Thromboresistance of Silicones Modified with PEO-Silane Amphiphiles. Academic Article uri icon


  • The antifouling properties of poly(ethylene oxide) (PEO)-silane amphiphiles as surface-modifying additives (SMAs) in a condensation cure silicone have been previously demonstrated against simple protein solutions. Comprising an oligo(dimethylsiloxane) tether (m = 13 or 30) and PEO segment (n = 8), sustained protein resistance was achieved even in the absence of a cross-linkable triethoxysilane group, particularly when comprising the longer tether. To probe their potential for thromboresistance, PEO-silane amphiphile SMAs were used to bulk-modify silicones and evaluated for adhesion resistance against whole human blood under both static and dynamic conditions. Both a cross-linkable (XL diblock, m = 13) and a non-cross-linkable (Diblock, m = 30) SMA were evaluated at various concentrations (5-50 mol SMA/g silicone) in a condensation cure silicone. Under static conditions, silicones modified with either SMA at concentrations of 10 mol/g or greater were effective in reducing adhesion of human fibrinogen and platelets. Dynamic testing further showed that modified silicones were able to reduce protein adsorption and thrombus formation. This occurred at 5 and 10 mol/g for silicones modified with XL diblock, m = 13 and Diblock, m = 30 SMAs, respectively. Combined, these results indicate the effectiveness of PEO-silane amphiphiles as SMAs in silicone for improved thromboresistance.

published proceedings

  • ACS Biomater Sci Eng

author list (cited authors)

  • Ngo, B., Barry, M. E., Lim, K. K., Johnson, J. C., Luna, D. J., Pandian, N., Jain, A., & Grunlan, M. A.

citation count

  • 6

complete list of authors

  • Ngo, Bryan Khai D||Barry, Mikayla E||Lim, Kendrick K||Johnson, Jessica C||Luna, David J||Pandian, Navaneeth KR||Jain, Abhishek||Grunlan, Melissa A

publication date

  • April 2020