Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists.
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Bivalent molecules containing two beta-turn mimics with side chains that correspond to hot-spots on the neurotrophin NT-3 were prepared. Binding assays showed the mimetics to be selective TrkC ligands, and biological assays showed one mimetic to be an antagonist of the TrkC receptor.
author list (cited authors)
Liu, J., Brahimi, F., Saragovi, H. U., & Burgess, K.
complete list of authors
Liu, Jing||Brahimi, Fouad||Saragovi, H Uri||Burgess, Kevin