Genetic Mechanisms of Vancomycin Resistance in Clostridioides difficile: A Systematic Review. Academic Article

abstract

• Antimicrobial resistance to treatments for Clostridioides difficile infection (CDI) poses a significant threat to global health. C. difficile is widely thought to be susceptible to oral vancomycin, which is increasingly the mainstay of CDI treatment. However, clinical labs do not conduct C. difficile susceptibility testing, presenting a challenge to detecting the emergence and impact of resistance. In this systematic review, we describe gene determinants and associated clinical and laboratory mechanisms of vancomycin resistance in C. difficile, including drug-binding site alterations, efflux pumps, RNA polymerase mutations, and biofilm formation. Additional research is needed to further characterize these mechanisms and understand their clinical impact.

authors

• Hurdle, Julian

published proceedings

• Antibiotics (Basel)

altmetric score

• 6.25

author list (cited authors)

• Eubank, T. A., Gonzales-Luna, A. J., Hurdle, J. G., & Garey, K. W.

citation count

• 7

complete list of authors

• Eubank, Taryn A||Gonzales-Luna, Anne J||Hurdle, Julian G||Garey, Kevin W

publication date

• February 2022

publisher

• MDPI  Publisher

published in

• Antibiotics  Journal

keywords

• Antimicrobial Resistance
• Biofilm
• Clostridium Difficile
• Efflux Pumps
• Plasmids
• Reduced Susceptibility
• Van Genes

PubMed Central ID

• 35203860

Digital Object Identifier (DOI)

• 10.3390/antibiotics11020258

start page

• 258

end page

• 258

volume

• 11

issue

• 2

URL

• http://dx.doi.org/10.3390/antibiotics11020258