N-substituted 3-acetyltetramic acid derivatives as antibacterial agents. Academic Article

abstract

• In order to expand the structure-activity relationship of tetramic acid molecules with structural similarity to the antibiotic reutericyclin, 22 compounds were synthesized and tested against a panel of clinically relevant bacteria. Key structural changes on the tetramic acid core affected antibacterial activity. Various compounds in the N-alkyl 3-acetyltetramic acid series exhibited good activity against Gram-positive bacterial pathogens including Bacillus anthracis, Propionibacterium acnes, Enterococcus faecalis, and both Methicillin-sensitive and -resistant Staphylococcus aureus.

authors

• Hurdle, Julian

published proceedings

• J Med Chem

altmetric score

• 3

author list (cited authors)

• Yendapally, R., Hurdle, J. G., Carson, E. I., Lee, R. B., & Lee, R. E.

citation count

• 39

complete list of authors

• Yendapally, Raghunandan||Hurdle, Julian G||Carson, Elizabeth I||Lee, Robin B||Lee, Richard E

publication date

• March 2008

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of Medicinal Chemistry  Journal

keywords

• Animals
• Anti-Bacterial Agents
• Chlorocebus Aethiops
• Furans
• Gram-Positive Bacteria
• Methicillin Resistance
• Microbial Sensitivity Tests
• Stereoisomerism
• Structure-Activity Relationship
• Vero Cells

PubMed Central ID

• 18281930

Digital Object Identifier (DOI)

• 10.1021/jm701356q

start page

• 1487

end page

• 1491

volume

• 51

issue

• 5

URL

• http://dx.doi.org/10.1021/jm701356q