A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling Academic Article uri icon

abstract

  • Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.

altmetric score

  • 171.234

author list (cited authors)

  • Leslie, D. C., Waterhouse, A., Berthet, J. B., Valentin, T. M., Watters, A. L., Jain, A., ... Ingber, D. E.

citation count

  • 311

publication date

  • October 2014