Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists. Academic Article

abstract

• Bivalent molecules containing two beta-turn mimics with side chains that correspond to hot-spots on the neurotrophin NT-3 were prepared. Binding assays showed the mimetics to be selective TrkC ligands, and biological assays showed one mimetic to be an antagonist of the TrkC receptor.

authors

• Burgess, Kevin

published proceedings

• J Med Chem

altmetric score

• 7

author list (cited authors)

• Liu, J., Brahimi, F., Saragovi, H. U., & Burgess, K.

citation count

• 16

complete list of authors

• Liu, Jing||Brahimi, Fouad||Saragovi, H Uri||Burgess, Kevin

publication date

• July 2010

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of Medicinal Chemistry  Journal

keywords

• Amino Acid Motifs
• Animals
• Cell Survival
• Diketopiperazines
• Mice
• NIH 3T3 Cells
• Neurotrophin 3
• Protein Kinase Inhibitors
• Receptor, Trkc
• Signal Transduction

PubMed Central ID

• 20540510

Digital Object Identifier (DOI)

• 10.1021/jm100148d

start page

• 5044

end page

• 5048

volume

• 53

issue

• 13

URL

• http://dx.doi.org/10.1021/jm100148d