LONG-TERM EFFECTS OF FOOD-DEPRIVATION .2. IMPACT ON MORPHINE REACTIVITY Academic Article

abstract

• Exposure to a series of inescapable shocks elicits a hormonally mediated opioid hypoalgesia in rats. In addition, it has a long-term effect on the opioid system: it increases reactivity to a low dose of morphine. Here we looked at whether another manipulation that elicits a hormonally mediated opioid hypoalgesiafood deprivationhas a similar sensitizing effect. Subjects were placed on a restricted diet for 48 h. Opiate reactivity was then assessed 24 h after food was returned. In Experiment 1, previously food-deprived subjects exhibited a stronger hypoalgesia on the tailflick test 30 min after an injection of morphine. In Experiment 2, a history of food deprivation increased the duration of morphine hypoalgesia as well as its onset. In Experiment 3, food deprivation per se induced hypoalgesia, but only during the early part of the dark cycle. 1992, Psychonomic Society, Inc.. All rights reserved.

authors

• Grau, James

published proceedings

• PSYCHOBIOLOGY

author list (cited authors)

• BILES, M. K., ILLICH, P. A., & GRAU, J. W.

citation count

• 5

complete list of authors

• BILES, MK||ILLICH, PA||GRAU, JW

publication date

• January 1992

publisher

• Springer Nature  Publisher

published in

• PSYCHOBIOLOGY  Journal

keywords

• Drug Abuse (nida Only)
• Nutrition
• Substance Abuse

Digital Object Identifier (DOI)

• 10.3758/bf03327167

start page

• 85

end page

• 91

volume

• 20

issue

• 1

URL

• http://dx.doi.org/10.3758/bf03327167