Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes. Academic Article uri icon


  • A series of methylated imidazolium salts with varying substituents on the 4 and 5 positions of the imidazole ring were synthesized. These salts were reacted with silver acetate to afford their corresponding silver N-heterocyclic carbene (NHC) complexes. These complexes were then evaluated for their stability in water as well as for their antimicrobial efficacy against a variety of bacterial strains associated with cystic fibrosis and chronic lung infections.

published proceedings

  • J Med Chem

altmetric score

  • 6

author list (cited authors)

  • Hindi, K. M., Siciliano, T. J., Durmus, S., Panzner, M. J., Medvetz, D. A., Reddy, D. V., ... Youngs, W. J.

citation count

  • 183

complete list of authors

  • Hindi, Khadijah M||Siciliano, Tammy J||Durmus, Semih||Panzner, Matthew J||Medvetz, Doug A||Reddy, D Venkat||Hogue, Lisa A||Hovis, Christine E||Hilliard, Julia K||Mallet, Rebekah J||Tessier, Claire A||Cannon, Carolyn L||Youngs, Wiley J

publication date

  • March 2008