Opiate antagonists and long-term analgesic reaction induced by inescapable shock in rats. Academic Article uri icon

abstract

  • Five experiments examined the influence of opiate antagonists on both the short-term analgesic reaction resulting 30 min after exposure to inescapable shock and the long-term analgesic reaction resulting after reexposure to shock 24 hr after inescapable shock exposure. Experiment 1 showed that the long-term analgesic reaction could be reduced by administration of naltrexone prior to exposure to inescapable tail shock. Experiment 2 showed that the reduction in the long-term analgesic reaction produced by naltrexone was dose-dependent. Experiment 3 showed that the long-term analgesic reaction could also be reduced by administration of naltrexone prior to reexposure to shock. Experiment 4 showed that the long-term analgesic reaction could be reduced by administration of large dose of naloxone prior to reexposure to shock. Experiment 5 showed that the short-term analgesic reaction was reduced by naltrexone administered prior to inescapable shock. Some implications of these results for the biochemical substrates of both learned helplessness and stress-induced analgesia are discussed.

published proceedings

  • J Comp Physiol Psychol

author list (cited authors)

  • Maier, S. F., Davies, S., Grau, J. W., Jackson, R. L., Morrison, D. H., Moye, T., Madden, J., & Barchas, J. D.

citation count

  • 166

complete list of authors

  • Maier, SF||Davies, S||Grau, JW||Jackson, RL||Morrison, DH||Moye, T||Madden, J||Barchas, JD

publication date

  • December 1980