Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists. Academic Article uri icon


  • Bivalent molecules containing two beta-turn mimics with side chains that correspond to hot-spots on the neurotrophin NT-3 were prepared. Binding assays showed the mimetics to be selective TrkC ligands, and biological assays showed one mimetic to be an antagonist of the TrkC receptor.

published proceedings

  • J Med Chem

altmetric score

  • 7

author list (cited authors)

  • Liu, J., Brahimi, F., Saragovi, H. U., & Burgess, K.

citation count

  • 16

complete list of authors

  • Liu, Jing||Brahimi, Fouad||Saragovi, H Uri||Burgess, Kevin

publication date

  • July 2010