Biological
• Nutritional Sciences
• Polymorphism, Genetic
• Vitamin B Complex

PubMed Central ID

• 22353665

Digital Object Identifier (DOI)

• 10.1159/000334586

start page

• 293

end page

• 305

volume

• 4

issue

• 5