Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead. Academic Article uri icon

abstract

  • Lead on! In the course of screening flavonoid and resveratrol libraries, abyssinone II, a naturally occurring prenylated flavonoid, was found to exhibit relatively good antitubercular and antibacterial activity. Preliminary mechanistic studies revealed that abyssinone II hyperpolarizes the bacterial membrane potential and inhibits the biosynthesis of key cellular macromolecules (DNA, RNA, and protein).

published proceedings

  • ChemMedChem

altmetric score

  • 4

author list (cited authors)

  • Sun, D., Hurdle, J. G., Lee, R., Lee, R., Cushman, M., & Pezzuto, J. M.

citation count

  • 27

complete list of authors

  • Sun, Dianqing||Hurdle, Julian G||Lee, Robin||Lee, Richard||Cushman, Mark||Pezzuto, John M

publication date

  • September 2012

publisher