Multiscale modeling of vascular pathophysiology using 3d bioprinting Conference Paper uri icon

abstract

  • 2019 Omnipress - All rights reserved. Vascular diseases, such as atherosclerosis, peripheral artery disease, and thrombosis, are the leading cause of death and mortality worldwide, accounting for over 17 million deaths per year. [1] If the status quo remains, the number of deaths is projected to reach epidemic proportions by 2030 (> 23.6 million). [1] Most vascular research aims to unravel the complex mechanisms that drive disease progression, from a molecular to organ-level, utilizing in vivo animal models or in vitro culture techniques. Despite major advancements, traditional strategies are often limited at identifying, quantifying, and dissecting specific cellular and molecular targets that regulate disease development and progression. Therefore, there is an unmet clinical need to develop a modeling approach that can advance our knowledge and facilitate the design of next generation therapeutic interventions. To address these limitations, we have developed a three-dimensional (3D) bioprinted blood vessel that is able to recapitulate the dynamic complexity that makes up our arterial system (Fig. 1).

published proceedings

  • Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

author list (cited authors)

  • Gold, K., Dedas, R., Snell, T., Pandian, N., Jain, A., & Gaharwar, A. K.

publication date

  • January 1, 2019 11:11 AM