The Roles of SUMO in Metabolic Regulation. Academic Article

abstract

• Protein modification with the small ubiquitin-related modifier (SUMO) can affect protein function, enzyme activity, protein-protein interactions, protein stability, protein targeting and cellular localization. SUMO influences the function and regulation of metabolic enzymes within pathways, and in some cases targets entire metabolic pathways by affecting the activity of transcription factors or by facilitating the translocation of entire metabolic pathways to subcellular compartments. SUMO modification is also a key component of nutrient- and metabolic-sensing mechanisms that regulate cellular metabolism. In addition to its established roles in maintaining metabolic homeostasis, there is increasing evidence that SUMO is a key factor in facilitating cellular stress responses through the regulation and/or adaptation of the most fundamental metabolic processes, including energy and nucleotide metabolism. This review focuses on the role of SUMO in cellular metabolism and metabolic disease.

authors

• Stover, Patrick

published proceedings

• Adv Exp Med Biol

altmetric score

• 4.5

author list (cited authors)

• Kamynina, E., & Stover, P. J.

citation count

• 15

complete list of authors

• Kamynina, Elena||Stover, Patrick J

publication date

• February 2017

publisher

• Springer Nature  Publisher

published in

• Advances in Experimental Medicine and Biology  Journal

keywords

• Animals
• Energy Metabolism
• Homeostasis
• Humans
• Lipids
• METABOLISM
• Metabolic Disease
• Mitochondria
• One-carbon Metabolism
• SUMO
• Signal Transduction
• Small Ubiquitin-Related Modifier Proteins
• Stress, Physiological
• Sumoylation
• Ubiquitin-Protein Ligases

PubMed Central ID

• 28197911

Digital Object Identifier (DOI)

• 10.1007/978-3-319-50044-7_9

start page

• 143

end page

• 168

volume

• 963

URL

• http://dx.doi.org/10.1007/978-3-319-50044-7_9