HR job title
- Professor
- Contact Info
- 713-677-7806
- ORCiD
- 0000-0003-0351-4034
Dashwood, Rod Distinguished Professor and Director
Positions
- Distinguished Professor and Director, Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology
Research integrates multiomic, genetic, epigenetic and immune approaches for precision oncology and immunoprevention. Epigenetic 'readers', 'writers' and 'erasers' are targeted that reversibly regulate immune players in the antigen-presentation pathway. Cell-based molecular mechanistic assays are combined with preclinical models coupled to polypectomy. Clinical specimens, spheroids and organoids from patients undergoing colectomy provide for human translation.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Works By Students
- Background
- Contact
- Other
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Overview
Publications
selected publications
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academic article
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Zhang, S., Kapoor, S., Tripathi, C., Perez, J. T., Mohan, N., Dashwood, W. M., ... Dashwood, R.
(2023).
Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis. 7(1), 20.
-
Chen, Y., Li, J., Neja, S., Menon, R., Jayaraman, A., Lee, K., ... Dashwood, R.
(2022).
Abstract A013: Metabolomics of acute vs. chronic spinach intake in an Apc-mutant genetic background: linoleate and butanoate metabolites targeting HDAC activity and IFN- signaling. Cancer Prevention Research.
15(12_Supplement_2), a013-a013.
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Kapoor, S., Damiani, E., Wang, S., Dharmanand, R., Tripathi, C., Tovar Perez, J. E., ... Dashwood, R. H.
(2022).
BRD9 Inhibition by Natural Polyphenols Targets DNA Damage/Repair and Apoptosis in Human Colon Cancer Cells. Nutrients.
14(20), 4317-4317.
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Tripathi, C., & Dashwood, R. H.
(2022).
Abstract 5631: Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis. Cancer Research.
82(12_Supplement), 5631-5631.
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Perez, J., & Dashwood, R. H.
(2022).
Abstract 5632: Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells. Cancer Research.
82(12_Supplement), 5632-5632.
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Kapoor, S., & Dashwood, R. H.
(2022).
Abstract 5712: Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception. Cancer Research.
82(12_Supplement), 5712-5712.
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Mohan, N., & Dashwood, R. H.
(2022).
Abstract 5713: Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer. Cancer Research.
82(12_Supplement), 5713-5713.
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Neja, S., & Dashwood, R. H.
(2022).
Abstract 5815: Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake. Cancer Research.
82(12_Supplement), 5815-5815.
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Chen, Y., Li, J., Neja, S., Kapoor, S., Tovar Perez, J. E., Tripathi, C., ... Dashwood, R.
(2022).
Metabolomics of Acute vs. Chronic Spinach Intake in an Apc-Mutant Genetic Background: Linoleate and Butanoate Metabolites Targeting HDAC Activity and IFN- Signaling. Cells.
11(3), 573-573.
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Xiao, Y., Lian, H., Zhong, X. S., Krishnachaitanya, S. S., Cong, Y., Dashwood, R. H., ... Li, Q.
(2022).
Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7. 13, 1020902.
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Mohammed, A., Dashwood, R. H., Dickinson, S., Disis, M. L., Jaffee, E. M., Johnson, B. D., ... Miller, M. S.
(2021).
Translational Advances in Cancer Prevention Agent Development (TACPAD) Virtual Workshop on Immunomodulatory Agents: Report. Journal of Cancer Prevention.
26(4), 309-317.
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Demirhan, Y. E., Rajendran, P., Dashwood, W., Kapoor, S., Ulusan, A., Tripathi, C., ... Dashwood, R.
(2021).
S318 Optimized Lower Dose Combinations of Sulindac Plus Erlotinib Sustained Antitumor Efficacy and Reduced Toxicity in a Preclinical Model of FAP. 116(1), s138-s138.
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Kapoor, S., Gustafson, T., Zhang, M., Chen, Y., Li, J., Nguyen, N., ... Dashwood, R.
(2021).
Abstract 2106: Combined deacetylase and bromodomain inhibition downregulates ERCC2 and suppresses growth of metastatic colon cancer cells. 81(13_Supplement), 2106-2106.
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Miller, M. S., Allen, P. J., Brown, P. H., Chan, A. T., Clapper, M. L., Dashwood, R. H., ... Mohammed, A.
(2021).
Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting. Journal of Cancer Prevention.
26(1), 71-82.
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Kapoor, S., Gustafson, T., Zhang, M., Chen, Y., Li, J., Nguyen, N., ... Dashwood, R. H.
(2021).
Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells. Cancers.
13(6), 1438-1438.
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Ulusan, A. M., Rajendran, P., Dashwood, W. M., Yavuz, O. F., Kapoor, S., Gustafson, T. A., ... Dashwood, R. H.
(2021).
Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP). 14(3), 325-336.
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Dashwood, R. H.
(2021).
Cancer interception by interceptor molecules: mechanistic, preclinical and human translational studies with chlorophylls. Genes and Environment.
43(1), 8.
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Chen, Y., Li, J., Menon, R., Jayaraman, A., Lee, K., Huang, Y., ... Dashwood, R. H.
(2021).
Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics. Gut Microbes.
13(1), 1972756.
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Damiani, E., Duran, M. N., Mohan, N., Rajendran, P., & Dashwood, R. H.
(2020).
Targeting Epigenetic 'Readers' with Natural Compounds for Cancer Interception. Journal of Cancer Prevention.
25(4), 189-203.
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Johnson, G. S., Rajendran, P., & Dashwood, R. H.
(2020).
CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis. Cancer Science.
111(10), 3416-3425.
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Davis, J. S., Kanikarla-Marie, P., Gagea, M., Yu, P. L., Fang, D., Sebastian, M., ... Kopetz, S.
(2020).
Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development. BMC Cancer.
20(1), 871.
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Davis, J. S., Kanikarla, P., Yu, P. L., Gagea, M., Fang, D., Sebastian, M., ... Kopetz, S.
(2020).
Abstract 1: Sulindac plus phospholipid is effective for polyp reduction and safer than sulindac alone. Cancer Research.
80(16_Supplement), 1-1.
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Kline, K. T., Lian, H., Zhong, X. S., Luo, X., Winston, J. H., Cong, Y., ... Li, Q.
(2020).
Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood. JOURNAL OF IMMUNOLOGY.
204(4), 980-989.
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Zhang, Z., Garzotto, M., Davis, E. W., Mori, M., Stoller, W. A., Farris, P. E., ... Shannon, J.
(2020).
Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial. 72(1), 74-87.
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Bhattacharjee, S., Li, J., & Dashwood, R. H.
(2020).
Emerging crosstalk between long non-coding RNAs and Nrf2 signaling. Cancer Letters.
490, 154-164.
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Bhattacharjee, S., & Dashwood, R. H.
(2020).
Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals. Antioxidants.
9(9), 865-865.
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Dashwood, R. H.
(2020).
Memories of a friend and colleague - Takashi Sugimura. Mutation Research: Reviews.
786, 108337-108337.
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Li, J., Zhao, S., Lee, M., Yin, Y., Li, J., Zhou, Y., ... Sun, D.
(2020).
Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma. Science Advances.
6(42), eabb5427.
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Johnson, G. S., Rajendran, P., Li, L. i., Chen, Y., Dashwood, W. M., Nhung, N., ... Dashwood, R. H.
(2019).
CCAR2 acetylation establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition. 79(13), 2614-2614.
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Lian, H., Zhong, X. S., Kline, K., Luo, X., Winston, J., Cong, Y., ... Li, Q.
(2019).
991 Matrix Metalloproteinase 7 Contributes to Intestinal Barrier Dysfunction by Suppressing Tight Junction Proteins. GASTROENTEROLOGY.
156(6), s-211.
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Rajendran, P., Johnson, G., Li, L. i., Chen, Y., Dashwood, M., Nguyen, N., ... Dashwood, R.
(2019).
Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition. Cancer Research.
79(5), 918-927.
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Zhang, J., Tan, P., Guo, L., Gong, J., Ma, J., Li, J., ... Huang, Y.
(2019).
p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene.
38(11), 1905-1919.
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Housley, L., Magana, A. A., Hsu, A., Beaver, L. M., Wong, C. P., Stevens, J. F., ... Ho, E.
(2018).
Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts. Molecular Nutrition and Food Research.
62(19), e1700665-1700665.
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Okonkwo, A., Mitra, J., Johnson, G. S., Li, L. i., Dashwood, W. M., Hegde, M. L., ... Rajendran, P.
(2018).
Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs. Molecular Nutrition and Food Research.
62(18), e1800228-1800228.
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Hasaniya, N. W., Premaratne, S., Zhang, W. W., Razzuk, A. M., McNamara, J. J., & Dashwood, R. H.
(2018).
Preparation, Characterization and Electron Paramagnetic Resonance (EPR) Spectroscopic Studies of OXANOH. Free Radicals and Antioxidants.
8(2), 70-73.
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Reddy, D. S., Wu, X., Golub, V. M., Dashwood, W. M., & Dashwood, R. H.
(2018).
Measuring Histone Deacetylase Inhibition in the Brain. Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.].
81(1), e41-e41.
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Zhong, X. S., Luo, X., Winston, J., Nayeem, S., Kline, K., Dashwood, R., ... Li, Q.
(2018).
1084 - Neonatal Colonic Inflammation Aggravates Epithelial Injury Through Mir-196 When Exposed to Another Episode of Inflammation in Adult-Life. GASTROENTEROLOGY.
154(6), s-212.
-
Beaver, L. M., Lhr, C. V., Clarke, J. D., Glasser, S. T., Watson, G. W., Wong, C. P., ... Ho, E.
(2018).
Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice. 2(3), nzy002-2003001.
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Yun, C., Dashwood, W., Kwong, L. N., Gao, S., Yin, T., Ling, Q., ... Hu, M.
(2018).
Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.
148, 42-50.
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Zhong, X. S., Winston, J. H., Luo, X., Kline, K. T., Nayeem, S. Z., Cong, Y., ... Li, Q.
(2018).
Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life. 6(1), 65-78.
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Wang, R., Chen, Y., Dashwood, W., Li, Q., Lhr, C. V., Fischer, K., ... Dashwood, R. H.
(2017).
Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. Molecular Carcinogenesis.
56(7), 1733-1742.
-
Ertem, F. U., Zhang, W., Chang, K., Dashwood, W., Rajendran, P., Sun, D., ... Dashwood, R. H.
(2017).
Prevention by tolfenamic acid and characterization of the molecular targets in Pirc and FAP colorectal adenomas. Cancer Research.
77(13_Supplement), 2229-2229.
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Kumar, R., Herold, J. L., Schady, D., Davis, J., Kopetz, S., Martinez-Moczygemba, M., ... Xu, Y. i.
(2017).
Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development. PLOS Pathogens.
13(7), e1006440-e1006440.
-
Johnson, G. S., Li, J., Beaver, L. M., Dashwood, W. M., Sun, D., Rajendran, P., ... Dashwood, R. H.
(2017).
A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells. Molecular Nutrition and Food Research.
61(4), 1600769-1600769.
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Johnson, G. S., Li, J., Beaver, L. M., Dashwood, W. M., Sun, D., Rajendran, P., ... Dashwood, R. H.
(2017).
Front cover: A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphanetreated colon cancer cells. Molecular Nutrition and Food Research.
61(4), 1770041-1770041.
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Chen, Y., Wang, R., Dashwood, W., Lhr, C. V., Williams, D. E., Ho, E., Mertens-Talcott, S., & Dashwood, R. H.
(2017).
A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat. Archives of Toxicology.
91(10), 3415-3425.
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Beaver, L. M., Kuintzle, R., Buchanan, A., Wiley, M. W., Glasser, S. T., Wong, C. P., ... Ho, E.
(2017).
Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
42, 72-83.
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Palomera-Sanchez, Z., Watson, G. W., Wong, C. P., Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E.
(2017).
The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
47, 113-119.
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Madeen, E. P., Lhr, C. V., You, H., Siddens, L. K., Krueger, S. K., Dashwood, R. H., ... Williams, D. E.
(2017).
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Molecular Carcinogenesis.
56(1), 163-171.
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Kim, H., Banerjee, N., Barnes, R. C., Pfent, C. M., Talcott, S. T., Dashwood, R. H., & Mertens-Talcott, S. U.
(2017).
Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo. Molecular Carcinogenesis.
56(1), 197-207.
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Ertem, F. U., Zhang, W., Chang, K., Mohaiza Dashwood, W., Rajendran, P., Sun, D., ... Dashwood, R. H.
(2017).
Oncogenic targets Mmp7, S100a9, Nppb and Aldh1a3 from transcriptome profiling of FAP and Pirc adenomas are downregulated in response to tumor suppression by Clotam. International Journal of Cancer.
140(2), 460-468.
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Kim, E., Bisson, W. H., Lhr, C. V., Williams, D. E., Ho, E., Dashwood, R. H., & Rajendran, P.
(2016).
Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors. Current Topics in Medicinal Chemistry.
16(7), 714-731.
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Kim, H., Banerjee, N., Ivanov, I., Pfent, C. M., Prudhomme, K. R., Bisson, W. H., ... Mertens-Talcott, S. U.
(2016).
Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. Molecular Nutrition and Food Research.
60(9), 1912-1923.
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Ertem, F. U., Dashwood, W., Rajendran, P., Raju, G., Rashid, A., & Dashwood, R.
(2016).
Novel polypectomy system in a preclinical model of colon cancer. Cancer Research.
76(14_Supplement), 839-839.
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Ertem, F., Dashwood, W., Rajendran, P., Raju, G., Rashid, A., & Dashwood, R.
(2016).
Development of a murine colonoscopic polypectomy model(withvideos). Gastrointestinal Endoscopy.
83(6), 1272-1276.
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Watson, G. W., Wickramasekara, S., Fang, Y., Maier, C. S., Williams, D. E., Dashwood, R. H., Perez, V. I., & Ho, E.
(2016).
HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells. EXPERIMENTAL BIOLOGY AND MEDICINE.
241(11), 1177-1185.
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Kim, H., Banerjee, N., Ivanov, I., Pfent, C. M., Prudhomme, K. R., Bisson, W. H., ... MertensTalcott, S. U.
(2016).
Inside front cover: Comparison of antiinflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. Molecular Nutrition and Food Research.
60(9), na-na.
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Wang, R., Kang, Y., Lhr, C. V., Fischer, K. A., Bradford, C. S., Johnson, G., ... Dashwood, R. H.
(2016).
Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer. Cancer Letters.
381(2), 341-348.
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Rajendran, P., Dashwood, W., Li, L. i., Kang, Y., Kim, E., Johnson, G., ... Dashwood, R. H.
(2015).
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. Clinical Epigenetics.
7(1), 102.
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Buchert, M., Rohde, F., Eissmann, M., Tebbutt, N., Williams, B., Tan, C. W., ... Janssen, K.
(2015).
A hypermorphic epithelial -catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations. Disease Models and Mechanisms.
8(11), 1361-1373.
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Dashwood, R. H.
(2015).
Abstract CN12-02: Dietary HDAC inhibitors: Prevention or therapy?. Cancer Prevention Research.
8(10_Supplement), cn12-02-cn12-02.
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Watson, G. W., Wickramasekara, S., Fang, Y., Palomera-Sanchez, Z., Maier, C. S., Williams, D. E., ... Ho, E.
(2015).
Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells. Molecular Nutrition and Food Research.
59(10), 1954-1961.
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Paquette, C. E., Kent, M. L., Peterson, T. S., Wang, R., Dashwood, R. H., & Lhr, C. V.
(2015).
Immunohistochemical characterization of intestinal neoplasia in zebrafish Danio rerio indicates epithelial origin. Diseases of Aquatic Organisms.
116(3), 191-197.
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Nolte-'t Hoen, E., Van Rooij, E., Bushell, M., Zhang, C., Dashwood, R. H., James, W., Harris, C., & Baltimore, D.
(2015).
The role of microRNA in nutritional control. Journal of Internal Medicine.
278(2), 99-109.
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Atwell, L. L., Hsu, A., Wong, C. P., Stevens, J. F., Bella, D., Yu, T., ... Ho, E.
(2015).
Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Molecular Nutrition and Food Research.
59(3), 424-433.
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Watson, G. W., Wickramasekara, S., Maier, C. S., Williams, D. E., Dashwood, R. H., & Ho, E.
(2015).
Assessment of global proteome in LNCaP cells by 2D-RP/RP LC-MS/MS following sulforaphane exposure. EuPA Open Proteomics.
9, 34-40.
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Atwell, L. L., Beaver, L. M., Shannon, J., Williams, D. E., Dashwood, R. H., & Ho, E.
(2015).
Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention. Current pharmacology reports.
1(2), 102-111.
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Kang, Y., Nian, H., Rajendran, P., Kim, E., Dashwood, W. M., Pinto, J. T., ... Dashwood, R. H.
(2014).
HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. Cell Death and Disease.
5(10), e1476-e1476.
-
Beaver, L. M., Buchanan, A., Sokolowski, E. I., Riscoe, A. N., Wong, C. P., Chang, J. H., ... Ho, E.
(2014).
Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Molecular Nutrition and Food Research.
58(10), 2001-2013.
-
Jariyasopit, N., Zimmermann, K., Schrlau, J., Arey, J., Atkinson, R., Yu, T., ... Simonich, S.
(2014).
Heterogeneous reactions of particulate matter-bound PAHs and NPAHs with NO3/N2O5, OH radicals, and O3 under simulated long-range atmospheric transport conditions: reactivity and mutagenicity. Environmental Science and Technology (Washington).
48(17), 10155-10164.
-
Jariyasopit, N., McIntosh, M., Zimmermann, K., Arey, J., Atkinson, R., Cheong, P., ... Massey Simonich, S. L.
(2014).
Novel nitro-PAH formation from heterogeneous reactions of PAHs with NO2, NO3/N2O5, and OH radicals: prediction, laboratory studies, and mutagenicity. Environmental Science and Technology (Washington).
48(1), 412-419.
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Watson, G. W., Wickramasekara, S., Palomera-Sanchez, Z., Black, C., Maier, C. S., Williams, D. E., Dashwood, R. H., & Ho, E.
(2014).
SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells. Oncogenesis.
3(12), e131-e131.
-
Wong, C. P., Hsu, A., Buchanan, A., Palomera-Sanchez, Z., Beaver, L. M., Houseman, E. A., ... Ho, E.
(2014).
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One.
9(1), e86787-e86787.
-
Cerella, C., Michiels, C., Dashwood, R. H., Surh, Y., & Diederich, M.
(2013).
Metabolism and cancer: old and new players. International Journal of Cell Biology.
2013, 293201-2.
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Kaur, P., Shorey, L. E., Ho, E., Dashwood, R. H., & Williams, D. E.
(2013).
The epigenome as a potential mediator of cancer and disease prevention in prenatal development. Nutrition Reviews.
71(7), 441-457.
-
Rajendran, P., Kidane, A. I., Yu, T., Dashwood, W., Bisson, W. H., Lhr, C. V., ... Dashwood, R. H.
(2013).
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics.
8(6), 612-623.
-
Wang, R., Lhr, C. V., Fischer, K., Dashwood, W. M., Greenwood, J. A., Ho, E., ... Dashwood, R. H.
(2013).
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. International Journal of Cancer.
132(5), 1004-1012.
-
Shorey, L. E., Madeen, E. P., Atwell, L. L., Ho, E., Lhr, C. V., Pereira, C. B., Dashwood, R. H., & Williams, D. E.
(2013).
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane. TOXICOLOGY AND APPLIED PHARMACOLOGY.
270(1), 60-69.
-
W Watson, G., M Beaver, L., E Williams, D., H Dashwood, R., & Ho, E.
(2013).
Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. American Association of Pharmaceutical Scientists (AAPS) Journal.
15(4), 951-961.
-
Parasramka, M. A., Dashwood, W. M., Wang, R., Abdelli, A., Bailey, G. S., Williams, D. E., Ho, E., & Dashwood, R. H.
(2012).
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Molecular Nutrition and Food Research.
56(8), 1259-1269.
-
Shorey, L. E., Hagman, A. M., Williams, D. E., Ho, E., Dashwood, R. H., & Benninghoff, A. D.
(2012).
3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One.
7(4), e34975-e34975.
-
Parasramka, M. A., Ho, E., Williams, D. E., & Dashwood, R. H.
(2012).
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Molecular Carcinogenesis.
51(3), 213-230.
-
Beaver, L. M., Yu, T., Sokolowski, E. I., Williams, D. E., Dashwood, R. H., & Ho, E.
(2012).
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. TOXICOLOGY AND APPLIED PHARMACOLOGY.
263(3), 345-351.
-
Parasramka, M. A., Dashwood, W. M., Wang, R., Saeed, H. H., Williams, D. E., Ho, E., & Dashwood, R. H.
(2012).
A role for low-abundance miRNAs in colon cancer: the miR-206/Krppel-like factor 4 (KLF4) axis. Clinical Epigenetics.
4(1), 16.
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McQuistan, T. J., Simonich, M. T., Pratt, M. M., Pereira, C. B., Hendricks, J. D., Dashwood, R. H., Williams, D. E., & Bailey, G. S.
(2012).
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study. Food and Chemical Toxicology.
50(2), 341-352.
-
Lee, S., Richardson, R. L., Dashwood, R. H., & Baek, S. J.
(2012).
Capsaicin represses transcriptional activity of -catenin in human colorectal cancer cells. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
23(6), 646-655.
-
Rajendran, P., Ho, E., Williams, D. E., & Dashwood, R. H.
(2011).
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clinical Epigenetics.
3(1), 4.
-
Hsu, A., Wong, C. P., Yu, Z., Williams, D. E., Dashwood, R. H., & Ho, E.
(2011).
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clinical Epigenetics.
3(1), 3.
-
Hasaniya, N. W., Premaratne, S., Zhang, W. W., Razzuk, A., Abdul-Ghani, A. A., Dashwood, R. H., ... McNamara, J. J.
(2011).
Amelioration of ischemia-reperfusion injury in an isolated rabbit lung model using OXANOH. Vascular and Endovascular Surgery.
45(7), 581-591.
-
Li, Q., Luo, C., Lhr, C. V., & Dashwood, R. H.
(2011).
Activator protein-2 functions as a master regulator of multiple transcription factors in the mouse liver. 41(8), 776-783.
-
Wang, W., Jariyasopit, N., Schrlau, J., Jia, Y., Tao, S., Yu, T., ... Simonich, S.
(2011).
Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games. Environmental Science and Technology (Washington).
45(16), 6887-6895.
-
Clarke, J. D., Hsu, A., Yu, Z., Dashwood, R. H., & Ho, E.
(2011).
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Molecular Nutrition and Food Research.
55(7), 999-1009.
-
Surh, Y., Dashwood, R. H., Na, H., & Ji, L. L.
(2011).
Introduction to Nutrition and physical activity in aging, obesity, and cancer. Annals of the New York Academy of Sciences.
1229(1), vii-viii.
-
Rajendran, P., Williams, D. E., Ho, E., & Dashwood, R. H.
(2011).
Metabolism as a key to histone deacetylase inhibition. Critical Reviews in Biochemistry and Molecular Biology.
46(3), 181-199.
-
Wang, R., Dashwood, W., Nian, H., Lhr, C. V., Fischer, K. A., Tsuchiya, N., ... Dashwood, R. H.
(2011).
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). International Journal of Cancer.
128(11), 2581-2590.
-
Rajendran, P., Delage, B., Dashwood, W. M., Yu, T., Wuth, B., Williams, D. E., Ho, E., & Dashwood, R. H.
(2011).
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Molecular Cancer.
10(1), 68.
-
Ho, E., Beaver, L. M., Williams, D. E., & Dashwood, R. H.
(2011).
Dietary factors and epigenetic regulation for prostate cancer prevention. Advances in Nutrition.
2(6), 497-510.
-
Hsu, A., Bruno, R. S., Lhr, C. V., Taylor, A. W., Dashwood, R. H., Bray, T. M., & Ho, E.
(2011).
Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFB pathway in the Noble rat model. JOURNAL OF NUTRITIONAL BIOCHEMISTRY.
22(5), 502-510.
-
Wang, R., & Dashwood, R. H.
(2011).
Endothelins and their receptors in cancer: identification of therapeutic targets. Pharmacological Research.
63(6), 519-524.
-
Clarke, J. D., Hsu, A., Williams, D. E., Dashwood, R. H., Stevens, J. F., Yamamoto, M., & Ho, E.
(2011).
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharmaceutical Research.
28(12), 3171-3179.
-
Ho, E., & Dashwood, R. H.
(2010).
Dietary manipulation of histone structure and function. Journal of Nutrigenetics and Nutrigenomics.
3(4-6), 231-238.
-
Larsen, C. A., & Dashwood, R. H.
(2010).
(-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells. Archives of Biochemistry and Biophysics.
501(1), 52-57.
-
Kwon, I., Wang, R., Thangaraju, M., Shuang, H., Liu, K., Dashwood, R., ... Browning, D. D.
(2010).
PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4. Oncogene.
29(23), 3423-3434.
-
Larsen, C. A., Dashwood, R. H., & Bisson, W. H.
(2010).
Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance. Pharmacological Research.
62(6), 457-464.
-
Jubert, C., Mata, J., Bench, G., Dashwood, R., Pereira, C., Tracewell, W., ... Bailey, G.
(2009).
Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers. Cancer Prevention Research.
2(12), 1015-1022.
-
Chimploy, K., Daz, G. D., Li, Q., Carter, O., Dashwood, W., Mathews, C. K., ... Dashwood, R. H.
(2009).
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. International Journal of Cancer.
125(9), 2086-2094.
-
Larsen, C. A., Bisson, W. H., & Dashwood, R. H.
(2009).
Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. Journal of Medicinal Chemistry.
52(21), 6543-6545.
-
Nian, H., Bisson, W. H., Dashwood, W., Pinto, J. T., & Dashwood, R. H.
(2009).
Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. Carcinogenesis.
30(8), 1416-1423.
-
Lee, J., Nian, H., Cooper, A., Sinha, R., Dai, J., Bisson, W. H., Dashwood, R. H., & Pinto, J. T.
(2009).
Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prevention Research.
2(7), 683-693.
-
Hasaniya, N. W., Premaratne, S., Zhang, W. W., Razzuk, A. M., Abdul-Ghani, A. A., Siera, M., ... McNamara, J. J.
(2009).
Ischemia-reperfusion injury in the lung: quantitation using electron microscopy. Vascular and Endovascular Surgery.
43(2), 170-177.
-
Nian, H., Delage, B., Ho, E., & Dashwood, R. H.
(2009).
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
50(3), 213-221.
-
Castro, D. J., Lhr, C. V., Fischer, K. A., Waters, K. M., Webb-Robertson, B., Dashwood, R. H., Bailey, G. S., & Williams, D. E.
(2009).
Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis. Carcinogenesis.
30(2), 315-320.
-
Li, Q., Lhr, C. V., & Dashwood, R. H.
(2009).
Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse. Cancer Letters.
283(1), 36-42.
-
Ho, E., Clarke, J. D., & Dashwood, R. H.
(2009).
Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. The Journal of Nutrition.
139(12), 2393-2396.
-
Ashktorab, H., Belgrave, K., Hosseinkhah, F., Brim, H., Nouraie, M., Takkikto, M., ... Smoot, D.
(2009).
Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. DIGESTIVE DISEASES AND SCIENCES.
54(10), 2109-2117.
-
Larsen, C. A., & Dashwood, R. H.
(2009).
Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide. Biochemical and Biophysical Research Communications.
389(3), 527-530.
-
Ashktorab, H., Dashwood, R. H., Dashwood, M. M., Zaidi, S. I., Hewitt, S. M., Green, W. R., ... Smoot, D. T.
(2008).
H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria. Helicobacter (Oxford).
13(6), 506-517.
-
Nian, H., Delage, B., Pinto, J. T., & Dashwood, R. H.
(2008).
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis.
29(9), 1816-1824.
-
Wang, R., Dashwood, W. M., Lhr, C. V., Fischer, K. A., Nakagama, H., Williams, D. E., & Dashwood, R. H.
(2008).
beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet. Cancer Science.
99(9), 1754-1759.
-
Castro, D. J., Yu, Z., Lhr, C. V., Pereira, C. B., Giovanini, J. N., Fischer, K. A., ... Williams, D. E.
(2008).
Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine. Carcinogenesis.
29(8), 1581-1586.
-
Delage, B., & Dashwood, R. H.
(2008).
Dietary manipulation of histone structure and function. Annual Review of Nutrition.
28(1), 347-366.
-
Wang, R., Dashwood, W. M., Lhr, C. V., Fischer, K. A., Pereira, C. B., Louderback, M., ... Dashwood, R. H.
(2008).
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. Carcinogenesis.
29(4), 834-839.
-
Dashwood, R. H., & Ho, E.
(2008).
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. Nutrition Reviews.
66 Suppl 1(Suppl 1), S36-S38.
-
Simonich, M. T., McQuistan, T., Jubert, C., Pereira, C., Hendricks, J. D., Schimerlik, M., ... Bailey, G. S.
(2008).
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout. Food and Chemical Toxicology.
46(3), 1014-1024.
-
Clarke, J. D., Dashwood, R. H., & Ho, E.
(2008).
Multi-targeted prevention of cancer by sulforaphane. Cancer Letters.
269(2), 291-304.
-
Simonich, M. T., Egner, P. A., Roebuck, B. D., Orner, G. A., Jubert, C., Pereira, C., ... Bailey, G. S.
(2007).
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis.
28(6), 1294-1302.
-
Yu, T. W., & Dashwood, R. H.
(2007).
Measuring antigenotoxic effects using the ames test and comet assay. American biotechnology laboratory.
25(6), 22-23.
-
Myzak, M. C., Tong, P., Dashwood, W., Dashwood, R. H., & Ho, E.
(2007).
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. EXPERIMENTAL BIOLOGY AND MEDICINE.
232(2), 227-234.
-
Li, Q., Dashwood, W. M., Zhong, X., Nakagama, H., & Dashwood, R. H.
(2007).
Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. Oncogene.
26(42), 6194-6202.
-
Carter, O., Dashwood, R. H., Wang, R., Dashwood, W. M., Orner, G. A., Fischer, K. A., ... Williams, D. E.
(2007).
Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts. Nutrition and Cancer: an international journal.
58(1), 60-65.
-
Higdon, J. V., Delage, B., Williams, D. E., & Dashwood, R. H.
(2007).
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacological Research.
55(3), 224-236.
-
Dashwood, R. H., & Ho, E.
(2007).
Dietary histone deacetylase inhibitors: from cells to mice to man. Seminars in Cancer Biology.
17(5), 363-369.
-
Dashwood, R. H.
(2007).
Frontiers in polyphenols and cancer prevention. 137(1 Suppl), 267S-269S.
-
Dashwood, R. H.
(2006).
Xenobiotic metabolism relevance to cancer. The Journal of Nutrition.
136(10), 2681S-2682S.
-
Myzak, M. C., Ho, E., & Dashwood, R. H.
(2006).
Dietary agents as histone deacetylase inhibitors. Molecular Carcinogenesis.
45(6), 443-446.
-
Myzak, M. C., Hardin, K., Wang, R., Dashwood, R. H., & Ho, E.
(2006).
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis.
27(4), 811-819.
-
Myzak, M. C., Dashwood, W. M., Orner, G. A., Ho, E., & Dashwood, R. H.
(2006).
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. The FASEB Journal.
20(3), 506-508.
-
Dashwood, R. H., Myzak, M. C., & Ho, E.
(2006).
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?. Carcinogenesis.
27(2), 344-349.
-
Yu, Z., Loehr, C. V., Fischer, K. A., Louderback, M. A., Krueger, S. K., Dashwood, R. H., ... Williams, D. E.
(2006).
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Research.
66(2), 755-762.
-
Myzak, M. C., & Dashwood, R. H.
(2006).
Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Letters.
233(2), 208-218.
-
Myzak, M. C., & Dashwood, R. H.
(2006).
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. Current Drug Targets.
7(4), 443-452.
-
Orner, G. A., Roebuck, B. D., Dashwood, R. H., & Bailey, G. S.
(2006).
Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats. Journal of Carcinogenesis.
5(1), 6-6.
-
Wang, R., Dashwood, W. M., Bailey, G. S., Williams, D. E., & Dashwood, R. H.
(2006).
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
601(1-2), 11-18.
-
Cope, R. B., Loehr, C., Dashwood, R., & Kerkvliet, N. I.
(2006).
Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol. Photochemical and Photobiological Sciences.
5(5), 499-507.
-
Dashwood, W., Carter, O., Al-Fageeh, M., Li, Q., & Dashwood, R. H.
(2005).
Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
591(1-2), 161-172.
-
Yu, T., Xu, M., & Dashwood, R. H.
(2004).
Antimutagenic activity of spearmint. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
44(5), 387-393.
-
Carter, O., Bailey, G. S., & Dashwood, R. H.
(2004).
The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells. 134(12 Suppl), 3441S-3444S.
-
Orner, G. A., Dashwood, W., & Dashwood, R. H.
(2004).
Tumor-suppressing effects of antioxidants from tea. 134(11), 3177S-3178S.
-
Li, Q., & Dashwood, R. H.
(2004).
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. 279(44), 45669-45675.
-
Myzak, M. C., Karplus, P. A., Chung, F., & Dashwood, R. H.
(2004).
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. 64(16), 5767-5774.
-
Li, Q., Dashwood, W., Zhong, X., Al-Fageeh, M., & Dashwood, R. H.
(2004).
Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters. Genomics.
83(2), 231-242.
-
Mastaloudis, A., Yu, T., O'Donnell, R. P., Frei, B., Dashwood, R. H., & Traber, M. G.
(2004).
Endurance exercise results in DNA damage as detected by the comet assay. Free Radical Biology and Medicine.
36(8), 966-975.
-
Al-Fageeh, M., Li, Q., Dashwood, W. M., Myzak, M. C., & Dashwood, R. H.
(2004).
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. Oncogene.
23(28), 4839-4846.
-
Blum, C. A., Tanaka, T., Zhong, X., Li, Q., Dashwood, W., Pereira, C., Xu, M., & Dashwood, R. H.
(2003).
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. Molecular Carcinogenesis.
36(4), 195-203.
-
Daz, G. D., Li, Q., & Dashwood, R. H.
(2003).
Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Research.
63(6), 1254-1261.
-
Orner, G. A., Dashwood, W., Blum, C. A., Daz, G. D., Li, Q., & Dashwood, R. H.
(2003).
Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. Carcinogenesis.
24(2), 263-267.
-
Blum, C. A., Xu, M., Orner, G. A., Daro Daz, G., Li, Q., Dashwood, W. M., Bailey, G. S., & Dashwood, R. H.
(2003).
Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
523-524, 217-223.
-
Dashwood, R. H., & Xu, M.
(2003).
The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol. Food and Chemical Toxicology.
41(8), 1185-1192.
-
Dashwood, R. H.
(2003).
Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis. 36(1), 35-42.
-
Amantana, A., Santana-Rios, G., Butler, J. A., Xu, M., Whanger, P. D., & Dashwood, R. H.
(2002).
Antimutagenic activity of selenium-enriched green tea toward the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline. Biological Trace Element Research.
86(2), 177-191.
-
Dashwood, W., Orner, G. A., & Dashwood, R. H.
(2002).
Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. Biochemical and Biophysical Research Communications.
296(3), 584-588.
-
Franke, A. A., Custer, L. J., Cooney, R. V., Tanaka, Y., Xu, M., & Dashwood, R. H.
(2002).
Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin. Advances in Experimental Medicine and Biology.
505, 123-133.
-
Dashwood, R. H.
(2002).
Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
511(2), 89-112.
-
Orner, G. A., Dashwood, W., Blum, C. A., Daz, G. D., Li, Q., Al-Fageeh, M., ... Dashwood, R. H.
(2002).
Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
506-507, 121-127.
-
Li, Q., Dixon, B. M., Al-Fageeh, M., Blum, C. A., & Dashwood, R. H.
(2002).
Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. Gene.
283(1-2), 255-262.
-
Santana-Rios, G., Orner, G. A., Xu, M., Izquierdo-Pulido, M., & Dashwood, R. H.
(2001).
Inhibition by white tea of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced colonic aberrant crypts in the F344 rat. Nutrition and Cancer: an international journal.
41(1-2), 98-103.
-
Blum, C. A., Xu, M., Orner, G. A., Fong, A. T., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
Erratum: -Catenin mutation in rat colon tumors initiated by 1,2-dimenthylhydrazine and 2-amino-3-methylimidazo [4,5-f]quinoline, and the effect of post-initiation treatment with chlorophylin and indole-3-carbinol (Carcinogenesis (2001) vol. 22 (315-320)). Carcinogenesis.
22(4), 685.
-
Xu, M., Orner, G. A., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
Erratum: Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl-imidazo[4,5-f] quinoline (Carcinogenesis (2001) vol. 22 (309-314)). Carcinogenesis.
22(4), 685.
-
Xu, M., Orner, G. A., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo. Carcinogenesis.
22(2), 309-314.
-
Blum, C. A., Xu, M., Orner, G. A., Fong, A. T., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. Carcinogenesis.
22(2), 315-320.
-
Yu, Z., Xu, M., Santana-Rios, G., Shen, R., Izquierdo-Pulido, M., Williams, D. E., & Dashwood, R. H.
(2001).
A comparison of whole wheat, refined wheat and wheat bran as inhibitors of heterocyclic amines in the Salmonella mutagenicity assay and in the rat colonic aberrant crypt focus assay. Food and Chemical Toxicology.
39(7), 655-665.
-
Dashwood, R. H., Xu, M., Orner, G. A., & Horio, D. T.
(2001).
Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2-amino-3-methylimidaz. European Journal of Cancer Prevention.
10(2), 139-145.
-
Xu, M., Orner, G. A., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl-imidazo[4,5-f]quinoline (vol 22, pg 309, 2001). Carcinogenesis.
22(4), 685-685.
-
Santana-Rios, G., Orner, G. A., Amantana, A., Provost, C., Wu, S. Y., & Dashwood, R. H.
(2001).
Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
495(1-2), 61-74.
-
Blum, C. A., Xu, M., Orner, G. A., Fong, A. T., Bailey, G. S., Stoner, G. D., Horio, D. T., & Dashwood, R. H.
(2001).
beta-catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo [4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol (vol 22, pg 315, 2001). Carcinogenesis.
22(4), 685-685.
-
Magnuson, B. A., South, E. H., Exon, J. H., Dashwood, R. H., Xu, M., Hendrix, K., & Hubele, S.
(2000).
Increased susceptibility of adult rats to azoxymethane-induced aberrant crypt foci. Cancer Letters.
161(2), 185-193.
-
Xu, M., Chen, R., & Dashwood, R. H.
(1999).
Effect of carcinogen dose fractionation, diet and source of F344 rat on the induction of colonic aberrant crypts by 2-amino-3-methylimidazo[4,5-f]quinoline. Carcinogenesis.
20(12), 2293-2298.
-
Dashwood, R. H., Xu, M., Hernaez, J. F., Hasaniya, N., Youn, K., & Razzuk, A.
(1999).
Cancer chemopreventive mechanisms of tea against heterocyclic amine mutagens from cooked meat. Experimental Biology and Medicine.
220(4), 239-243.
-
Suzui, M., Ushijima, T., Dashwood, R. H., Yoshimi, N., Sugimura, T., Mori, H., & Nagao, M.
(1999).
Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone. Molecular Carcinogenesis.
24(3), 232-237.
-
Xu, M., & Dashwood, R. H.
(1999).
Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis. Cancer Letters.
143(2), 179-183.
-
Breinholt, V., Arbogast, D., Loveland, P., Pereira, C., Dashwood, R., Hendricks, J., & Bailey, G.
(1999).
Chlorophyllin chemoprevention in trout initiated by aflatoxin B(1) bath treatment: An evaluation of reduced bioavailability vs. target organ protective mechanisms. TOXICOLOGY AND APPLIED PHARMACOLOGY.
158(2), 141-151.
-
Santana-Rios, G., & Dashwood, R. H.
(1999).
Time to discontinue antigenotoxicity studies of dietary fiber?. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
429(2), 269-271.
-
Dashwood, R. H.
(1999).
Early detection and prevention of colorectal cancer (review). Oncology Reports: an international journal devoted to fundamental and applied research in oncology.
6(2), 277-281.
-
Dashwood, R. H.
(1998).
Cancer chemoprevention from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
405(1), 109-110.
-
Dashwood, R. H.
(1998).
The "Sufficiency Principle" from the perspective of cancer prevention. Japanese Journal of Clinical Oncology.
28(6), 410-411.
-
Dashwood, R. H., & Bailey, G. S.
(1998).
Use of fish and fish transgenics in laboratory and field genotoxicology studies - Preface. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
399(2), 123-124.
-
Dashwood, R. H., Suzui, M., Nakagama, H., Sugimura, T., & Nagao, M.
(1998).
High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. Cancer Research.
58(6), 1127-1129.
-
Hernaez, J. F., Xu, M., & Dashwood, R. H.
(1998).
Antimutagenic activity of tea towards 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline: effect of tea concentration and brew time on electrophile scavenging. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
402(1-2), 299-306.
-
Dashwood, R., Negishi, T., Hayatsu, H., Breinholt, V., Hendricks, J., & Bailey, G.
(1998).
Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
399(2), 245-253.
-
Dashwood, R. H.
(1998).
Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?. CHEMICO-BIOLOGICAL INTERACTIONS.
110(1-2), 1-5.
-
Bailey, G. S., Dashwood, R., Loveland, P. M., Pereira, C., & Hendricks, J. D.
(1998).
Molecular dosimetry in fish: quantitative target organ DNA adduction and hepatocarcinogenicity for four aflatoxins by two exposure routes in rainbow trout. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
399(2), 233-244.
-
Hernaez, J., Xu, M., & Dashwood, R.
(1997).
Effects of tea and chlorophyllin on the mutagenicity of N-hydroxy-IQ: studies of enzyme inhibition, molecular complex formation, and degradation/scavenging of the active metabolites. 30(4), 468-474.
-
Xu, M., Schut, H. A., Bjeldanes, L. F., Williams, D. E., Bailey, G. S., & Dashwood, R. H.
(1997).
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts by indole-3-carbinol: dose-response studies in the rat colon. Carcinogenesis.
18(11), 2149-2153.
-
Hasaniya, N., Youn, K., Xu, M., Hernaez, J., & Dashwood, R.
(1997).
Inhibitory activity of green and black tea in a free radical-generating system using 2-amino-3-methylimidazo[4,5-f]quinoline as substrate. Japanese journal of cancer research : Gann.
88(6), 553-558.
-
Dashwood, R.
(1997).
Chlorophylls as anticarcinogens (review). International Journal of Oncology.
10(4), 721-727.
-
Dashwood, R. H.
(1997).
The importance of using pure chemicals in (anti) mutagenicity studies: chlorophyllin as a case in point. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
381(2), 283-286.
-
Hayashi, R., Luk, H., Horio, D., & Dashwood, R.
(1996).
Inhibition of apoptosis in colon tumors induced in the rat by 2-amino-3-methylimidazo[4,5-f]quinoline. Cancer Research.
56(19), 4307-4310.
-
Xu, M., Bailey, A. C., Hernaez, J. F., Taoka, C. R., Schut, H. A., & Dashwood, R. H.
(1996).
Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis.
17(7), 1429-1434.
-
Dashwood, R., Yamane, S., & Larsen, R.
(1996).
Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens. 27(3), 211-218.
-
Guo, D., Schut, H. A., Davis, C. D., Snyderwine, E. G., Bailey, G. S., & Dashwood, R. H.
(1995).
Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis.
16(12), 2931-2937.
-
Liew, C., Schut, H. A., Chin, S. F., Pariza, M. W., & Dashwood, R. H.
(1995).
Protection of conjugated linoleic acids against 2-amino-3- methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. Carcinogenesis.
16(12), 3037-3043.
-
Schut, H. A., & Dashwood, R. H.
(1995).
Inhibition of DNA adduct formation of 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) by dietary indole-3-carbinol (I3C) in the mammary gland, colon, and liver of the female F-344 rat. Annals of the New York Academy of Sciences.
768(1), 210-214.
-
Breinholt, V., Schimerlik, M., Dashwood, R., & Bailey, G.
(1995).
Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen. CHEMICAL RESEARCH IN TOXICOLOGY.
8(4), 506-514.
-
Tachino, N., Hayashi, R., Liew, C., Bailey, G., & Dashwood, R.
(1995).
Evidence for ras gene mutation in 2-amino-3-methylimidazo[4,5-f]quinoline-induced colonic aberrant crypts in the rat. Molecular Carcinogenesis.
12(4), 187-192.
-
Guo, D., Horio, D. T., Grove, J. S., & Dashwood, R. H.
(1995).
Inhibition by chlorophyllin of 2-amino-3-methylimidazo-[4,5-f]quinoline-induced tumorigenesis in the male F344 rat. Cancer Letters.
95(1-2), 161-165.
-
Takahashi, N., Dashwood, R. H., Bjeldanes, L. F., Williams, D. E., & Bailey, G. S.
(1995).
Mechanisms of indole-3-carbinol (I3C) anticarcinogenesis: inhibition of aflatoxin B1-DNA adduction and mutagenesis by I3C acid condensation products. Food and Chemical Toxicology.
33(10), 851-857.
-
Takahashi, N., Dashwood, R. H., Bjeldanes, L. F., Bailey, G. S., & Williams, D. E.
(1995).
Regulation of hepatic cytochrome P4501A by indole-3-carbinol: transient induction with continuous feeding in rainbow trout. Food and Chemical Toxicology.
33(2), 111-120.
-
Dashwood, R., & Guo, D.
(1995).
Protective properties of chlorophylls against the covalent binding of heterocyclic amines to DNA in vitro and in vivo. 23, 181-189.
-
Dashwood, R. H., Fong, A. T., Arbogast, D. N., Bjeldanes, L. F., Hendricks, J. D., & Bailey, G. S.
(1994).
Anticarcinogenic activity of indole-3-carbinol acid products: ultrasensitive bioassay by trout embryo microinjection. Cancer Research.
54(13), 3617-3619.
-
Guo, D., & Dashwood, R.
(1994).
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding in rats given chlorophyllin: dose-response and time-course studies in the liver and colon. Carcinogenesis.
15(4), 763-766.
-
Tachino, N., Guo, D., Dashwood, W. M., Yamane, S., Larsen, R., & Dashwood, R.
(1994).
Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
308(2), 191-203.
-
Fong, A. T., Dashwood, R. H., Cheng, R., Mathews, C., Ford, B., Hendricks, J. D., & Bailey, G. S.
(1993).
Carcinogenicity, metabolism and Ki-ras proto-oncogene activation by 7,12-dimethylbenz[a]anthracene in rainbow trout embryos. Carcinogenesis.
14(4), 629-635.
-
Dashwood, R., & Guo, D.
(1993).
Antimutagenic potency of chlorophyllin in the Salmonella assay and its correlation with binding constants of mutagen-inhibitor complexes. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
22(3), 164-171.
-
Dashwood, R., & Guo, D.
(1992).
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding by chlorophyllin: studies of enzyme inhibition and molecular complex formation. Carcinogenesis.
13(7), 1121-1126.
-
Bailey, G., Hendricks, J., & Dashwood, R.
(1992).
Anticarcinogenesis in fish. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
267(2), 243-250.
-
Dashwood, R., & Liew, C.
(1992).
Chlorophyllin-enhanced excretion of urinary and fecal mutagens in rats given 2-amino-3-methylimidazo[4,5-f]quinoline. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
20(3), 199-205.
-
Dashwood, R. H.
(1992).
Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to rat liver DNA. Carcinogenesis.
13(1), 113-118.
-
Dashwood, R. H., Breinholt, V., & Bailey, G. S.
(1991).
Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay. Carcinogenesis.
12(5), 939-942.
-
Dashwood, R. H., Fong, A. T., Williams, D. E., Hendricks, J. D., & Bailey, G. S.
(1991).
Promotion of aflatoxin B1 carcinogenesis by the natural tumor modulator indole-3-carbinol: influence of dose, duration, and intermittent exposure on indole-3-carbinol promotional potency. Cancer Research.
51(9), 2362-2365.
-
Bailey, G. S., Dashwood, R. H., Fong, A. T., Williams, D. E., Scanlan, R. A., & Hendricks, J. D.
(1991).
Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: quantitative analysis of inhibition versus promotion. IARC scientific publications.
105(105), 275-280.
-
Fong, A. T., Swanson, H. I., Dashwood, R. H., Williams, D. E., Hendricks, J. D., & Bailey, G. S.
(1990).
Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation. Biochemical Pharmacology.
39(1), 19-26.
-
Dashwood, R. H., Loveland, P. M., Fong, A. T., Hendricks, J. D., & Bailey, G. S.
(1990).
Combined in vivo DNA binding and tumor dose-response studies to investigate the molecular dosimetry concept. Progress in clinical and biological research.
340D, 335-344.
-
Dashwood, R. H., Fong, A. T., Hendricks, J. D., & Bailey, G. S.
(1990).
Tumor dose-response studies with aflatoxin B1 and the ambivalent modulator indole-3-carbinol: inhibitory versus promotional potency. Basic life sciences.
52, 361-365.
-
Dashwood, R. H., Uyetake, L., Fong, A. T., Hendricks, J. D., & Bailey, G. S.
(1989).
In vivo disposition of the natural anti-carcinogen indole-3-carbinol after po administration to rainbow trout. Food and Chemical Toxicology.
27(6), 385-392.
-
DASHWOOD, R. H., UYETAKE, L., FONG, A. T., HENDRICKS, J. D., & BAILEY, G. S.
(1989).
THE SYNTHESIS OF [H-3] INDOLE-3-CARBINOL, A NATURAL ANTI-CARCINOGEN FROM CRUCIFEROUS VEGETABLES. Journal of Labelled Compounds and Radiopharmaceuticals.
27(8), 901-907.
-
Dashwood, R. H., Arbogast, D. N., Fong, A. T., Pereira, C., Hendricks, J. D., & Bailey, G. S.
(1989).
Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response. Carcinogenesis.
10(1), 175-181.
-
DASHWOOD, R. H., & COMBES, R. D.
(1988).
LEVELS OF METABOLIC COMPLEXITY IN ASSAYS EMPLOYING THE INVIVO EQUIVALENT DOSE (IVED) CONCEPT - REPLY. MUTAGENESIS.
3(6), 528-531.
-
Dashwood, R. H., Arbogast, D. N., Fong, A. T., Hendricks, J. D., & Bailey, G. S.
(1988).
Mechanisms of anti-carcinogenesis by indole-3-carbinol: detailed in vivo DNA binding dose-response studies after dietary administration with aflatoxin B1. Carcinogenesis.
9(3), 427-432.
-
Dashwood, R. H., Combes, R. D., & Ashby, J.
(1988).
DNA-binding studies with 6BT and 5I: implications for DNA-binding/carcinogenicity and DNA-binding/mutagenicity correlations. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
198(1), 61-68.
-
Fong, A. T., Hendricks, J. D., Dashwood, R. H., Van Winkle, S., & Bailey, G. S.
(1988).
Formation and persistence of ethylguanines in liver DNA of rainbow trout (Salmo gairdneri) treated with diethylnitrosamine by water exposure. Food and Chemical Toxicology.
26(8), 699-704.
-
Fong, A. T., Hendricks, J. D., Dashwood, R. H., Van Winkle, S., Lee, B. C., & Bailey, G. S.
(1988).
Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, beta-naphthoflavone, and Aroclor 1254. TOXICOLOGY AND APPLIED PHARMACOLOGY.
96(1), 93-100.
-
Dashwood, R. H., & Combes, R. D.
(1987).
The use of in vivo-like concentrations of chemicals for validation of in vitro short-term genotoxicity assays--an in vivo equivalent dose concept. MUTAGENESIS.
2(4), 249-251.
-
Dashwood, R. H., & Combes, R. D.
(1987).
Deficiencies in the covalent binding index (CBI) for expressing in vivo binding to DNA with respect to predicting chemical carcinogenicity. A proposal for a target-organ binding index. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.
190(3), 173-175.
-
Dashwood, R. H., Combes, R. D., & Ashby, J.
(1987).
Combined radiolabelling distribution and covalent DNA-binding studies to discriminate between a carcinogen/noncarcinogen pair of monoazo dyes related to the hepatocarcinogen butter yellow (DAB). Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.
11(SUPPL. 11), 99-101.
-
Dashwood, R. H., Combes, R. D., Paton, D., & Ashby, J.
(1986).
Mutagenicity to Salmonella of four derivatives of the azo mutagen 5I: some implications for structure--activity databases and the evaluation of combinations of mutagens. MUTAGENESIS.
1(4), 261-265.
-
Dashwood, R. H., Combes, R. D., & Ashby, J.
(1986).
The disposition and in vivo covalent binding to liver DNA of the monoazodyes 6-(p-dimethylaminophenylazo)benzothiazole (6BT) and 5-(p-dimethylaminophenylazo)indazole (5I) after administration to the rat. Carcinogenesis.
7(6), 1029-1033.
-
DASHWOOD, R. H., COMBES, R. D., & ASHBY, J.
(1986).
LIMITATIONS OF INVITRO ASSAYS FOR DISTINGUISHING BETWEEN A CARCINOGEN NON-CARCINOGEN PAIR OF MONOAZO DYES. Food and Chemical Toxicology.
24(6-7), 707-708.
-
Beaver, L. M., Lhr, C. V., Clarke, J. D., Glasser, S. T., Watson, G. W., Wong, C. P., ... Ho, E.
Broccoli sprouts delay prostate cancer formation and decrease prostate cancer severity with a concurrent decrease in HDAC3 protein expression in TRAMP mice. Current Developments in Nutrition.
cdn.117.002378-cdn.117.002378.
-
Zhang, S., Kapoor, S., Tripathi, C., Perez, J. T., Mohan, N., Dashwood, W. M., ... Dashwood, R.
(2023).
Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis. 7(1), 20.
-
chapter
-
Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E.
(2012).
Chemoprevention of Prostate Cancer with Cruciferous Vegetables: Role of Epigenetics. Nutrition, Diet and Cancer.
(pp. 49-81).
Springer Nature.
-
Delage, B., & Dashwood, R.
(2008).
Targeting the Epigenome with Dietary Agents. Dietary Modulation of Cell Signaling Pathways.
(pp. 337-369).
Taylor & Francis.
-
Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E.
(2012).
Chemoprevention of Prostate Cancer with Cruciferous Vegetables: Role of Epigenetics. Nutrition, Diet and Cancer.
(pp. 49-81).
Springer Nature.
-
conference paper
-
Mohan, N., & Dashwood, R. H.
(2022).
Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer. Cancer Research.
-
Mohan, N., & Dashwood, R. H.
(2022).
Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer. Cancer Research.
-
Perez, J., & Dashwood, R. H.
(2022).
Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells. Cancer Research.
-
Perez, J., & Dashwood, R. H.
(2022).
Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells. Cancer Research.
-
Kapoor, S., & Dashwood, R. H.
(2022).
Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception. Cancer Research.
-
Kapoor, S., & Dashwood, R. H.
(2022).
Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception. Cancer Research.
-
Tripathi, C., & Dashwood, R. H.
(2022).
Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis. Cancer Research.
-
Tripathi, C., & Dashwood, R. H.
(2022).
Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis. Cancer Research.
-
Neja, S., & Dashwood, R. H.
(2022).
Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake. Cancer Research.
-
Neja, S., & Dashwood, R. H.
(2022).
Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake. Cancer Research.
-
Rajendran, P., Damiani, E., Wang, S., Dashwood, W., & Dashwood, R. H.
(2020).
Dietary polyphenols as epigenetic 'reader' inhibitors. Cancer Research.
3477-3477.
-
Rajendran, P., Ulusan, A., Dashwood, W., Kapoor, S., Mohammed, A., Sei, S., ... Dashwood, R. H.
(2020).
Optimization of dosing regimens of sulindac in combination with erlotinib for small intestine and colorectal cancer prevention. Cancer Research.
21-21.
-
Johnson, G. S., Rajendran, P., Li, L. i., Chen, Y., Dashwood, W. M., Nguyen, N., ... Dashwood, R. H.
(2019).
Abstract 2614: CCAR2 acetylation establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition. 2614-2614.
-
Ulusan, A., Rajendran, P., Dashwood, W., Mohammed, A., Sei, S., Brown, P. H., Vilar-Sanchez, E., & Dashwood, R. H.
(2019).
Abstract 5074: Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP. 5074-5074.
-
Ulusan, A., Rajendran, P., Dashwood, W., Mohammed, A., Sei, S., Brown, P. H., Vilar-Sanchez, E., & Dashwood, R. H.
(2019).
Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP. Cancer Research.
5074-5074.
-
Li, Q., Zhong, X. S., Nyeem, S. Z., Kline, K. T., Peng, J., Fujise, K., & Dashwood, R. H.
(2018).
Experimental colitis impedes cardiac function through epigenetic mechanisms. EUROPEAN HEART JOURNAL.
994-995.
-
Chen, Y., Wang, R., Dashwood, W., Lhr, C., Williams, D. E., Ho, E., Mertens-Talcott, S., & Dashwood, R. H.
(2017).
Abstract 4428: A miRNA signature linked to human environmental risk defined from carcinogen-induced and genetically-driven colon carcinogenesis models. Cancer Research.
4428-4428.
-
Kaiser, M. C., Rajendran, P., Dashwood, M. W., Levine, M. A., Michaels, A., Frei, B., & Dashwood, R. H.
(2013).
An epigenetic perspective on pharmacologic ascorbate in colon cancer. The FASEB Journal.
248.3-248.3.
-
Beaver, L. M., Buchanan, A., Sokolowski, E. I., Chang, J. H., Wong, C. P., Williams, D. E., Dashwood, R. H., & Ho, E.
(2013).
Genome-wide transcriptome analysis of the effects of sulforphane on normal and prostate cancer cells. The FASEB Journal.
248.2-248.2.
-
Atwell, L. L., Clarke, J. D., Hsu, A., Bella, D., Stevens, J. F., Dashwood, R. H., Williams, D. E., & Ho, E.
(2013).
Sulforaphane bioavailability and bioactivity in humans. The FASEB Journal.
636.26-636.26.
-
Romagnolo, D. F., Dashwood, R., Stover, P. J., Waterland, R. A., & Ziegler, T. R.
(2012).
Nutritional regulation of epigenetic changes. Advances in Nutrition.
749-750.
-
Shorey, L. E., Kaur, P., Rosato, C., Houseman, E. A., Ho, E., Dashwood, R. H., Benninghoff, A. D., & Williams, D. E.
(2012).
Analysis of genome-wide DNA methylation in CCRF-CEM cells confirms hypermethylation at reported epigenetic markers of T-cell lymphoblastic leukemia and identifies novel therapeutic targets with reduced methylation upon treatment with dietary indoles. Cancer Research.
5430-5430.
-
Rajendran, P., Kidane, A. I., Yu, T., Dashwood, W., Ho, E., Williams, D. E., & Dashwood, R. H.
(2012).
Differential effects of sulforaphane and related isothiocyanates on HDAC turnover and the DNA damage response in colon cancer cells. Cancer Research.
lb-184-lb-184.
-
Beaver, L. M., Chang, J. H., Williams, D. E., Dashwood, R. H., & Ho, E.
(2012).
An RNA-seq approach to identify mechanisms by which the phytochemical sulforaphane acts to prevent prostate cancer. The FASEB Journal.
647.10-647.10.
-
Beaver, L. M., Yu, T., Sokolowski, E. I., Hsu, A., Williams, D. E., Dashwood, R. H., & Ho, E.
(2012).
Chemopreventative phytochemical 3,3 '-diindolylmethane inhibits histone deacetylases in prostate cancer cells. The FASEB Journal.
366.6-366.6.
-
Nian, H., & Dashwood, R. H.
(2010).
Alpha-keto acid metabolites of organoselenium compounds inhibit HDAC activity. The FASEB Journal.
894.7-894.7.
-
Dashwood, R. H.
(2010).
Metabolism as a key to HDAC inhibition by dietary constituents. The FASEB Journal.
413.1-413.1.
-
Dashwood, R. H.
(2007).
Frontiers in polyphenols and cancer prevention. The Journal of Nutrition.
267S-269S.
-
Myzak, M. C., Hardin, K., Yan, M., Tong, P., Dashwood, R., & Ho, E.
(2006).
Sulforaphane inhibits HDAC activity in prostate cancer cells, retards growth of PC3 xenografts, and inhibits HDAC activity in vivo. The FASEB Journal.
A150-A150.
-
Dashwood, R. H.
(2006).
Weak ligands as HDAC inhibitors: useful for chemoprevention?. CHEMICO-BIOLOGICAL INTERACTIONS.
191-191.
-
Carter, O., Bailey, G. S., & Dashwood, R. H.
(2004).
The dietary phytochemical chlorophyllin alters e-cadherin and beta-catenin expression in human colon cancer cells. The Journal of Nutrition.
3441S-3444S.
-
Yu, T. W., Dashwood, R. H., & Xu, M.
(2004).
Antimutagenic activity of spearmint (Mentha spicata L.). ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.
239-239.
-
Hemingway, R. W., McGraw, G. W., Helms, G. L., Proteau, R. R., Mata, J. E., & Dashwood, R. H.
(2004).
Catechin-(4 alpha,-8)-epigallocatechin-3-gallate: Production, proof of structure, properties. ACS National Meeting Book of Abstracts.
U250-U250.
-
Myzak, M. C., Hardin, K., Dashwood, R. H., & Ho, E.
(2004).
HDAC inhibition by sulforaphane during hyperplasia, intermediate and late stages of prostate cancer. Cancer Epidemiology, Biomarkers and Prevention.
1847S-1847S.
-
Orner, G. A., Elias, V. D., & Dashwood, R. H.
(2004).
Modulation of Wnt signaling by white tea plus celecoxib. Cancer Epidemiology, Biomarkers and Prevention.
1845S-1845S.
-
Orner, G., Dashwood, W. M., Tebbutt, N. C., Li, Q., Heath, J. K., Myzak, M. C., Ernst, M., & Dashwood, R. H.
(2003).
Cancer chemoprevention by a combination of white tea plus sulindac in a mouse model expressing an oncogenic form of beta-catenin. Cancer Epidemiology, Biomarkers and Prevention.
1287S-1287S.
-
Orner, G. A., Dashwood, W. M., Li, Q. J., Al-Fageeh, M., Tebbutt, N., Heath, J. K., Ernst, M., & Dashwood, R. H.
(2002).
Cellular effects of tea antioxidants in vitro and in mouse models of colon cancer. Free Radical Biology and Medicine.
S302-S302.
-
Orner, G. A., Dashwood, W. M., Li, Q. J., Al-Fageeh, M., Tebbutt, N., Heath, J. K., Ernst, M., & Dashwood, R. H.
(2002).
Cellular effects of tea antioxidants in vitro and in mouse models of colorectal cancer: modulation of Wnt signaling. FREE RADICAL RESEARCH.
16-20.
-
Amantana, A., Santana-Rios, G., Butler, J. A., Whanger, P. D., & Dashwood, R.
(2000).
Antimutagenic activity of selenium-enriched green tea towards a cooked meat mutagen. The FASEB Journal.
A537-A537.
-
Santana-Rios, G., Provost, C., Amantana, A., & Dashwood, R. H.
(2000).
Antimutagenic activity of white tea. ACS National Meeting Book of Abstracts.
U487-U487.
-
Franke, A. A., Dashwood, R. H., Xu, M., & Custer, L. J.
(2000).
Cancer-protective effects and bioavailability of flavonoids. ACS National Meeting Book of Abstracts.
U54-U54.
-
WILLIAMS, D. E., DASHWOOD, R. H., HENDRICKS, J. D., & BAILEY, G. S.
(1989).
ANTICARCINOGENS AND TUMOR PROMOTERS IN FOODS. 101-150.
-
DASHWOOD, R. H., ARBOGAST, D., HENDRICKS, J., FONG, A., & BAILEY, G. S.
(1988).
CONCOMITANT INVIVO DNA-BINDING TUMOR DOSE-RESPONSE STUDIES WITH AFLATOXIN-B1 AND THE NATURAL INHIBITOR INDOLE-3-CARBINOL. Proceedings / Annual Meeting of the American Association for Cancer Research [and] Annual Meeting of the American Society of Clinical Oncology. American Association for Cancer Research. Meeting.
135-135.
-
BAILEY, G., FONG, A., SWANSON, H., WILLIAMS, D., DASHWOOD, R., & HENDRICKS, J.
(1988).
EFFECT OF DIETARY INDOLE-3-CARBINOL (I3C), B-NAPHTHOFLAVONE (BNF), AND AROCLOR-1254 (PCB) ON DIETHYLNITROSAMINE (DEN) AND AFLATOXIN-B1 (AFB1) CARCINOGENESIS IN TROUT. The FASEB Journal.
A1413-A1413.
-
DASHWOOD, R. H., COMBES, R. D., & ASHBY, J.
(1987).
COMPARISON OF THE ACTIVATION OF A CARCINOGEN NON-CARCINOGEN PAIR OF MONOAZO DYES USING INVITRO AND INVIVO GENOTOXICITY ASSAYS - THE USE OF AN INVIVO EQUIVALENT DOSE CONCEPT. 335-335.
-
DASHWOOD, R. H., COMBES, R. D., & ASHBY, J.
(1987).
ON THE LACK OF SPECIFICITY OF THE SALMONELLA MUTAGENICITY ASSAY. MUTAGENESIS.
301-301.
-
DASHWOOD, R. H.
(1987).
THE RELATIONSHIP BETWEEN COVALENT DNA-BINDING AND REVERTANT YIELD IN THE SALMONELLA MUTAGENICITY (AMES) ASSAY - IMPLICATIONS FOR ASSAY SPECIFICITY. 27-27.
-
DASHWOOD, R. H., COMBES, R. D., & ASHBY, J.
(1986).
ADAPTATION OF INVITRO AND INVIVO BINDING ASSAYS TO DISCRIMINATE BETWEEN A CARCINOGEN NON-CARCINOGEN PAIR OF MUTAGENIC MONOAZO DYES. MUTAGENESIS.
389-389.
-
DASHWOOD, R. H., COMBES, R. D., & ASHBY, J.
(1986).
IMPLICATIONS FOR STRUCTURE ACTIVITY DATABASES AND THE EVALUATION OF COMBINATIONS OF MUTAGENS IN THE SALMONELLA ASSAY, AS ILLUSTRATED BY STUDIES WITH THE MUTAGENIC NON-CARCINOGEN 5I. MUTAGENESIS.
392-392.
-
DASHWOOD, R. H., & COMBES, R. D.
(1986).
MUTAGENICITY OF THE 2 CARCINOGEN NON-CARCINOGEN PAIRS BENZO[A]PYRENE, PYRENE AND 2-ACETYLAMINOFLUORENE, 4-ACETYLAMINOFLUORENE AND THEIR RESPECTIVE RAT URINE CONCENTRATES AS PART OF THE IPCS COLLABORATIVE TRIAL. MUTAGENESIS.
76-76.
-
DASHWOOD, R. H., COMBES, R. D., ASHBY, J., & PATON, D.
(1986).
STRUCTURE ACTIVITY STUDIES WITH 5-DIMETHYLAMINOPHENYLAZOINDAZOLE AND RELATED MONOAZO DYES IN THE SALMONELLA MAMMALIAN MICROSOME ASSAY. MUTAGENESIS.
69-69.
-
Mohan, N., & Dashwood, R. H.
(2022).
Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer. Cancer Research.
-
institutional repository document
-
Chen, Y., Li, J., Menon, R., Jayaraman, A., Lee, K., Huang, Y., ... Dashwood, R.
(2021).
Reshaping the Gut Microbiome in An Apc-Mutant Genetic Background: Mechanistic Insights From Integrated Multi-Omics
-
Chen, Y., Li, J., Menon, R., Jayaraman, A., Lee, K., Huang, Y., ... Dashwood, R.
(2021).
Reshaping the Gut Microbiome in An Apc-Mutant Genetic Background: Mechanistic Insights From Integrated Multi-Omics
Research
principal investigator on
- Immunoepigenetic Targeting of MHC Regulators in FAP awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2023 - 2028
- CCAR2 as a Target for Prevention of Colorectal Cancer awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023
- Comparative Mechanisms of Cancer Chemoprevention awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2014 - 2017
Teaching
teaching activities
- IBST691 Research Credit: Medical Sci Instructor
Works By Students
chaired theses and dissertations
-
Chen, Ying-Shiuan (2019-02). Molecular Profiling of Prevention Strategies Using Rodent Models of Colorectal Cancer.
-
Johnson, Gavin S. (2019-04). Expanding Epigenetic Mechanisms of Sulforaphane in Colorectal Cancer: Pseudogenes and Protein Acetylation.
-
Perkins, Ashley Lyn (2015-08). Examining the Roles of Beta-Catenin and HDAC6 in Primary Cilia Signaling in ccRCC and CRC.
-
Yin, Yue (2021-07). Comprehensive Data Analysis Toolkit Development for a Low Input Bisulfite Sequencing.
Background
education and training
- Ph.D. in Genetic Toxicology, University of Portsmouth - (Portsmouth, Portsmouth, United Kingdom) 1986
- M.S. in Toxicology, University of Surrey - (Guildford, Surrey, United Kingdom) 1983
- B.S. in Biological Sciences (Cellular Toxicology), Plymouth University - (Plymouth, Plymouth, United Kingdom) 1982
- Oregon State University - (Corvallis, Oregon, United States) , Postdoctoral Training 1990
awards and honors
Contact
first name
- Rod
has last name
- Dashwood
mailing address
-
Texas A&M Health and School of Medicine
Center for Epigenetics & Disease Prevention
1201 TAMUS
Houston, TX 77030-3303
USA
Other
In the News
- 2023 University Distinguished Professor News Release
- An Early Target for Acetylation in Colon Cancer Cells Treated with Sulforaphane News Release
- Center for Epigenetics and Disease Prevention receives Texas A&M Board of Regents stamp of approval News Release
- Debunking a TikTok Trend News Release
- Director of New Center Looks for Foods That Protect Health News Release
- Eight Faculty Earn Texas A&M’s Highest Honor News Release
- Highly effective tumor detection strategy for common childhood brain tumors News Release
- Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma News Release
- Research explains why you should eat your broccoli News Release
- Scientists Develop Highly Effective Detection Strategy For Childhood Brain Tumors News Release
- Texas A&M Advances Global Disease Prevention with Launch of Field-to-Clinic Initiative News Release
- Texas A&M Health Faculty Rank Among Top 2 Percent Of Scholars Worldwide News Release
- Two Texas A&M Health faculty named Distinguished Professors News Release
- You are what you eat? Food fights disease News Release
- rdashwood@tamu.edu