Third-hand Smoke: Impact on Hemostasis and Thrombogenesis. Academic Article uri icon


  • Cigarette smoking is a major risk factor for acute coronary thrombosis. In fact, both active/first-hand smoke and passive/second-hand smoke exposure are known to increase the risk of coronary thrombosis. Although recently a new risk has been identified and termed third-hand smoke (THS), which is the residual tobacco smoke contaminant that remains after a cigarette is extinguished, it remains to be determined whether it can also enhance the risk of thrombogenesis, much like first-hand smoke and second-hand smoke. Therefore, the present studies investigated the impact of THS exposure in the context of platelet biology and related disease states. It was found that THS-exposed mice exhibited an enhanced platelet aggregation and secretion responses as well as enhanced integrin GPIIb-IIIa activation. Furthermore, it was found that THS exposure shortens the tail bleeding time and the occlusion time in a model of thrombosis. Thus, our data demonstrate for the first time (at least in mice) that THS exposure increases the risk of thrombosis-based disease states, which is attributed, at least in part, to their hyperactive platelets.

published proceedings

  • J Cardiovasc Pharmacol

altmetric score

  • 18

author list (cited authors)

  • Karim, Z. A., Alshbool, F. Z., Vemana, H. P., Adhami, N., Dhall, S., Espinosa, E., Martins-Green, M., & Khasawneh, F. T.

citation count

  • 32

complete list of authors

  • Karim, Zubair A||Alshbool, Fatima Z||Vemana, Hari Priya||Adhami, Neema||Dhall, Sandeep||Espinosa, Enma VP||Martins-Green, Manuela||Khasawneh, Fadi T

publication date

  • January 2015