Sensitizing cancer cells: is it really all about U? Academic Article

abstract

• In this issue of Cancer Cell, Hu et al. report that TMPK and RNR, two key enzymes in deoxyribonucleotide biosynthesis, co-localize to damaged DNA and produce nucleotides necessary for DNA repair while suppressing uracil incorporation. TMPK inhibition disrupts this balance and selectively sensitizes cancer cells to low-dose chemotherapy.

authors

• Stover, Patrick

published proceedings

• Cancer Cell

altmetric score

• 1

author list (cited authors)

• Stover, P. J., & Weiss, R. S.

citation count

• 8

complete list of authors

• Stover, Patrick J||Weiss, Robert S

publication date

• July 2012

publisher

• Elsevier  Publisher

published in

• Cancer Cell  Journal

keywords

• 31 Biological Sciences
• 32 Biomedical And Clinical Sciences
• 3211 Oncology And Carcinogenesis
• Cancer
• Genetics

PubMed Central ID

• 22789532

Digital Object Identifier (DOI)

• 10.1016/j.ccr.2012.06.010

start page

• 3

end page

• 4

volume

• 22

issue

• 1

URL

• http://dx.doi.org/10.1016/j.ccr.2012.06.010