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Dashwood, PhD, FRSB, Roderick Professor and Director

Positions

The current focus is on integrating genetic/epigenetic/immune mechanisms in colorectal cancer etiology. The genetic basis of oncology is studied using cultured human cancer cells and preclinical approaches, including the Apc-mutant polyposis in rat colon (Pirc) model coupled to a novel murine polypectomy methodology. Epigenomic aspects are studied through alterations in epigenetic 'readers', 'writers' and 'erasers', via combined deacetylase plus bromodomain inhibition, which also modulates immune-related players in cancer cells. Deacetylase/bromodomain expression and protein acetylation changes also are examined in clinical specimens, organoids, 3D spheroids, and human volunteers undergoing colonoscopy, thereby providing clinical translation of the research.

Research Areas research areas

HR job title

  • Professor