Long-term stress-induced analgesia and activation of the opiate system. uri icon

abstract

  • Exposure of rats to a series of inescapable shocks produced in sequence both an early naltrexone-insensitive and a late naltrexone-reversible analgesic reaction. Activation of the opiate system was necessary and sufficient to produce an analgesic reaction 24 hours later on exposure to a small amount of shock. The amount of inescapable shock which induced naltrexone-reversible analgesia also produced hyperreactivity to morphine 24 hours later.

published proceedings

  • Science

author list (cited authors)

  • Grau, J. W., Hyson, R. L., Maier, S. F., Madden, J., & Barchas, J. D.

citation count

  • 246

complete list of authors

  • Grau, JW||Hyson, RL||Maier, SF||Madden, J||Barchas, JD

publication date

  • September 1981