THE IMPACT OF NALTREXONE AND MORPHINE-TOLERANCE ON MILD SHOCK-INDUCED HYPOALGESIA Academic Article

abstract

• We have previously shown that exposure to mild shock elicits a strong hypoalgesia on the tailflick test in rats. The present studies explored the role of endogenous opioids in producing this hypoalgesia. Experiment 1 evaluated the impact offive doses ofnaltrexone (0,0.44,1.75,7, and 28 mg/kg); Experiment 2100ked at the impact ofmorphine tolerance. Both a low dose ofnaltrexone (1.75 mg/kg) and morphine tolerance attenuated the hypoalgesia observed 610 min after mild shock. By contrast, neither morphine tolerance nor a high dose of naltrexone (28 mg/kg) had a significant impact on the hypoalgesia observed 2 min after shock. These findings suggest that mild shock elicits both a transient nonopioid and a long-Iasting opioid hypoalgesia. 1991, Psychonomic Society, Inc.. All rights reserved.

authors

• Grau, James

published proceedings

• PSYCHOBIOLOGY

author list (cited authors)

• GRAU, J. W., BILES, M. K., & ILLICH, P. A.

citation count

• 6

complete list of authors

• GRAU, JW||BILES, MK||ILLICH, PA

publication date

• January 1991

publisher

• Springer Nature  Publisher

published in

• PSYCHOBIOLOGY  Journal

keywords

• Drug Abuse (nida Only)
• Substance Abuse

Digital Object Identifier (DOI)

• 10.1007/bf03337961

start page

• 85

end page

• 90

volume

• 19

issue

• 1

URL

• http://dx.doi.org/10.1007/bf03337961