Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis. Academic Article uri icon


  • Traditional nuclear magnetic resonance (NMR) spectroscopy relies on the versatile chemical information conveyed by spectra. To complement conventional NMR, Laplace NMR explores diffusion and relaxation phenomena to reveal details on molecular motions. Under a broad concept of ultrafast multidimensional Laplace NMR, here we introduce an ultrafast diffusion-relaxation correlation experiment enhancing the resolution and information content of corresponding 1D experiments as well as reducing the experiment time by one to two orders of magnitude or more as compared with its conventional 2D counterpart. We demonstrate that the method allows one to distinguish identical molecules in different physical environments and provides chemical resolution missing in NMR spectra. Although the sensitivity of the new method is reduced due to spatial encoding, the single-scan approach enables one to use hyperpolarized substances to boost the sensitivity by several orders of magnitude, significantly enhancing the overall sensitivity of multidimensional Laplace NMR.

published proceedings

  • Nat Commun

altmetric score

  • 7

author list (cited authors)

  • Ahola, S., Zhivonitko, V. V., Mankinen, O., Zhang, G., Kantola, A. M., Chen, H., ... Telkki, V.

citation count

  • 69

complete list of authors

  • Ahola, Susanna||Zhivonitko, Vladimir V||Mankinen, Otto||Zhang, Guannan||Kantola, Anu M||Chen, Hsueh-Ying||Hilty, Christian||Koptyug, Igor V||Telkki, Ville-Veikko

publication date

  • January 2015