HR job title
- Professor
- Contact Info
Hurdle, Julian Associate Professor
Positions
- Associate Professor, Institute of Biosciences and Technology, College of Medicine
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- Research
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Overview
Publications
selected publications
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academic article
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Rutherford, J. T., Avad, K., Dureja, C., Norseeda, K., Gc, B., Wu, C., ... Hurdle, J. G.
(2024).
Evaluation of Fusobacterium nucleatum Enoyl-ACP Reductase (FabK) as a Narrow-Spectrum Drug Target. ACS Infectious Diseases.
-
Dureja, C., Rutherford, J. T., Pavel, F., Norseeda, K., Prah, I., Sun, D., Hevener, K. E., & Hurdle, J. G.
(2024).
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy. Antimicrobial Agents and Chemotherapy.
e0122223.
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Olaitan, A. O., Dureja, C., Youngblom, M. A., Topf, M. A., Shen, W., Gonzales-Luna, A. J., ... Hurdle, J. G.
(2023).
Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile. Nature Communications.
14(1), 4130.
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Gonzales-Luna, A. J., Dureja, C., Eubank, T. A., Garey, K. W., & Hurdle, J. G.
(2023).
Surveillance of Clostridioides difficile Antimicrobial Resistance in the United States. Clinical Infectious Diseases.
76(11), 2038-2039.
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Eubank, T. A., Dureja, C., Hurdle, J. G., Garey, K. W., & Gonzales-Luna, A. J.
(2022).
380. A molecular epidemiological exploration of reduced vancomycin susceptibility in Clostridioides difficile. Open Forum Infectious Diseases.
9(Suppl 2), ofac492.458.
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Lancaster, C., Eubank, T. A., Gonzales-Luna, A. J., Dureja, C., Hurdle, J., & Garey, K. W.
(2022).
401. Rigor and Reproducibility of Clostridioides difficile susceptibility testing. Open Forum Infectious Diseases.
9(Supplement_2),
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Eubank, T. A., Gonzales-Luna, A. J., Hurdle, J. G., & Garey, K. W.
(2022).
Genetic Mechanisms of Vancomycin Resistance in Clostridioides difficile: A Systematic Review. Antibiotics.
11(2), 258-258.
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Dureja, C., Olaitan, A. O., & Hurdle, J. G.
(2022).
Mechanisms and impact of antimicrobial resistance in Clostridioides difficile. Current Opinion in Microbiology.
66, 63-72.
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Marreddy, R., Olaitan, A. O., May, J. N., Dong, M., & Hurdle, J. G.
(2021).
Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing. 9(2), e0044821-e00421.
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Wu, X., Shen, W., Deshpande, A., Olaitan, A. O., Palmer, K. L., Garey, K. W., & Hurdle, J. G.
(2021).
The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests. Journal of Clinical Microbiology.
59(9), e0058521-e00521.
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Gonzales-Luna, A. J., Olaitan, A. O., Shen, W., Deshpande, A., Carlson, T. J., Dotson, K. M., ... Garey, K. W.
(2021).
Reduced Susceptibility to Metronidazole Is Associated With Initial Clinical Failure in Clostridioides difficile Infection. Open Forum Infectious Diseases.
8(8), ofab365.
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Gonzales-Luna, A. J., Spinler, J. K., Oezguen, N., Khan, M., Danhof, H. A., Endres, B. T., ... Garey, K. W.
(2021).
Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation. Anaerobe.
70, 102387-102387.
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Deshpande, A., Wu, X., Huo, W., Palmer, K. L., & Hurdle, J. G.
(2020).
Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases. Antimicrobial Agents and Chemotherapy.
64(8), e00415-e00420.
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Shen, W., Deshpande, A., Hevener, K. E., Endres, B. T., Garey, K. W., Palmer, K. L., & Hurdle, J. G.
(2020).
Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates. Journal of Antimicrobial Chemotherapy.
75(4), 859-867.
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Sapkota, M., Marreddy, R., Wu, X., Kumar, M., & Hurdle, J. G.
(2020).
The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection. Anaerobe.
61, 102129-102129.
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Jones, J. A., Prior, A. M., Marreddy, R., Wahrmund, R. D., Hurdle, J. G., Sun, D., & Hevener, K. E.
(2019).
Small-Molecule Inhibition of the C. difficile FAS-II Enzyme, FabK, Results in Selective Activity. ACS Chemical Biology.
14(7), 1528-1535.
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Endres, B. T., Begum, K., Sun, H., Walk, S. T., Memariani, A., Lancaster, C., ... Garey, K. W.
(2019).
Epidemic Clostridioides difficile Ribotype 027 Lineages: Comparisons of Texas Versus Worldwide Strains. Open Forum Infectious Diseases.
6(2), ofz013.
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Marreddy, R., Wu, X., Sapkota, M., Prior, A. M., Jones, J. A., Sun, D., Hevener, K. E., & Hurdle, J. G.
(2019).
The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection. ACS Infectious Diseases.
5(2), 208-217.
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Gonzales-Luna, A. J., Shen, W., Deshpande, A., Dotson, K. M., Lancaster, C., Hurdle, J., & Garey, K. W.
(2019).
840. Clinical Failure Rates Associated with Hemin-induced Metronidazole Resistance in Clostridioides difficile. Open Forum Infectious Diseases.
6(Supplement_2), s11-s11.
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Zhang, M., Prior, A. M., Maddox, M. M., Shen, W., Hevener, K. E., Bruhn, D. F., ... Sun, D.
(2018).
Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives. ACS Omega.
3(12), 18343-18360.
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Tsutsumi, L. S., Elmore, J. M., Dang, U. T., Wallace, M. J., Marreddy, R., Lee, R. B., ... Sun, D.
(2018).
Solid-Phase Synthesis and Antibacterial Activity of Cyclohexapeptide Wollamide B Analogs. ACS combinatorial science.
20(3), 172-185.
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Gonzales-Luna, A., Shen, W., Dotson, K., Lancaster, C., Endres, B., Hossain, F., ... Hurdle, J.
(2018).
710. Increased Clinical Failure Rates Associated with Reduced Metronidazole Susceptibility in Clostridioides difficile. Open Forum Infectious Diseases.
5(suppl_1), s255-s256.
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Hurdle, J. G., & Deshpande, A.
(2018).
Bacterial persister cells tackled. Nature.
556(7699), 40-41.
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Cherian, P. T., Cheramie, M. N., Marreddy, R., Fernando, D. M., Hurdle, J. G., & Lee, R. E.
(2018).
New -lactam - Tetramic acid hybrids show promising antibacterial activities. Bioorganic and Medicinal Chemistry Letters.
28(18), 3105-3112.
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Cherian, P. T., Deshpande, A., Cheramie, M. N., Bruhn, D. F., Hurdle, J. G., & Lee, R. E.
(2017).
Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics. Journal of Antibiotics: an international journal devoted to research on bioactive microbial products.
70(1), 65-72.
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Li, C., Sarotti, A. M., Huang, P., Dang, U. T., Hurdle, J. G., Kondratyuk, T. P., ... Cao, S.
(2017).
NF-B inhibitors, unique -pyranol--lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462. Scientific Reports.
7(1), 10424.
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Boottanun, P., Potisap, C., Hurdle, J. G., & Sermswan, R. W.
(2017).
Secondary metabolites from Bacillus amyloliquefaciens isolated from soil can kill Burkholderia pseudomallei. AMB Express.
7(1), 16.
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Dang, U. T., Zamora, I., Hevener, K. E., Adhikari, S., Wu, X., & Hurdle, J. G.
(2016).
Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden. Antimicrobial Agents and Chemotherapy.
60(9), 5604-5607.
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Tao, L., Zhang, J., Meraner, P., Tovaglieri, A., Wu, X., Gerhard, R., ... Dong, M.
(2016).
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature.
538(7625), 350-355.
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Cherian, P. T., Wu, X., Yang, L., Scarborough, J. S., Singh, A. P., Alam, Z. A., Lee, R. E., & Hurdle, J. G.
(2015).
Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection. Journal of Antimicrobial Chemotherapy.
70(11), 3061-3069.
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Tsutsumi, L. S., Owusu, Y. B., Hurdle, J. G., & Sun, D.
(2014).
Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review. Current Topics in Medicinal Chemistry.
14(1), 152-175.
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Feng, L. i., Maddox, M. M., Alam, M. Z., Tsutsumi, L. S., Narula, G., Bruhn, D. F., ... Sun, D.
(2014).
Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives. Journal of Medicinal Chemistry.
57(20), 8398-8420.
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Wu, X., & Hurdle, J. G.
(2014).
The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection. Canadian Journal of Microbiology.
60(4), 251-254.
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Kumar, M., Adhikari, S., & Hurdle, J. G.
(2014).
Action of nitroheterocyclic drugs against Clostridium difficile. International Journal of Antimicrobial Agents.
44(4), 314-319.
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Cherian, P. T., Wu, X., Maddox, M. M., Singh, A. P., Lee, R. E., & Hurdle, J. G.
(2014).
Chemical modulation of the biological activity of reutericyclin: a membrane-active antibiotic from Lactobacillus reuteri. Scientific Reports.
4(1), 4721.
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Lee, R. E., Hurdle, J. G., Liu, J., Bruhn, D. F., Matt, T., Scherman, M. S., ... Lenaerts, A. J.
(2014).
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux. Nature Medicine.
20(2), 152-158.
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Rakesh, .., Bruhn, D. F., Scherman, M. S., Woolhiser, L. K., Madhura, D. B., Maddox, M. M., ... Lee, R. E.
(2014).
Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis. PLoS ONE.
9(2), e87909-e87909.
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Wu, X., Alam, M. Z., Feng, L., Tsutsumi, L. S., Sun, D., & Hurdle, J. G.
(2014).
Prospects for flavonoid and related phytochemicals as nature-inspired treatments for Clostridium difficile infection. 116(1), 23-31.
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Wu, X., Cherian, P. T., Lee, R. E., & Hurdle, J. G.
(2013).
The membrane as a target for controlling hypervirulent Clostridium difficile infections. Journal of Antimicrobial Chemotherapy.
68(4), 806-815.
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Wu, X., & Hurdle, J. G.
(2013).
Screening for a diamond in the rough. Chemistry and Biology.
20(9), 1091-1092.
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Shen, L. i., Maddox, M. M., Adhikari, S., Bruhn, D. F., Kumar, M., Lee, R. E., ... Sun, D.
(2013).
Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents. Journal of Antibiotics: an international journal devoted to research on bioactive microbial products.
66(6), 319-325.
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Sun, D., Hurdle, J. G., Lee, R., Lee, R., Cushman, M., & Pezzuto, J. M.
(2012).
Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead. ChemMedChem: chemistry enabling drug discovery.
7(9), 1541-1545.
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Hurdle, J. G., Heathcott, A. E., Yang, L., Yan, B., & Lee, R. E.
(2011).
Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations. Journal of Antimicrobial Chemotherapy.
66(8), 1773-1776.
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Brown, J. R., North, E. J., Hurdle, J. G., Morisseau, C., Scarborough, J. S., Sun, D., ... Lee, R. E.
(2011).
The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorganic and Medicinal Chemistry.
19(18), 5585-5595.
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Hurdle, J. G., O'Neill, A. J., Chopra, I., & Lee, R. E.
(2011).
Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. Nature Reviews Microbiology.
9(1), 62-75.
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Hevener, K. E., Yun, M., Qi, J., Kerr, I. D., Babaoglu, K., Hurdle, J. G., ... Lee, R. E.
(2010).
Structural studies of pterin-based inhibitors of dihydropteroate synthase. Journal of Medicinal Chemistry.
53(1), 166-177.
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Hurdle, J. G., Yendapally, R., Sun, D., & Lee, R. E.
(2009).
Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections. Antimicrobial Agents and Chemotherapy.
53(9), 4028-4031.
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Budha, N. R., Lee, R. B., Hurdle, J. G., Lee, R. E., & Meibohm, B.
(2009).
A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria. Tuberculosis.
89(5), 378-385.
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Sun, D., Scherman, M. S., Jones, V., Hurdle, J. G., Woolhiser, L. K., Knudson, S. E., ... Lee, R. E.
(2009).
Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity. Bioorganic and Medicinal Chemistry.
17(10), 3588-3594.
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Grimes, K. D., Lu, Y., Zhang, Y., Luna, V. A., Hurdle, J. G., Carson, E. I., ... Lee, R. E.
(2008).
Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria. ChemMedChem: chemistry enabling drug discovery.
3(12), 1936-1945.
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Hurdle, J. G., Lee, R. B., Budha, N. R., Carson, E. I., Qi, J., Scherman, M. S., ... Lee, R. E.
(2008).
A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents. Journal of Antimicrobial Chemotherapy.
62(5), 1037-1045.
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Yendapally, R., Hurdle, J. G., Carson, E. I., Lee, R. B., & Lee, R. E.
(2008).
N-substituted 3-acetyltetramic acid derivatives as antibacterial agents. Journal of Medicinal Chemistry.
51(5), 1487-1491.
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Hurdle, J. G., O'Neill, A. J., Mody, L., Chopra, I., & Bradley, S. F.
(2005).
In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis. Journal of Antimicrobial Chemotherapy.
56(6), 1166-1168.
-
Hurdle, J. G., O'Neill, A. J., & Chopra, I.
(2005).
Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents. Antimicrobial Agents and Chemotherapy.
49(12), 4821-4833.
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Hurdle, J. G., O'Neill, A. J., Ingham, E., Fishwick, C., & Chopra, I.
(2004).
Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques. Antimicrobial Agents and Chemotherapy.
48(11), 4366-4376.
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Hurdle, J. G., O'Neill, A. J., & Chopra, I.
(2004).
Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections. Journal of Antimicrobial Chemotherapy.
54(2), 549-552.
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Hurdle, J. G., O'Neill, A. J., & Chopra, I.
(2004).
The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden. Journal of Antimicrobial Chemotherapy.
53(1), 102-104.
-
Rutherford, J. T., Avad, K., Dureja, C., Norseeda, K., Gc, B., Wu, C., ... Hurdle, J. G.
(2024).
Evaluation of Fusobacterium nucleatum Enoyl-ACP Reductase (FabK) as a Narrow-Spectrum Drug Target. ACS Infectious Diseases.
-
chapter
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Wu, X., & Hurdle, J. G.
(2013).
The Membrane as a Novel Target Site for Antibiotics to Kill Persisting Bacterial Pathogens. Antibiotics.
(pp. 183-216).
Wiley.
-
Wu, X., & Hurdle, J. G.
(2013).
The Membrane as a Novel Target Site for Antibiotics to Kill Persisting Bacterial Pathogens. Antibiotics.
(pp. 183-216).
Wiley.
-
institutional repository document
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Dureja, C., Rutherford, J. T., Pavel, F., Norseeda, K., Prah, I., Sun, D., Hevener, K. E., & Hurdle, J. G.
(2023).
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy
-
Olaitan, A. O., Dureja, C., Youngblom, M. A., Topf, M. A., Shen, W., Gonzales-Luna, A. J., ... Hurdle, J. G.
(2022).
Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile
-
Marreddy, R., Picker, J., Phelps, G. A., Powell, R., Cherian, P. T., Bowling, J. J., ... Hurdle, J. G.
(2022).
The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks
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Deshpande, A., Olaitan, A. O., Mckelvey, A. M., Rutherford, J. T., & Hurdle, J. G.
(2022).
The Ferrous Iron Transporter FeoB1 is Essential for Clostridioides difficile Toxin Production and Pathogenesis in Mice
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Marreddy, R., Olaitan, A. O., May, J. N., Dong, M., & Hurdle, J. G.
(2020).
Ebselen Exhibits Antimicrobial Activity Against Clostridioides difficile By Disrupting Redox Associated Metabolism
-
Deshpande, A., Wu, X., Huo, W., Palmer, K. L., & Hurdle, J. G.
(2020).
Chromosomal Resistance to Metronidazole in Clostridioides difficile can be Mediated By Epistasis Between Iron Homeostasis and Oxidoreductases
-
Alam, M. Z., Wu, X., Mascio, C., Chesnel, L., & Hurdle, J. G.
(2015).
Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile. Antimicrobial Agents and Chemotherapy.
-
Dureja, C., Rutherford, J. T., Pavel, F., Norseeda, K., Prah, I., Sun, D., Hevener, K. E., & Hurdle, J. G.
(2023).
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy
Research
principal investigator on
- High Throughput Screening for Non-antibiotic inhibitors of Clostridium difficile Pathophysiology awarded by National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States) 2019 - 2023
- Decoding the clinical impact of the recent evolution of metronidazole resistance on Clostridium difficile infection awarded by National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States) 2018 - 2022
- Relationships Among Metronidazole Resistance, Pharmacodynamics and Treatment Outcomes in Clostridium Difficile Infection awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2019
co-principal investigator on
investigator on
Teaching
teaching activities
- IBST689 Sptp: Research In Progress Instructor
- IBST691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Microbiology, University of Leeds - (Leeds, United Kingdom) 2005
- B.Sc. in Biology and Chemistry, University of the West Indies - (Bridgetown, Barbados) 2000
Contact
first name
- Julian
has last name
- Hurdle
Other
- jhurdle@tamu.edu