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- 1 979 845 2584
Grau, James Professor
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Overview
Publications
selected publications
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academic article
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Grau, J. W., Hudson, K. E., Tarbet, M. M., & Strain, M. M.
(2022).
Behavioral studies of spinal conditioning: The spinal cord is smarter than you think it is. Journal of Experimental Psychology Animal Learning and Cognition.
48(4), 435-457.
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Hudson, K. E., & Grau, J. W.
(2022).
Ionic Plasticity: Common Mechanistic Underpinnings of Pathology in Spinal Cord Injury and the Brain. Cells.
11(18), 2910-2910.
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Fauss, G., Hudson, K. E., & Grau, J. W.
(2022).
Role of Descending Serotonergic Fibers in the Development of Pathophysiology after Spinal Cord Injury (SCI): Contribution to Chronic Pain, Spasticity, and Autonomic Dysreflexia. Biology.
11(2), 234-234.
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Baine, R. E., Johnston, D. T., Strain, M. M., Henwood, M. K., Davis, J. A., Reynolds, J. A., Giles, E. D., & Grau, J. W.
(2022).
Noxious Stimulation Induces Acute Hemorrhage and Impairs Long-Term Recovery after Spinal Cord Injury (SCI) in Female Rats: Evidence Estrous Cycle May Have a Modulatory Effect. 3(1), 70-86.
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Strain, M. M., Johnston, D. T., Baine, R. E., Reynolds, J. A., Huang, Y., Henwood, M. K., ... Grau, J. W.
(2021).
Hemorrhage and Locomotor Deficits Induced by Pain Input after Spinal Cord Injury Are Partially Mediated by Changes in Hemodynamics. JOURNAL OF NEUROTRAUMA.
38(24), 3406-3430.
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Fauss, G., Strain, M. M., Huang, Y., Reynolds, J. A., Davis, J. A., Henwood, M. K., West, C. R., & Grau, J. W.
(2021).
Contribution of Brain Processes to Tissue Loss After Spinal Cord Injury: Does a Pain-Induced Rise in Blood Pressure Fuel Hemorrhage?. 15, 733056.
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Hoy, K. C., Strain, M. M., Turtle, J. D., Lee, K. H., Huie, J. R., Hartman, J. J., ... Grau, J. W.
(2020).
Evidence That the Central Nervous System Can Induce a Modification at the Neuromuscular Junction That Contributes to the Maintenance of a Behavioral Response. Journal of Neuroscience.
40(48), 9186-9209.
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Grau, J. W., Baine, R. E., Bean, P. A., Davis, J. A., Fauss, G. N., Henwood, M. K., ... Strain, M. M.
(2020).
Learning to promote recovery after spinal cord injury. Experimental Neurology.
330, 113334-113334.
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Davis, J. A., Bopp, A. C., Henwood, M. K., Baine, R. E., Cox, C. C., & Grau, J. W.
(2020).
Pharmacological Transection of Brain-Spinal Cord Communication Blocks Pain-Induced Hemorrhage and Locomotor Deficits after Spinal Cord Injury in Rats. JOURNAL OF NEUROTRAUMA.
37(15), 1729-1739.
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Turtle, J. D., Henwood, M. K., Strain, M. M., Huang, Y., Miranda, R. C., & Grau, J. W.
(2019).
Engaging pain fibers after a spinal cord injury fosters hemorrhage and expands the area of secondary injury. Experimental Neurology.
311, 115-124.
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Reynolds, J. A., Henwood, M. K., Turtle, J. D., Baine, R. E., Johnston, D. T., & Grau, J. W.
(2019).
Brain-Dependent Processes Fuel Pain-Induced Hemorrhage After Spinal Cord Injury. Frontiers in Systems Neuroscience.
13, 44.
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Huang, Y., & Grau, J. W.
(2018).
Ionic plasticity and pain: The loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain. Experimental Neurology.
306, 105-116.
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Grau, J. W., & Huang, Y.
(2018).
Metaplasticity within the spinal cord: Evidence brain-derived neurotrophic factor (BDNF), tumor necrosis factor (TNF), and alterations in GABA function (ionic plasticity) modulate pain and the capacity to learn. Neurobiology of Learning and Memory.
154, 121-135.
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Turtle, J. D., Strain, M. M., Reynolds, J. A., Huang, Y., Lee, K. H., Henwood, M. K., Garraway, S. M., & Grau, J. W.
(2018).
Pain Input After Spinal Cord Injury (SCI) Undermines Long-Term Recovery and Engages Signal Pathways That Promote Cell Death. Frontiers in Systems Neuroscience.
12, 27.
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Huang, Y., Lee, K. H., & Grau, J. W.
(2017).
Complete spinal cord injury (SCI) transforms how brain derived neurotrophic factor (BDNF) affects nociceptive sensitization. Experimental Neurology.
288, 38-50.
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Baumbauer, K. M., Turtle, J. D., & Grau, J. W.
(2017).
Fixed spaced stimulation restores adaptive plasticity within the spinal cord: Identifying the eliciting conditions. Physiology and Behavior.
174, 1-9.
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Khaing, Z. Z., Agrawal, N. K., Park, J. H., Xin, S., Plumton, G. C., Lee, K. H., ... Grau, J. W.
(2016).
Localized and sustained release of brain-derived neurotrophic factor from injectable hydrogel/microparticle composites fosters spinal learning after spinal cord injury. Journal of Materials Chemistry B.
4(47), 7560-7571.
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Hansen, C. N., Faw, T. D., White, S., Buford, J. A., Grau, J. W., & Basso, D. M.
(2016).
Sparing of Descending Axons Rescues Interneuron Plasticity in the Lumbar Cord to Allow Adaptive Learning After Thoracic Spinal Cord Injury. Frontiers in Neural Circuits.
10(MAR), 11.
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Huang, Y., Lee, K. H., Murphy, L., Garraway, S. M., & Grau, J. W.
(2016).
Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization. Experimental Neurology.
285(Pt A), 82-95.
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Lee, K. H., Huang, Y., & Grau, J. W.
(2016).
Learning about Time within the Spinal Cord II: Evidence that Temporal Regularity Is Encoded by a Spinal Oscillator. Frontiers in Behavioral Neuroscience.
10(FEB), 14.
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Lee, K. H., Turtle, J. D., Huang, Y., Strain, M. M., Baumbauer, K. M., & Grau, J. W.
(2015).
Learning about time within the spinal cord: evidence that spinal neurons can abstract and store an index of regularity. Frontiers in Behavioral Neuroscience.
9(OCTOBER), 274.
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Huie, J. R., Stuck, E. D., Lee, K. H., Irvine, K., Beattie, M. S., Bresnahan, J. C., Grau, J. W., & Ferguson, A. R.
(2015).
AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury. 2(5), eneuro.0091-eneu15.2015.
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Grau, J. W.
(2014).
Learning from the spinal cord: how the study of spinal cord plasticity informs our view of learning. Neurobiology of Learning and Memory.
108, 155-171.
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Hoy, K. C., Huie, J. R., & Grau, J. W.
(2013).
AMPA receptor mediated behavioral plasticity in the isolated rat spinal cord. 236(1), 319-326.
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Baumbauer, K. M., Lee, K. H., Puga, D. A., Woller, S. A., Hughes, A. J., & Grau, J. W.
(2012).
Temporal regularity determines the impact of electrical stimulation on tactile reactivity and response to capsaicin in spinally transected rats. Neuroscience.
227, 119-133.
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Ferguson, A. R., Huie, J. R., Crown, E. D., & Grau, J. W.
(2012).
Central nociceptive sensitization vs. spinal cord training: opposing forms of plasticity that dictate function after complete spinal cord injury. Frontiers in Physiology.
3, 396.
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Huie, J. R., Baumbauer, K. M., Lee, K. H., Bresnahan, J. C., Beattie, M. S., Ferguson, A. R., & Grau, J. W.
(2012).
Glial tumor necrosis factor alpha (TNF) generates metaplastic inhibition of spinal learning. PLoS ONE.
7(6), e39751-e39751.
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Huie, J. R., Garraway, S. M., Baumbauer, K. M., Hoy, K. C., Beas, B. S., Montgomery, K. S., Bizon, J. L., & Grau, J. W.
(2012).
Brain-derived neurotrophic factor promotes adaptive plasticity within the spinal cord and mediates the beneficial effects of controllable stimulation. Neuroscience.
200, 74-90.
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Baumbauer, K. M., & Grau, J. W.
(2011).
Timing in the absence of supraspinal input III: regularly spaced cutaneous stimulation prevents and reverses the spinal learning deficit produced by peripheral inflammation. BEHAVIORAL NEUROSCIENCE.
125(1), 37-45.
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Baumbauer, K. M., Huie, J. R., Hughes, A. J., & Grau, J. W.
(2009).
Timing in the absence of supraspinal input II: regularly spaced stimulation induces a lasting alteration in spinal function that depends on the NMDA receptor, BDNF release, and protein synthesis. Journal of Neuroscience.
29(46), 14383-14393.
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Vichaya, E. G., Baumbauer, K. M., Carcoba, L. M., Grau, J. W., & Meagher, M. W.
(2009).
Spinal glia modulate both adaptive and pathological processes. Brain, Behavior, and Immunity.
23(7), 969-976.
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Baumbauer, K. M., Hoy, K. C., Huie, J. R., Hughes, A. J., Woller, S. A., Puga, D. A., Setlow, B., & Grau, J. W.
(2008).
Timing in the absence of supraspinal input I: variable, but not fixed, spaced stimulation of the sciatic nerve undermines spinally-mediated instrumental learning. Neuroscience.
155(4), 1030-1047.
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Washburn, S. N., Maultsby, M. L., Puga, D. A., & Grau, J. W.
(2008).
Opioid regulation of spinal cord plasticity: evidence the kappa-2 opioid receptor agonist GR89696 inhibits learning within the rat spinal cord. Neurobiology of Learning and Memory.
89(1), 1-16.
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Washburn, S. N., Patton, B. C., Ferguson, A. R., Hudson, K. L., & Grau, J. W.
(2007).
Exposure to intermittent nociceptive stimulation under pentobarbital anesthesia disrupts spinal cord function in rats. Psychopharmacology.
192(2), 243-252.
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Gmez-Pinilla, F., Huie, J. R., Ying, Z., Ferguson, A. R., Crown, E. D., Baumbauer, K. M., Edgerton, V. R., & Grau, J. W.
(2007).
BDNF and learning: Evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression. Neuroscience.
148(4), 893-906.
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Bigbee, A. J., Crown, E. D., Ferguson, A. R., Roy, R. R., Tillakaratne, N., Grau, J. W., & Edgerton, V. R.
(2007).
Two chronic motor training paradigms differentially influence acute instrumental learning in spinally transected rats. Behavioural Brain Research.
180(1), 95-101.
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Ferguson, A. R., Crown, E. D., & Grau, J. W.
(2006).
Nociceptive plasticity inhibits adaptive learning in the spinal cord. Neuroscience.
141(1), 421-431.
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Crown, E. D., & Grau, J. W.
(2005).
Evidence that descending serotonergic systems protect spinal cord plasticity against the disruptive effect of uncontrollable stimulation. Experimental Neurology.
196(1), 164-176.
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Liu, G. T., Ferguson, A. R., Crown, E. D., Bopp, A. C., Miranda, R. C., & Grau, J. W.
(2005).
Instrumental learning within the rat spinal cord: localization of the essential neural circuit. BEHAVIORAL NEUROSCIENCE.
119(2), 538-547.
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Grau, J. W., & Joynes, R. L.
(2005).
A Neural-Functionalist Approach to Learning. International Journal of Comparative Psychology.
18(1),
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Grau, J. W., & Joynes, R. L.
(2005).
Neurofunctionalism Revisited: Learning is More Than You Think It Is. International Journal of Comparative Psychology.
18(1),
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Crown, E. D., Grau, J. W., & Meagher, M. W.
(2004).
Pain in a balance: noxious events engage opposing processes that concurrently modulate nociceptive reactivity. BEHAVIORAL NEUROSCIENCE.
118(6), 1418-1426.
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Ferguson, A. R., Hook, M. A., Garcia, G., Bresnahan, J. C., Beattie, M. S., & Grau, J. W.
(2004).
A Simple Post Hoc Transformation that Improves the Metric Properties of the BBB Scale for Rats with Moderate to Severe Spinal Cord Injury. JOURNAL OF NEUROTRAUMA.
21(11), 1601-1613.
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Ferguson, A. R., Patton, B. C., Bopp, A. C., Meagher, M. W., & Grau, J. W.
(2004).
Brief exposure to a mild stressor enhances morphine-conditioned place preference in male rats. Psychopharmacology.
175(1), 47-52.
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Joynes, R. L., & Grau, J. W.
(2004).
Instrumental learning within the spinal cord: III. Prior exposure to noncontingent shock induces a behavioral deficit that is blocked by an opioid antagonist. Neurobiology of Learning and Memory.
82(1), 35-51.
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Joynes, R. L., Janjua, K., & Grau, J. W.
(2004).
Instrumental learning within the spinal cord: VI. The NMDA receptor antagonist, AP5, disrupts the acquisition and maintenance of an acquired flexion response. Behavioural Brain Research.
154(2), 431-438.
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Ferguson, A. R., Washburn, S. N., Crown, E. D., & Grau, J. W.
(2003).
GABA(A) receptor activation is involved in noncontingent shock inhibition of instrumental conditioning in spinal rats. BEHAVIORAL NEUROSCIENCE.
117(4), 799-812.
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Joynes, R. L., Ferguson, A. R., Crown, E. D., Patton, B. C., & Grau, J. W.
(2003).
Instrumental learning within the spinal cord: V. Evidence the behavioral deficit observed after noncontingent nociceptive stimulation reflects an intraspinal modification. Behavioural Brain Research.
141(2), 159-170.
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Crown, E. D., Ferguson, A. R., Joynes, R. L., & Grau, J. W.
(2002).
Instrumental learning within the spinal cord: IV. Induction and retention of the behavioral deficit observed after noncontingent shock. 116(6), 1032-1051.
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Crown, E. D., Ferguson, A. R., Joynes, R. L., & Grau, J. W.
(2002).
Instrumental learning within the spinal cord. II. Evidence for central mediation. Physiology and Behavior.
77(2-3), 259-267.
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Crown, E. D., & Grau, J. W.
(2001).
Preserving and restoring behavioral potential within the spinal cord using an instrumental training paradigm. Journal of Neurophysiology.
86(2), 845-855.
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Meagher, M. W., Ferguson, A. R., Crown, E. D., McLemore, S., King, T. E., Sieve, A. N., & Grau, J. W.
(2001).
Shock-induced hyperalgesia: IV. Generality. Journal of Experimental Psychology: Animal Learning and Cognition.
27(3), 219-238.
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Sieve, A. N., King, T. E., Ferguson, A. R., Grau, J. W., & Meagher, M. W.
(2001).
Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacology.
153(2), 180-190.
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Crown, E. D., King, T. E., Meagher, M. W., & Grau, J. W.
(2000).
Shock-induced hyperalgesia: III. Role of the bed nucleus of the stria terminalis and amygdaloid nuclei. BEHAVIORAL NEUROSCIENCE.
114(3), 561-573.
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McLemore, S., Crown, E. D., Meagher, M. W., & Grau, J. W.
(1999).
Shock-induced hyperalgesia: II. Role of the dorsolateral periaqueductal gray. BEHAVIORAL NEUROSCIENCE.
113(3), 539-549.
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King, T. E., Crown, E. D., Sieve, A. N., Joynes, R. L., Grau, J. W., & Meagher, M. W.
(1999).
Shock-induced hyperalgesia: evidence forebrain systems play an essential role. Behavioural Brain Research.
100(1-2), 33-42.
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Grau, J. W., Barstow, D. G., & Joynes, R. L.
(1998).
Instrumental learning within the spinal cord: I. Behavioral properties. BEHAVIORAL NEUROSCIENCE.
112(6), 1366-1386.
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King, T. E., Joynes, R. L., & Grau, J. W.
(1997).
Tail-flick test: II. The role of supraspinal systems and avoidance learning. BEHAVIORAL NEUROSCIENCE.
111(4), 754-767.
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Joynes, R. L., Illich, P. A., & Grau, J. W.
(1997).
Evidence for spinal conditioning in intact rats. Neurobiology of Learning and Memory.
67(1), 64-68.
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Joynes, R. L., & Grau, J. W.
(1996).
Mechanisms of Pavlovian conditioning: role of protection from habituation in spinal conditioning. 110(6), 1375-1387.
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King, T. E., Joynes, R. L., Meagher, M. W., & Grau, J. W.
(1996).
Impact of shock on pain reactivity: II. Evidence for enhanced pain. Journal of Experimental Psychology Animal Learning and Cognition.
22(3), 265-278.
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Prentice, T. W., Joynes, R. L., Meagher, M. W., & Grau, J. W.
(1996).
Impact of shock on pain reactivity: III. The magnitude of hypoalgesia observed depends on test location. BEHAVIORAL NEUROSCIENCE.
110(3), 528-541.
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Grau, J. W., King, T. E., Burks, K. D., Kallina, C. F., & Meagher, M. W.
(1996).
The relationship between shock severity and the form of the antinociception observed in pentobarbital-anesthetized rats. PSYCHOBIOLOGY.
24(1), 71-84.
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Illich, P. A., King, T. A., & Grau, J. W.
(1995).
Impact of shock on pain reactivity: I. Whether hypo- or hyperalgesia is observed depends on how pain reactivity is tested. Journal of Experimental Psychology: Animal Learning and Cognition.
21(4), 331-347.
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Meagher, M. W., Barter, J., King, T. E., & Grau, J. W.
(1995).
Presentation of a distractor speeds the decay of a pentobarbital-insensitive nonopioid hypoalgesia in rats. PSYCHOBIOLOGY.
23(4), 314-321.
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Kallina, C. F., & Grau, J. W.
(1995).
Tail-flick test. I: Impact of a suprathreshold exposure to radiant heat on pain reactivity in rats. Physiology and Behavior.
58(1), 161-168.
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Illich, P. A., Salinas, J. A., & Grau, J. W.
(1994).
Latent inhibition, overshadowing, and blocking of a conditioned antinociceptive response in spinalized rats. Behavioral and Neural Biology.
62(2), 140-150.
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Meagher, M. W., Chen, P. S., Salinas, J. A., & Grau, J. W.
(1993).
Activation of the opioid and nonopioid hypoalgesic systems at the level of the brainstem and spinal cord: does a coulometric relation predict the emergence or form of environmentally induced hypoalgesia?. BEHAVIORAL NEUROSCIENCE.
107(3), 493-505.
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Meagher, M. W., Chen, P., Salinas, J. A., & Grau, J. W.
(1993).
Activation of the Opioid and Nonopioid Hypoalgesic Systems at the Level of the Brainstem and Spinal Cord: Does a Coulometric Relation Predict the Emergence or Form of Environmentally Induced Hypoalgesia?. BEHAVIORAL NEUROSCIENCE.
107(3), 493-505.
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BILES, M. K., ILLICH, P. A., & GRAU, J. W.
(1992).
LONG-TERM EFFECTS OF FOOD-DEPRIVATION .2. IMPACT ON MORPHINE REACTIVITY. PSYCHOBIOLOGY.
20(1), 85-91.
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ILLICH, P. A., & GRAU, J. W.
(1991).
CONDITIONED CHANGES IN PAIN REACTIVITY .1. A DISCRETE CS ELICITS HYPOALGESIA, NOT HYPERALGESIA, ON THE TAIL-FLICK TEST. 22(4), 421-438.
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Illich, P. A., Salinas, J. A., & Grau, J. W.
(1991).
Conditioned changes in pain reactivity: II. In search of the elusive phenomenon of conditioned hyperalgesia. 105(3), 478-481.
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Grau, J. W., Illich, P. A., Chen, P. S., & Meagher, M. W.
(1991).
Role of cholinergic systems in pain modulation: I. Impact of scopolamine on environmentally induced hypoalgesia and pain reactivity. BEHAVIORAL NEUROSCIENCE.
105(1), 62-81.
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ILLICH, P. A., ALLEN, A. R., & GRAU, J. W.
(1991).
LONG-TERM EFFECTS OF FOOD-DEPRIVATION .1. IMPACT ON PAIN REACTIVITY AND SHOCK-INDUCED HYPOALGESIA. PSYCHOBIOLOGY.
19(4), 345-354.
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Grau, J. W., Illich, P. A., Chen, P., & Meagher, M. W.
(1991).
Role of Cholinergic Systems in Pain Modulation: I. Impact of Scopolamine on Environmentally Induced Hypoalgesia and Pain Reactivity. BEHAVIORAL NEUROSCIENCE.
105(1), 62-81.
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GRAU, J. W., BILES, M. K., & ILLICH, P. A.
(1991).
THE IMPACT OF NALTREXONE AND MORPHINE-TOLERANCE ON MILD SHOCK-INDUCED HYPOALGESIA. PSYCHOBIOLOGY.
19(1), 85-90.
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ILLICH, P. A., & GRAU, J. W.
(1990).
THE IMPACT OF SHOCK ON REACTIVITY TO A TACTILE STIMULUS. Learning and Motivation.
21(3), 287-298.
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Grau, J. W., Salinas, J. A., Illich, P. A., & Meagher, M. W.
(1990).
Associative learning and memory for an antinociceptive response in the spinalized rat. BEHAVIORAL NEUROSCIENCE.
104(3), 489-494.
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Meagher, M. W., Grau, J. W., & King, R. A.
(1990).
Role of supraspinal systems in environmentally induced antinociception: effect of spinalization and decerebration on brief shock-induced and long shock-induced antinociception. BEHAVIORAL NEUROSCIENCE.
104(2), 328-338.
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Grau, J. W., Salinas, J. A., Illich, P. A., & Meagher, M. W.
(1990).
Associative Learning and Memory for an Antinociceptive Response in the Spinalized Rat. BEHAVIORAL NEUROSCIENCE.
104(3), 489-494.
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Meagher, M. W., Grau, J. W., & King, R. A.
(1989).
Frontal cortex lesions block the opioid and nonopioid hypoalgesia elicited by brief shocks but not the nonopioid hypoalgesia elicited by long shocks. BEHAVIORAL NEUROSCIENCE.
103(6), 1366-1371.
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Meagher, M. W., Grau, J. W., & King, R. A.
(1989).
Frontal Cortex Lesions Block the Opioid and Nonopioid Hypoalgesia Elicited by Brief Shocks but Not the Nonopioid Hypoalgesia Elicited by Long Shocks. BEHAVIORAL NEUROSCIENCE.
103(6), 1366-1371.
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Grau, J. W., & Kemler Nelson, D. G.
(1988).
The distinction between integral and separable dimensions: evidence for the integrality of pitch and loudness. Journal of Experimental Psychology: General.
117(4), 347-370.
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Grau, J. W.
(1987).
Activation of the opioid and nonopioid analgesic systems: evidence for a memory hypothesis and against the coulometric hypothesis. Journal of Experimental Psychology: Animal Learning and Cognition.
13(3), 215-225.
-
Grau, J. W.
(1987).
The central representation of an aversive event maintains the opioid and nonopioid forms of analgesia. 101(2), 272-288.
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Rescorla, R. A., Grau, J. W., & Durlach, P. J.
(1985).
Analysis of the unique cue in configural discriminations. Journal of Experimental Psychology: Animal Learning and Cognition.
11(3), 356-366.
-
Grau, J. W.
(1984).
Influence of naloxone on shock-induced freezing and analgesia. BEHAVIORAL NEUROSCIENCE.
98(2), 278-292.
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Grau, J. W., & Rescorla, R. A.
(1984).
Role of context in autoshaping. Journal of Experimental Psychology Animal Learning and Cognition.
10(3), 324-332.
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Moye, T. B., Hyson, R. L., Grau, J. W., & Maier, S. F.
(1983).
Immunization of opioid analgesia: Effects of prior escapable shock on subsequent shock-induced and morphine-induced antinociception. Learning and Motivation.
14(2), 238-251.
-
Maier, S. F., Drugan, R. C., & Grau, J. W.
(1982).
Controllability, coping behavior, and stress-induced analgesia in the rat. Pain.
12(1), 47-56.
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Hyson, R. L., Ashcraft, L. J., Drugan, R. C., Grau, J. W., & Maier, S. F.
(1982).
Extent and control of shock affects naltrexone sensitivity of stress-induced analgesia and reactivity to morphine. Pharmacology, Biochemistry and Behavior.
17(5), 1019-1025.
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Grau, J. W., Hyson, R. L., Maier, S. F., Madden, J., & Barchas, J. D.
(1981).
Long-term stress-induced analgesia and activation of the opiate system. Science.
213(4514), 1409-1411.
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Drugan, R. C., Grau, J. W., Maier, S. F., Madden, J., & Barchas, J. D.
(1981).
Cross tolerance between morphine and the long-term analgesic reaction to inescapable shock. Pharmacology, Biochemistry and Behavior.
14(5), 677-682.
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Moye, T. B., Coon, D. J., Grau, J. W., & Maier, S. F.
(1981).
Therapy and immunization of long-term analgesia in rats. Learning and Motivation.
12(2), 133-148.
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Maier, S. F., Davies, S., Grau, J. W., Jackson, R. L., Morrison, D. H., Moye, T., Madden, J., & Barchas, J. D.
(1980).
Opiate antagonists and long-term analgesic reaction induced by inescapable shock in rats. 94(6), 1172-1183.
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Maier, S. F., Coon, D. J., McDaniel, M. A., Jackson, R. L., & Grau, J.
(1979).
The time course of learned helplessness, inactivity, and nociceptive deficits in rats. Learning and Motivation.
10(4), 467-487.
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Strain, M. M., Hook, M. A., Reynolds, J. D., Huang, Y., Henwood, M. K., & Grau, J. W.
A brief period of moderate noxious stimulation induces hemorrhage and impairs locomotor recovery after spinal cord injury. Physiology and Behavior.
212, 112695-112695.
-
Ferguson, A. R., Hook, M. A., Garcia, G., Bresnahan, J. C., Beattie, M. S., & Grau, J. W.
A simple post hoc transformation that improves the metric properties of the BBB scale for rats with moderate to severe spinal cord injury. JOURNAL OF NEUROTRAUMA.
21(11), 1601-1613.
-
Hook, M. A., Washburn, S. N., Moreno, G., Woller, S. A., Puga, D., Lee, K. H., & Grau, J. W.
An IL-1 receptor antagonist blocks a morphine-induced attenuation of locomotor recovery after spinal cord injury. Brain, Behavior, and Immunity.
25(2), 349-359.
-
Hook, M. A., & Grau, J. W.
An animal model of functional electrical stimulation: evidence that the central nervous system modulates the consequences of training. Spinal Cord.
45(11), 702-712.
-
Woller, S. A., Moreno, G. L., Hart, N., Wellman, P. J., Grau, J. W., & Hook, M. A.
Analgesia or addiction?: implications for morphine use after spinal cord injury. JOURNAL OF NEUROTRAUMA.
29(8), 1650-1662.
-
Brown, A. K., Woller, S. A., Moreno, G., Grau, J. W., & Hook, M. A.
Exercise therapy and recovery after SCI: evidence that shows early intervention improves recovery of function. Spinal Cord.
49(5), 623-628.
-
Ferguson, A. R., Bolding, K. A., Huie, J. R., Hook, M. A., Santillano, D. R., Miranda, R. C., & Grau, J. W.
Group I metabotropic glutamate receptors control metaplasticity of spinal cord learning through a protein kinase C-dependent mechanism. Journal of Neuroscience.
28(46), 11939-11949.
-
Grau, J. W., Huie, J. R., Garraway, S. M., Hook, M. A., Crown, E. D., Baumbauer, K. M., ... Ferguson, A. R.
Impact of behavioral control on the processing of nociceptive stimulation. Frontiers in Physiology.
3, 262.
-
Grau, J. W., Crown, E. D., Ferguson, A. R., Washburn, S. N., Hook, M. A., & Miranda, R. C.
Instrumental learning within the spinal cord: underlying mechanisms and implications for recovery after injury. Behavioral and Cognitive Neuroscience Reviews.
5(4), 191-239.
-
Garraway, S. M., Turtle, J. D., Huie, J. R., Lee, K. H., Hook, M. A., Woller, S. A., & Grau, J. W.
Intermittent noxious stimulation following spinal cord contusion injury impairs locomotor recovery and reduces spinal brain-derived neurotrophic factor-tropomyosin-receptor kinase signaling in adult rats. Neuroscience.
199, 86-102.
-
Hook, M. A., Moreno, G., Woller, S., Puga, D., Hoy, K., Balden, R., & Grau, J. W.
Intrathecal morphine attenuates recovery of function after a spinal cord injury. JOURNAL OF NEUROTRAUMA.
26(5), 741-752.
-
Ferguson, A. R., Huie, J. R., Crown, E. D., Baumbauer, K. M., Hook, M. A., Garraway, S. M., ... Grau, J. W.
Maladaptive spinal plasticity opposes spinal learning and recovery in spinal cord injury. Frontiers in Physiology.
3, 399.
-
Grau, J. W., Huie, J. R., Lee, K. H., Hoy, K. C., Huang, Y., Turtle, J. D., ... Garraway, S. M.
Metaplasticity and behavior: how training and inflammation affect plastic potential within the spinal cord and recovery after injury. Frontiers in Neural Circuits.
8(SEP), 100.
-
Strickland, E. R., Hook, M. A., Balaraman, S., Huie, J. R., Grau, J. W., & Miranda, R. C.
MicroRNA dysregulation following spinal cord contusion: implications for neural plasticity and repair. Neuroscience.
186, 146-160.
-
Hook, M. A., Ferguson, A. R., Garcia, G., Washburn, S. N., Koehly, L. M., & Grau, J. W.
Monitoring recovery after injury: procedures for deriving the optimal test window. JOURNAL OF NEUROTRAUMA.
21(1), 109-118.
-
Turtle, J. D., Strain, M. M., Aceves, M., Huang, Y., Reynolds, J. A., Hook, M. A., & Grau, J. W.
Pain Input Impairs Recovery after Spinal Cord Injury: Treatment with Lidocaine. JOURNAL OF NEUROTRAUMA.
34(6), 1200-1208.
-
Hook, M. A., Huie, J. R., & Grau, J. W.
Peripheral inflammation undermines the plasticity of the isolated spinal cord. BEHAVIORAL NEUROSCIENCE.
122(1), 233-249.
-
Garraway, S. M., Woller, S. A., Huie, J. R., Hartman, J. J., Hook, M. A., Miranda, R. C., ... Grau, J. W.
Peripheral noxious stimulation reduces withdrawal threshold to mechanical stimuli after spinal cord injury: role of tumor necrosis factor alpha and apoptosis. Pain.
155(11), 2344-2359.
-
Strickland, E. R., Woller, S. A., Garraway, S. M., Hook, M. A., Grau, J. W., & Miranda, R. C.
Regulatory effects of intermittent noxious stimulation on spinal cord injury-sensitive microRNAs and their presumptive targets following spinal cord contusion. Frontiers in Neural Circuits.
8, 117.
-
Grau, J. W., & Hook, M. A.
Spinal neurons exhibit a surprising capacity to learn and a hidden vulnerability when freed from the brain's control. Current Neurology and Neuroscience Reports.
6(3), 177-180.
-
Strickland, E. R., Woller, S. A., Hook, M. A., Grau, J. W., & Miranda, R. C.
The association between spinal cord trauma-sensitive miRNAs and pain sensitivity, and their regulation by morphine. Neurochemistry International.
77, 40-49.
-
Patton, B. C., Hook, M. A., Ferguson, A. R., Crown, E. D., & Grau, J. W.
The behavioral deficit observed following noncontingent shock in spinalized rats is prevented by the protein synthesis inhibitor cycloheximide. BEHAVIORAL NEUROSCIENCE.
118(3), 653-658.
-
Hook, M. A., Liu, G. T., Washburn, S. N., Ferguson, A. R., Bopp, A. C., Huie, J. R., & Grau, J. W.
The impact of morphine after a spinal cord injury. Behavioural Brain Research.
179(2), 281-293.
-
Grau, J. W., Washburn, S. N., Hook, M. A., Ferguson, A. R., Crown, E. D., Garcia, G., Bolding, K. A., & Miranda, R. C.
Uncontrollable stimulation undermines recovery after spinal cord injury. JOURNAL OF NEUROTRAUMA.
21(12), 1795-1817.
-
Grau, J. W., Huang, Y., Turtle, J. D., Strain, M. M., Miranda, R. C., Garraway, S. M., & Hook, M. A.
When Pain Hurts: Nociceptive Stimulation Induces a State of Maladaptive Plasticity and Impairs Recovery after Spinal Cord Injury. JOURNAL OF NEUROTRAUMA.
34(10), 1873-1890.
-
Grau, J. W., Hudson, K. E., Tarbet, M. M., & Strain, M. M.
(2022).
Behavioral studies of spinal conditioning: The spinal cord is smarter than you think it is. Journal of Experimental Psychology Animal Learning and Cognition.
48(4), 435-457.
-
book
-
Domjan, M. P.
(2014).
The Principles of Learning and Behavior. Cengage Learning.
-
Patterson, M. M., & Grau, J. W.
(2011).
Spinal Cord Plasticity Alterations in Reflex Function. Springer Science & Business Media.
-
Domjan, M. P.
(2014).
The Principles of Learning and Behavior. Cengage Learning.
-
chapter
-
Grau, J. W., & Patterson, M. M.
(2017).
Neural Plasticity of Spinal Reflexes. Reference Module in Neuroscience and Biobehavioral Psychology.
Elsevier.
-
Allen, C., Grau, J. W., & Meagher, M. W.
(2009).
The Lower Bounds of Cognition: What Do Spinal Cords Reveal?. The Oxford Handbook of Philosophy and Neuroscience.
(pp. 129-142).
Oxford University Press (OUP).
-
Grau, J. W., & Joynes, R. L.
(2001).
Pavlovian and instrumental conditioning within the spinal cord: Methodological issues. Patterson, M. M., & Grau, J. W. (Eds.),
Spinal Cord Plasticity.
(pp. 13-54).
Springer Nature.
-
Grau, J. W., & Patterson, M. M.
(2017).
Neural Plasticity of Spinal Reflexes. Reference Module in Neuroscience and Biobehavioral Psychology.
Elsevier.
-
conference paper
-
Johnston, T., Baine, R., Hudson, K., Lout, E., & Grau, J. W.
(2019).
BUMETANIDE PROMOTES FUNCTIONAL RECOVERY OF HINDLIMB FUNCTION AND REDUCES HEMORRHAGE AFTER SPINAL CORD INJURY. JOURNAL OF NEUROTRAUMA.
A57-A58.
-
Baine, R., Strain, M., Henwood, M., Johnston, D. T., Davis, J., & Grau, J. W.
(2019).
PAIN INPUT AFTER SPINAL CORD INJURY INCREASES TISSUE LOSS AND IMPAIRS LONG-TERM RECOVERY IN FEMALE RATS. JOURNAL OF NEUROTRAUMA.
A72-A72.
-
Fauss, G., Strain, M. M., Huang, Y. J., Reynolds, J. A., Davis, J. A., Henwood, M. K., West, C. R., & Grau, J. W.
(2018).
NOXIOUS STIMULATION AFTER SPINAL CORD INJURY (SCI) INDUCES A BRAIN-DEPENDENT INCREASE IN HEMORRHAGE. JOURNAL OF NEUROTRAUMA.
A176-A177.
-
Davis, J. A., Fauss, G., Strain, M. M., Henwood, M. K., & Grau, J. W.
(2018).
PAIN INDUCED HEMORRHAGE AFTER SPINAL CORD INJURY IS BLOCKED BY LIDOCAINE APPLIED ROSTRALLY TO INJURY. JOURNAL OF NEUROTRAUMA.
A48-A49.
-
Henwood, M. K., Strain, M. M., Reynolds, J. A., Fauss, G., Davis, J. A., & Grau, J. W.
(2018).
PAIN-INDUCED HEMORRHAGE AFTER SCI DEPENDS ON LESION SEVERITY AND TIME SINCE INJURY. JOURNAL OF NEUROTRAUMA.
A37-A38.
-
Huie, J. R., Stuck, E. D., Lee, K. H., Irvine, K. A., Bresnahan, J. C., Beattie, M. S., Grau, J. W., & Ferguson, A. R.
(2014).
PERIPHERAL NOCICEPTIVE INPUT OVERDRIVES AMPA RECEPTOR ACTIVITY TO PRODUCE MALADAPTIVE PLASTICITY AFTER SPINAL CORD INJURY (SCI). JOURNAL OF NEUROTRAUMA.
A6-A7.
-
Hook, M. A., Joynes, R. L., Crown, E. D., Ferguson, A. R., & Grau, J. W.
(2005).
A rodent model of functional electrical stimulation: Evidence spinal neurons modulate adaptive capacity. JOURNAL OF NEUROTRAUMA.
1172-1172.
-
Bopp, A. C., Ferguson, A. R., Liu, G., & Grau, J. W.
(2004).
Brain dependent processes contribute to the adverse consequences of uncontrollable stimulation on the recovery of function. JOURNAL OF NEUROTRAUMA.
1290-1290.
-
Ferguson, A. R., Ferguson, A. R., Hook, M. A., & Grau, J. W.
(2004).
Loss of learning in the spinal cord: Role of glutamate systems. JOURNAL OF NEUROTRAUMA.
1338-1338.
-
Washburn, S. N., Hook, M. A., Ferguson, A. R., Crown, E. D., Garcia, G., Bolding, K. A., Miranda, R. C., & Grau, J. W.
(2004).
Uncontrollable stimulation undermines recovery of function after spinal cord injury. JOURNAL OF NEUROTRAUMA.
1291-1291.
-
Johnston, T., Baine, R., Hudson, K., Lout, E., & Grau, J. W.
(2019).
BUMETANIDE PROMOTES FUNCTIONAL RECOVERY OF HINDLIMB FUNCTION AND REDUCES HEMORRHAGE AFTER SPINAL CORD INJURY. JOURNAL OF NEUROTRAUMA.
A57-A58.
Research
principal investigator on
- Nociceptive Input After Spinal Cord Injury (SCI) Expands the Region of Secondary Injury and Undermines Long-Term Recovery awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023
- Nociceptive (Pain) Input After Spinal Cord Injury (SCI) Enhances Secondary Injury: Identifying Treatments That Can Be Translated to Clinical Practice awarded by United States Army - (Washington D.C., District of Columbia, United States) 2018 - 2021
- Effect of Inflammation on Recovery and Pain After Spinal Cord Injury awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2016 - 2019
- How and when does peripheral input affect recovery after SCI awarded by Craig H Neilsen Foundation - (Los Angeles, California, United States) 2014 - 2018
co-principal investigator on
Teaching
teaching activities
- GENE491 Hnr-research Instructor
- NRSC340 Psyc Of Learning Instructor
- NRSC485 Directed Studies Instructor
- NRSC491 Hnr-research Instructor
- NRSC606 Learning Instructor
- NRSC685 Directed Studies Instructor
- NRSC691 Research Instructor
- PBSI340 Psyc Of Learning Instructor
- PBSI485 Directed Studies Instructor
- PBSI491 Hnr-research Instructor
- PBSI606 Learning Instructor
- PBSI685 Directed Studies Instructor
- PBSI691 Research Instructor
- PSYC340 Psyc Of Learning Instructor
- PSYC606 Learning Instructor
Works By Students
chaired theses and dissertations
-
Bopp, Anne Caroline (2006-10). Shock induces a deficit in the recovery of function after a contusion injury: identifying the relative contributions of the brain and spinal cord.
-
Ferguson, Adam Richard (2004-09). Neuropathic pain and the inhibition of learning within the spinal cord.
-
Hoy, Kevin (2012-10). Contribution of the Peripheral Nervous System to Instrumental Learning and Performance.
-
Hoy, Kevin Corcoran (2009-05). AMPA-receptor mediated plasticity within the rat spinal cord.
-
Huang, Yung-Jen (2015-05). Spinal Cord Injury (SCI) Switches How GABA Affects Nociceptive Plasticity.
-
Huie, John Russell (2009-05). The role of BDNF in spinal learning.
-
Huie, John Russell (2012-02). The Role of Tumor Necrosis Factor-Alpha in Maladaptive Spinal Plasticity.
-
Lee, Kuan Hsien (2013-08). Timing in the Absence of Supraspinal Input: Effects of Temporally Regular Stimulation on Spinal Plasticity.
-
Malamakal, Misty Marie (2017-08). The Relationship Between Blood Pressure, Locomotor Performance, and Hemorrhage After Noxious Input.
-
Puga, Denise Alejandra (2009-05). The opponent consequences of intermittent and continuous stimulation within the rat spinal cord.
-
Puga, Denise Alejandra (2012-07). Pain Processing in the Isolated Spinal Cord: Adaptive Nociceptive Modifications.
-
Strickland, Eric (2013-05). MicroRNA Dysregulation Following Spinal Cord Contusion: Implications for Neural Plasticity and Neuropathic Pain.
-
Turtle, Joel Dylan (2018-01). Acute Pain after Spinal Cord Injury: Impaired Recovery through Inflammation, Cell Death, and Hemorrhage.
-
Washburn, Stephanie Nicole (2006-08). Role of the opioid system in the behavioral deficit observed after uncontrollable shock.
-
Washburn, Stephanie Nicole (2009-05). The role of stress in recovery of function after spinal cord injury.
Background
education and training
- Ph.D. in Psychology, University of Pennsylvania - (Philadelphia, Pennsylvania, United States) 1985
- M.A. in Psychology, University of Pennsylvania - (Philadelphia, Pennsylvania, United States) 1982
- B.A. in Psychology and Molecular, Cellular and Developmental Biology, University of Colorado Boulder - (Boulder, Colorado, United States) 1981
awards and honors
Contact
first name
- James
has last name
- Grau
mailing address
-
Texas A&M University
Psychology
4235 TAMU
College Station, TX 77843-4235
USA
Other
- j-grau@tamu.edu