HR job title
- Associate Professor and Department Head of Pharmaceutical Sciences
- Contact Info
Khasawneh, Fadi Associate Professor and Department Head of Pharmaceutical Sciences
Positions
- Associate Professor and Department Head of Pharmaceutical Sciences, Pharmacy Practice, Irma Lerma Rangel School of Pharmacy
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Alarabi, A. B., Mohsen, A., Taleb, Z. B., Mizuguchi, K., Alshbool, F. Z., & Khasawneh, F. T.
(2023).
Predicting thrombotic cardiovascular outcomes induced by waterpipe-associated chemicals using comparative toxicogenomic database: Genes, phenotypes, and pathways. LIFE SCIENCES.
323, 121694-121694.
-
Ramirez, J., Alarabi, A. B., Khasawneh, F. T., & Alshbool, F. Z.
(2022).
A Novel Antibody Targeting the Second Extracellular Loop of the Serotonin 5-HT2A Receptor Inhibits Platelet Function. International Journal of Molecular Sciences.
23(15), 8794-8794.
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Alarabi, A., Ali, H., Lozano, P., Khasawneh, F. T., & Alshbool, F. Z.
(2022).
Abstract 156: Prenatal Exposure To Electronic Delivery Systems Modulates Platelet Reactivity, Epigenetics And Gene Expression In Mice. Arteriosclerosis, Thrombosis and Vascular Biology.
42(Suppl_1), a156-a156.
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Alarabi, A. B., Mohsen, A., Mizuguchi, K., Alshbool, F. Z., & Khasawneh, F. T.
(2022).
Co-expression analysis to identify key modules and hub genes associated with COVID-19 in platelets. BMC Medical Genomics.
15(1), 83.
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Villalobos-Garca, D., Ali, H., Alarabi, A. B., El-Halawany, M. S., Alshbool, F. Z., & Khasawneh, F. T.
(2022).
Exposure of Mice to Thirdhand Smoke Modulates In Vitro and In Vivo Platelet Responses. International Journal of Molecular Sciences.
23(10), 5595-5595.
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Alarabi, A. B., Ali, H. E., Lozano, P. A., Rodrigues, L. A., Halawany, M. S., Alshbool, F. Z., & Khasawneh, F. T.
(2022).
In Utero Thirdhand Smoke Modulates Platelet Gene Expression in Exposed Mice. The FASEB Journal.
36(S1),
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Ali, H., Alarabi, A. B., Karim, Z. A., Rodriguez, V., Hernandez, K. R., Lozano, P. A., ... Khasawneh, F. T.
(2022).
In utero thirdhand smoke exposure modulates platelet function in a sex-dependent manner. Haematologica: the hematology journal.
107(1), 312-315.
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Lozano, P. A., Alarabi, A. B., Garcia, S. E., Boakye, E. T., Kingbong, H. T., Naddour, E., ... Alshbool, F. Z.
(2022).
The Antidepressant Duloxetine Inhibits Platelet Function and Protects against Thrombosis. International Journal of Molecular Sciences.
23(5), 2587-2587.
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Alarabi, A. B., Lozano, P. A., Khasawneh, F. T., & Alshbool, F. Z.
(2022).
The effect of emerging tobacco related products and their toxic constituents on thrombosis. LIFE SCIENCES.
290, 120255-120255.
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Alarabi, A., Ali, H., Karim, Z., Rodriguez, V., Hernandez, K., Lozano, P., Alshbool, F., & Khasawneh, F
(2021).
Investigation of the Mechanistic Impact of Prenatal Exposure to Thirdhand Smoke on Platelet Activation. The FASEB Journal.
35(S1),
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Lozano, P., Garcia, S., Boakye, E., Kingbong, H., Naddour, E., Alarabi, A., Khasawneh, F., & Alshbool, F
(2021).
The Antidepressant Duloxetine Inhibits Platelet Function and Protects against Thrombosis. The FASEB Journal.
35(S1),
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Alarabi, A., Karim, Z., Lozano, P., Khasawneh, F. T., & Alshbool, F. Z.
(2021).
Abstract 126: Exposure To Thirdhand Hookah Smoke Elevates The Risk Of Thrombogenesis By Enhancing Platelet Function. Arteriosclerosis, Thrombosis and Vascular Biology.
41(Suppl_1),
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Malhotra, A., Reddy, I. K., Fulford, M., Khasawneh, F. T., Tiwari, A. K., & Feng, X.
(2021).
Strategies for the integration of foundational and clinical sciences in doctor of pharmacy programs. 4(10), 1307-1314.
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Ramirez, J., Karim, Z. A., Alarabi, A. B., Hernandez, K. R., Taleb, Z. B., Rivera, J. O., Khasawneh, F. T., & Alshbool, F. Z
(2020).
The JUUL E-Cigarette Elevates the Risk of Thrombosis and Potentiates Platelet Activation. Journal of Cardiovascular Pharmacology and Therapeutics.
25(6), 578-586.
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Alarabi, A., Karim, Z., Hinojos, V., Lozano, P. A., Hernandez, K., Montes Ramirez, J., Khasawneh, F. T., & Alshbool, F. Z.
(2020).
Abstract 13598: The G-protein BetaGamma Subunits Regulate Platelet Function. Circulation.
142(Suppl_3),
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Srinivasan, S., Mir, F., Huang, J., Khasawneh, F., Lam, S. C., & Le Breton, G. C.
(2020).
Cangrelor (ARC69931MX) produces global inhibition of human platelet function by increasing cAMP levels through a Giindependent mechanism. The FASEB Journal.
23(S1), lb382-lb382.
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Ortiz-Muoz, G., Yu, M. A., Lefranais, E., Mallavia, B., Valet, C., Tian, J. J., ... Looney, M. R.
(2020).
Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. Journal of Clinical Investigation.
130(4), 2041-2053.
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DiVall, M., Abate, M. A., Blake, E. W., Carter, J., Chadha, G. S., Jackowski, R. M., ... Wagner, J. L.
(2020).
Recommendations for integration of foundational and clinical sciences throughout the pharmacy curriculum. Currents in Pharmacy Teaching and Learning.
12(11), 1371-1374.
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Alarabi, A. B., Karim, Z. A., Ramirez, J., Hernandez, K. R., Lozano, P. A., Rivera, J. O., Alshbool, F. Z., & Khasawneh, F. T.
(2020).
Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis. Arteriosclerosis, Thrombosis and Vascular Biology.
40(2), 335-349.
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Alarabi, A. B., Karim, Z. A., Hinojos, V., Lozano, P. A., Hernandez, K. R., Montes Ramirez, J. E., ... Alshbool, F. Z.
(2020).
The G-protein subunits regulate platelet function. LIFE SCIENCES.
262, 118481-118481.
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Paez Espinosa, E. V., Lin, O. A., Karim, Z. A., Alshbool, F. Z., & Khasawneh, F. T.
(2019).
Mouse transient receptor potential channel type 6 selectively regulates agonist-induced platelet function. Biochemistry and Biophysics Reports.
20, 100685-100685.
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Hassanzadah, M., Bitar, A. H., Khanfar, N. M., Khasawneh, F. T., Lutfy, K., & Shankar, G. S.
(2019).
A retrospective cohort study of the prevalence of anxiety and agitation in schizophrenic smokers and the unmet needs of smoking cessation programs. Medicine.
98(40), e17375-e17375.
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Qasim, H., Karim, Z. A., Hernandez, K. R., Lozano, D., Khasawneh, F. T., & Alshbool, F. Z.
(2019).
Arhgef1 Plays a Vital Role in Platelet Function and Thrombogenesis. Journal of the American Heart Association.
8(9), e011712.
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Alshbool, F. Z., Karim, Z. A., & Khasawneh, F. T.
(2019).
Investigation of Novel Inhibitor for the Serotonin 5HT2A Receptor. The FASEB Journal.
33(S1), 670.3-670.3.
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Hernandez, K. R., Karim, Z. A., Qasim, H., Druey, K. M., Alshbool, F. Z., & Khasawneh, F. T.
(2019).
Regulator of G-Protein Signaling 16 Is a Negative Modulator of Platelet Function and Thrombosis. Journal of the American Heart Association.
8(5), e011273.
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Qasim, H., Alarabi, A. B., Alzoubi, K. H., Karim, Z. A., Alshbool, F. Z., & Khasawneh, F. T.
(2019).
The effects of hookah/waterpipe smoking on general health and the cardiovascular system. Environmental Health and Preventive Medicine.
24(1), 58.
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Zhu, Y., Romero, E. L., Ren, X., Sanca, A. J., Du, C., Liu, C., ... Geng, B.
(2018).
Author Correction: Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine. Nature Communications.
9(1), 4278.
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Zhu, Y., Romero, E. L., Ren, X., Sanca, A. J., Du, C., Liu, C., ... Geng, B.
(2018).
Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine. Nature Communications.
9(1), 3952.
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Alshbool, F. Z., Karim, Z. A., Espinosa, E., Lin, O. A., & Khasawneh, F. T.
(2018).
Investigation of a Thromboxane A2 Receptor-Based Vaccine for Managing Thrombogenesis. Journal of the American Heart Association.
7(13), e009139.
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Karim, Z. A., Hensch, N. R., Qasim, H., Alshbool, F. Z., & Khasawneh, F. T.
(2018).
Role of IB kinase in regulating the remodeling of the CARMA1-Bcl10-MALT1 complex. Biochemical and Biophysical Research Communications.
500(2), 268-274.
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Qasim, H., Karim, Z. A., Silva-Espinoza, J. C., Khasawneh, F. T., Rivera, J. O., Ellis, C. C., ... Alshbool, F. Z.
(2018).
Short-Term E-Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice. Journal of the American Heart Association.
7(15), e009264.
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Qasim, H., Karim, Z. A., Rivera, J. O., Khasawneh, F. T., & Alshbool, F. Z.
(2017).
Impact of Electronic Cigarettes on the Cardiovascular System. Journal of the American Heart Association.
6(9), e006353.
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Hensch, N. R., Karim, Z. A., Pineda, J., Mercado, N., Alshbool, F. Z., & Khasawneh, F. T.
(2017).
P2Y12 antibody inhibits platelet activity and protects against thrombogenesis. Biochemical and Biophysical Research Communications.
493(2), 1069-1074.
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Karim, Z. A., Alshbool, F. Z., Vemana, H. P., Conlon, C., Druey, K. M., & Khasawneh, F. T.
(2016).
CXCL12 regulates platelet activation via the regulator of G-protein signaling 16. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
1863(2), 314-321.
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Dhall, S., Karim, Z. A., Khasawneh, F. T., & Martins-Green, M.
(2016).
Platelet Hyperactivity in TNFSF14/LIGHT Knockout Mouse Model of Impaired Healing. Advances in Wound Care.
5(10), 421-431.
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Hensch, N. R., Karim, Z. A., Druey, K. M., Tansey, M. G., & Khasawneh, F. T.
(2016).
RGS10 Negatively Regulates Platelet Activation and Thrombogenesis. PLoS One.
11(11), e0165984-e0165984.
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Vemana, H. P., Karim, Z., Conlon, C., & Khasawneh, F.
(2015).
A New Player in Platelet Function. The FASEB Journal.
29(S1),
-
Vemana, H. P., Karim, Z. A., Conlon, C., & Khasawneh, F. T.
(2015).
A critical role for the transient receptor potential channel type 6 in human platelet activation. PLoS One.
10(4), e0125764-e0125764.
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Dhall, S., Wijesinghe, D. S., Karim, Z. A., Castro, A., Vemana, H. P., Khasawneh, F. T., Chalfant, C. E., & Martins-Green, M.
(2015).
Arachidonic acid-derived signaling lipids and functions in impaired healing. WOUND REPAIR AND REGENERATION.
23(5), 644-656.
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Karim, Z. A., Vemana, H. P., Alshbool, F. Z., Lin, O. A., Alshehri, A. M., Javaherizadeh, P., Paez Espinosa, E. V., & Khasawneh, F. T.
(2015).
Characterization of a novel function-blocking antibody targeted against the platelet P2Y1 receptor. Arteriosclerosis, Thrombosis and Vascular Biology.
35(3), 637-644.
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Karim, Z. A., Vemana, H. P., & Khasawneh, F. T.
(2015).
MALT1-ubiquitination triggers non-genomic NF-B/IKK signaling upon platelet activation. PLoS One.
10(3), e0119363-e0119363.
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Alshbool, F. Z., Karim, Z. A., Vemana, H. P., Conlon, C., Lin, O. A., & Khasawneh, F. T.
(2015).
The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis. Biochemical and Biophysical Research Communications.
462(4), 378-382.
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Karim, Z. A., Alshbool, F. Z., Vemana, H. P., Adhami, N., Dhall, S., Espinosa, E., Martins-Green, M., & Khasawneh, F. T.
(2015).
Third-hand Smoke: Impact on Hemostasis and Thrombogenesis. Journal of Cardiovascular Pharmacology.
66(2), 177-182.
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Khasawneh, F. T., & Shankar, G. S.
(2014).
Minimizing cardiovascular adverse effects of atypical antipsychotic drugs in patients with schizophrenia. Cardiology Research and Practice.
2014, 273060-8.
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Lin, O. A., Karim, Z. A., Vemana, H. P., Espinosa, E., & Khasawneh, F. T.
(2014).
The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One.
9(1), e87026-e87026.
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Khasawneh, F. T., Espinosa, E. V., Lin, O. A., & Murad, J. P.
(2013).
Abstract 39: The Transient Receptor-Potential Channel 6 Regulates Thromboxane A2 Receptor-Operated Calcium Entry and Plays a Critical Role in Platelet Function. Arteriosclerosis, Thrombosis and Vascular Biology.
33(suppl_1),
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Murad, J. P., Lin, O. A., Espinosa, E., & Khasawneh, F. T.
(2013).
Current and experimental antibody-based therapeutics: insights, breakthroughs, setbacks and future directions. Current Molecular Medicine.
13(1), 165-178.
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Lin, O., Espinosa, E., & Khasawneh, F. T.
(2013).
The 5HT2A Receptor Antagonists Pizotifen and Cyproheptadine Inhibit Serotoninenhanced Platelet Function. The FASEB Journal.
27(S1), 1096.17-1096.17.
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Murad, J. P., Espinosa, E., Ting, H. J., & Khasawneh, F. T.
(2012).
Characterization of the in vivo antiplatelet activity of the antihypertensive agent losartan. Journal of Cardiovascular Pharmacology and Therapeutics.
17(3), 308-314.
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Ting, H. J., Murad, J. P., Espinosa, E., & Khasawneh, F. T.
(2012).
Thromboxane A2 receptor: biology and function of a peculiar receptor that remains resistant for therapeutic targeting. Journal of Cardiovascular Pharmacology and Therapeutics.
17(3), 248-259.
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Espinosa, E., Murad, J. P., Ting, H. J., & Khasawneh, F. T.
(2012).
Transient Receptor Potential Channel 6: Role in Hemostasis and Thrombogenesis. The FASEB Journal.
26(S1), 1116.2-1116.2.
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Murad, J. P., Espinosa, E., Ting, H. J., McClure, D., & Khasawneh, F. T.
(2012).
A Novel Antithrombotic Agent Targeting the Human Thromboxane A2 Receptor. The FASEB Journal.
26(S1), 1116.1-1116.1.
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Murad, J. P., Espinosa, E., Ting, H. J., McClure, D., & Khasawneh, F. T.
(2012).
A novel antibody targeting the ligand binding domain of the thromboxane A receptor exhibits antithrombotic properties in vivo. Biochemical and Biophysical Research Communications.
421(3), 456-461.
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Paez Espinosa, E. V., Murad, J. P., & Khasawneh, F. T.
(2012).
Aspirin: pharmacology and clinical applications. Thrombosis.
2012, 173124-15.
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Paez Espinosa, E. V., Murad, J. P., Ting, H. J., & Khasawneh, F. T.
(2012).
Mouse transient receptor potential channel 6: role in hemostasis and thrombogenesis. Biochemical and Biophysical Research Communications.
417(2), 853-856.
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Murad, J. P., Espinosa, E., Ting, H. J., & Khasawneh, F. T.
(2012).
The C-terminal segment of the second extracellular loop of the thromboxane A2 receptor plays an important role in platelet aggregation. Biochemical Pharmacology.
83(1), 88-96.
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Murad, J. P., Ting, H. J., & Khasawneh, F. T.
(2011).
A Novel Mechanism for Calcium Entry Into Blood Platelets. The FASEB Journal.
25(S1), lb356-lb356.
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Murad, J. P., Ting, H. J., & Khasawneh, F. T.
(2011).
The Second Extracellular Loop of the Thromboxane Receptor Plays an Important Role in Platelet Activation. The FASEB Journal.
25(S1), 1089.6-1089.6.
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Zargarzadeh, A. H., Jacob, S., Klotz, R. S., & Khasawneh, F. T.
(2011).
Clinical pharmacists and basic scientists: do patients and physicians need this collaboration?. 33(6), 886-894.
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Guerra, C., Morris, D., Sipin, A., Kung, S., Franklin, M., Gray, D., ... Venketaraman, V.
(2011).
Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals. PLoS One.
6(12), e28378-e28378.
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Gussin, H. A., Khasawneh, F. T., Xie, A. n., Feng, F., Memic, A., Qian, H., Le Breton, G. C., & Pepperberg, D. R.
(2011).
Subunit-specific polyclonal antibody targeting human 1 GABA(C) receptor. Experimental Eye Research.
93(1), 59-64.
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Murad, J. P., Ting, H. J., & Khasawneh, F. T.
(2010).
The Transient Receptor-Potential Channel 6 Plays a Critical Role In Platelet Function. Blood.
116(21), 3201-3201.
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Ting, H. J., & Khasawneh, F.
(2010).
Drug Rediscovery: Glybenclamide Exhibits Thromboxane Receptor Dependent Antithrombotic Activity. The FASEB Journal.
24(S1), 574.1-574.1.
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Khasawneh, F. T., & Ting, H. J.
(2010).
A Novel Antagonist for the Thromboxane A2 Receptor. The FASEB Journal.
24(S1), 574.5-574.5.
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Ting, H. J., & Khasawneh, F. T.
(2010).
Glybenclamide: an antidiabetic with in vivo antithrombotic activity. European Journal of Pharmacology.
649(1-3), 249-254.
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Ting, H. J., & Khasawneh, F. T.
(2010).
Platelet function and Isoprostane biology. Should isoprostanes be the newest member of the orphan-ligand family?. Journal of Biomedical Science.
17(1), 24-24.
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Ting, H. J., Murray, W. J., & Khasawneh, F. T.
(2010).
Repurposing an old drug for a new use: glybenclamide exerts antiplatelet activity by interacting with the thromboxane A(2) receptor. Acta Pharmacologica Sinica.
31(2), 150-159.
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Ting, H. J., & Khasawneh, F. T.
(2009).
Glybenclamide Exhibits Thromboxane ReceptorDependent Antiplatelet Effects. The FASEB Journal.
23(S1), lb385-lb385.
-
Ting, H. J., Shankar, G., & Khasawneh, F. T.
(2009).
Investigation of the Anti-Platelet Activity of a Novel Function-Blocking Antibody Targeting the Human Thromboxane A2 Receptor Protein. Blood.
114(22), 4019-4019.
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Srinivasan, S., Mir, F., Huang, J., Khasawneh, F. T., Lam, S., & Le Breton, G. C.
(2009).
The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels. Journal of Biological Chemistry.
284(24), 16108-16117.
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Khasawneh, F. T., Huang, J., Mir, F., Srinivasan, S., Tiruppathi, C., & Le Breton, G. C.
(2008).
Characterization of isoprostane signaling: evidence for a unique coordination profile of 8-iso-PGF(2alpha) with the thromboxane A(2) receptor, and activation of a separate cAMP-dependent inhibitory pathway in human platelets. Biochemical Pharmacology.
75(12), 2301-2315.
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Khasawneh, F. T., Huang, J., Tiruppathi, C., & Le Breton, G. C.
(2007).
Molecular characterization of the 8isoPGF2 interaction with the thromboxane A2 receptor and its signaling mechanisms in human platelets. The FASEB Journal.
21(5), a427-aa28.
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Khasawneh, F. T., Huang, J., Turek, J. W., & Le Breton, G. C.
(2006).
Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein. Journal of Biological Chemistry.
281(37), 26951-26965.
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Khasawneh, F. T., Huang, J., Turek, J. W., & Le Breton, G. C.
(2005).
Differential Mapping of the Amino Acids Mediating Agonist and Antagonist Coordination with the Human Thromboxane A2 Receptor Protein. Blood.
106(11), 3571-3571.
-
Ting, H. J., Murray, W. J., & Khasawneh, F. T.
Drug Rediscovery: Glybenclamide Exhibits Thromboxane Receptor-Dependent Antithrombotic Activity. Blood.
114(22), 2994-2994.
-
Alarabi, A. B., Mohsen, A., Taleb, Z. B., Mizuguchi, K., Alshbool, F. Z., & Khasawneh, F. T.
(2023).
Predicting thrombotic cardiovascular outcomes induced by waterpipe-associated chemicals using comparative toxicogenomic database: Genes, phenotypes, and pathways. LIFE SCIENCES.
323, 121694-121694.
-
chapter
-
Venketaraman, V., Morris, D., Donohou, C., Sipin, A., Kung, S., Oh, H., ... Donahue, C.
(2011).
Role of Cytokines and Chemokines in HIV Infection. HIV and AIDS - Updates on Biology, Immunology, Epidemiology and Treatment Strategies.
IntechOpen.
-
Venketaraman, V., Morris, D., Donohou, C., Sipin, A., Kung, S., Oh, H., ... Donahue, C.
(2011).
Role of Cytokines and Chemokines in HIV Infection. HIV and AIDS - Updates on Biology, Immunology, Epidemiology and Treatment Strategies.
IntechOpen.
-
institutional repository document
-
Alarabi, A. B., Mohsen, A., Mizuguchi, K., Alshbool, F. Z., & Khasawneh, F. T.
(2021).
Co-expression analysis to identify key modules and hub genes associated with COVID19 in Platelets
-
Alarabi, A. B., Mohsen, A., Mizuguchi, K., Alshbool, F. Z., & Khasawneh, F. T.
(2021).
Co-expression Analysis to Identify Key Modules and Hub Genes Associated With COVID19 in Platelets
-
Alarabi, A. B., Mohsen, A., Mizuguchi, K., Alshbool, F. Z., & Khasawneh, F. T.
(2021).
Co-expression analysis to identify key modules and hub genes associated with COVID19 in Platelets
-
patent
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Breton, G. L., Huang, J., Srinivasan, S., & Khasawneh, F.
(2013).
Peptides and methods for inhibiting Galpha protein signaling
-
Breton, G. L., Huang, J., Srinivasan, S., & Khasawneh, F.
(2013).
Peptides and methods for inhibiting Galpha protein signaling
Research
principal investigator on
Teaching
teaching activities
- PHAR610 Principles Drug Action I Instructor
- PHSC685 Directed Studies Instructor
- PHSC689 Sptp: Adv. Pharmacology Instructor
- PHSC691 Research Instructor
Background
education and training
- Ph.D. in Pharmacology, University of Illinois at Chicago - (Chicago, Illinois, United States) 2007
- B.S. in Pharmacy, Jordan University of Science and Technology - (Irbid, Irbid, Jordan) 1999
Contact
first name
- Fadi
has last name
- Khasawneh
Other
- fkhasawneh@tamu.edu