Low-Cost and Simple Fabrication of Nanoplasmonic Paper for Coupled Chromatography Separation and Surface Enhanced Raman Detection. Academic Article uri icon


  • Surface-enhanced Raman scattering (SERS) is a powerful analytical tool which enables the detection and identification of analytes adsorbed on nanostructured noble metals. However, SERS analysis of complex mixtures can be challenging due to spectral overlap and interference. In this report, we demonstrate a method to simplify the identification of mixed-analyte samples by coupling SERS detection with chromatographic separation on a nanoplasmonic paper substrate. This "nanopaper" substrate is a silver coated glass microfiber filter paper which possesses large SERS enhancement and can serve as a stationary phase in paper chromatography. Nanopaper is easily synthesized using the silver mirror reaction, making it a highly accessible technology. Nanopaper was successfully used as a combined paper chromatography-SERS (PC-SERS) substrate in the separation and identification of mixed organic dyes. It was further employed to separate and identify lycopene and -carotene in commercial food products, demonstrating the versatility and utility of nanopaper in the identification of complex mixtures.

published proceedings

  • ACS Sens

altmetric score

  • 1

author list (cited authors)

  • Weatherston, J. D., Seguban, R., Hunt, D., & Wu, H.

citation count

  • 23

complete list of authors

  • Weatherston, Joshua D||Seguban, Ricci Kirsten O||Hunt, Dawson||Wu, Hung-Jen

publication date

  • April 2018