HR job title
- Professor
- Contact Info
- 713-677-7806
- Websites
- ORCiD
- 0000-0003-0351-4034
Dashwood, Roderick University Distinguished Professor
Positions
- Distinguished Professor, Center for Epigenetics and Disease Prevention, Texas A&M University Naresh K. Vashisht College of Medicine, Health Science Center
- Director, Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology
- John S. Dunn Chair in Disease Prevention, Institute of Biosciences and Technology, Texas A&M University Naresh K. Vashisht College of Medicine
Research integrates multiomic, genetic, epigenetic and immune approaches for precision oncology. Epigenetic readers, writers and erasers that reversibly regulate immune players in the antigen presentation pathway are of current mechanistic interest. Molecular and cell-based assays are combined with preclinical models coupled to polypectomy. Clinical specimens and organoids from patients undergoing colectomy provide for human translation. Supported by the NCI, NINDS/NIA, and the John S. Dunn Foundation.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Works By Students
- Background
- Contact
- Other
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Overview
Publications
selected publications
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academic article
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Mohan, N., Johnson, G. S., Tovar Perez, J. E., Dashwood, W. M., Rajendran, P., & Dashwood, R. H.
(2024).
Alternative splicing of BAZ1A in colorectal cancer disrupts the DNA damage response and increases chemosensitization. Cell Death and Disease.
15(8), 570.
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Tovar Perez, J. E., Zhang, S., Hodgeman, W., Kapoor, S., Rajendran, P., Kobayashi, K. S., & Dashwood, R. H.
(2024).
Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception. Clinical Epigenetics.
16(1), 83.
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Liu, M., Zhong, X. S., Krishnachaitanya, S. S., Ou, R., Dashwood, R. H., Powell, D. W., & Li, Q.
(2024).
Erlotinib suppresses tumorigenesis in a mouse model of colitis-associated cancer. Biomedicine and Pharmacotherapy.
175, 116580-116580.
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Tripathi, C., Perez, J., Kapoor, S., Muhsin, A., Dashwood, W. M., Demirhan, Y., ... Dashwood, R. H.
(2024).
Abstract 5276: Immunomodulatory activity of intermittent low-dose erlotinib plus sulindac: Implications for hereditary and sporadic colorectal cancer. Cancer Research.
84(6_Supplement), 5276-5276.
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Mohan, N., Dashwood, R. H., & Rajendran, P.
(2024).
AZ of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer. Cancers.
16(6), 1104-1104.
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Neja, S., Dashwood, W. M., Dashwood, R. H., & Rajendran, P.
(2024).
Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors. Nutrients.
16(3), 396-396.
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Zhong, X. S., Ou, R., Liu, M., Krishnachaitanya, S., Dashwood, R., Powell, D. W., & Li, Q.
(2023).
Su1677 ERLOTINIB SUPPRESSES TUMORIGENESIS IN A MOUSE MODEL OF COLITIS-ASSOCIATED CANCER. Gastroenterology.
164(6), s-639.
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Zhang, S., Kapoor, S., Tripathi, C., Perez, J. T., Mohan, N., Dashwood, W. M., ... Dashwood, R.
(2023).
Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis. npj Precision Oncology.
7(1), 20.
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Chen, Y., Li, J., Neja, S., Menon, R., Jayaraman, A., Lee, K., ... Dashwood, R.
(2022).
Abstract A013: Metabolomics of acute vs. chronic spinach intake in an Apc-mutant genetic background: linoleate and butanoate metabolites targeting HDAC activity and IFN- signaling. Cancer Prevention Research.
15(12_Supplement_2), a013-a013.
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Kapoor, S., Damiani, E., Wang, S., Dharmanand, R., Tripathi, C., Tovar Perez, J. E., ... Dashwood, R. H.
(2022).
BRD9 Inhibition by Natural Polyphenols Targets DNA Damage/Repair and Apoptosis in Human Colon Cancer Cells. Nutrients.
14(20), 4317-4317.
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Tripathi, C., & Dashwood, R. H.
(2022).
Abstract 5631: Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis. Cancer Research.
82(12_Supplement), 5631-5631.
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Perez, J., & Dashwood, R. H.
(2022).
Abstract 5632: Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells. Cancer Research.
82(12_Supplement), 5632-5632.
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Kapoor, S., & Dashwood, R. H.
(2022).
Abstract 5712: Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception. Cancer Research.
82(12_Supplement), 5712-5712.
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Mohan, N., & Dashwood, R. H.
(2022).
Abstract 5713: Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer. Cancer Research.
82(12_Supplement), 5713-5713.
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Neja, S., & Dashwood, R. H.
(2022).
Abstract 5815: Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake. Cancer Research.
82(12_Supplement), 5815-5815.
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Chen, Y., Li, J., Neja, S., Kapoor, S., Tovar Perez, J. E., Tripathi, C., ... Dashwood, R.
(2022).
Metabolomics of Acute vs. Chronic Spinach Intake in an Apc-Mutant Genetic Background: Linoleate and Butanoate Metabolites Targeting HDAC Activity and IFN- Signaling. Cells.
11(3), 573-573.
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Xiao, Y., Lian, H., Zhong, X. S., Krishnachaitanya, S. S., Cong, Y., Dashwood, R. H., ... Li, Q.
(2022).
Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7. Frontiers in Immunology.
13, 1020902.
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Mohammed, A., Dashwood, R. H., Dickinson, S., Disis, M. L., Jaffee, E. M., Johnson, B. D., ... Miller, M. S.
(2021).
Translational Advances in Cancer Prevention Agent Development (TACPAD) Virtual Workshop on Immunomodulatory Agents: Report. Journal of Cancer Prevention.
26(4), 309-317.
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Demirhan, Y. E., Rajendran, P., Dashwood, W., Kapoor, S., Ulusan, A., Tripathi, C., ... Dashwood, R.
(2021).
S318 Optimized Lower Dose Combinations of Sulindac Plus Erlotinib Sustained Antitumor Efficacy and Reduced Toxicity in a Preclinical Model of FAP. AMERICAN JOURNAL OF GASTROENTEROLOGY.
116(1), s138-s138.
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Kapoor, S., Gustafson, T., Zhang, M., Chen, Y., Li, J., Nguyen, N., ... Dashwood, R.
(2021).
Abstract 2106: Combined deacetylase and bromodomain inhibition downregulates ERCC2 and suppresses growth of metastatic colon cancer cells. Cancer Research.
81(13_Supplement), 2106-2106.
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Miller, M. S., Allen, P. J., Brown, P. H., Chan, A. T., Clapper, M. L., Dashwood, R. H., ... Mohammed, A.
(2021).
Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting. Journal of Cancer Prevention.
26(1), 71-82.
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Kapoor, S., Gustafson, T., Zhang, M., Chen, Y., Li, J., Nguyen, N., ... Dashwood, R. H.
(2021).
Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells. Cancers.
13(6), 1438-1438.
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Dashwood, R. H.
(2021).
Cancer interception by interceptor molecules: mechanistic, preclinical and human translational studies with chlorophylls. Genes and Environment.
43(1), 8.
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Ulusan, A. M., Rajendran, P., Dashwood, W. M., Yavuz, O. F., Kapoor, S., Gustafson, T. A., ... Dashwood, R. H.
(2021).
Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP). Cancer Prevention Research.
14(3), 325-336.
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Chen, Y., Li, J., Menon, R., Jayaraman, A., Lee, K., Huang, Y., ... Dashwood, R. H.
(2021).
Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics. Gut Microbes.
13(1), 1972756.
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Damiani, E., Duran, M. N., Mohan, N., Rajendran, P., & Dashwood, R. H.
(2020).
Targeting Epigenetic 'Readers' with Natural Compounds for Cancer Interception. Journal of Cancer Prevention.
25(4), 189-203.
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Li, J., Zhao, S., Lee, M., Yin, Y., Li, J., Zhou, Y., ... Sun, D.
(2020).
Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma. Science Advances.
6(42), eabb5427.
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Bhattacharjee, S., Li, J., & Dashwood, R. H.
(2020).
Emerging crosstalk between long non-coding RNAs and Nrf2 signaling. Cancer Letters.
490, 154-164.
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Johnson, G. S., Rajendran, P., & Dashwood, R. H.
(2020).
CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis. Cancer Science.
111(10), 3416-3425.
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Dashwood, R. H.
(2020).
Memories of a friend and colleague - Takashi Sugimura. Mutation Research - Reviews in Mutation Research.
786, 108337-108337.
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Bhattacharjee, S., & Dashwood, R. H.
(2020).
Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals. Antioxidants.
9(9), 865-865.
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Davis, J. S., Kanikarla-Marie, P., Gagea, M., Yu, P. L., Fang, D., Sebastian, M., ... Kopetz, S.
(2020).
Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development. BMC Cancer.
20(1), 871.
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Davis, J. S., Kanikarla, P., Yu, P. L., Gagea, M., Fang, D., Sebastian, M., ... Kopetz, S.
(2020).
Abstract 1: Sulindac plus phospholipid is effective for polyp reduction and safer than sulindac alone. Cancer Research.
80(16), 1-1.
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Kline, K. T., Lian, H., Zhong, X. S., Luo, X., Winston, J. H., Cong, Y., ... Li, Q.
(2020).
Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood. Journal of Immunology.
204(4), 980-989.
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Zhang, Z., Garzotto, M., Davis, E. W., Mori, M., Stoller, W. A., Farris, P. E., ... Shannon, J.
(2020).
Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial. Nutrition and Cancer.
72(1), 74-87.
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Johnson, G. S., Rajendran, P., Li, L. i., Chen, Y., Dashwood, W. M., Nhung, N., ... Dashwood, R. H.
(2019).
CCAR2 acetylation establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition. Cancer Research.
79(13), 2614-2614.
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Lian, H., Zhong, X. S., Kline, K., Luo, X., Winston, J., Cong, Y., ... Li, Q.
(2019).
991 Matrix Metalloproteinase 7 Contributes to Intestinal Barrier Dysfunction by Suppressing Tight Junction Proteins. Gastroenterology.
156(6), s-211.
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Zhang, J., Tan, P., Guo, L., Gong, J., Ma, J., Li, J., ... Huang, Y.
(2019).
p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene.
38(11), 1905-1919.
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Rajendran, P., Johnson, G., Li, L. i., Chen, Y., Dashwood, M., Nguyen, N., ... Dashwood, R.
(2019).
Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition. Cancer Research.
79(5), 918-927.
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Housley, L., Magana, A. A., Hsu, A., Beaver, L. M., Wong, C. P., Stevens, J. F., ... Ho, E.
(2018).
Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts. Molecular Nutrition and Food Research.
62(19), e1700665-1700665.
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Okonkwo, A., Mitra, J., Johnson, G. S., Li, L. i., Dashwood, W. M., Hegde, M. L., ... Rajendran, P.
(2018).
Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs. Molecular Nutrition and Food Research.
62(18), e1800228-1800228.
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Hasaniya, N. W., Premaratne, S., Zhang, W. W., Razzuk, A. M., McNamara, J. J., & Dashwood, R. H.
(2018).
Preparation, Characterization and Electron Paramagnetic Resonance (EPR) Spectroscopic Studies of OXANOH. Free Radicals and Antioxidants.
8(2), 70-73.
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Reddy, D. S., Wu, X., Golub, V. M., Dashwood, W. M., & Dashwood, R. H.
(2018).
Measuring Histone Deacetylase Inhibition in the Brain. Current Protocols in Pharmacology.
81(1), e41-e41.
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Zhong, X. S., Luo, X., Winston, J., Nayeem, S., Kline, K., Dashwood, R., ... Li, Q.
(2018).
1084 - Neonatal Colonic Inflammation Aggravates Epithelial Injury Through Mir-196 When Exposed to Another Episode of Inflammation in Adult-Life. Gastroenterology.
154(6), s-212.
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Beaver, L. M., Lhr, C. V., Clarke, J. D., Glasser, S. T., Watson, G. W., Wong, C. P., ... Ho, E.
(2018).
Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice. Current Developments in Nutrition.
2(3), nzy002-2003001.
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Yun, C., Dashwood, W., Kwong, L. N., Gao, S., Yin, T., Ling, Q., ... Hu, M.
(2018).
Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.
148, 42-50.
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Beaver, L. M., Lhr, C. V., Clarke, J. D., Glasser, S. T., Watson, G. W., Wong, C. P., ... Ho, E.
(2018).
Broccoli sprouts delay prostate cancer formation and decrease prostate cancer severity with a concurrent decrease in HDAC3 protein expression in TRAMP mice. Current Developments in Nutrition.
cdn.117.002378-cdn.117.002378.
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Zhong, X. S., Winston, J. H., Luo, X., Kline, K. T., Nayeem, S. Z., Cong, Y., ... Li, Q.
(2018).
Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life. CMGH Cellular and Molecular Gastroenterology and Hepatology.
6(1), 65-78.
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Chen, Y., Wang, R., Dashwood, W., Lhr, C. V., Williams, D. E., Ho, E., Mertens-Talcott, S., & Dashwood, R. H.
(2017).
A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat. Archives of Toxicology.
91(10), 3415-3425.
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Palomera-Sanchez, Z., Watson, G. W., Wong, C. P., Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E.
(2017).
The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
47, 113-119.
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Wang, R., Chen, Y., Dashwood, W., Li, Q., Lhr, C. V., Fischer, K., ... Dashwood, R. H.
(2017).
Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. Molecular Carcinogenesis.
56(7), 1733-1742.
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Ertem, F. U., Zhang, W., Chang, K., Dashwood, W., Rajendran, P., Sun, D., ... Dashwood, R. H.
(2017).
Prevention by tolfenamic acid and characterization of the molecular targets in Pirc and FAP colorectal adenomas. Cancer Research.
77(13_Supplement), 2229-2229.
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Kumar, R., Herold, J. L., Schady, D., Davis, J., Kopetz, S., Martinez-Moczygemba, M., ... Xu, Y. i.
(2017).
Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development. PLOS Pathogens.
13(7), e1006440-e1006440.
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Johnson, G. S., Li, J., Beaver, L. M., Dashwood, W. M., Sun, D., Rajendran, P., ... Dashwood, R. H.
(2017).
A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells. Molecular Nutrition and Food Research.
61(4), 1600769-1600769.
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Johnson, G. S., Li, J., Beaver, L. M., Dashwood, W. M., Sun, D., Rajendran, P., ... Dashwood, R. H.
(2017).
Front cover: A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphanetreated colon cancer cells. Molecular Nutrition and Food Research.
61(4), 1770041-1770041.
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Beaver, L. M., Kuintzle, R., Buchanan, A., Wiley, M. W., Glasser, S. T., Wong, C. P., ... Ho, E.
(2017).
Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
42, 72-83.
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Ertem, F. U., Zhang, W., Chang, K., Mohaiza Dashwood, W., Rajendran, P., Sun, D., ... Dashwood, R. H.
(2017).
Oncogenic targets Mmp7, S100a9, Nppb and Aldh1a3 from transcriptome profiling of FAP and Pirc adenomas are downregulated in response to tumor suppression by Clotam. International Journal of Cancer.
140(2), 460-468.
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Madeen, E. P., Lhr, C. V., You, H., Siddens, L. K., Krueger, S. K., Dashwood, R. H., ... Williams, D. E.
(2017).
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Molecular Carcinogenesis.
56(1), 163-171.
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Kim, H., Banerjee, N., Barnes, R. C., Pfent, C. M., Talcott, S. T., Dashwood, R. H., & Mertens-Talcott, S. U.
(2017).
Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo. Molecular Carcinogenesis.
56(1), 197-207.
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Kim, E., Bisson, W. H., Lhr, C. V., Williams, D. E., Ho, E., Dashwood, R. H., & Rajendran, P.
(2016).
Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors. Current Topics in Medicinal Chemistry.
16(7), 714-731.
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Wang, R., Kang, Y., Lhr, C. V., Fischer, K. A., Bradford, C. S., Johnson, G., ... Dashwood, R. H.
(2016).
Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer. Cancer Letters.
381(2), 341-348.
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Kim, H., Banerjee, N., Ivanov, I., Pfent, C. M., Prudhomme, K. R., Bisson, W. H., ... Mertens-Talcott, S. U.
(2016).
Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. Molecular Nutrition and Food Research.
60(9), 1912-1923.
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Kim, H., Banerjee, N., Ivanov, I., Pfent, C. M., Prudhomme, K. R., Bisson, W. H., ... MertensTalcott, S. U.
(2016).
Inside front cover: Comparison of antiinflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. Molecular Nutrition and Food Research.
60(9), na-na.
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Ertem, F. U., Dashwood, W., Rajendran, P., Raju, G., Rashid, A., & Dashwood, R.
(2016).
Novel polypectomy system in a preclinical model of colon cancer. Cancer Research.
76(14_Supplement), 839-839.
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Ertem, F., Dashwood, W., Rajendran, P., Raju, G., Rashid, A., & Dashwood, R.
(2016).
Development of a murine colonoscopic polypectomy model(withvideos). Gastrointestinal Endoscopy.
83(6), 1272-1276.
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Watson, G. W., Wickramasekara, S., Fang, Y., Maier, C. S., Williams, D. E., Dashwood, R. H., Perez, V. I., & Ho, E.
(2016).
HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells. Experimental Biology and Medicine.
241(11), 1177-1185.
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Rajendran, P., Dashwood, W., Li, L. i., Kang, Y., Kim, E., Johnson, G., ... Dashwood, R. H.
(2015).
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. Clinical Epigenetics.
7(1), 102.
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Watson, G. W., Wickramasekara, S., Maier, C. S., Williams, D. E., Dashwood, R. H., & Ho, E.
(2015).
Assessment of global proteome in LNCaP cells by 2D-RP/RP LC-MS/MS following sulforaphane exposure. EuPA Open Proteomics.
9, 34-40.
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Buchert, M., Rohde, F., Eissmann, M., Tebbutt, N., Williams, B., Tan, C. W., ... Janssen, K.
(2015).
A hypermorphic epithelial -catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations. DMM Disease Models and Mechanisms.
8(11), 1361-1373.
-
Paquette, C. E., Kent, M. L., Peterson, T. S., Wang, R., Dashwood, R. H., & Lhr, C. V.
(2015).
Immunohistochemical characterization of intestinal neoplasia in zebrafish Danio rerio indicates epithelial origin. Diseases of Aquatic Organisms.
116(3), 191-197.
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Johnson, G., Beaver, L., Williams, D. E., Ho, E., & Dashwood, R. H.
(2015).
Abstract B33: Regulation and function of Nrf2-associated long noncoding RNA. Cancer Prevention Research.
8(10_Supplement), b33-b33.
-
Dashwood, R. H.
(2015).
Abstract CN12-02: Dietary HDAC inhibitors: Prevention or therapy?. Cancer Prevention Research.
8(10_Supplement), cn12-02-cn12-02.
-
Watson, G. W., Wickramasekara, S., Fang, Y., Palomera-Sanchez, Z., Maier, C. S., Williams, D. E., ... Ho, E.
(2015).
Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells. Molecular Nutrition and Food Research.
59(10), 1954-1961.
-
Nolte-'t Hoen, E., Van Rooij, E., Bushell, M., Zhang, C., Dashwood, R. H., James, W., Harris, C., & Baltimore, D.
(2015).
The role of microRNA in nutritional control. Journal of Internal Medicine.
278(2), 99-109.
-
Atwell, L. L., Beaver, L. M., Shannon, J., Williams, D. E., Dashwood, R. H., & Ho, E.
(2015).
Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention. Current Pharmacology Reports.
1(2), 102-111.
-
Atwell, L., Clarke, J., Hsu, A., Bella, D., Choi, J., Stevens, J., ... Ho, E.
(2015).
Plasma Metabolomic Profiles in Healthy Adults following Consumption of Broccoli Sprouts. The FASEB Journal.
29(S1),
-
Atwell, L. L., Hsu, A., Wong, C. P., Stevens, J. F., Bella, D., Yu, T., ... Ho, E.
(2015).
Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Molecular Nutrition and Food Research.
59(3), 424-433.
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Watson, G. W., Wickramasekara, S., Palomera-Sanchez, Z., Black, C., Maier, C. S., Williams, D. E., Dashwood, R. H., & Ho, E.
(2014).
SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells. Oncogenesis.
3(12), e131-e131.
-
Kang, Y., Nian, H., Rajendran, P., Kim, E., Dashwood, W. M., Pinto, J. T., ... Dashwood, R. H.
(2014).
HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. Cell Death and Disease.
5(10), e1476-e1476.
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Beaver, L. M., Buchanan, A., Sokolowski, E. I., Riscoe, A. N., Wong, C. P., Chang, J. H., ... Ho, E.
(2014).
Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Molecular Nutrition and Food Research.
58(10), 2001-2013.
-
Jariyasopit, N., Zimmermann, K., Schrlau, J., Arey, J., Atkinson, R., Yu, T., ... Simonich, S.
(2014).
Heterogeneous reactions of particulate matter-bound PAHs and NPAHs with NO3/N2O5, OH radicals, and O3 under simulated long-range atmospheric transport conditions: reactivity and mutagenicity. Environmental Science and Technology.
48(17), 10155-10164.
-
Atwell, L., Clarke, J., Hsu, A., Bella, D., Stevens, J., Dashwood, R., Williams, D., & Ho, E.
(2014).
Bioavailability and metabolomic targets of sulforaphane in humans (1036.2). The FASEB Journal.
28(S1),
-
Beaver, L., Buchanan, A., Sokolowski, E., Glasser, S., Wong, C., Chang, J., ... Ho, E.
(2014).
Sulforaphane alters the expression of long intragenic noncoding RNAs that are dysregulated in prostate cancer cells (644.10). The FASEB Journal.
28(S1),
-
Watson, G., Wickramasekara, S., PalomeraSanchez, Z., Black, C., Maier, C., Williams, D., Dashwood, R., & Ho, E.
(2014).
Sulforaphane influences histone methylation in advanced prostate cancer cells (1045.15). The FASEB Journal.
28(S1),
-
Wong, C. P., Hsu, A., Buchanan, A., Palomera-Sanchez, Z., Beaver, L. M., Houseman, E. A., ... Ho, E.
(2014).
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS ONE.
9(1), e86787-e86787.
-
Jariyasopit, N., McIntosh, M., Zimmermann, K., Arey, J., Atkinson, R., Cheong, P., ... Massey Simonich, S. L.
(2014).
Novel nitro-PAH formation from heterogeneous reactions of PAHs with NO2, NO3/N2O5, and OH radicals: prediction, laboratory studies, and mutagenicity. Environmental Science and Technology.
48(1), 412-419.
-
W Watson, G., M Beaver, L., E Williams, D., H Dashwood, R., & Ho, E.
(2013).
Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. AAPS Journal.
15(4), 951-961.
-
Shorey, L. E., Madeen, E. P., Atwell, L. L., Ho, E., Lhr, C. V., Pereira, C. B., Dashwood, R. H., & Williams, D. E.
(2013).
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane. TOXICOLOGY AND APPLIED PHARMACOLOGY.
270(1), 60-69.
-
Kaur, P., Shorey, L. E., Ho, E., Dashwood, R. H., & Williams, D. E.
(2013).
The epigenome as a potential mediator of cancer and disease prevention in prenatal development. Nutrition Reviews.
71(7), 441-457.
-
Rajendran, P., Kidane, A. I., Yu, T., Dashwood, W., Bisson, W. H., Lhr, C. V., ... Dashwood, R. H.
(2013).
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics.
8(6), 612-623.
-
Wang, R., Lhr, C. V., Fischer, K., Dashwood, W. M., Greenwood, J. A., Ho, E., ... Dashwood, R. H.
(2013).
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. International Journal of Cancer.
132(5), 1004-1012.
-
Parasramka, M. A., Dashwood, W. M., Wang, R., Saeed, H. H., Williams, D. E., Ho, E., & Dashwood, R. H.
(2012).
A role for low-abundance miRNAs in colon cancer: the miR-206/Krppel-like factor 4 (KLF4) axis. Clinical Epigenetics.
4(1), 16.
-
Beaver, L. M., Yu, T., Sokolowski, E. I., Williams, D. E., Dashwood, R. H., & Ho, E.
(2012).
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. TOXICOLOGY AND APPLIED PHARMACOLOGY.
263(3), 345-351.
-
Parasramka, M. A., Dashwood, W. M., Wang, R., Abdelli, A., Bailey, G. S., Williams, D. E., Ho, E., & Dashwood, R. H.
(2012).
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Molecular Nutrition and Food Research.
56(8), 1259-1269.
-
Lee, S., Richardson, R. L., Dashwood, R. H., & Baek, S. J.
(2012).
Capsaicin represses transcriptional activity of -catenin in human colorectal cancer cells. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
23(6), 646-655.
-
Shorey, L. E., Hagman, A. M., Williams, D. E., Ho, E., Dashwood, R. H., & Benninghoff, A. D.
(2012).
3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS ONE.
7(4), e34975-e34975.
-
Parasramka, M. A., Ho, E., Williams, D. E., & Dashwood, R. H.
(2012).
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Molecular Carcinogenesis.
51(3), 213-230.
-
McQuistan, T. J., Simonich, M. T., Pratt, M. M., Pereira, C. B., Hendricks, J. D., Dashwood, R. H., Williams, D. E., & Bailey, G. S.
(2012).
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study. Food and Chemical Toxicology.
50(2), 341-352.
-
Rajendran, P., Ho, E., Williams, D. E., & Dashwood, R. H.
(2011).
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clinical Epigenetics.
3(1), 4.
-
Clarke, J. D., Hsu, A., Williams, D. E., Dashwood, R. H., Stevens, J. F., Yamamoto, M., & Ho, E.
(2011).
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharmaceutical Research.
28(12), 3171-3179.
-
Hsu, A., Wong, C. P., Yu, Z., Williams, D. E., Dashwood, R. H., & Ho, E.
(2011).
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clinical Epigenetics.
3(1), 3.
-
Ho, E., Beaver, L. M., Williams, D. E., & Dashwood, R. H.
(2011).
Dietary factors and epigenetic regulation for prostate cancer prevention. Advances in Nutrition.
2(6), 497-510.
-
Hasaniya, N. W., Premaratne, S., Zhang, W. W., Razzuk, A., Abdul-Ghani, A. A., Dashwood, R. H., ... McNamara, J. J.
(2011).
Amelioration of ischemia-reperfusion injury in an isolated rabbit lung model using OXANOH. Vascular and Endovascular Surgery.
45(7), 581-591.
-
Wang, W., Jariyasopit, N., Schrlau, J., Jia, Y., Tao, S., Yu, T., ... Simonich, S.
(2011).
Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games. Environmental Science and Technology.
45(16), 6887-6895.
-
Li, Q., Luo, C., Lhr, C. V., & Dashwood, R. H.
(2011).
Activator protein-2 functions as a master regulator of multiple transcription factors in the mouse liver. Hepatology Research.
41(8), 776-783.
-
Clarke, J. D., Hsu, A., Yu, Z., Dashwood, R. H., & Ho, E.
(2011).
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Molecular Nutrition and Food Research.
55(7), 999-1009.
-
Surh, Y., Dashwood, R. H., Na, H., & Ji, L. L.
(2011).
Introduction to Nutrition and physical activity in aging, obesity, and cancer. Annals of the New York Academy of Sciences.
1229(1), vii-viii.
-
Wang, R., & Dashwood, R. H.
(2011).
Endothelins and their receptors in cancer: identification of therapeutic targets. Pharmacological Research.
63(6), 519-524.
-
Rajendran, P., Williams, D. E., Ho, E., & Dashwood, R. H.
(2011).
Metabolism as a key to histone deacetylase inhibition. Critical Reviews in Biochemistry and Molecular Biology.
46(3), 181-199.
-
Wang, R., Dashwood, W., Nian, H., Lhr, C. V., Fischer, K. A., Tsuchiya, N., ... Dashwood, R. H.
(2011).
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). International Journal of Cancer.
128(11), 2581-2590.
-
Rajendran, P., Delage, B., Dashwood, W. M., Yu, T., Wuth, B., Williams, D. E., Ho, E., & Dashwood, R. H.
(2011).
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Molecular Cancer.
10(1), 68.
-
Hsu, A., Bruno, R. S., Lhr, C. V., Taylor, A. W., Dashwood, R. H., Bray, T. M., & Ho, E.
(2011).
Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFB pathway in the Noble rat model. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
22(5), 502-510.
-
Larsen, C. A., Dashwood, R. H., & Bisson, W. H.
(2010).
Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance. Pharmacological Research.
62(6), 457-464.
-
Ho, E., & Dashwood, R. H.
(2010).
Dietary manipulation of histone structure and function. World Review of Nutrition and Dietetics.
101, 95-102.
-
Larsen, C. A., & Dashwood, R. H.
(2010).
(-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells. Archives of Biochemistry and Biophysics.
501(1), 52-57.
-
Kwon, I., Wang, R., Thangaraju, M., Shuang, H., Liu, K., Dashwood, R., ... Browning, D. D.
(2010).
PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4. Oncogene.
29(23), 3423-3434.
-
Ho, E., & Dashwood, R. H.
(2010).
Dietary manipulation of histone structure and function. Journal of Nutrigenetics and Nutrigenomics.
3(4-6), 231-238.
-
Ho, E., Clarke, J. D., & Dashwood, R. H.
(2009).
Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. Journal of Nutrition.
139(12), 2393-2396.
-
Jubert, C., Mata, J., Bench, G., Dashwood, R., Pereira, C., Tracewell, W., ... Bailey, G.
(2009).
Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers. Cancer Prevention Research.
2(12), 1015-1022.
-
Larsen, C. A., & Dashwood, R. H.
(2009).
Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide. Biochemical and Biophysical Research Communications.
389(3), 527-530.
-
Larsen, C. A., Bisson, W. H., & Dashwood, R. H.
(2009).
Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. Journal of Medicinal Chemistry.
52(21), 6543-6545.
-
Chimploy, K., Daz, G. D., Li, Q., Carter, O., Dashwood, W., Mathews, C. K., ... Dashwood, R. H.
(2009).
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. International Journal of Cancer.
125(9), 2086-2094.
-
Ashktorab, H., Belgrave, K., Hosseinkhah, F., Brim, H., Nouraie, M., Takkikto, M., ... Smoot, D.
(2009).
Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. DIGESTIVE DISEASES AND SCIENCES.
54(10), 2109-2117.
-
Li, Q., Lhr, C. V., & Dashwood, R. H.
(2009).
Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse. Cancer Letters.
283(1), 36-42.
-
Nian, H., Bisson, W. H., Dashwood, W., Pinto, J. T., & Dashwood, R. H.
(2009).
Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. Carcinogenesis.
30(8), 1416-1423.
-
Lee, J., Nian, H., Cooper, A., Sinha, R., Dai, J., Bisson, W. H., Dashwood, R. H., & Pinto, J. T.
(2009).
Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prevention Research.
2(7), 683-693.
-
Hasaniya, N. W., Premaratne, S., Zhang, W. W., Razzuk, A. M., Abdul-Ghani, A. A., Siera, M., ... McNamara, J. J.
(2009).
Ischemia-reperfusion injury in the lung: quantitation using electron microscopy. Vascular and Endovascular Surgery.
43(2), 170-177.
-
Nian, H., Delage, B., Ho, E., & Dashwood, R. H.
(2009).
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
50(3), 213-221.
-
Castro, D. J., Lhr, C. V., Fischer, K. A., Waters, K. M., Webb-Robertson, B., Dashwood, R. H., Bailey, G. S., & Williams, D. E.
(2009).
Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis. Carcinogenesis.
30(2), 315-320.
-
Ashktorab, H., Dashwood, R. H., Dashwood, M. M., Zaidi, S. I., Hewitt, S. M., Green, W. R., ... Smoot, D. T.
(2008).
H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria. Helicobacter.
13(6), 506-517.
-
Wang, R., Dashwood, W., Nian, H., Tsuchiya, N., Nakagama, H., & Dashwood, R.
(2008).
Abstract B84: NADPH oxidase 1 (NOX1) and related NOX isoforms as key mediators of NFB signaling in colon cancer. Cancer Prevention Research.
1(7_Supplement), b84-b84.
-
Clarke, J. D., Dashwood, R. H., & Ho, E.
(2008).
Multi-targeted prevention of cancer by sulforaphane. Cancer Letters.
269(2), 291-304.
-
Wang, R., Dashwood, W. M., Lhr, C. V., Fischer, K. A., Nakagama, H., Williams, D. E., & Dashwood, R. H.
(2008).
beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet. Cancer Science.
99(9), 1754-1759.
-
Nian, H., Delage, B., Pinto, J. T., & Dashwood, R. H.
(2008).
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis.
29(9), 1816-1824.
-
Castro, D. J., Yu, Z., Lhr, C. V., Pereira, C. B., Giovanini, J. N., Fischer, K. A., ... Williams, D. E.
(2008).
Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine. Carcinogenesis.
29(8), 1581-1586.
-
Dashwood, R. H., & Ho, E.
(2008).
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. Nutrition Reviews.
66 Suppl 1(Suppl 1), S36-S38.
-
Delage, B., & Dashwood, R. H.
(2008).
Dietary manipulation of histone structure and function. Annual Review of Nutrition.
28(1), 347-366.
-
Wang, R., Dashwood, W. M., Lhr, C. V., Fischer, K. A., Pereira, C. B., Louderback, M., ... Dashwood, R. H.
(2008).
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. Carcinogenesis.
29(4), 834-839.
-
Simonich, M. T., McQuistan, T., Jubert, C., Pereira, C., Hendricks, J. D., Schimerlik, M., ... Bailey, G. S.
(2008).
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout. Food and Chemical Toxicology.
46(3), 1014-1024.
-
Dashwood, R. H., & Ho, E.
(2007).
Dietary histone deacetylase inhibitors: from cells to mice to man. Seminars in Cancer Biology.
17(5), 363-369.
-
Li, Q., Dashwood, W. M., Zhong, X., Nakagama, H., & Dashwood, R. H.
(2007).
Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. Oncogene.
26(42), 6194-6202.
-
Carter, O., Dashwood, R. H., Wang, R., Dashwood, W. M., Orner, G. A., Fischer, K. A., ... Williams, D. E.
(2007).
Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts. Nutrition and Cancer.
58(1), 60-65.
-
Simonich, M. T., Egner, P. A., Roebuck, B. D., Orner, G. A., Jubert, C., Pereira, C., ... Bailey, G. S.
(2007).
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis.
28(6), 1294-1302.
-
Yu, T. W., & Dashwood, R. H.
(2007).
Measuring antigenotoxic effects using the ames test and comet assay. American biotechnology laboratory.
25(6), 22-23.
-
Higdon, J. V., Delage, B., Williams, D. E., & Dashwood, R. H.
(2007).
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacological Research.
55(3), 224-236.
-
Myzak, M. C., Tong, P., Dashwood, W., Dashwood, R. H., & Ho, E.
(2007).
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Experimental Biology and Medicine.
232(2), 227-234.
-
Dashwood, R. H.
(2007).
Frontiers in polyphenols and cancer prevention. Journal of Nutrition.
137(1 Suppl), 267S-269S.
-
Wang, R., Dashwood, W. M., Bailey, G. S., Williams, D. E., & Dashwood, R. H.
(2006).
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
601(1-2), 11-18.
-
Dashwood, R. H.
(2006).
Xenobiotic metabolism relevance to cancer. Journal of Nutrition.
136(10), 2681S-2682S.
-
Myzak, M. C., Ho, E., & Dashwood, R. H.
(2006).
Dietary agents as histone deacetylase inhibitors. Molecular Carcinogenesis.
45(6), 443-446.
-
Cope, R. B., Loehr, C., Dashwood, R., & Kerkvliet, N. I.
(2006).
Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol. Photochemical and Photobiological Sciences.
5(5), 499-507.
-
Myzak, M. C., & Dashwood, R. H.
(2006).
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. Current Drug Targets.
7(4), 443-452.
-
Myzak, M. C., Hardin, K., Wang, R., Dashwood, R. H., & Ho, E.
(2006).
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis.
27(4), 811-819.
-
Myzak, M. C., Dashwood, W. M., Orner, G. A., Ho, E., & Dashwood, R. H.
(2006).
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. The FASEB Journal.
20(3), 506-508.
-
Myzak, M. C., & Dashwood, R. H.
(2006).
Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Letters.
233(2), 208-218.
-
Orner, G. A., Roebuck, B. D., Dashwood, R. H., & Bailey, G. S.
(2006).
Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats. Journal of Carcinogenesis.
5(1), 6-6.
-
Dashwood, R. H., Myzak, M. C., & Ho, E.
(2006).
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?. Carcinogenesis.
27(2), 344-349.
-
Kwon, D., Yoon, S., Carter, O., Bailey, G. S., & Dashwood, R. H.
(2006).
Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells. BioFactors.
26(4), 231-244.
-
Yu, Z., Loehr, C. V., Fischer, K. A., Louderback, M. A., Krueger, S. K., Dashwood, R. H., ... Williams, D. E.
(2006).
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Research.
66(2), 755-762.
-
Dashwood, W., Carter, O., Al-Fageeh, M., Li, Q., & Dashwood, R. H.
(2005).
Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
591(1-2), 161-172.
-
Carter, O., Bailey, G. S., & Dashwood, R. H.
(2004).
The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells. Journal of Nutrition.
134(12 Suppl), 3441S-3444S.
-
Orner, G. A., Dashwood, W., & Dashwood, R. H.
(2004).
Tumor-suppressing effects of antioxidants from tea. Journal of Nutrition.
134(11), 3177S-3178S.
-
Li, Q., & Dashwood, R. H.
(2004).
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. Journal of Biological Chemistry.
279(44), 45669-45675.
-
Myzak, M. C., Karplus, P. A., Chung, F., & Dashwood, R. H.
(2004).
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Research.
64(16), 5767-5774.
-
Al-Fageeh, M., Li, Q., Dashwood, W. M., Myzak, M. C., & Dashwood, R. H.
(2004).
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. Oncogene.
23(28), 4839-4846.
-
Mastaloudis, A., Yu, T., O'Donnell, R. P., Frei, B., Dashwood, R. H., & Traber, M. G.
(2004).
Endurance exercise results in DNA damage as detected by the comet assay. Free Radical Biology and Medicine.
36(8), 966-975.
-
Li, Q., Dashwood, W., Zhong, X., Al-Fageeh, M., & Dashwood, R. H.
(2004).
Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters. Genomics.
83(2), 231-242.
-
Yu, T., Xu, M., & Dashwood, R. H.
(2004).
Antimutagenic activity of spearmint. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
44(5), 387-393.
-
Dashwood, R. H., & Xu, M.
(2003).
The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol. Food and Chemical Toxicology.
41(8), 1185-1192.
-
Blum, C. A., Tanaka, T., Zhong, X., Li, Q., Dashwood, W., Pereira, C., Xu, M., & Dashwood, R. H.
(2003).
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. Molecular Carcinogenesis.
36(4), 195-203.
-
Daz, G. D., Li, Q., & Dashwood, R. H.
(2003).
Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Research.
63(6), 1254-1261.
-
Blum, C. A., Xu, M., Orner, G. A., Daro Daz, G., Li, Q., Dashwood, W. M., Bailey, G. S., & Dashwood, R. H.
(2003).
Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
523-524, 217-223.
-
Orner, G. A., Dashwood, W., Blum, C. A., Daz, G. D., Li, Q., & Dashwood, R. H.
(2003).
Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. Carcinogenesis.
24(2), 263-267.
-
Dashwood, R. H.
(2003).
Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis. 36(1), 35-42.
-
Orner, G. A., Dashwood, W., Blum, C. A., Daz, G. D., Li, Q., Al-Fageeh, M., ... Dashwood, R. H.
(2002).
Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
506-507, 121-127.
-
Dashwood, W., Orner, G. A., & Dashwood, R. H.
(2002).
Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. Biochemical and Biophysical Research Communications.
296(3), 584-588.
-
Dashwood, R. H.
(2002).
Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
511(2), 89-112.
-
Amantana, A., Santana-Rios, G., Butler, J. A., Xu, M., Whanger, P. D., & Dashwood, R. H.
(2002).
Antimutagenic activity of selenium-enriched green tea toward the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline. Biological Trace Element Research.
86(2), 177-191.
-
Li, Q., Dixon, B. M., Al-Fageeh, M., Blum, C. A., & Dashwood, R. H.
(2002).
Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. Gene.
283(1-2), 255-262.
-
Franke, A. A., Custer, L. J., Cooney, R. V., Tanaka, Y., Xu, M., & Dashwood, R. H.
(2002).
Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin. Advances in Experimental Medicine and Biology.
505, 123-133.
-
Santana-Rios, G., Orner, G. A., Xu, M., Izquierdo-Pulido, M., & Dashwood, R. H.
(2001).
Inhibition by white tea of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced colonic aberrant crypts in the F344 rat. Nutrition and Cancer.
41(1-2), 98-103.
-
Santana-Rios, G., Orner, G. A., Amantana, A., Provost, C., Wu, S. Y., & Dashwood, R. H.
(2001).
Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
495(1-2), 61-74.
-
Yu, Z., Xu, M., Santana-Rios, G., Shen, R., Izquierdo-Pulido, M., Williams, D. E., & Dashwood, R. H.
(2001).
A comparison of whole wheat, refined wheat and wheat bran as inhibitors of heterocyclic amines in the Salmonella mutagenicity assay and in the rat colonic aberrant crypt focus assay. Food and Chemical Toxicology.
39(7), 655-665.
-
Dashwood, R. H., Xu, M., Orner, G. A., & Horio, D. T.
(2001).
Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2-amino-3-methylimidaz. European Journal of Cancer Prevention.
10(2), 139-145.
-
Blum, C. A., Xu, M., Orner, G. A., Fong, A. T., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
Erratum: -Catenin mutation in rat colon tumors initiated by 1,2-dimenthylhydrazine and 2-amino-3-methylimidazo [4,5-f]quinoline, and the effect of post-initiation treatment with chlorophylin and indole-3-carbinol (Carcinogenesis (2001) vol. 22 (315-320)). Carcinogenesis.
22(4), 685.
-
Xu, M., Orner, G. A., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
Erratum: Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl-imidazo[4,5-f] quinoline (Carcinogenesis (2001) vol. 22 (309-314)). Carcinogenesis.
22(4), 685.
-
Blum, C. A., Xu, M., Orner, G. A., Fong, A. T., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
-catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo [4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol (vol 22, pg 315, 2001). Carcinogenesis.
22(4), 685-685.
-
Xu, M., Orner, G. A., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl-imidazo[4,5-f]quinoline (vol 22, pg 309, 2001). Carcinogenesis.
22(4), 685-685.
-
Xu, M., Orner, G. A., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo. Carcinogenesis.
22(2), 309-314.
-
Blum, C. A., Xu, M., Orner, G. A., Fong, A. T., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. Carcinogenesis.
22(2), 315-320.
-
Bonnesen, C., Eggleston, I. M., & Hayes, J. D.
(2001).
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Research.
61(16), 6120-6130.
-
Magnuson, B. A., South, E. H., Exon, J. H., Dashwood, R. H., Xu, M., Hendrix, K., & Hubele, S.
(2000).
Increased susceptibility of adult rats to azoxymethane-induced aberrant crypt foci. Cancer Letters.
161(2), 185-193.
-
Xu, M., Chen, R., & Dashwood, R. H.
(1999).
Effect of carcinogen dose fractionation, diet and source of F344 rat on the induction of colonic aberrant crypts by 2-amino-3-methylimidazo[4,5-f]quinoline. Carcinogenesis.
20(12), 2293-2298.
-
Santana-Rios, G., & Dashwood, R. H.
(1999).
Time to discontinue antigenotoxicity studies of dietary fiber?. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
429(2), 269-271.
-
Xu, M., & Dashwood, R. H.
(1999).
Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis. Cancer Letters.
143(2), 179-183.
-
Breinholt, V., Arbogast, D., Loveland, P., Pereira, C., Dashwood, R., Hendricks, J., & Bailey, G.
(1999).
Chlorophyllin chemoprevention in trout initiated by aflatoxin B(1) bath treatment: An evaluation of reduced bioavailability vs. target organ protective mechanisms. TOXICOLOGY AND APPLIED PHARMACOLOGY.
158(2), 141-151.
-
Dashwood, R. H., Xu, M., Hernaez, J. F., Hasaniya, N., Youn, K., & Razzuk, A.
(1999).
Cancer Chemopreventive Mechanisms of Tea Against Heterocyclic Amine Mutagens from Cooked Meat. Experimental Biology and Medicine.
220(4), 239-243.
-
Dashwood, R. H., Xu, M., Hernaez, J. F., Hasaniya, N., Youn, K., & Razzuk, A.
(1999).
Cancer chemopreventive mechanisms of tea against heterocyclic amine mutagens from cooked meat. Experimental Biology and Medicine.
220(4), 239-243.
-
Suzui, M., Ushijima, T., Dashwood, R. H., Yoshimi, N., Sugimura, T., Mori, H., & Nagao, M.
(1999).
Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone. Molecular Carcinogenesis.
24(3), 232-237.
-
Dashwood, R. H.
(1999).
Early detection and prevention of colorectal cancer (review). Oncology Reports.
6(2), 277-281.
-
Dashwood, R. H.
(1998).
Cancer chemoprevention from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
405(1), 109-110.
-
Hernaez, J. F., Xu, M., & Dashwood, R. H.
(1998).
Antimutagenic activity of tea towards 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline: effect of tea concentration and brew time on electrophile scavenging. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
402(1-2), 299-306.
-
Dashwood, R. H.
(1998).
The "Sufficiency Principle" from the perspective of cancer prevention. Japanese Journal of Clinical Oncology.
28(6), 410-411.
-
Dashwood, R., Negishi, T., Hayatsu, H., Breinholt, V., Hendricks, J., & Bailey, G.
(1998).
Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
399(2), 245-253.
-
Bailey, G. S., Dashwood, R., Loveland, P. M., Pereira, C., & Hendricks, J. D.
(1998).
Molecular dosimetry in fish: quantitative target organ DNA adduction and hepatocarcinogenicity for four aflatoxins by two exposure routes in rainbow trout. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
399(2), 233-244.
-
Dashwood, R. H., & Bailey, G. S.
(1998).
Use of fish and fish transgenics in laboratory and field genotoxicology studies - Preface. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
399(2), 123-124.
-
Dashwood, R. H., Suzui, M., Nakagama, H., Sugimura, T., & Nagao, M.
(1998).
High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. Cancer Research.
58(6), 1127-1129.
-
Dashwood, R. H.
(1998).
Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?. CHEMICO-BIOLOGICAL INTERACTIONS.
110(1-2), 1-5.
-
Hernaez, J., Xu, M., & Dashwood, R.
(1997).
Effects of tea and chlorophyllin on the mutagenicity of N-hydroxy-IQ: studies of enzyme inhibition, molecular complex formation, and degradation/scavenging of the active metabolites. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
30(4), 468-474.
-
Dashwood, R. H.
(1997).
The importance of using pure chemicals in (anti) mutagenicity studies: chlorophyllin as a case in point. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
381(2), 283-286.
-
Xu, M., Schut, H. A., Bjeldanes, L. F., Williams, D. E., Bailey, G. S., & Dashwood, R. H.
(1997).
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts by indole-3-carbinol: dose-response studies in the rat colon. Carcinogenesis.
18(11), 2149-2153.
-
Hasaniya, N., Youn, K., Xu, M., Hernaez, J., & Dashwood, R.
(1997).
Inhibitory activity of green and black tea in a free radical-generating system using 2-amino-3-methylimidazo[4,5-f]quinoline as substrate. Japanese journal of cancer research : Gann.
88(6), 553-558.
-
Dashwood, R.
(1997).
Chlorophylls as anticarcinogens (review). International Journal of Oncology.
10(4), 721-727.
-
Hayashi, R., Luk, H., Horio, D., & Dashwood, R.
(1996).
Inhibition of apoptosis in colon tumors induced in the rat by 2-amino-3-methylimidazo[4,5-f]quinoline. Cancer Research.
56(19), 4307-4310.
-
Xu, M., Bailey, A. C., Hernaez, J. F., Taoka, C. R., Schut, H. A., & Dashwood, R. H.
(1996).
Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis.
17(7), 1429-1434.
-
Dashwood, R., Yamane, S., & Larsen, R.
(1996).
Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
27(3), 211-218.
-
Guo, D., Schut, H. A., Davis, C. D., Snyderwine, E. G., Bailey, G. S., & Dashwood, R. H.
(1995).
Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis.
16(12), 2931-2937.
-
Liew, C., Schut, H. A., Chin, S. F., Pariza, M. W., & Dashwood, R. H.
(1995).
Protection of conjugated linoleic acids against 2-amino-3- methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. Carcinogenesis.
16(12), 3037-3043.
-
Takahashi, N., Dashwood, R. H., Bjeldanes, L. F., Williams, D. E., & Bailey, G. S.
(1995).
Mechanisms of indole-3-carbinol (I3C) anticarcinogenesis: inhibition of aflatoxin B1-DNA adduction and mutagenesis by I3C acid condensation products. Food and Chemical Toxicology.
33(10), 851-857.
-
Schut, H. A., & Dashwood, R. H.
(1995).
Inhibition of DNA adduct formation of 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) by dietary indole-3-carbinol (I3C) in the mammary gland, colon, and liver of the female F-344 rat. Annals of the New York Academy of Sciences.
768(1), 210-214.
-
Guo, D., Horio, D. T., Grove, J. S., & Dashwood, R. H.
(1995).
Inhibition by chlorophyllin of 2-amino-3-methylimidazo-[4,5-f]quinoline-induced tumorigenesis in the male F344 rat. Cancer Letters.
95(1-2), 161-165.
-
Breinholt, V., Schimerlik, M., Dashwood, R., & Bailey, G.
(1995).
Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen. CHEMICAL RESEARCH IN TOXICOLOGY.
8(4), 506-514.
-
Tachino, N., Hayashi, R., Liew, C., Bailey, G., & Dashwood, R.
(1995).
Evidence for ras gene mutation in 2-amino-3-methylimidazo[4,5-f]quinoline-induced colonic aberrant crypts in the rat. Molecular Carcinogenesis.
12(4), 187-192.
-
Takahashi, N., Dashwood, R. H., Bjeldanes, L. F., Bailey, G. S., & Williams, D. E.
(1995).
Regulation of hepatic cytochrome P4501A by indole-3-carbinol: transient induction with continuous feeding in rainbow trout. Food and Chemical Toxicology.
33(2), 111-120.
-
Dashwood, R., & Guo, D.
(1995).
Protective properties of chlorophylls against the covalent binding of heterocyclic amines to DNA in vitro and in vivo. 23, 181-189.
-
Tachino, N., Guo, D., Dashwood, W. M., Yamane, S., Larsen, R., & Dashwood, R.
(1994).
Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
308(2), 191-203.
-
Dashwood, R. H., Fong, A. T., Arbogast, D. N., Bjeldanes, L. F., Hendricks, J. D., & Bailey, G. S.
(1994).
Anticarcinogenic activity of indole-3-carbinol acid products: ultrasensitive bioassay by trout embryo microinjection. Cancer Research.
54(13), 3617-3619.
-
Guo, D., & Dashwood, R.
(1994).
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding in rats given chlorophyllin: dose-response and time-course studies in the liver and colon. Carcinogenesis.
15(4), 763-766.
-
Fong, A. T., Dashwood, R. H., Cheng, R., Mathews, C., Ford, B., Hendricks, J. D., & Bailey, G. S.
(1993).
Carcinogenicity, metabolism and Ki-ras proto-oncogene activation by 7,12-dimethylbenz[a]anthracene in rainbow trout embryos. Carcinogenesis.
14(4), 629-635.
-
Dashwood, R., & Guo, D.
(1993).
Antimutagenic potency of chlorophyllin in the Salmonella assay and its correlation with binding constants of mutagen-inhibitor complexes. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
22(3), 164-171.
-
Dashwood, R., & Guo, D.
(1992).
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding by chlorophyllin: studies of enzyme inhibition and molecular complex formation. Carcinogenesis.
13(7), 1121-1126.
-
Bailey, G., Hendricks, J., & Dashwood, R.
(1992).
Anticarcinogenesis in fish. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
267(2), 243-250.
-
Dashwood, R., & Liew, C.
(1992).
Chlorophyllin-enhanced excretion of urinary and fecal mutagens in rats given 2-amino-3-methylimidazo[4,5-f]quinoline. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
20(3), 199-205.
-
Dashwood, R. H.
(1992).
Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to rat liver DNA. Carcinogenesis.
13(1), 113-118.
-
Dashwood, R. H., Breinholt, V., & Bailey, G. S.
(1991).
Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay. Carcinogenesis.
12(5), 939-942.
-
Dashwood, R. H., Fong, A. T., Williams, D. E., Hendricks, J. D., & Bailey, G. S.
(1991).
Promotion of aflatoxin B1 carcinogenesis by the natural tumor modulator indole-3-carbinol: influence of dose, duration, and intermittent exposure on indole-3-carbinol promotional potency. Cancer Research.
51(9), 2362-2365.
-
Bailey, G. S., Dashwood, R. H., Fong, A. T., Williams, D. E., Scanlan, R. A., & Hendricks, J. D.
(1991).
Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: quantitative analysis of inhibition versus promotion. IARC scientific publications.
105(105), 275-280.
-
Dashwood, R. H., Loveland, P. M., Fong, A. T., Hendricks, J. D., & Bailey, G. S.
(1990).
Combined in vivo DNA binding and tumor dose-response studies to investigate the molecular dosimetry concept. Progress in clinical and biological research.
340D, 335-344.
-
Fong, A. T., Swanson, H. I., Dashwood, R. H., Williams, D. E., Hendricks, J. D., & Bailey, G. S.
(1990).
Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation. Biochemical Pharmacology.
39(1), 19-26.
-
Dashwood, R. H., Fong, A. T., Hendricks, J. D., & Bailey, G. S.
(1990).
Tumor dose-response studies with aflatoxin B1 and the ambivalent modulator indole-3-carbinol: inhibitory versus promotional potency. Basic life sciences.
52, 361-365.
-
DASHWOOD, R. H., UYETAKE, L., FONG, A. T., HENDRICKS, J. D., & BAILEY, G. S.
(1989).
THE SYNTHESIS OF [H-3] INDOLE-3-CARBINOL, A NATURAL ANTI-CARCINOGEN FROM CRUCIFEROUS VEGETABLES. Journal of Labelled Compounds and Radiopharmaceuticals.
27(8), 901-907.
-
Dashwood, R. H., Uyetake, L., Fong, A. T., Hendricks, J. D., & Bailey, G. S.
(1989).
In vivo disposition of the natural anti-carcinogen indole-3-carbinol after po administration to rainbow trout. Food and Chemical Toxicology.
27(6), 385-392.
-
Dashwood, R. H., Arbogast, D. N., Fong, A. T., Pereira, C., Hendricks, J. D., & Bailey, G. S.
(1989).
Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response. Carcinogenesis.
10(1), 175-181.
-
DASHWOOD, R. H., & COMBES, R. D.
(1988).
LEVELS OF METABOLIC COMPLEXITY IN ASSAYS EMPLOYING THE INVIVO EQUIVALENT DOSE (IVED) CONCEPT - REPLY. MUTAGENESIS.
3(6), 528-531.
-
Fong, A. T., Hendricks, J. D., Dashwood, R. H., Van Winkle, S., Lee, B. C., & Bailey, G. S.
(1988).
Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, beta-naphthoflavone, and Aroclor 1254. TOXICOLOGY AND APPLIED PHARMACOLOGY.
96(1), 93-100.
-
Fong, A. T., Hendricks, J. D., Dashwood, R. H., Van Winkle, S., & Bailey, G. S.
(1988).
Formation and persistence of ethylguanines in liver DNA of rainbow trout (Salmo gairdneri) treated with diethylnitrosamine by water exposure. Food and Chemical Toxicology.
26(8), 699-704.
-
Dashwood, R. H., Combes, R. D., & Ashby, J.
(1988).
DNA-binding studies with 6BT and 5I: implications for DNA-binding/carcinogenicity and DNA-binding/mutagenicity correlations. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
198(1), 61-68.
-
Dashwood, R. H., Arbogast, D. N., Fong, A. T., Hendricks, J. D., & Bailey, G. S.
(1988).
Mechanisms of anti-carcinogenesis by indole-3-carbinol: detailed in vivo DNA binding dose-response studies after dietary administration with aflatoxin B1. Carcinogenesis.
9(3), 427-432.
-
Dashwood, R. H., & Combes, R. D.
(1987).
The use of in vivo-like concentrations of chemicals for validation of in vitro short-term genotoxicity assays--an in vivo equivalent dose concept. MUTAGENESIS.
2(4), 249-251.
-
Dashwood, R. H., & Combes, R. D.
(1987).
Deficiencies in the covalent binding index (CBI) for expressing in vivo binding to DNA with respect to predicting chemical carcinogenicity. A proposal for a target-organ binding index. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS.
190(3), 173-175.
-
Dashwood, R. H., Combes, R. D., & Ashby, J.
(1987).
Combined radiolabelling distribution and covalent DNA-binding studies to discriminate between a carcinogen/noncarcinogen pair of monoazo dyes related to the hepatocarcinogen butter yellow (DAB). Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.
11(SUPPL. 11), 99-101.
-
Dashwood, R. H., Combes, R. D., Paton, D., & Ashby, J.
(1986).
Mutagenicity to Salmonella of four derivatives of the azo mutagen 5I: some implications for structure--activity databases and the evaluation of combinations of mutagens. MUTAGENESIS.
1(4), 261-265.
-
DASHWOOD, R. H., COMBES, R. D., & ASHBY, J.
(1986).
LIMITATIONS OF INVITRO ASSAYS FOR DISTINGUISHING BETWEEN A CARCINOGEN NON-CARCINOGEN PAIR OF MONOAZO DYES. Food and Chemical Toxicology.
24(6-7), 707-708.
-
Dashwood, R. H., Combes, R. D., & Ashby, J.
(1986).
The disposition and in vivo covalent binding to liver DNA of the monoazodyes 6-(p-dimethylaminophenylazo)benzothiazole (6BT) and 5-(p-dimethylaminophenylazo)indazole (5I) after administration to the rat. Carcinogenesis.
7(6), 1029-1033.
-
Cerella, C., Michiels, C., Dashwood, R. H., Surh, Y., & Diederich, M.
Metabolism and cancer: old and new players. International Journal of Cell Biology.
2013(1), 293201-2.
-
Mohan, N., Johnson, G. S., Tovar Perez, J. E., Dashwood, W. M., Rajendran, P., & Dashwood, R. H.
(2024).
Alternative splicing of BAZ1A in colorectal cancer disrupts the DNA damage response and increases chemosensitization. Cell Death and Disease.
15(8), 570.
-
book
-
Dashwood, R. H., Duncan, A. M., Hagen, T. M., Hu, F. B., Johnson, E. J., Jones, P., ... Zeisel, S. H.
(2013).
Foreword. Thieme.
-
Dashwood, R. H., Duncan, A. M., Hagen, T. M., Hu, F. B., Johnson, E. J., Jones, P., ... Zeisel, S. H.
(2013).
Foreword. Thieme.
-
chapter
-
Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E.
(2012).
Chemoprevention of Prostate Cancer with Cruciferous Vegetables: Role of Epigenetics. Nutrition, Diet and Cancer.
(pp. 49-81).
Springer Nature.
-
Delage, B., & Dashwood, R. H.
(2009).
Nutrients, histone modifications, and chromatin remodeling in chronic inflammation. NUTRIENTS AND EPIGENETICS.
(pp. 127-154).
CRC Press.
-
Delage, B., & Dashwood, R.
(2008).
Targeting the Epigenome with Dietary Agents. Dietary Modulation of Cell Signaling Pathways.
(pp. 337-369).
Taylor & Francis.
-
Dashwood, R. H., Fong, A. T., Hendricks, J. D., & Bailey, G. S.
(1990).
Tumor Dose-Response Studies with Aflatoxin B1 and the Ambivalent Modulator Indole-3-Carbinol: Inhibitory Versus Promotional Potency. Basic life sciences.
Antimutagenesis and Anticarcinogenesis Mechanisms II.
(pp. 361-365).
Springer Nature.
-
Dashwood, R. H., Combes, R. D., & Ashby, J.
(1987).
Combined Radiolabelling Distribution and Covalent DNA-Binding Studies to Discriminate Between a Carcinogen/Noncarcinogen Pair of Monoazo Dyes Related to the Hepatocarcinogen Butter Yellow (DAB). Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.
Mechanisms and Models in Toxicology.
(pp. 99-101).
Springer Nature.
-
Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E.
(2012).
Chemoprevention of Prostate Cancer with Cruciferous Vegetables: Role of Epigenetics. Nutrition, Diet and Cancer.
(pp. 49-81).
Springer Nature.
-
conference paper
-
Mohan, N., & Dashwood, R. H.
(2022).
Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer. Cancer Research.
-
Mohan, N., & Dashwood, R. H.
(2022).
Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer. Cancer Research.
-
Perez, J., & Dashwood, R. H.
(2022).
Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells. Cancer Research.
-
Perez, J., & Dashwood, R. H.
(2022).
Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells. Cancer Research.
-
Kapoor, S., & Dashwood, R. H.
(2022).
Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception. Cancer Research.
-
Kapoor, S., & Dashwood, R. H.
(2022).
Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception. Cancer Research.
-
Tripathi, C., & Dashwood, R. H.
(2022).
Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis. Cancer Research.
-
Tripathi, C., & Dashwood, R. H.
(2022).
Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis. Cancer Research.
-
Neja, S., & Dashwood, R. H.
(2022).
Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake. Cancer Research.
-
Neja, S., & Dashwood, R. H.
(2022).
Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake. Cancer Research.
-
Chen, Y., Li, J., Neja, S., Menon, R., Jayaraman, A., Lee, K., ... Dashwood, R.
(2022).
Metabolomics of acute vs. chronic spinach intake in an Apc-mutant genetic background: linoleate and butanoate metabolites targeting HDAC activity and IFN- signaling. Cancer Prevention Research.
-
Chen, Y., Li, J., Neja, S., Menon, R., Jayaraman, A., Lee, K., ... Dashwood, R.
(2022).
Metabolomics of acute vs. chronic spinach intake in an Apc-mutant genetic background: linoleate and butanoate metabolites targeting HDAC activity and IFN- signaling. Cancer Prevention Research.
-
Kapoor, S., Gustafson, T., Zhang, M., Chen, Y., Li, J., Nhung, N., ... Dashwood, R.
(2021).
Combined deacetylase and bromodomain inhibition downregulates ERCC2 and suppresses growth of metastatic colon cancer cells. Cancer Research.
-
Demirhan, Y. E., Rajendran, P., Dashwood, W., Kapoor, S., Ulusan, A., Tripathi, C., ... Dashwood, R.
(2021).
Optimized Lower Dose Combinations of Sulindac Plus Erlotinib Sustained Antitumor Efficacy and Reduced Toxicity in a Preclinical Model of FAP. AMERICAN JOURNAL OF GASTROENTEROLOGY.
S138-S138.
-
Rajendran, P., Damiani, E., Wang, S., Dashwood, W., & Dashwood, R. H.
(2020).
Dietary polyphenols as epigenetic 'reader' inhibitors. Cancer Research.
3477-3477.
-
Rajendran, P., Ulusan, A., Dashwood, W., Kapoor, S., Mohammed, A., Sei, S., ... Dashwood, R. H.
(2020).
Optimization of dosing regimens of sulindac in combination with erlotinib for small intestine and colorectal cancer prevention. Cancer Research.
21-21.
-
Johnson, G. S., Rajendran, P., Li, L. i., Chen, Y., Dashwood, W. M., Nguyen, N., ... Dashwood, R. H.
(2019).
Abstract 2614: CCAR2 acetylation establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition. 2614-2614.
-
Ulusan, A., Rajendran, P., Dashwood, W., Mohammed, A., Sei, S., Brown, P. H., Vilar-Sanchez, E., & Dashwood, R. H.
(2019).
Abstract 5074: Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP. 5074-5074.
-
Ulusan, A., Rajendran, P., Dashwood, W., Mohammed, A., Sei, S., Brown, P. H., Vilar-Sanchez, E., & Dashwood, R. H.
(2019).
Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP. Cancer Research.
5074-5074.
-
Lian, H., Zhong, X. S., Kline, K., Luo, X., Winston, J., Cong, Y., ... Li, Q.
(2019).
MATRIX METALLOPROTEINASE 7 CONTRIBUTES TO INTESTINAL BARRIER DYSFUNCTION BY SUPPRESSING TIGHT JUNCTION PROTEINS. Gastroenterology.
S211-S211.
-
Li, Q., Zhong, X. S., Nyeem, S. Z., Kline, K. T., Peng, J., Fujise, K., & Dashwood, R. H.
(2018).
Experimental colitis impedes cardiac function through epigenetic mechanisms. European Heart Journal.
994-995.
-
Zhong, X. S., Luo, X., Winston, J., Nayeem, S., Kline, K., Dashwood, R., ... Li, Q.
(2018).
NEONATAL COLONIC INFLAMMATION AGGRAVATES EPITHELIAL INJURY THROUGH MIR-196 WHEN EXPOSED TO ANOTHER EPISODE OF INFLAMMATION IN ADULT-LIFE. Gastroenterology.
S212-S212.
-
Chen, Y., Wang, R., Dashwood, W., Lhr, C., Williams, D. E., Ho, E., Mertens-Talcott, S., & Dashwood, R. H.
(2017).
A miRNA signature linked to human environmental risk defined from carcinogen-induced and genetically-driven colon carcinogenesis models. Cancer Research.
4428-4428.
-
Atwell, L., Clarke, J., Hsu, A., Bella, D., Stevens, J., Dashwood, R., Williams, D., & Ho, E.
(2014).
Bioavailability and metabolomic targets of sulforaphane in humans. The FASEB Journal.
-
Kaiser, M. C., Rajendran, P., Dashwood, M. W., Levine, M. A., Michaels, A., Frei, B., & Dashwood, R. H.
(2013).
An epigenetic perspective on pharmacologic ascorbate in colon cancer. The FASEB Journal.
248.3-248.3.
-
Beaver, L. M., Buchanan, A., Sokolowski, E. I., Chang, J. H., Wong, C. P., Williams, D. E., Dashwood, R. H., & Ho, E.
(2013).
Genome-wide transcriptome analysis of the effects of sulforphane on normal and prostate cancer cells. The FASEB Journal.
248.2-248.2.
-
Atwell, L. L., Clarke, J. D., Hsu, A., Bella, D., Stevens, J. F., Dashwood, R. H., Williams, D. E., & Ho, E.
(2013).
Sulforaphane bioavailability and bioactivity in humans. The FASEB Journal.
636.26-636.26.
-
Romagnolo, D. F., Dashwood, R., Stover, P. J., Waterland, R. A., & Ziegler, T. R.
(2012).
Nutritional regulation of epigenetic changes. Advances in Nutrition.
749-750.
-
Shorey, L. E., Kaur, P., Rosato, C., Houseman, E. A., Ho, E., Dashwood, R. H., Benninghoff, A. D., & Williams, D. E.
(2012).
Analysis of genome-wide DNA methylation in CCRF-CEM cells confirms hypermethylation at reported epigenetic markers of T-cell lymphoblastic leukemia and identifies novel therapeutic targets with reduced methylation upon treatment with dietary indoles. Cancer Research.
5430-5430.
-
Rajendran, P., Kidane, A. I., Yu, T., Dashwood, W., Ho, E., Williams, D. E., & Dashwood, R. H.
(2012).
Differential effects of sulforaphane and related isothiocyanates on HDAC turnover and the DNA damage response in colon cancer cells. Cancer Research.
lb-184-lb-184.
-
Beaver, L. M., Chang, J. H., Williams, D. E., Dashwood, R. H., & Ho, E.
(2012).
An RNA-seq approach to identify mechanisms by which the phytochemical sulforaphane acts to prevent prostate cancer. The FASEB Journal.
647.10-647.10.
-
Beaver, L. M., Yu, T., Sokolowski, E. I., Hsu, A., Williams, D. E., Dashwood, R. H., & Ho, E.
(2012).
Chemopreventative phytochemical 3,3-diindolylmethane inhibits histone deacetylases in prostate cancer cells. The FASEB Journal.
366.6-366.6.
-
Nian, H., & Dashwood, R. H.
(2010).
Alpha-keto acid metabolites of organoselenium compounds inhibit HDAC activity. The FASEB Journal.
894.7-894.7.
-
Dashwood, R. H.
(2010).
Metabolism as a key to HDAC inhibition by dietary constituents. The FASEB Journal.
413.1-413.1.
-
Dashwood, R. H.
(2007).
Frontiers in polyphenols and cancer prevention. Journal of Nutrition.
267S-269S.
-
Myzak, M. C., Hardin, K., Yan, M., Tong, P., Dashwood, R., & Ho, E.
(2006).
Sulforaphane inhibits HDAC activity in prostate cancer cells, retards growth of PC3 xenografts, and inhibits HDAC activity in vivo. The FASEB Journal.
A150-A150.
-
Jubert, C., Simonich, M., Roebuck, B., Orner, G., Dashwood, R., Williams, D., & Bailey, G.
(2006).
Chlorophylls purified by a new large-scale method inhibit aflatoxin carcinogenesis in the rat. Cancer Research.
-
Orner, G. A., Elias, V. D., Pereira, C. B., & Dashwood, R. H.
(2006).
Interactions between white tea and sulindac in the prevention of intestinal cancer. Cancer Research.
-
Simonich, M. T., McQuistan, T., Jubert, C., Pereira, C., Hendricks, J., Dashwood, R., Williams, D., & George, B.
(2006).
Natural chlorophyll inhibits dibenzo[a,l]pyrene-induced liver and stomach carcinogenesis in rainbow trout. Cancer Research.
-
Li, Q., & Dashwood, R. H.
(2006).
Suppression of intestinal tumorigenesis by activator protein 2. Cancer Research.
-
Dashwood, R. H.
(2006).
Weak ligands as HDAC inhibitors: useful for chemoprevention?. CHEMICO-BIOLOGICAL INTERACTIONS.
191-191.
-
Carter, O., Bailey, G. S., & Dashwood, R. H.
(2004).
The dietary phytochemical chlorophyllin alters e-cadherin and -catenin expression in human colon cancer cells. Journal of Nutrition.
3441S-3444S.
-
Yu, T. W., Dashwood, R. H., & Xu, M.
(2004).
Antimutagenic activity of spearmint (Mentha spicata L.). ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
239-239.
-
Hemingway, R. W., McGraw, G. W., Helms, G. L., Proteau, R. R., Mata, J. E., & Dashwood, R. H.
(2004).
Catechin-(4,-8)-epigallocatechin-3-gallate:: Production, proof of structure, properties. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
U250-U250.
-
Myzak, M. C., Hardin, K., Dashwood, R. H., & Ho, E.
(2004).
HDAC inhibition by sulforaphane during hyperplasia, intermediate and late stages of prostate cancer. Cancer Epidemiology, Biomarkers and Prevention.
1847S-1847S.
-
Orner, G. A., Elias, V. D., & Dashwood, R. H.
(2004).
Modulation of Wnt signaling by white tea plus celecoxib. Cancer Epidemiology, Biomarkers and Prevention.
1845S-1845S.
-
Orner, G., Dashwood, W. M., Tebbutt, N. C., Li, Q., Heath, J. K., Myzak, M. C., Ernst, M., & Dashwood, R. H.
(2003).
Cancer chemoprevention by a combination of white tea plus sulindac in a mouse model expressing an oncogenic form of -catenin. Cancer Epidemiology, Biomarkers and Prevention.
1287S-1287S.
-
Orner, G. A., Dashwood, W. M., Li, Q. J., Al-Fageeh, M., Tebbutt, N., Heath, J. K., Ernst, M., & Dashwood, R. H.
(2002).
Cellular effects of tea antioxidants in vitro and in mouse models of colon cancer. Free Radical Biology and Medicine.
S302-S302.
-
Orner, G. A., Dashwood, W. M., Li, Q. J., Al-Fageeh, M., Tebbutt, N., Heath, J. K., Ernst, M., & Dashwood, R. H.
(2002).
Cellular effects of tea antioxidants in vitro and in mouse models of colorectal cancer:: modulation of Wnt signaling. FREE RADICAL RESEARCH.
16-20.
-
Mastaloudis, A., Yu, D., Frei, B., Dashwood, R., & Traber, M. G.
(2002).
Gender differences in DNA damage produced during an ultramarathon run as measured by the comet assay. Free Radical Biology and Medicine.
S334-S334.
-
Amantana, A., Santana-Rios, G., Butler, J. A., Whanger, P. D., & Dashwood, R.
(2000).
Antimutagenic activity of selenium-enriched green tea towards a cooked meat mutagen. The FASEB Journal.
A537-A537.
-
Santana-Rios, G., Provost, C., Amantana, A., & Dashwood, R. H.
(2000).
Antimutagenic activity of white tea. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
U487-U487.
-
Franke, A. A., Dashwood, R. H., Xu, M., & Custer, L. J.
(2000).
Cancer-protective effects and bioavailability of flavonoids. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
U54-U54.
-
WILLIAMS, D. E., DASHWOOD, R. H., HENDRICKS, J. D., & BAILEY, G. S.
(1989).
ANTICARCINOGENS AND TUMOR PROMOTERS IN FOODS. 101-150.
-
DASHWOOD, R. H., ARBOGAST, D., HENDRICKS, J., FONG, A., & BAILEY, G. S.
(1988).
CONCOMITANT INVIVO DNA-BINDING TUMOR DOSE-RESPONSE STUDIES WITH AFLATOXIN-B1 AND THE NATURAL INHIBITOR INDOLE-3-CARBINOL. Proceedings / Annual Meeting of the American Association for Cancer Research [and] Annual Meeting of the American Society of Clinical Oncology. American Association for Cancer Research. Meeting.
135-135.
-
BAILEY, G., FONG, A., SWANSON, H., WILLIAMS, D., DASHWOOD, R., & HENDRICKS, J.
(1988).
EFFECT OF DIETARY INDOLE-3-CARBINOL (I3C), B-NAPHTHOFLAVONE (BNF), AND AROCLOR-1254 (PCB) ON DIETHYLNITROSAMINE (DEN) AND AFLATOXIN-B1 (AFB1) CARCINOGENESIS IN TROUT. The FASEB Journal.
A1413-A1413.
-
DASHWOOD, R. H., COMBES, R. D., & ASHBY, J.
(1987).
COMPARISON OF THE ACTIVATION OF A CARCINOGEN NON-CARCINOGEN PAIR OF MONOAZO DYES USING INVITRO AND INVIVO GENOTOXICITY ASSAYS - THE USE OF AN INVIVO EQUIVALENT DOSE CONCEPT. 335-335.
-
DASHWOOD, R. H., COMBES, R. D., & ASHBY, J.
(1987).
ON THE LACK OF SPECIFICITY OF THE SALMONELLA MUTAGENICITY ASSAY. MUTAGENESIS.
301-301.
-
DASHWOOD, R. H.
(1987).
THE RELATIONSHIP BETWEEN COVALENT DNA-BINDING AND REVERTANT YIELD IN THE SALMONELLA MUTAGENICITY (AMES) ASSAY - IMPLICATIONS FOR ASSAY SPECIFICITY. 27-27.
-
DASHWOOD, R. H., COMBES, R. D., & ASHBY, J.
(1986).
ADAPTATION OF INVITRO AND INVIVO BINDING ASSAYS TO DISCRIMINATE BETWEEN A CARCINOGEN NON-CARCINOGEN PAIR OF MUTAGENIC MONOAZO DYES. MUTAGENESIS.
389-389.
-
DASHWOOD, R. H., COMBES, R. D., & ASHBY, J.
(1986).
IMPLICATIONS FOR STRUCTURE ACTIVITY DATABASES AND THE EVALUATION OF COMBINATIONS OF MUTAGENS IN THE SALMONELLA ASSAY, AS ILLUSTRATED BY STUDIES WITH THE MUTAGENIC NON-CARCINOGEN 5I. MUTAGENESIS.
392-392.
-
DASHWOOD, R. H., & COMBES, R. D.
(1986).
MUTAGENICITY OF THE 2 CARCINOGEN NON-CARCINOGEN PAIRS BENZO[A]PYRENE, PYRENE AND 2-ACETYLAMINOFLUORENE, 4-ACETYLAMINOFLUORENE AND THEIR RESPECTIVE RAT URINE CONCENTRATES AS PART OF THE IPCS COLLABORATIVE TRIAL. MUTAGENESIS.
76-76.
-
DASHWOOD, R. H., COMBES, R. D., ASHBY, J., & PATON, D.
(1986).
STRUCTURE ACTIVITY STUDIES WITH 5-DIMETHYLAMINOPHENYLAZOINDAZOLE AND RELATED MONOAZO DYES IN THE SALMONELLA MAMMALIAN MICROSOME ASSAY. MUTAGENESIS.
69-69.
-
Mohan, N., & Dashwood, R. H.
(2022).
Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer. Cancer Research.
-
institutional repository document
-
Chen, Y., Li, J., Menon, R., Jayaraman, A., Lee, K., Huang, Y., ... Dashwood, R.
(2021).
Reshaping the Gut Microbiome in An Apc-Mutant Genetic Background: Mechanistic Insights From Integrated Multi-Omics
-
Chen, Y., Li, J., Menon, R., Jayaraman, A., Lee, K., Huang, Y., ... Dashwood, R.
(2021).
Reshaping the Gut Microbiome in An Apc-Mutant Genetic Background: Mechanistic Insights From Integrated Multi-Omics
Research
principal investigator on
- PREVENT Cancer Preclinical Drug Development Program: Preclinical Efficacy and Intermediate Endpoint Biomarkers awarded by National Cancer Institute - (Rockville, Maryland, United States) 2024 - 2029
- Immunoepigenetic Targeting of MHC Regulators in FAP awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2023 - 2028
- CCAR2 as a Target for Prevention of Colorectal Cancer awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023
- Comparative Mechanisms of Cancer Chemoprevention awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2014 - 2017
Teaching
teaching activities
- IBST691 Research Credit: Medical Sci Instructor
Works By Students
chaired theses and dissertations
-
Chen, Ying-Shiuan (2019-02). Molecular Profiling of Prevention Strategies Using Rodent Models of Colorectal Cancer.
-
Johnson, Gavin S. (2019-04). Expanding Epigenetic Mechanisms of Sulforaphane in Colorectal Cancer: Pseudogenes and Protein Acetylation.
-
Perkins, Ashley Lyn (2015-08). Examining the Roles of Beta-Catenin and HDAC6 in Primary Cilia Signaling in ccRCC and CRC.
-
Yin, Yue (2021-07). Comprehensive Data Analysis Toolkit Development for a Low Input Bisulfite Sequencing.
Background
education and training
- Ph.D. in Genetic Toxicology, University of Portsmouth - (Portsmouth, Portsmouth, United Kingdom) 1986
- M.S. in Toxicology, University of Surrey - (Guildford, Surrey, United Kingdom) 1983
- B.S. in Biological Sciences (Cellular Toxicology), Plymouth University - (Plymouth, Plymouth, United Kingdom) 1982
- Oregon State University - (Corvallis, Oregon, United States) , Postdoctoral Training 1990
awards and honors
Contact
first name
- Roderick
has last name
- Dashwood
mailing address
-
Texas A&M Health and College of Medicine
Center for Epigenetics & Disease Prevention
1201 TAMUS
Houston, TX 77030-3303
USA
Other
In the News
- 2023 University Distinguished Professor News Release
- A&M researchers link eating spinach to reducing colon cancer risk News Release
- An Early Target for Acetylation in Colon Cancer Cells Treated with Sulforaphane News Release
- Center for Epigenetics and Disease Prevention receives Texas A&M Board of Regents stamp of approval News Release
- Colorectal cancer and COVID-19: Inhibitors to combat both News Release
- Debunking a TikTok Trend News Release
- Director of New Center Looks for Foods That Protect Health News Release
- Eating Spinach Could Protect Against Colon Cancer News Release
- Eight Faculty Earn Texas A&M’s Highest Honor News Release
- Highly effective tumor detection strategy for common childhood brain tumors News Release
- Q&A: Cutting-edge research explores how diet causes and prevents cancer News Release
- Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma News Release
- Research explains why you should eat your broccoli News Release
- Research explains why you should eat your broccoli News Release
- Scientists Develop Highly Effective Detection Strategy For Childhood Brain Tumors News Release
- Targeting ACE2-BRD4 in Cancer and COVID-19 News Release
- Texas A&M Advances Global Disease Prevention with Launch of Field-to-Clinic Initiative News Release
- Texas A&M Health Awarded $3 Million From National Cancer Institute News Release
- Texas A&M Health Faculty Rank Among Top 2 Percent Of Scholars Worldwide News Release
- Two Texas A&M Health faculty named Distinguished Professors News Release
- You are what you eat? Food fights disease News Release
- rdashwood@tamu.edu