Kinetic C−H Oxidative Addition vs Thermodynamic C−X Oxidative Addition of Chlorobenzene by a Neutral Rh(I) System. A Density Functional Theory Study Academic Article uri icon


  • Density functional theory (DFT) is used to explore competitive C-H and C-Cl oxidative additions (OA) of chlorobenzene by the neutral Rh(I) complex: (PNP)Rh(I) [PNP = bis(Z-2-(dimethylphosphino)vinyl)amino]. Consistent with experimental results, our calculation shows that C-Cl OA (DeltaG(double dagger) = 16.0 kcal x mol(-1)) is kinetically competitive with C-H OA (DeltaG(double dagger) = 16.7 kcal x mol(-1)) and that the C-Cl OA is thermodynamically preferred by 28.3 kcal x mol(-1) over the most stable C-H OA product. Hence, the only experimentally observed product was from C-Cl OA.

author list (cited authors)

  • Wu, H., & Hall, M. B.

publication date

  • January 1, 2009 11:11 AM