Research integrates multiomic, genetic, epigenetic and immune approaches for precision oncology and immunoprevention. Epigenetic 'readers', 'writers' and 'erasers' are targeted that reversibly regulate immune players in the antigen-presentation pathway. Cell-based molecular mechanistic assays are combined with preclinical models coupled to polypectomy. Clinical specimens, spheroids and organoids from patients undergoing colectomy provide for human translation.