HR job title
- Professor
- Contact Info
- 1 979 862 3099
Hilty, Christian Professor
Positions
- Professor, Chemistry, College of Arts and Sciences
We are developing and applying Magnetic resonance techniques for the investigation of rapid processes and molecular dynamics. Hyperpolarization of nuclear spins yields unprecedented levels of signal, which enables us to acquire NMR spectra of reactions as they occur, in real time. Applications of these techniques include the fields of enzyme catalysis, reactions in organic chemistry, polymers, and more.
To enable the use of hyperpolarization in NMR, we develop new hardware and specially adapted NMR experiments, and investigate the dynamics of hyperpolarized spin systems.
Hand-in-hand with hyperpolarization, we use modern multi-dimensional NMR for the investigation of basic determinants of protein structure and function, including of membrane proteins.
To enable the use of hyperpolarization in NMR, we develop new hardware and specially adapted NMR experiments, and investigate the dynamics of hyperpolarized spin systems.
Hand-in-hand with hyperpolarization, we use modern multi-dimensional NMR for the investigation of basic determinants of protein structure and function, including of membrane proteins.
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Overview
Publications
selected publications
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academic article
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Pham, P., & Hilty, C.
(2023).
Biomolecular interactions studied by low-field NMR using SABRE hyperpolarization. Chemical Science.
14(37), 10258-10263.
-
Hu, J., Kim, J., & Hilty, C.
(2022).
Detection of Protein-Ligand Interactions by 19F Nuclear Magnetic Resonance Using Hyperpolarized Water. Journal of Physical Chemistry Letters.
13(17), 3819-3823.
-
Hilty, C., Kurzbach, D., & Frydman, L.
(2022).
Hyperpolarized water as universal sensitivity booster in biomolecular NMR. Nature Protocols.
17(7), 1621-1657.
-
Jaroszewicz, M. J., Liu, M., Kim, J., Zhang, G., Kim, Y., Hilty, C., & Frydman, L.
(2022).
Time- and site-resolved kinetic NMR for real-time monitoring of off-equilibrium reactions by 2D spectrotemporal correlations. Nature Communications.
13(1), 833.
-
Kim, Y., Samouei, H., & Hilty, C.
(2021).
Polyolefin catalysis of propene, 1-butene and isobutene monitored using hyperpolarized NMR. Chemical Science.
12(8), 2823-2828.
-
Kim, J., Mandal, R., & Hilty, C.
(2021).
2D NMR spectroscopy of refolding RNase Sa using polarization transfer from hyperpolarized water. Journal of Magnetic Resonance.
326, 106942-106942.
-
Mandal, R., Pham, P., & Hilty, C.
(2021).
Characterization of protein-ligand interactions by SABRE. Chemical Science.
12(39), 12950-12958.
-
Wang, Y., & Hilty, C.
(2020).
Amplification of Nuclear Overhauser Effect Signals by Hyperpolarization for Screening of Ligand Binding to Immobilized Target Proteins. Analytical Chemistry.
92(20), 13718-13723.
-
Kim, J., Mandal, R., & Hilty, C.
(2020).
Characterization of Membrane Protein-Lipid Interactions in Unfolded OmpX with Enhanced Time Resolution by Hyperpolarized NMR. ChemBioChem.
21(19), 2861-2867.
-
Wang, Y., Kim, J., & Hilty, C.
(2020).
Determination of protein-ligand binding modes using fast multi-dimensional NMR with hyperpolarization. Chemical Science.
11(23), 5935-5943.
-
Kim, J., Kim, Y., Luu, Q. S., Kim, J., Qi, C., Hilty, C., & Lee, Y.
(2020).
Indirect detection of intermediate in decarboxylation reaction of phenylglyoxylic acid by hyperpolarized 13C NMR. Chemical Communications.
56(95), 15000-15003.
-
Wang, Y., & Hilty, C.
(2019).
Determination of Ligand Binding Epitope Structures Using Polarization Transfer from Hyperpolarized Ligands. Journal of Medicinal Chemistry.
62(5), 2419-2427.
-
Kim, J., Mandal, R., & Hilty, C.
(2019).
Observation of Fast Two-Dimensional NMR Spectra during Protein Folding Using Polarization Transfer from Hyperpolarized Water. Journal of Physical Chemistry Letters.
10(18), 5463-5467.
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Kim, Y., Chen, C., & Hilty, C.
(2018).
Direct observation of Ru-alkylidene forming into ethylene in ring-closing metathesis from hyperpolarized 1 H NMR. Chemical Communications.
54(34), 4333-4336.
-
Zhang, G., & Hilty, C.
(2018).
Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry. Magnetic Resonance in Chemistry.
56(7), 566-582.
-
Kim, Y., Liu, M., & Hilty, C.
(2018).
Determination of binding affinities using hyperpolarized NMR with simultaneous 4-channel detection. Journal of Magnetic Resonance.
295, 80-86.
-
Chen, C., Wang, Y., & Hilty, C.
(2018).
Intermolecular interactions determined by NOE build-up in macromolecules from hyperpolarized small molecules. Methods.
138-139, 69-75.
-
Liu, M., Kim, Y., & Hilty, C.
(2017).
Characterization of Chemical Exchange Using Relaxation Dispersion of Hyperpolarized Nuclear Spins. Analytical Chemistry.
89(17), 9154-9158.
-
Liu, M., & Hilty, C.
(2017).
Metabolic Measurements of Nonpermeating Compounds in Live Cells Using Hyperpolarized NMR. Analytical Chemistry.
90(2), 1217-1222.
-
Kim, J., Liu, M., & Hilty, C.
(2017).
Modeling of Polarization Transfer Kinetics in Protein Hydration Using Hyperpolarized Water. The Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter.
121(27), 6492-6498.
-
Ragavan, M., Iconaru, L. I., Park, C., Kriwacki, R. W., & Hilty, C.
(2017).
Real-Time Analysis of Folding upon Binding of a Disordered Protein by Using Dissolution DNPNMR Spectroscopy. Angewandte Chemie International Edition.
56(25), 7070-7073.
-
Wang, Y., Ragavan, M., & Hilty, C.
(2016).
Site specific polarization transfer from a hyperpolarized ligand of dihydrofolate reductase. Journal of Biomolecular NMR.
65(1), 41-48.
-
Zhu, Y., Chen, C., Wilson, Z., Savukov, I., & Hilty, C.
(2016).
Milli-tesla NMR and spectrophotometry of liquids hyperpolarized by dissolution dynamic nuclear polarization. Journal of Magnetic Resonance.
270, 71-76.
-
Kim, Y., Liu, M., & Hilty, C.
(2016).
Parallelized Ligand Screening Using Dissolution Dynamic Nuclear Polarization. Analytical Chemistry.
88(22), 11178-11183.
-
Zhang, G., Schilling, F., Glaser, S. J., & Hilty, C.
(2016).
Reaction monitoring using hyperpolarized NMR with scaling of heteronuclear couplings by optimal tracking. Journal of Magnetic Resonance.
272, 123-128.
-
Rembert, K. B., Okur, H. I., Hilty, C., & Cremer, P. S.
(2015).
An NH moiety is not required for anion binding to amides in aqueous solution. Langmuir.
31(11), 3459-3464.
-
Chen, H., Kim, Y., Nath, P., & Hilty, C.
(2015).
An ultra-low cost NMR device with arbitrary pulse programming. Journal of Magnetic Resonance.
255, 100-105.
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Ardenkjaer-Larsen, J., Boebinger, G. S., Comment, A., Duckett, S., Edison, A. S., Engelke, F., ... Frydman, L
(2015).
Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy. Angewandte Chemie International Edition.
54(32), 9162-9185.
-
Chen, H., & Hilty, C
(2015).
Implementation and characterization of flow injection in dissolution dynamic nuclear polarization NMR spectroscopy. ChemPhysChem.
16(12), 2646-2652.
-
Chen, C., Shih, W., & Hilty, C.
(2015).
In Situ Determination of Tacticity, Deactivation, and Kinetics in [rac-(C2H4(1-Indenyl)2)ZrMe][B(C6F5)4] and [Cp2ZrMe][B(C6F5)4]-Catalyzed Polymerization of 1-Hexene Using (13)C Hyperpolarized NMR. Journal of the American Chemical Society.
137(21), 6965-6971.
-
Min, H., Sekar, G., & Hilty, C
(2015).
Polarization Transfer from Ligands Hyperpolarized by Dissolution Dynamic Nuclear Polarization for Screening in Drug Discovery. ChemMedChem: chemistry enabling drug discovery.
10(9), 1559-1563.
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Ahola, S., Zhivonitko, V. V., Mankinen, O., Zhang, G., Kantola, A. M., Chen, H., ... Telkki, V.
(2015).
Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis. Nature Communications.
6(1), 8363.
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Hladlkov, J., Heyda, J., Rembert, K. B., Okur, H. I., Kurra, Y., Liu, W. R., ... Jungwirth, P.
(2013).
Effects of End Group Termination on Salting-Out Constants for Triglycine. Journal of Physical Chemistry Letters.
4(23), 4069-4073.
-
Paterov, J., Rembert, K. B., Heyda, J., Kurra, Y., Okur, H. I., Liu, W. R., ... Jungwirth, P.
(2013).
Reversal of the hofmeister series: specific ion effects on peptides. The Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter.
117(27), 8150-8158.
-
Lee, Y., Heo, G. S., Zeng, H., Wooley, K. L., & Hilty, C.
(2013).
Detection of living anionic species in polymerization reactions using hyperpolarized NMR. Journal of the American Chemical Society.
135(12), 4636-4639.
-
Wang, Y., Fang, X., Chen, H., Wu, B. o., Wang, Z. U., Hilty, C., & Liu, W. R.
(2013).
Genetic incorporation of twelve meta-substituted phenylalanine derivatives using a single pyrrolysyl-tRNA synthetase mutant. ACS Chemical Biology.
8(2), 405-415.
-
Chen, H., & Hilty, C
(2013).
Hyperpolarized Hadamard spectroscopy using flow NMR. Analytical Chemistry.
85(15), 7385-7390.
-
Savukov, I. M., Chen, H., Karaulanov, T., & Hilty, C.
(2013).
Method for accurate measurements of nuclear-spin optical rotation for applications in correlated optical-NMR spectroscopy. Journal of Magnetic Resonance.
232, 31-38.
-
Chen, H., Ragavan, M., & Hilty, C
(2013).
Protein folding studied by dissolution dynamic nuclear polarization. Angewandte Chemie International Edition.
52(35), 9192-9195.
-
Lee, Y., Zeng, H., Mazur, A., Wegstroth, M., Carlomagno, T., Reese, M., ... Hilty, C.
(2012).
Hyperpolarized binding pocket nuclear Overhauser effect for determination of competitive ligand binding. Angewandte Chemie International Edition.
51(21), 5179-5182.
-
Lee, Y., Zeng, H., Ruedisser, S., Gossert, A. D., & Hilty, C
(2012).
Nuclear magnetic resonance of hyperpolarized fluorine for characterization of protein-ligand interactions. Journal of the American Chemical Society.
134(42), 17448-17451.
-
Hwang, S., Shao, Q., Williams, H., Hilty, C., & Gao, Y. Q.
(2011).
Methanol strengthens hydrogen bonds and weakens hydrophobic interactions in proteins--a combined molecular dynamics and NMR study. 115(20), 6653-6660.
-
Chen, H., Lee, Y., Bowen, S., & Hilty, C.
(2011).
Spontaneous emission of NMR signals in hyperpolarized proton spin systems. Journal of Magnetic Resonance.
208(2), 204-209.
-
Hwang, S., & Hilty, C.
(2011).
Folding of a tryptophan zipper peptide investigated on the basis of the nuclear Overhauser effect and thermal denaturation. The Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter.
115(51), 15355-15361.
-
Ragavan, M., Chen, H., Sekar, G., & Hilty, C
(2011).
Solution NMR of polypeptides hyperpolarized by dynamic nuclear polarization. Analytical Chemistry.
83(15), 6054-6059.
-
Choutko, A., Glttli, A., Fernndez, C., Hilty, C., Wthrich, K., & van Gunsteren, W. F.
(2011).
Membrane protein dynamics in different environments: simulation study of the outer membrane protein X in a lipid bilayer and in a micelle. European Biophysics Journal.
40(1), 39-58.
-
Hilty, C., & Bowen, S.
(2010).
An NMR Experiment Based on Off-the-Shelf Digital Data-Acquisition Equipment. Journal of Chemical Education.
87(7), 747-749.
-
Hilty, C., & Bowen, S
(2010).
Applications of dynamic nuclear polarization to the study of reactions and reagents in organic and biomolecular chemistry. Organic and Biomolecular Chemistry.
8(15), 3361-3365.
-
Zeng, H., Lee, Y., & Hilty, C
(2010).
Quantitative rate determination by dynamic nuclear polarization enhanced NMR of a Diels-Alder reaction. Analytical Chemistry.
82(21), 8897-8902.
-
Bowen, S., & Hilty, C
(2010).
Rapid sample injection for hyperpolarized NMR spectroscopy. Physical Chemistry Chemical Physics.
12(22), 5766-5770.
-
Zeng, H., Bowen, S., & Hilty, C.
(2009).
Sequentially acquired two-dimensional NMR spectra from hyperpolarized sample. Journal of Magnetic Resonance.
199(2), 159-165.
-
Lee, D., Walter, K., Brckner, A., Hilty, C., Becker, S., & Griesinger, C.
(2008).
Bilayer in small bicelles revealed by lipid-protein interactions using NMR spectroscopy. Journal of the American Chemical Society.
130(42), 13822-13823.
-
Bowen, S., Zeng, H., & Hilty, C
(2008).
Chemical shift correlations from hyperpolarized NMR by off-resonance decoupling. Analytical Chemistry.
80(15), 5794-5798.
-
Verpillat, F., Ledbetter, M. P., Xu, S., Michalak, D. J., Hilty, C., Bouchard, L., ... Pines, A
(2008).
Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor. Proceedings of the National Academy of Sciences of the United States of America.
105(7), 2271-2273.
-
Harel, E., Hilty, C., Koen, K., McDonnell, E. E., & Pines, A.
(2007).
Time-of-flight flow imaging of two-component flow inside a microfluidic chip. Physical Review Letters.
98(1), 017601.
-
Batteas, J. D., Cremer, P. S., Gaede, H. C., Hilty, C., North, S. W., & Son, D. H.
(2007).
Assessment of reforms in the physical chemistry laboratory. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
234.
-
Schrder, L., Lowery, T. J., Hilty, C., Wemmer, D. E., & Pines, A.
(2006).
Molecular imaging using a targeted magnetic resonance hyperpolarized biosensor. Science.
314(5798), 446-449.
-
Lee, D., Hilty, C., Wider, G., & Wthrich, K.
(2006).
Effective rotational correlation times of proteins from NMR relaxation interference. Journal of Magnetic Resonance.
178(1), 72-76.
-
McDonnell, E. E., Han, S., Hilty, C., Pierce, K. L., & Pines, A
(2005).
NMR analysis on microfluidic devices by remote detection. Analytical Chemistry.
77(24), 8109-8114.
-
Seebach, D., Mathad, R. I., Kimmerlin, T., Mahajan, Y. R., Bindschadler, P., Rueping, M., ... Etezady-Esfarjani, T.
(2005).
NMR-solution structures in methanol of an alpha-heptapeptide, of a beta(3)/beta(2)-nonapeptide, and of an all-beta(3)-icosapeptide carrying the 20 proteinogenic side chains. Helvetica Chimica Acta.
88(7), 1969-1982.
-
Hilty, C., Lowery, T. J., Wemmer, D. E., & Pines, A
(2005).
Spectrally resolved magnetic resonance imaging of a xenon biosensor. Angewandte Chemie International Edition.
45(1), 70-73.
-
Hilty, C., Wider, G., Fernndez, C., & Wthrich, K.
(2004).
Membrane protein-lipid interactions in mixed micelles studied by NMR spectroscopy with the use of paramagnetic reagents. ChemBioChem.
5(4), 467-473.
-
Fernndez, C., Hilty, C., Wider, G., Gntert, P., & Wthrich, K.
(2004).
NMR structure of the integral membrane protein OmpX. Journal of Molecular Biology.
336(5), 1211-1221.
-
Hilty, C., Wider, G., Fernndez, C., & Wthrich, K.
(2003).
Stereospecific assignments of the isopropyl methyl groups of the membrane protein OmpX in DHPC micelles. Journal of Biomolecular NMR.
27(4), 377-382.
-
Etezady-Esfarjani, T., Hilty, C., Wuthrich, K., Rueping, M., Schreiber, J., & Seebach, D.
(2002).
NMR-structural investigations of a beta(3)-dodecapeptide with proteinogenic side chains in methanol and in aqueous solutions. Helvetica Chimica Acta.
85(5), 1197-1209.
-
Fernndez, C., Hilty, C., Wider, G., & Wthrich, K.
(2002).
Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America.
99(21), 13533-13537.
-
Hilty, C., Fernndez, C., Wider, G., & Wthrich, K.
(2002).
Side chain NMR assignments in the membrane protein OmpX reconstituted in DHPC micelles. Journal of Biomolecular NMR.
23(4), 289-301.
-
Hilty, C., & Winterhalter, M.
(2001).
Facilitated substrate transport through membrane proteins. Physical Review Letters.
86(24), 5624-5627.
-
Kim, Y., & Hilty, C.
Affinity screening using competitive binding with fluorine-19 hyperpolarized ligands. Angewandte Chemie International Edition.
54(16), 4941-4944.
-
Hilty, C., & Ragavan, M
Application of blind source separation to real-time dissolution dynamic nuclear polarization. Analytical Chemistry.
87(2), 1004-1008.
-
Zhang, G., Schilling, F., Glaser, S. J., & Hilty, C.
Chemical shift correlations from hyperpolarized NMR using a single SHOT. Analytical Chemistry.
85(5), 2875-2881.
-
Kim, J., Liu, M., Chen, H., & Hilty, C.
Determination of Intermolecular Interactions Using Polarization Compensated Heteronuclear Overhauser Effect of Hyperpolarized Spins. Analytical Chemistry.
87(21), 10982-10987.
-
Hwang, S., & Hilty, C.
Folding determinants of disulfide bond forming protein B explored by solution nuclear magnetic resonance spectroscopy. Proteins: Structure, Function, and Bioinformatics.
79(5), 1365-1375.
-
Hilty, C., McDonnell, E. E., Granwehr, J., Pierce, K. L., Han, S., & Pines, A
Microfluidic gas-flow profiling using remote-detection NMR. Proceedings of the National Academy of Sciences of the United States of America.
102(42), 14960-14963.
-
Rembert, K. B., Paterov, J., Heyda, J., Hilty, C., Jungwirth, P., & Cremer, P. S.
Molecular mechanisms of ion-specific effects on proteins. Journal of the American Chemical Society.
134(24), 10039-10046.
-
Baker, K. A., Hilty, C., Peti, W., Prince, A., Pfaffinger, P. J., Wider, G., Wthrich, K., & Choe, S.
NMR-derived dynamic aspects of N-type inactivation of a Kv channel suggest a transient interaction with the T1 domain. Biochemistry.
45(6), 1663-1672.
-
Tafer, H., Hiller, S., Hilty, C., Fernndez, C., & Wthrich, K.
Nonrandom structure in the urea-unfolded Escherichia coli outer membrane protein X (OmpX). Biochemistry.
43(4), 860-869.
-
Telkki, V., Hilty, C., Garcia, S., Harel, E., & Pines, A
Quantifying the diffusion of a fluid through membranes by double phase encoded remote detection magnetic resonance imaging. The Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter.
111(50), 13929-13936.
-
Bowen, S., Sekar, G., & Hilty, C
Rapid determination of biosynthetic pathways using fractional isotope enrichment and high-resolution dynamic nuclear polarization enhanced NMR. NMR in Biomedicine.
24(8), 1016-1022.
-
Anwar, M. S., Hilty, C., Chu, C., Bouchard, L., Pierce, K. L., & Pines, A
Spin coherence transfer in chemical transformations monitored by remote detection NMR. Analytical Chemistry.
79(7), 2806-2811.
-
Bowen, S., & Hilty, C
Temporal chemical shift correlations in reactions studied by hyperpolarized nuclear magnetic resonance. Analytical Chemistry.
81(11), 4543-4547.
-
Bowen, S., & Hilty, C
Time-resolved dynamic nuclear polarization enhanced NMR spectroscopy. Angewandte Chemie International Edition.
47(28), 5235-5237.
-
Koptyug, I. V., Kovtunov, K. V., Burt, S. R., Anwar, M. S., Hilty, C., Han, S., Pines, A., & Sagdeev, R. Z
para-Hydrogen-induced polarization in heterogeneous hydrogenation reactions. Journal of the American Chemical Society.
129(17), 5580-5586.
-
Pham, P., & Hilty, C.
(2023).
Biomolecular interactions studied by low-field NMR using SABRE hyperpolarization. Chemical Science.
14(37), 10258-10263.
-
chapter
-
Kim, Y., & Hilty, C.
(2019).
Applications of Dissolution-DNP for NMR Screening. METHODS IN ENZYMOLOGY.
BIOLOGICAL NMR, PT B.
(pp. 501-526).
Elsevier.
-
Kim, Y., Wang, Y., Chen, H., & Hilty, C.
(2018).
In-Vitro Dissolution Dynamic Nuclear Polarization for Sensitivity Enhancement of NMR with Biological Molecules. Methods in molecular biology (Clifton, N.J.).
PROTEIN NMR: METHODS AND PROTOCOLS.
(pp. 155-168).
Springer Nature.
-
Kim, Y., & Hilty, C.
(2019).
Applications of Dissolution-DNP for NMR Screening. METHODS IN ENZYMOLOGY.
BIOLOGICAL NMR, PT B.
(pp. 501-526).
Elsevier.
-
conference paper
-
Chen, C., Shih, W., & Hilty, C.
(2017).
Early time kinetics and mechanisms of polymerization reactions by hyperpolarized NMR. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
Chen, C., Shih, W., & Hilty, C.
(2015).
Metallocene-catalyzed olefin polymerization studied by dissolution dynamic nuclear polarization (DNP) NMR. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
North, S., Gaede, H. C., Batteas, J. D., Son, D. H., Hilty, C., & Cremer, P. S.
(2008).
CHED 1468-Assessment of reforms in the physical chemistry laboratory at Texas A&M University. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
Hilty, C., Bowen, S., & Zeng, H.
(2008).
PHYS 241-Time-resolved NMR by dynamic nuclear polarization. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
Granwehr, J., Harel, E., Hilty, C., Garcia, S., Chavez, L., Pines, A., Sen, P. N., & Song, Y.
(2007).
Dispersion measurements using time-of-flight remote detection MRI. Magnetic Resonance Imaging.
449-452.
-
Fernndez, C., Hilty, C., Bonjour, S., Adeishvili, K., Pervushin, K., & Wthrich, K.
(2001).
Solution NMR studies of the integral membrane proteins OmpX and OmpA from Escherichia coli. FEBS Letters.
173-178.
-
Winterhalter, M., Hilty, C., Bezrukov, S. M., Nardin, C., Meier, W., & Fournier, D.
(2001).
Controlling membrane permeability with bacterial porins: application to encapsulated enzymes. Talanta.
965-971.
-
Chen, C., Shih, W., & Hilty, C.
(2017).
Early time kinetics and mechanisms of polymerization reactions by hyperpolarized NMR. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
Research
principal investigator on
- Hyperpolarization Assisted and Structure Based Screening of Protein-Ligand Interactions in Live Cells awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2023
- Characterization of Macromolecular Dynamics Using Para-hydrogen Induced Polarization of Nuclear Spins awarded by National Science Foundation - (Arlington, Virginia, United States) 2019 - 2022
- Characterization of Solvent-Macromolecule Interactions using Dissolution Dynamic Nuclear Polarization awarded by National Science Foundation - (Arlington, Virginia, United States) 2014 - 2019
- Collaborative Research: DNP-Enhanced Nuclear-Spin Optical-Rotation Spectroscopy awarded by National Science Foundation - (Arlington, Virginia, United States) 2014 - 2019
- Development of Platform for Ligand Screening using Hyperpolarized NMR awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2018
Teaching
teaching activities
- BICH691 Research Instructor
- BIOT684 Directed Pro Internship: In-ab Instructor
- BIOT684 Directed Prof Internship Instructor
- CHEM101 Fund Of Chemistry I Instructor
- CHEM107 Gen Chem For Engineers Instructor
- CHEM119 Fund Of Chemistry I Instructor
- CHEM322 Physical Chemistry Instructor
- CHEM325 Physical Chem Lab I Instructor
- CHEM326 Physical Chem Lab Ii Instructor
- CHEM327 Physical Chem I Instructor
- CHEM415 Analytical Chemistry Instructor
- CHEM491 Hnr-research Instructor
- CHEM681 Seminar Instructor
- CHEM682 Dept Research Seminar Instructor
- CHEM685 Directed Studies Instructor
- CHEM690 Theory Of Chem Resrch Instructor
- CHEM691 Research Instructor
- CHEM691 Research Instructor
Works By Students
chaired theses and dissertations
-
Bowen, Sean Michael (2012-02). The Application of Dynamic Nuclear Polarization Enhanced NMR to Non-Equilibrium Systems.
-
Chen, Chia-Hsiu (2018-08). Characterization of Olefin Polymerization Reactions Using Dissolution Dynamic Nuclear Polarization.
-
Chen, Hsueh-Ying (2015-05). Methods for Determination of Structure and Kinetics in the Study of Macromolecules Using Dissolution DNP NMR.
-
Hwang, SoYoun (2012-07). Investigation of Peptide Folding by Nuclear Magnetic Resonance Spectroscopy.
-
Kim, Yaewon (2018-11). Methods for Ligand Screening by Dissolution DNP Assisted NMR Spectroscopy.
-
Lee, Youngbok (2013-03). Application of Dissolution Dynamic Nuclear Polarization to the Characterization of Reactions Involving Large Molecules.
-
Min, Hlaing (2014-08). Nuclear Magnetic Resonance based Characterization of the Protein Binding Pocket using Hyperpolarized Ligand.
-
Ragavan, Mukundan (2014-06). Dissolution Dynamic Nuclear Polarization of Polypeptides.
-
Sekar, Giridhar (2014-10). NMR Studies of Membrane Associating Peptides and Implications in Autotransporter Function.
-
Zeng, Haifeng (2012-07). Quantitative Determination of Chemical Processes by Dynamic Nuclear Polarization Enhanced Nuclear Magnetic Resonance Spectroscopy.
-
Zhang, Guannan (2017-10). The Application of Fast Correlation Methods with Dissolution DNP Enhanced NMR.
Background
education and training
awards and honors
- Association of Former Students College-Level Teaching Distinguished Achievement Award, The, conferred by Texas A&M University - (College Station, Texas, United States), 2016
- Faculty Early Career Development (CAREER) Program, conferred by National Science Foundation - (Arlington, Virginia, United States), 2009
- New Faculty Award, conferred by Camille and Henry Dreyfus Foundation - (New York, New York, United States), 2006
Contact
first name
- Christian
has last name
- Hilty
mailing address
-
Texas A&M University
Chemistry Department
3255 TAMU
College Station, TX 77843-3255
USA
Other
- chilty@tamu.edu