Journal of Medicinal Chemistry
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Overview
publication venue for
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Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease.
2024
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Piptide Chemotypes for Perturbation of the Interaction of Urokinase with Its Receptor..
65:12925-12932.
2022
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Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of Nirmatrelvir..
65:8686-8698.
2022
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Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target..
65:409-423.
2022
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Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases..
64:11267-11287.
2021
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Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain..
64:10997-11013.
2021
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HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability..
63:15906-15945.
2020
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Nature-Inspired (di)Azine-Bridged Bisindole Alkaloids with Potent Antibacterial In Vitro and In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus..
63:12623-12641.
2020
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Confronting Racism in Chemistry Journals..
63:6575-6577.
2020
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Update to Our Reader, Reviewer, and Author Communities-April 2020..
63:4409-4410.
2020
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Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity..
63:3298-3316.
2020
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Cyanine-Gemcitabine Conjugates as Targeted Theranostic Agents for Glioblastoma Tumor Cells..
62:9236-9245.
2019
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Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase..
62:4483-4499.
2019
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Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease..
62:6146-6162.
2019
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Determination of Ligand Binding Epitope Structures Using Polarization Transfer from Hyperpolarized Ligands..
62:2419-2427.
2019
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Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB1..
60:1089-1104.
2017
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New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics..
58:814-826.
2015
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Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives..
57:8398-8420.
2014
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Optimization of chemical functionalities of indole-2-carboxamides to improve allosteric parameters for the cannabinoid receptor 1 (CB1)..
57:3040-3052.
2014
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Structure-activity relationship study of indole-2-carboxamides identifies a potent allosteric modulator for the cannabinoid receptor 1 (CB1)..
56:7965-7975.
2013
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Double-targeting using a TrkC ligand conjugated to dipyrrometheneboron difluoride (BODIPY) based photodynamic therapy (PDT) agent..
56:7608-7614.
2013
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Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors..
55:10424-10436.
2012
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In vitro and in vivo antitumor activities and DNA binding mode of five coordinated cyclometalated organoplatinum(II) complexes containing biphosphine ligands..
54:6166-6176.
2011
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Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists..
53:5044-5048.
2010
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In vitro and in vivo photocytotoxicity of boron dipyrromethene derivatives for photodynamic therapy..
53:2865-2874.
2010
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Structural studies of pterin-based inhibitors of dihydropteroate synthase..
53:166-177.
2010
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Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies..
52:6543-6545.
2009
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Magnetically aligned bicelles to study the orientation of lipophilic ligands in membrane bilayers..
51:6793-6799.
2008
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Bornyl- and isobornyl-Delta8-tetrahydrocannabinols: a novel class of cannabinergic ligands..
51:6393-6399.
2008
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Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening..
51:5984-5992.
2008
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N-substituted 3-acetyltetramic acid derivatives as antibacterial agents..
51:1487-1491.
2008
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Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes..
51:1577-1583.
2008
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Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity..
50:6493-6500.
2007
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Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore..
50:3777-3785.
2007
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Synthesis and evaluation of 4/5-hydroxy-2,3-diaryl(substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anticancer agents..
50:1744-1753.
2007
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Dirhodium(II,II) complexes: molecular characteristics that affect in vitro activity..
49:6841-6847.
2006
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Synthesis from caffeine of a mixed N-heterocyclic carbene-silver acetate complex active against resistant respiratory pathogens..
49:6811-6818.
2006
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4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo..
48:5644-5647.
2005
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Adamantyl cannabinoids: a novel class of cannabinergic ligands..
48:4576-4585.
2005
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Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation..
48:1576-1587.
2005
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Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis..
47:355-374.
2004
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Molecular basis of neurotrophin-receptor interactions..
46:5277-5291.
2003
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Conformational study of lipophilic ligands in phospholipid model membrane systems by solution NMR..
46:4838-4846.
2003
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Selective formation of homo- and heterobivalent peptidomimetics..
46:3565-3567.
2003
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New templates for syntheses of ring-fused, C(10) beta-turn peptidomimetics leading to the first reported small-molecule mimic of neurotrophin-3..
45:4387-4390.
2002
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Synthesis and solution conformation of cyclo[RGDRGD]: a cyclic peptide with selectivity for the alpha V beta 3 receptor..
39:4520-4526.
1996
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Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid..
39:3556-3563.
1996
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Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells..
38:3146-3155.
1995
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Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids..
38:2820-2829.
1995
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Combinatorial technologies involving reiterative division/coupling/recombination: statistical considerations..
37:2985-2987.
1994
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Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'--P2' amide bond isostere..
37:3100-3107.
1994
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cis-4-Carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1 H)-one , a potent inhibitor of mammalian dihydroorotase..
31:1355-1359.
1988
Identity
International Standard Serial Number (ISSN)