Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes. Academic Article

abstract

• A series of methylated imidazolium salts with varying substituents on the 4 and 5 positions of the imidazole ring were synthesized. These salts were reacted with silver acetate to afford their corresponding silver N-heterocyclic carbene (NHC) complexes. These complexes were then evaluated for their stability in water as well as for their antimicrobial efficacy against a variety of bacterial strains associated with cystic fibrosis and chronic lung infections.

authors

• Cannon, Carolyn

published proceedings

• J Med Chem

altmetric score

• 6

author list (cited authors)

• Hindi, K. M., Siciliano, T. J., Durmus, S., Panzner, M. J., Medvetz, D. A., Reddy, D. V., ... Youngs, W. J.

citation count

• 183

complete list of authors

• Hindi, Khadijah M||Siciliano, Tammy J||Durmus, Semih||Panzner, Matthew J||Medvetz, Doug A||Reddy, D Venkat||Hogue, Lisa A||Hovis, Christine E||Hilliard, Julia K||Mallet, Rebekah J||Tessier, Claire A||Cannon, Carolyn L||Youngs, Wiley J

publication date

• March 2008

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of Medicinal Chemistry  Journal

keywords

• Acetates
• Anti-Bacterial Agents
• Burkholderia
• Crystallography, X-Ray
• Dose-Response Relationship, Drug
• Electrons
• Escherichia Coli
• Heterocyclic Compounds
• Methane
• Methylation
• Microbial Sensitivity Tests
• Models, Molecular
• Molecular Structure
• Organometallic Compounds
• Pseudomonas Aeruginosa
• Silver Compounds
• Structure-Activity Relationship
• Water

PubMed Central ID

• 18288795

Digital Object Identifier (DOI)

• 10.1021/jm0708679

start page

• 1577

end page

• 1583

volume

• 51

issue

• 6

URL

• http://dx.doi.org/10.1021/jm0708679