HR job title
- Associate Professor
- Contact Info
- 1 979 845 3361
- Websites
Wu, Hung-Jen Associate Professor
Positions
- Associate Professor, Chemical Engineering, College of Engineering
Dr. Wu uses nanostructured materials and analytical tools to develop diagnostic techniques for medical applications. His laboratory recently focuses on understanding the influences of multivalency and cell membrane environment on pathogen-host cell recognition. The applications of his techniques include, infectious diseases screening, exploring cell membrane function, and targeted drug delivery.
- Overview
- Publications
- Research
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- Works By Students
- Background
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Overview
Publications
selected publications
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academic article
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Hu, Q., Kuai, D., Park, H., Clark, H., Balbuena, P. B., Kwon, J. S., & Wu, H.
(2023).
Advancing Glycan Analysis: A New Platform Integrating SERS, Boronic Acids, and Machine Learning Algorithms. 2(12),
-
Singla, A., Simbassa, S. B., Chirra, B., Gairola, A., Southerland, M. R., Shah, K. N., ... Cannon, C. L.
(2022).
Hetero-Multivalent Targeted Liposomal Drug Delivery to Treat Pseudomonas aeruginosa Infections. ACS Applied Materials & Interfaces.
14(36), 40724-40737.
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Rajil, N., Esmaeili, S., Neuman, B. W., Nessler, R., Wu, H., Yi, Z., ... Scully, M. O.
(2022).
Quantum optical immunoassay: upconversion nanoparticle-based neutralizing assay for COVID-19. Scientific Reports.
12(1), 1263.
-
Lai, W., Mu, H., Lu, Y., Chen, H., Wen, J., Wu, H., Cheng, C., & Huang, J.
(2022).
Dual-cell culture system with identical culture environment for comparison of anti-cancer drug toxicity. Chemical Engineering Science.
253, 117555-117555.
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Gairola, A., Benjamin, A., Weatherston, J. D., Cirillo, J. D., & Wu, H.
(2022).
Recent Developments in Drug Delivery for Treatment of Tuberculosis by Targeting Macrophages. Advanced Therapeutics.
5(6), 2100193-2100193.
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Lee, D., Green, A., Wu, H., & Kwon, J.
(2021).
Hybrid PDE-kMC modeling approach to simulate multivalent lectin-glycan binding process. AIChE Journal.
67(12),
-
Choi, H., Lee, D., Singla, A., Kwon, J., & Wu, H.
(2019).
The influence of heteromultivalency on lectin-glycan binding behavior. GLYCOBIOLOGY.
29(5), 397-408.
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Godara, A., Rodriguez, M., Weatherston, J. D., Peabody, G. L., Wu, H., & Kao, K. C.
(2019).
Beneficial mutations for carotenoid production identified from laboratory-evolved Saccharomyces cerevisiae. 46(12), 1793-1804.
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Worstell, N. C., Singla, A., & Wu, H.
(2019).
Evaluation of hetero-multivalent lectin binding using a turbidity-based emulsion agglutination assay. Colloids and Surfaces B: Biointerfaces.
175, 84-90.
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Weatherston, J. D., Yuan, S., Mashuga, C. V., & Wu, H.
(2019).
Multi-functional SERS substrate: collection, separation, and identification of airborne chemical powders on a single device. Sensors and Actuators, B: Chemical.
297, 126765-126765.
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Lee, D., Singla, A., Wu, H., & Kwon, J.
(2018).
An Integrated Numerical and Experimental Framework for Modeling of CTB and GD1b Ganglioside Binding Kinetics. AIChE Journal.
64(11), 3882-3893.
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Lee, D., Mohr, A., Kwon, J., & Wu, H.
(2018).
Kinetic Monte Carlo modeling of multivalent binding of CTB proteins with GM1 receptors. Computers and Chemical Engineering.
118, 283-295.
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Worstell, N. C., Singla, A., Saenkham, P., Galbadage, T., Sule, P., Lee, D., ... Wu, H.
(2018).
Hetero-Multivalency of Pseudomonas aeruginosa Lectin LecA Binding to Model Membranes. Scientific Reports.
8(1), 8419.
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Weatherston, J. D., Seguban, R., Hunt, D., & Wu, H.
(2018).
Low-Cost and Simple Fabrication of Nanoplasmonic Paper for Coupled Chromatography Separation and Surface Enhanced Raman Detection. ACS Sensors.
3(4), 852-857.
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Contreras-Naranjo, J. C., Wu, H., & Ugaz, V. M.
(2017).
Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine. Lab on a Chip.
17(21), 3558-3577.
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Rimm, D. L., Han, G., Taube, J. M., Yi, E. S., Bridge, J. A., Flieder, D. B., ... Wistuba, I. I.
(2017).
A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung Cancer. JAMA Oncology.
3(8), 1051-1058.
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Huang, A., Wu, H., Iriyama, T., Zhang, Y., Sun, K., Song, A., ... Xia, Y.
(2017).
Elevated Adenosine Induces Placental DNA Hypomethylation Independent of A2B Receptor Signaling in Preeclampsia. HYPERTENSION.
70(1), 209-218.
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Yang, J., Wu, H., Li, Y., Zhang, X., & Darensbourg, D. J.
(2017).
Perfectly Alternating and Regioselective Copolymerization of Carbonyl Sulfide and Epoxides by Metal-Free Lewis Pairs. Angewandte Chemie International Edition.
56(21), 5774-5779.
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Liu, C., Zhao, Z., Fan, J., Lyon, C. J., Wu, H., Nedelkov, D., ... Hu, Y. e.
(2017).
Quantification of circulating Mycobacterium tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment monitoring. Proceedings of the National Academy of Sciences of the United States of America.
114(15), 3969-3974.
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Shanmugarajan, S., Zhang, Y. e., Moreno-Villanueva, M., Clanton, R., Rohde, L. H., Ramesh, G. T., Sibonga, J. D., & Wu, H.
(2017).
Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion. International Journal of Molecular Sciences.
18(11), 2443-2443.
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Krishnan, P., Singla, A., Lee, C., Weatherston, J. D., Worstell, N. C., & Wu, H.
(2017).
Hetero-multivalent binding of cholera toxin subunit B with glycolipid mixtures. Colloids and Surfaces B: Biointerfaces.
160, 281-288.
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Hong, C., Ning, Y., Wang, S., Wu, H., Carroll, R. J., & Chen, Y.
(2017).
PLMET: A Novel Pseudolikelihood-Based EM Test for Homogeneity in Generalilzed Exponential Tilt Mixture Models. JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION.
112(520), 1393-1404.
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Xu, Y., Qin, L., Sun, T., Wu, H., He, T., Yang, Z., ... Xu, J.
(2017).
Twist1 promotes breast cancer invasion and metastasis by silencing Foxa1 expression. Oncogene.
36(8), 1157-1166.
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Zhou, Q., Hou, Y., Zhang, L. i., Wang, J., Qiao, Y., Guo, S., ... Wu, H.
(2017).
Dual-pH Sensitive Charge-reversal Nanocomplex for Tumor-targeted Drug Delivery with Enhanced Anticancer Activity. Theranostics.
7(7), 1806-1819.
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Weatherston, J. D., Worstell, N. C., & Wu, H.
(2016).
Quantitative surface-enhanced Raman spectroscopy for kinetic analysis of aldol condensation using Ag-Au core-shell nanocubes. The Analyst.
141(21), 6051-6060.
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Yang, T., Li, W., Duan, X., Zhu, L., Fan, L. i., Qiao, Y., & Wu, H.
(2016).
Preparation of Two Types of Polymeric Micelles Based on Poly(-L-Malic Acid) for Antitumor Drug Delivery. PLoS ONE.
11(9), e0162607-e0162607.
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Worstell, N. C., Krishnan, P., Weatherston, J. D., & Wu, H.
(2016).
Binding Cooperativity Matters: A GM1-Like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array. PLoS ONE.
11(4), e0153265-e0153265.
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Zhou, Q., Yang, T., Qiao, Y., Guo, S., Zhu, L., & Wu, H.
(2015).
Preparation of poly(-L-malic acid)-based charge-conversional nanoconjugates for tumor-specific uptake and cellular delivery. 10(1), 1941-1952.
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Pan, H., Cui, H., Liu, S., Qian, Y. u., Wu, H., Li, L., ... Li, D.
(2014).
Lgr4 gene regulates corpus luteum maturation through modulation of the WNT-mediated EGFR-ERK signaling pathway. ENDOCRINOLOGY.
155(9), 3624-3637.
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Iversen, L., Tu, H., Lin, W., Christensen, S. M., Abel, S. M., Iwig, J., ... Groves, J. T.
(2014).
Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics. Science.
345(6192), 50-54.
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Morgan, J., Ritchie, L. E., Crucian, B. E., Theriot, C., Wu, H., Sams, C., ... Zwart, S. R.
(2014).
Increased dietary iron and radiation in rats promote oxidative stress, induce localized and systemic immune system responses, and alter colon mucosal environment. The FASEB Journal.
28(3), 1486-1498.
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Wu, H., Li, Y., Fan, J., Deng, Z., Hu, Z., Liu, X., ... Hu, Y. e.
(2014).
Antibody-free detection of Mycobacterium tuberculosis antigen using customized nanotraps. Analytical Chemistry.
86(4), 1988-1996.
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Fan, J., Niu, S., Dong, A., Shi, J., Wu, H., Fine, D. H., ... Zhao, Y.
(2014).
Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids. Nanomedicine: Nanotechnology, Biology and Medicine.
10(5), 879-888.
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Zhang, Y. e., Uhlemeyer, J., Hada, M., Asaithamby, A., Chen, D. J., & Wu, H.
(2014).
Proximity within interphase chromosome contributes to the breakpoint distribution in radiation-induced intrachromosomal exchanges. Life Sciences in Space Research.
2, 23-28.
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Wang, Z., Wu, H., Fine, D., Schmulen, J., Hu, Y. e., Godin, B., Zhang, J., & Liu, X.
(2013).
Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles. Lab on a Chip.
13(15), 2879-2882.
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Fine, D., Grattoni, A., Goodall, R., Bansal, S. S., Chiappini, C., Hosali, S., ... Ferrari, M.
(2013).
Silicon micro- and nanofabrication for medicine. Advanced healthcare materials.
2(5), 632-666.
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Fan, J., Huang, Y. i., Finoulst, I., Wu, H., Deng, Z., Xu, R., ... Hu, Y. e.
(2013).
Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay. Cancer Letters.
334(2), 202-210.
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Fan, J., Gallagher, J. W., Wu, H. J., Landry, M. G., Sakamoto, J., Ferrari, M., & Hu, Y.
(2012).
Low molecular weight protein enrichment on mesoporous silica thin films for biomarker discovery. Journal of Visualized Experiments.
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Smoligovets, A. A., Smith, A. W., Wu, H., Petit, R. S., & Groves, J. T.
(2012).
Characterization of dynamic actin associations with T-cell receptor microclusters in primary T cells. Journal of Cell Science.
125(Pt 3), 735-742.
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Yu, Y., Fay, N. C., Smoligovets, A. A., Wu, H., & Groves, J. T.
(2012).
Myosin IIA modulates T cell receptor transport and CasL phosphorylation during early immunological synapse formation. PLoS ONE.
7(2), e30704-e30704.
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Fan, J., Gallagher, J. W., Wu, H., Landry, M. G., Sakamoto, J., Ferrari, M., & Hu, Y. e.
(2012).
Low molecular weight protein enrichment on mesoporous silica thin films for biomarker discovery. Journal of Visualized Experiments.
3876.
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Wu, H., Henzie, J., Lin, W., Rhodes, C., Li, Z., Sartorel, E., ... Groves, J. T.
(2012).
Membrane-protein binding measured with solution-phase plasmonic nanocube sensors. Nature Methods.
9(12), 1189-1191.
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Chen, L., Wu, H., Pochynyuk, O. M., Reisenauer, M. R., Zhang, Z., Huang, L. e., ... Zhang, W.
(2011).
Af17 deficiency increases sodium excretion and decreases blood pressure. Journal of the American Society of Nephrology.
22(6), 1076-1086.
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George, M. W., Hall, M. B., Jina, O. S., Portius, P., Sun, X., Towrie, M., ... Zaric, S. D.
(2010).
Understanding the factors affecting the activation of alkane by Cp'Rh(CO)2 (Cp' = Cp or Cp*). Proceedings of the National Academy of Sciences of the United States of America.
107(47), 20178-20183.
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Yu, C., Wu, H., Kaizuka, Y., Vale, R. D., & Groves, J. T.
(2010).
Altered actin centripetal retrograde flow in physically restricted immunological synapses. PLoS ONE.
5(7), e11878-e11878.
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Wu, H., & Hall, M. B.
(2009).
Kinetic C-H oxidative addition vs thermodynamic C-X oxidative addition of chlorobenzene by a neutral Rh(I) system. A density functional theory study. The Journal of Physical Chemistry A: Isolated Molecules, Clusters, Radicals, and Ions; Environmental Chemistry, Geochemistry, and Astrochemistry; Theory.
113(43), 11706-11712.
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Gomez, E. W., Clack, N. G., Wu, H., & Groves, J. T.
(2009).
Like-charge interactions between colloidal particles are asymmetric with respect to sign. SOFT MATTER.
5(9), 1931-1936.
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Chen, Y., Wu, H., Wang, S., Koito, H., Li, J., Ye, F., ... Lu, Q. R.
(2009).
The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nature Neuroscience.
12(11), 1398-1406.
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Wu, H., Shah, S., Beckham, R., Meissner, K. E., & Bevan, M. A.
(2008).
Resonant effects in evanescent wave scattering of polydisperse colloids. Langmuir.
24(23), 13790-13795.
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Wu, H., & Hall, M. B.
(2008).
Density functional theory on the larger active site models for [NiFe] hydrogenases: Two-state reactivity?. 11(8), 790-804.
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Everett, W. N., Wu, H., Anekal, S. G., Sue, H., & Bevan, M. A.
(2007).
Diffusing colloidal probes of protein and synthetic macromolecule interactions. Biophysical Journal.
92(3), 1005-1013.
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Wu, H., & Hall, M. B.
(2007).
INOR 1058-Kinetic C-H oxidative addition vs. thermodynamic C-X oxidative addition to Ir(I) and Rh(I) systems: A density functional theory study. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
233, 226-226.
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Wu, H., Everett, W. N., Anekal, S. G., & Bevan, M. A.
(2006).
Mapping patterned potential energy landscapes with diffusing colloidal probes. Langmuir.
22(16), 6826-6836.
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Wu, H., Pangburn, T. O., Beckham, R. E., & Bevan, M. A.
(2005).
Measurement and interpretation of particle-particle and particle-wall interactions in levitated colloidal ensembles. Langmuir.
21(22), 9879-9888.
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Wu, H., & Bevan, M. A.
(2005).
Direct measurement of single and ensemble average particle-surface potential energy profiles. Langmuir.
21(4), 1244-1254.
-
Hwang, K., Wu, H., & Bevan, M. A.
(2004).
Specific ion-dependent attraction and phase behavior of polymer-coated colloids. Langmuir.
20(26), 11393-11401.
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Wu, H. L., Zhao, C. X., & Liang, H.
(2004).
Comparison of linear, nonlinear and semiparametric mixed-effects models for estimating HIV dynamic parameters. Biometrical Journal.
46(2), 233-245.
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Hu, Q., Kuai, D., Park, H., Clark, H., Balbuena, P. B., Kwon, J. S., & Wu, H.
(2023).
Advancing Glycan Analysis: A New Platform Integrating SERS, Boronic Acids, and Machine Learning Algorithms. 2(12),
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book
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Wu, H., & Swearingen, C. J.
(2016).
Guiguzi, China's first treatise on rhetoric: A critical translation and commentary
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Wu, H., & Swearingen, C. J.
(2016).
Guiguzi, China's first treatise on rhetoric: A critical translation and commentary
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chapter
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Lee, D., Mohr, A., Kwon, J., Wu, H., & Singla, A.
(2018).
Stochastic Modelling of CTB-receptor Binding Kinetics. Computer Aided Chemical Engineering.
13th International Symposium on Process Systems Engineering (PSE 2018).
(pp. 2143-2148).
Elsevier.
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Lee, D., Mohr, A., Kwon, J., Wu, H., & Singla, A.
(2018).
Stochastic Modelling of CTB-receptor Binding Kinetics. Computer Aided Chemical Engineering.
13th International Symposium on Process Systems Engineering (PSE 2018).
(pp. 2143-2148).
Elsevier.
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conference paper
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Hu, Q., Park, H., Kuai, D., Kwon, J., Balbuena, P., & Wu, H.
(2022).
Glycan detection based on Surface-enhanced Raman scattering and machine learning. GLYCOBIOLOGY.
994-994.
-
Wu, H., Singla, A., Kwon, J. S., Choi, H., & Lee, D.
(2020).
Hetero-Multivalent Binding of Lectin to Glycans on Cell Membranes. Biophysical Journal.
383A-383A.
-
Wu, H., Kwon, J. S., Choi, H., Singla, A., & Lee, D.
(2018).
The role of multivalency and surface diffusion of glycolipid in lectin-glycolipid recognition. GLYCOBIOLOGY.
1065-1066.
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Lee, D., Singla, A., Wu, H., & Kwon, J.
(2018).
Dynamic Modeling of Binding Kinetics Between GD1b Ganglioside and Cholera Toxin Subunit B. Proceedings of the ... American Control Conference. American Control Conference.
1999-2004.
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Singla, A., Worstell, N. C., Saenkham, P., Galbadage, T., Sule, P., Shah, K., ... Wu, H.
(2018).
A new way to target bacteria: Hetero-multivalent binding of glycolipids to Pseudomonas aeruginosa. GLYCOBIOLOGY.
1061-1062.
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Wu, H., Krishnan, P., Singla, A., Worstell, N. C., Weatherston, J. D., & Lee, C.
(2016).
Cholera Toxin subunit B binding to heterogeneous gangliosides on cell mimicking surfaces. GLYCOBIOLOGY.
1462-1462.
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Xu, Y., Feng, Z., Xu, Y., Mo, Q., Qin, L., Sun, T., ... Xu, J.
(2016).
TWIST1 silences FOXA1 transcription to promote breast cancer progression. Cancer Research.
p2-05-23-p2-05-23.
-
Wu, H., Liu, L., Zhang, X. i., & Ma, H.
(2016).
Quality of Video Oriented Pricing Incentive for Mobile Video Offloading. IEEE Infocom. Proceedings.
1-9.
-
Wu, H., Zirakzadeh, H., Han, J., Zhang, L., & Moon, H.
(2015).
HEAT TRANSFER IN A RIB AND PIN ROUGHENED ROTATING MULTI-PASS CHANNEL WITH HUB TURNING VANE AND TRAILING-EDGE SLOT EJECTION. v05at11a007-v05at11a007.
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Wu, H., Chirayath, S. S., & Hassan, Y. A.
(2013).
Generation of view factors for RELAP5 using MCNP. Transactions of the American Nuclear Society.
1703-1706.
-
Wang, Y., Wu, H., Wu, J., Zhao, H., Zhang, X., Mues, G., ... Kapadia, H.
(2009).
Identification and functional analysis of two novel PAX9 mutations. Cells, Tissues, Organs: in vivo, in vitro.
80-87.
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Bevan, M. A., Wu, H. J., & Everett, W. N.
(2005).
Direct measurement of multi-dimensional and multi-body colloidal and surface interactions. 1327.
-
Wu, H. J., Everett, W. N., & Bevan, M. A.
(2005).
Mapping potential energy landscapes on patterned surfaces using diffusing colloidal probe microscopy. 1158.
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Smith, D., Visintin, A., Zhang, W. L., Srinivasan, S., Anani, A., & Wu, H.
(1997).
Enhancement of rate capability of a MHx electrode by Pd coating of active material. 247-256.
-
Chang, C. C., Wu, H. H., Liu, J. C., & Chui, C. K.
(1997).
The wavelet-frame-based microcalcification detection. Proceedings of SPIE.
349-356.
-
Hu, Q., Park, H., Kuai, D., Kwon, J., Balbuena, P., & Wu, H.
(2022).
Glycan detection based on Surface-enhanced Raman scattering and machine learning. GLYCOBIOLOGY.
994-994.
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institutional repository document
Research
principal investigator on
- Design of hetero-multivalent targeted liposome for combating intracellular Mycobacterium tuberculosis awarded by National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States) 2020 - 2022
- A New Tool for the Analysis of Glycan Recognition in Lectin awarded by National Science Foundation - (Arlington, Virginia, United States) 2019 - 2022
- Study the Interaction Between Lipopolysaccharide-Binding Protein and Immune Cell Membranes awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2021
- Microvesicle Isolation from Mycobacterium Tuberculosis Infected Macrophage using Multi-stage Microfluidic Channel awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2014 - 2018
Teaching
teaching activities
- CHEN304 Chem Engr Fluid Ops Instructor
- CHEN313 Chem Engr Materials Instructor
- CHEN320 Chen Analysis Instructor
- CHEN481 Seminar Instructor
- CHEN489 Sptp: Chem & Biol Sensors Instructor
- CHEN489 Sptp: Chem Biol Sensors Instructor
- CHEN491 Hnr-research Instructor
- CHEN604 Chen Process Analy I Instructor
- CHEN681 Seminar Instructor
- CHEN684 Prof Internship: In-ab Instructor
- CHEN684 Professional Internship Instructor
- CHEN685 Directed Studies Instructor
- CHEN689 Sptp: Chem & Biol Sensors Instructor
- CHEN689 Sptp: Chem Biol Sensors Instructor
- CHEN691 Research Instructor
- CHEN695 Grad Mentoring Seminar I Instructor
- ENGR491 Hnr-research Instructor
Works By Students
chaired theses and dissertations
-
Krishnan, Pratik (2016-07). Quantifying Cooperative Binding of Cholera Toxin B with Gangliosides.
Background
education and training
- Ph.D. in Chemical Engineering, Texas A&M University - (College Station, Texas, United States) 2006
Contact
first name
- Hung-Jen
has last name
- Wu
mailing address
-
Texas A&M University
Chemical Engineering
3122 TAMU
College Station, TX 77843-3122
USA
Other
- hjwu@tamu.edu