Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis. Academic Article

abstract

• ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis. In colorectal cancer patients for whom high ACE2 plus high BRD4 expression is predictive of poor survival, pan-BET inhibition would need to consider proviral/antiviral actions of different BET proteins during SARS-CoV-2 infection.

authors

• Dashwood, Roderick
• Rajendran, Praveen

published proceedings

• NPJ Precis Oncol

altmetric score

• 16.05

author list (cited authors)

• Zhang, S., Kapoor, S., Tripathi, C., Perez, J. T., Mohan, N., Dashwood, W. M., ... Dashwood, R.

citation count

• 1

publication date

• February 2023

publisher

• Springer Nature  Publisher

keywords

• Cancer
• Clinical Research
• Colo-rectal Cancer
• Digestive Diseases
• Lung

Digital Object Identifier (DOI)

• 10.1038/s41698-023-00361-4

start page

• 20

volume

• 7

issue

• 1

URL

• http://dx.doi.org/10.1038/s41698-023-00361-4