Rapid sample injection for hyperpolarized NMR spectroscopy. Academic Article

abstract

• Due to its ability to enhance the signal of a single NMR scan by several orders of magnitude, solid-to-liquid state dynamic nuclear polarization (DNP) appears well suited for the analysis of minimal amounts of compounds, as well as for the study of rapid chemical reactions. A key requirement in enabling the application of DNP-NMR to typical small-molecule substances encountered in chemistry and biochemistry is the ability to obtain high-resolution spectra, while at the same time minimizing the loss of polarization due to spin relaxation between the separate steps of DNP polarization and NMR measurement. Here, we present data demonstrating the capability of measuring DNP enhanced NMR spectra of compounds with comparably short relaxation times, with only minimal line broadening attributable to the sample transfer process. We discuss the performance characteristics of a sample injection apparatus specifically designed to provide high-resolution DNP-NMR spectra of small molecule compounds.

authors

• Hilty, Christian

author list (cited authors)

• Bowen, S., & Hilty, C

citation count

• 115

complete list of authors

• Bowen, Sean||Hilty, Christian

publication date

• January 2010

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• Physical Chemistry Chemical Physics  Journal

keywords

• Electric Conductivity
• Glucose
• Magnetic Resonance Spectroscopy
• Phosphates
• Potassium Compounds
• Solvents

Digital Object Identifier (DOI)

• 10.1039/c002316g

start page

• 5766

end page

• 5770

volume

• 12

issue

• 22

URL

• http%3A%2F%2Fdx.doi.org%2F10.1039%2Fc002316g