The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection. Academic Article uri icon

abstract

  • Sporulation during Clostridioides difficile infection (CDI) contributes to recurrent disease. Cell division and sporulation both require peptidoglycan biosynthesis. We show C.difficile growth and sporulation is attenuated by antisenses to murA and murC or the MurA inhibitor fosfomycin. Thus, targeting the early steps of peptidoglycan biosynthesis might reduce the onset of recurrent CDI.

published proceedings

  • Anaerobe

altmetric score

  • 1

author list (cited authors)

  • Sapkota, M., Marreddy, R., Wu, X., Kumar, M., & Hurdle, J. G.

citation count

  • 5

complete list of authors

  • Sapkota, Madhab||Marreddy, Ravi KR||Wu, Xiaoqian||Kumar, Manish||Hurdle, Julian G

publication date

  • January 1, 2020 11:11 AM