HR job title
- Associate Professor
- Contact Info
- Websites
- ORCiD
- 0000-0003-2235-5139
Jain, Abhishek Associate Professor
Positions
- Associate Professor, Biomedical Engineering, College of Engineering
The overarching theme of my research is to design patient-specific and digital microengineered models of cardiovascular and hematologic diseases (such as, atherosclerosis) for enabling basic scientific discoveries and the advancement of precision and personalized healthcare.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Works By Students
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Deo, K. A., Murali, A., Tronolone, J. J., Mandrona, C., Lee, H. P., Rajput, S., ... Gaharwar, A. K.
(2024).
Granular Biphasic Colloidal Hydrogels for 3D Bioprinting. Advanced healthcare materials.
e2303810.
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Han, H. W., Pradhan, G., Villarreal, D., Kim, D. M., Jain, A., Gaharwar, A., ... Sun, Y.
(2024).
GHSR Deletion in -Cells of Male Mice: Ineffective in Obesity, but Effective in Protecting against Streptozotocin-Induced -Cell Injury in Aging. Nutrients.
16(10), 1464-1464.
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Ghosh, L. D., Mathur, T., Tronolone, J. J., Chuong, A., Rangel, K., Corvigno, S., Sood, A. K., & Jain, A.
(2024).
Angiogenesis-Enabled Human Ovarian Tumor Microenvironment-Chip Evaluates Pathophysiology of Platelets in Microcirculation. Advanced healthcare materials.
e2304263.
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Tronolone, J. J., Mohamed, N., & Jain, A.
(2024).
Engineering Lymphangiogenesis-On-Chip: The Independent and Cooperative Regulation by Biochemical Factors, Gradients, and Interstitial Fluid Flow. Advanced Biology.
e2400031.
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Mathur, T., Tronolone, J. J., & Jain, A.
(2024).
AngioMT: A MATLAB based 2D image-to-physics tool to predict oxygen transport in vascularized microphysiological systems. PLoS ONE.
19(5), e0299160-e0299160.
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Ghosh, L. D., & Jain, A.
(2023).
The prospects of microphysiological systems in modeling platelet pathophysiology in cancer. Platelets (London).
34(1), 2247489.
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Tronolone, J. J., Mathur, T., Chaftari, C. P., Sun, Y., & Jain, A.
(2023).
Machine learning chained neural network analysis of oxygen transport amplifies the physiological relevance of vascularized microphysiological systems. 8(6), e10582.
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Tronolone, J. J., Mathur, T., Chaftari, C. P., & Jain, A.
(2023).
Evaluation of the Morphological and Biological Functions of Vascularized Microphysiological Systems with Supervised Machine Learning. Annals of Biomedical Engineering.
51(8), 1723-1737.
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Selahi, A., & Jain, A.
(2023).
Engineered models of the lymphatic vascular system: Past, present, and future. 30(2-3), e12793.
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Tronolone, J. J., Mathur, T., Chaftari, C. P., & Jain, A.
(2023).
Evaluation of the morphological and biological functions of vascularized microphysiological systems with supervised machine learning. 4(01-27), 2023.01.12.523755.
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Mathur, T., Tronolone, J. J., & Jain, A.
(2023).
AngioMT: An in silico platform for digital sensing of oxygen transport through heterogenous microvascular networks. 4(01-27), 2023.01.09.523275.
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Abasi, S., Jain, A., Cooke, J. P., & Guiseppi-Elie, A.
(2023).
Electrically stimulated gene expression under exogenously applied electric fields. Frontiers in Molecular Biosciences.
10, 1161191.
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Mathur, T., Kumar, A., Flanagan, J. M., & Jain, A.
(2022).
Vascular Transcriptomics: Investigating Endothelial Activation and Vascular Dysfunction Using Blood Outgrowth Endothelial Cells, Organ-Chips, and RNA Sequencing. 2(10), e582.
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Tronolone, J. J., Mathur, T., Chaftari, C. P., & Jain, A.
(2022).
A machinelearned microvasculature optimizes physiological insulin secretion in a vascularized pancreaschip. 36(S1),
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Selahi, A., & Jain, A.
(2022).
LymphangionChip Experimental Platform Supports Coculture and Signaling Between Lymphatic Endothelial and Mural Cells. 36(S1),
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Mathur, T., Tronolone, J., & Jain, A.
(2022).
Next generation personalized blood vesselonchip: Mimicking patientspecific pathophysiology in sickle cell disease through bloodderived endothelial progenitors. 36(S1),
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Rajeeva Pandian, N. K., & Jain, A.
(2022).
In silico analyses of blood flow and oxygen transport in human micro-veins and valves. Clinical Hemorheology and Microcirculation.
81(1), 81-96.
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Rajput, S., Deo, K. A., Mathur, T., Lokhande, G., Singh, K. A., Sun, Y., ... Gaharwar, A. K.
(2022).
2D Nanosilicate for additive manufacturing: Rheological modifier, sacrificial ink and support bath. Bioprinting.
25, e00187-e00187.
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Pandian, N., & Jain, A.
(2022).
Microengineered Human Vein-Chip Recreates Venous Valve Architecture and its Contribution to COVID-19-induced Thrombosis. 10(2), 557-557.
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Selahi, A., Chakraborty, S., Muthuchamy, M., Zawieja, D. C., & Jain, A.
(2022).
Intracellular calcium dynamics of lymphatic endothelial and muscle cells co-cultured in a Lymphangion-Chip under pulsatile flow. The Analyst.
147(13), 2953-2965.
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Cooke, J. P., Connor, J. H., & Jain, A.
(2021).
Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy. 17(5), 53-62.
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Nava-Medina, I. B., Gold, K. A., Cooper, S. M., Robinson, K., Jain, A., Cheng, Z., & Gaharwar, A. K.
(2021).
Self-Oscillating 3D Printed Hydrogel Shapes. Advanced Materials Technologies.
6(12), 2100418-2100418.
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Mathur, T., Tronolone, J. J., & Jain, A.
(2021).
Abstract 11425: Vascular Organ-Chips Made from Blood. Circulation.
144(Suppl_1), a11425-a11425.
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Mathur, T., Tronolone, J. J., & Jain, A.
(2021).
Comparative Analysis of Blood-Derived Endothelial Cells for Designing Next-Generation Personalized Organ-on-Chips. Journal of the American Heart Association.
10(22), e022795.
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Gold, K. A., Saha, B., Rajeeva Pandian, N. K., Walther, B. K., Palma, J. A., Jo, J., ... Gaharwar, A. K.
(2021).
3D Bioprinted Multicellular Vascular Models. Advanced healthcare materials.
10(21), e2101141-2101141.
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Xin, S., Deo, K. A., Dai, J., Pandian, N., Chimene, D., Moebius, R. M., ... Alge, D. L.
(2021).
Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprinting. Science Advances.
7(42), eabk3087.
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Rajeeva Pandian, N. K., Connor, J. H., Cooke, J. P., & Jain, A.
(2021).
Abstract 111: Vein-Chip Is A New Experimental Model To Predict Pathophysiology Of SARS-CoV-2 Induced Thrombosis. Arteriosclerosis, Thrombosis and Vascular Biology.
41(Suppl_1),
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Mathur, T., Flanagan, J. M., & Jain, A.
(2021).
Tripartite collaboration of blood-derived endothelial cells, next generation RNA sequencing and bioengineered vessel-chip may distinguish vasculopathy and thrombosis among sickle cell disease patients. Bioengineering & Translational Medicine.
6(3), e10211.
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Saha, B., Mathur, T., Tronolone, J. J., Chokshi, M., Lokhande, G. K., Selahi, A., ... Jain, A.
(2021).
Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer. Science Advances.
7(30), eabg5283.
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Walther, B. K., Rajeeva Pandian, N. K., Gold, K. A., Kili, E. S., Sama, V., Gu, J., ... Jain, A.
(2021).
Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response. Lab on a Chip.
21(9), 1738-1751.
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Selahi, A., Fernando, T., Chakraborty, S., Muthuchamy, M., Zawieja, D. C., & Jain, A.
(2021).
Lymphangion-chip: a microphysiological system which supports co-culture and bidirectional signaling of lymphatic endothelial and muscle cells. Lab on a Chip.
22(1), 121-135.
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Ngo, B., Lim, K. K., Johnson, J. C., Jain, A., & Grunlan, M. A.
(2020).
Thromboresistance of Polyurethanes Modified with PEO-Silane Amphiphiles. Macromolecular Bioscience.
20(12), e2000193-2000193.
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Rajeeva Pandian, N. K., Walther, B. K., Suresh, R., Cooke, J. P., & Jain, A.
(2020).
Microengineered Human Vein-Chip Recreates Venous Valve Architecture and Its Contribution to Thrombosis. Small.
16(49), e2003401-2003401.
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Saha, B., Mathur, T., Handley, K. F., Hu, W., Afshar-Kharghan, V., Sood, A. K., & Jain, A.
(2020).
OvCa-Chip microsystem recreates vascular endothelium-mediated platelet extravasation in ovarian cancer. Blood Advances.
4(14), 3329-3342.
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Ngo, B., Barry, M. E., Lim, K. K., Johnson, J. C., Luna, D. J., Pandian, N., Jain, A., & Grunlan, M. A.
(2020).
Thromboresistance of Silicones Modified with PEO-Silane Amphiphiles. ACS Biomaterial Science and Engineering.
6(4), 2029-2037.
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Luna, D. J., R Pandian, N. K., Mathur, T., Bui, J., Gadangi, P., Kostousov, V. V., ... Jain, A.
(2020).
Tortuosity-powered microfluidic device for assessment of thrombosis and antithrombotic therapy in whole blood. Scientific Reports.
10(1), 5742.
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Mathur, T., Singh, K. A., R Pandian, N. K., Tsai, S., Hein, T. W., Gaharwar, A. K., Flanagan, J. M., & Jain, A.
(2019).
Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips. Lab on a Chip.
19(15), 2500-2511.
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Gold, K., Gaharwar, A. K., & Jain, A.
(2019).
Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing. 196, 2-17.
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Papa, A., Jiang, A., Korin, N., Chen, M. B., Langan, E. T., Waterhouse, A., ... Ingber, D. E.
(2019).
Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models. Science Translational Medicine.
11(479), eaau5898.
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Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., ... Otieno, M. A.
(2018).
Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems. Clinical Pharmacology and Therapeutics.
104(6), 1240-1248.
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Jain, A., Barrile, R., van der Meer, A. D., Mammoto, A., Mammoto, T., De Ceunynck, K., ... Ingber, D. E.
(2018).
Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics. Clinical Pharmacology and Therapeutics.
103(2), 332-340.
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Mannino, R. G., Pandian, N. K., Jain, A., & Lam, W. A.
(2018).
Engineering "Endothelialized" Microfluidics for Investigating Vascular and Hematologic Processes Using Non-Traditional Fabrication Techniques. Current Opinion in Biomedical Engineering.
5, 13-20.
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Pandian, N., Mannino, R. G., Lam, W. A., & Jain, A.
(2018).
Thrombosis-on-a-chip: Prospective impact of microphysiological models of vascular thrombosis. Current Opinion in Biomedical Engineering.
5, 29-34.
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De Ceunynck, K., Peters, C. G., Jain, A., Higgins, S. J., Aisiku, O., Fitch-Tewfik, J. L., ... Flaumenhaft, R.
(2018).
PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury. Proceedings of the National Academy of Sciences of the United States of America.
115(5), E982-E991.
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De Ceunynck, K., Peters, C. G., Chaudhry, S. A., Jain, A., Higgins, S. J., Aisiku, O., ... Flaumenhaft, R. C.
(2016).
A Chemical APC Mimetic Protects Endothelium from Thromboinflammatory Injury. Blood.
128(22), 3835-3835.
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Jain, A., Barrile, R., Aisiku, O., Ceunynck, K. D., van der Meer, A. D., Otieno, M. A., ... Ingber, D. E.
(2016).
Abstract 342: Analysis of Mechanism of a Novel Drug Candidate using an Organ-level Functional Microdevice that Reconstitutes Human Pulmonary Thrombosis. Arteriosclerosis, Thrombosis and Vascular Biology.
36(suppl_1),
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Jain, A., van der Meer, A. D., Papa, A., Barrile, R., Lai, A., Schlechter, B. L., ... Ingber, D. E.
(2016).
Abstract 529: Assessing Hemostasis and Platelet Function Using a Microfluidic Device Lined with Fixed Human Endothelium. Arteriosclerosis, Thrombosis and Vascular Biology.
36(suppl_1),
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Jain, A., Graveline, A., Waterhouse, A., Vernet, A., Flaumenhaft, R., & Ingber, D. E.
(2016).
A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function. Nature Communications.
7(1), 10176.
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Jain, A., van der Meer, A. D., Papa, A., Barrile, R., Lai, A., Schlechter, B. L., ... Ingber, D. E.
(2016).
Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium. Biomedical Microdevices.
18(4), 73.
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Jain, A., & Hou, I.
(2016).
R-PF: Enhancing Service Regularity for Legacy Scheduling Policy. IEEE Transactions on Wireless Communications.
15(1), 258-266.
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Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K., ... Ingber, D. E.
(2015).
Engineered in vitro disease models. 10(1), 195-262.
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Leslie, D. C., Waterhouse, A., Berthet, J. B., Valentin, T. M., Watters, A. L., Jain, A., ... Ingber, D. E.
(2014).
A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling. Nature Biotechnology.
32(11), 1134-1140.
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Cooper, R. M., Leslie, D. C., Domansky, K., Jain, A., Yung, C., Cho, M., ... Ingber, D. E.
(2014).
A microdevice for rapid optical detection of magnetically captured rare blood pathogens. Lab on a Chip.
14(1), 182-188.
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Jain, A., & Munn, L. L.
(2011).
Biomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip. Lab on a Chip.
11(17), 2941-2947.
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Munn, L. L., & Jain, A.
(2010).
Determinants of Leukocyte Margination in Rectangular Microchannels. 24(S1), 974.7-974.7.
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Jain, A., & Munn, L. L.
(2009).
Determinants of leukocyte margination in rectangular microchannels. PLoS ONE.
4(9), e7104-e7104.
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Jain, A., & Posner, J. D.
(2008).
Particle dispersion and separation resolution of pinched flow fractionation. Analytical Chemistry.
80(5), 1641-1648.
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Jain, A., Choudhary, S., Rai, L., & Singh, S. N.
(2005).
Flow analysis in a model can-type gas turbine combustor. 12, 389-397.
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Jain, A., & Munn, L. L.
Rare Blood Cell Separation on a Microfluidic Platform: A Case Study of Circulating Tumor Cells. The FASEB Journal.
25, 815.10-815.10.
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Deo, K. A., Murali, A., Tronolone, J. J., Mandrona, C., Lee, H. P., Rajput, S., ... Gaharwar, A. K.
(2024).
Granular Biphasic Colloidal Hydrogels for 3D Bioprinting. Advanced healthcare materials.
e2303810.
-
chapter
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Jain, A., Mathur, T., Pandian, N., & Selahi, A.
(2020).
Chapter 9 Organ-on-a-chip and 3D printing as preclinical models for medical research and practice. Precision Medicine for Investigators, Practitioners and Providers.
(pp. 83-95).
Elsevier.
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Jain, A., Mathur, T., Pandian, N., & Selahi, A.
(2020).
Chapter 9 Organ-on-a-chip and 3D printing as preclinical models for medical research and practice. Precision Medicine for Investigators, Practitioners and Providers.
(pp. 83-95).
Elsevier.
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conference paper
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Doktor, D. A., O'Connor, S. P., Tronolone, J. J., Jain, A., & Yakovlev, V. V.
(2021).
Impulsive stimulated Brillouin spectroscopy for non-invasive microfluidic-based viscoelastic measurements in vitro. Proceedings of SPIE.
116370s-116370s-8.
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Pandian, N., & Jain, A.
(2021).
Hemorheology and pathophysiology of COVID-19 induced thrombosis predicted by Vein- Chip. Biorheology: an international journal.
113-113.
-
Walther, B. K., Mojiri, A., Pandian, N., Ohayon, J., Wang, H., Gu, J., ... Cooke, J. P.
(2020).
An Innate YAP/TAZ Mechanosensing Deficit in Hutchinson-Gilford Progeria Syndrome. Circulation.
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Gold, K., Dedas, R., Snell, T., Pandian, N., Jain, A., & Gaharwar, A. K.
(2019).
Multiscale modeling of vascular pathophysiology using 3d bioprinting. Annual Meeting- Society for Biomaterials in Conjunction with the International Biomaterials Symposium.
36.
-
Doktor, D. A., O'Connor, S. P., Tronolone, J. J., Jain, A., & Yakovlev, V. V.
(2021).
Impulsive stimulated Brillouin spectroscopy for non-invasive microfluidic-based viscoelastic measurements in vitro. Proceedings of SPIE.
116370s-116370s-8.
Research
principal investigator on
- Determinants of COVID19-induced venous thrombosis and targeted therapy assessed with bioengineered vein-chip awarded by National Heart Lung and Blood Institute - (Bethesda, Maryland, United States) 2021 - 2025
- CAREER: Modeling human veins and venous pathology with organ-on-chip engineering for basic, translational and educational research awarded by Directorate for Engineering - (Arlington, Virginia, United States) 2020 - 2025
- An artery-on-a-chip containing blood outgrowth endothelium as a model of vaso-occlusion and drug testing in sickle cell disease awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2021
Teaching
teaching activities
- BMEN291 Hnr-research Instructor
- BMEN291 Hnr-research Instructor
- BMEN341 Biofluid Mechanics Instructor
- BMEN491 Hnr-research Instructor
- BMEN491 Hnr-research Instructor
- BMEN685 Directed Studies Instructor
- BMEN689 Sptp: Bioeng Cell Systems Instructor
- BMEN691 Research Instructor
- ENGR485 Directed Studies Instructor
- ENGR491 Hnr-research Instructor
Works By Students
chaired theses and dissertations
-
Rajeeva Pandian, Navaneeth Krishna (2021-08). Modeling Human Veins, Venous Thrombosis & Therapeutics with Organ-On-Chips.
Background
education and training
- Ph.D. in Biomedical Engineering, Boston University - (Boston, Massachusetts, United States) 2011
- M.S. in Biomedical Engineering, Boston University - (Boston, Massachusetts, United States) 2009
- M.S. in Mechanical Engineering, Arizona State University - (Tempe, Arizona, United States) 2007
- B.S. in Mechanical Engineering, Indian Institute of Technology Delhi - (New Delhi, India) 2003
awards and honors
Contact
first name
- Abhishek
has last name
- Jain
mailing address
-
Texas A&M University
Biomedical Engineering
3120 TAMU
College Station, TX 77843-3120
USA
Other
In the News
- A&M researchers developing new tools to fight ovarian cancer News Release
- Biomedical Engineering Assistant Professor Recognized With NSF CAREER Award News Release
- Doctoral Student Finds Alternative Cell Option For Organs-On-Chips News Release
- Researchers Find New Way To Detect Blood Clots News Release
- Researchers Go To The Source To Find New Tools To Treat Vascular Diseases News Release
- Texas A&M Researchers Explore Connections Between Ovarian Cancer And Blood Cells News Release
- a.jain@tamu.edu