Platelet function and Isoprostane biology. Should isoprostanes be the newest member of the orphan-ligand family? Academic Article

abstract

• While there have been many reports investigating the biological activity and signaling mechanisms of isoprostanes, their role in biology, particularly in platelets, appears to still be underestimated. Moreover, whether these lipids have their own receptors is still debated, despite multiple reports that discrete receptors for isoprostane do exist on platelets, vascular tissues, amongst others. This paper provides a review of the important literature of isoprostanes and provides reasoning that isoprostanes should be classified as orphan ligands until their receptor(s) is/are identified.

authors

• Khasawneh, Fadi

published proceedings

• J Biomed Sci

author list (cited authors)

• Ting, H. J., & Khasawneh, F. T.

citation count

• 44

complete list of authors

• Ting, Harold J||Khasawneh, Fadi T

publication date

• January 2010

publisher

• Springer Nature  Publisher

published in

• Journal of Biomedical Science  Journal

keywords

• Arachidonic Acid
• Blood Platelets
• Hemostasis
• Humans
• Isoprostanes
• Models, Molecular
• Molecular Structure
• Platelet Activation
• Signal Transduction

PubMed Central ID

• 20370921

Digital Object Identifier (DOI)

• 10.1186/1423-0127-17-24

start page

• 24

end page

• 24

volume

• 17

issue

• 1

URL

• http://dx.doi.org/10.1186/1423-0127-17-24