N-substituted 3-acetyltetramic acid derivatives as antibacterial agents. Academic Article uri icon


  • In order to expand the structure-activity relationship of tetramic acid molecules with structural similarity to the antibiotic reutericyclin, 22 compounds were synthesized and tested against a panel of clinically relevant bacteria. Key structural changes on the tetramic acid core affected antibacterial activity. Various compounds in the N-alkyl 3-acetyltetramic acid series exhibited good activity against Gram-positive bacterial pathogens including Bacillus anthracis, Propionibacterium acnes, Enterococcus faecalis, and both Methicillin-sensitive and -resistant Staphylococcus aureus.

published proceedings

  • J Med Chem

altmetric score

  • 3

author list (cited authors)

  • Yendapally, R., Hurdle, J. G., Carson, E. I., Lee, R. B., & Lee, R. E.

citation count

  • 39

complete list of authors

  • Yendapally, Raghunandan||Hurdle, Julian G||Carson, Elizabeth I||Lee, Robin B||Lee, Richard E

publication date

  • March 2008