The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection. Academic Article

abstract

• Sporulation during Clostridioides difficile infection (CDI) contributes to recurrent disease. Cell division and sporulation both require peptidoglycan biosynthesis. We show C.difficile growth and sporulation is attenuated by antisenses to murA and murC or the MurA inhibitor fosfomycin. Thus, targeting the early steps of peptidoglycan biosynthesis might reduce the onset of recurrent CDI.

authors

• Hurdle, Julian

published proceedings

• Anaerobe

altmetric score

• 1

author list (cited authors)

• Sapkota, M., Marreddy, R., Wu, X., Kumar, M., & Hurdle, J. G.

citation count

• 5

complete list of authors

• Sapkota, Madhab||Marreddy, Ravi KR||Wu, Xiaoqian||Kumar, Manish||Hurdle, Julian G

publication date

• January 2020

publisher

• Elsevier  Publisher

published in

• Anaerobe  Journal

keywords

• Alkyl And Aryl Transferases
• Anti-Bacterial Agents
• Antibiotic Drug-targets
• Clostridioides Difficile
• Clostridium Infections
• Enzyme Activation
• Enzyme Inhibitors
• Gene Expression Regulation, Bacterial
• Heat-resistant Spore Cortex
• Humans
• Mur Ligases
• Peptidoglycan
• Spores, Bacterial

Digital Object Identifier (DOI)

• 10.1016/j.anaerobe.2019.102129

start page

• 102129

end page

• 102129

volume

• 61

URL

• http://dx.doi.org/10.1016/j.anaerobe.2019.102129