HR job title
- Professor
- Contact Info
- 7136777520
Wang, Fen Professor
Positions
The laboratory focuses on understanding the molecular basis of cell signaling, and how aberrant cell signaling leads to birth defects and causes cancers. Using in vitro cell culture systems and in vivo mouse models, we study how the fibroblast growth factor (FGF) activates its receptor (FF) tyrosine kinase, and how the activated FF transmits the signals to downstream targets and regulates proliferation, differentiation, homeostasis, and function of the cells, as well as in organogenesis and development, including prostate and cardiovascular system development. The laboratory also employs molecular biology, cell biology, and mouse genetic technologies to study how aberrant FGF signals promote tumor initiation, progression, and metastasis. In addition, how environmental factors contribute to tumorigenesis and congenital birth defects by modulating FGF signal intensity and specificity is also under the scope of our research interests.
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Overview
Publications
selected publications
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academic article
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Liu, S., Lai, J., Feng, Y., Zhuo, Y., Zhang, H., Chen, Y., ... Zhong, W.
(2023).
Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial -oxidation in castration-resistant prostate cancer cells. Journal of Biological Chemistry.
299(1), 102720-102720.
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Hu, Q., Wang, C., Liu, F., He, J., Wang, F., Wang, W., & You, P.
(2019).
High serum levels of FGF21 are decreased in bipolar mania patients during psychotropic medication treatment and are associated with increased metabolism disturbance. Psychiatry Research.
272, 643-648.
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Ji, S., Liu, Q., Zhang, S., Chen, Q., Wang, C., Zhang, W., ... Zhou, D.
(2019).
FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis. Developmental Cell.
48(4), 460-474.e9.
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Riaz, S. K., Ke, Y., Wang, F., Kayani, M. A., & Malik, M.
(2019).
Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells. Scientific Reports.
9(1), 6620.
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Wang, C., Liu, Z., Ke, Y., & Wang, F.
(2019).
Intrinsic FGFR2 and Ectopic FGFR1 Signaling in the Prostate and Prostate Cancer. Frontiers in Genetics.
10(JAN), 12.
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Li, H., Mao, Y., Bouaziz, M., Yu, H., Qu, X., Wang, F., ... Zhang, X.
(2019).
Lens differentiation is controlled by the balance between PDGF and FGF signaling. PLOS Biology.
17(2), e3000133-e3000133.
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Wang, C., Ke, Y., Liu, S., Pan, S., Liu, Z., Zhang, H., ... Wang, F.
(2018).
Ectopic fibroblast growth factor receptor 1 promotes inflammation by promoting nuclear factor-B signaling in prostate cancer cells. 293(38), 14839-14849.
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Liu, J., Chen, G., Liu, Z., Liu, S., Cai, Z., You, P., ... Wang, F.
(2018).
Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer. Cancer Research.
78(16), 4459-4470.
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Li, Q., Alsaidan, O. A., Ma, Y., Kim, S., Liu, J., Albers, T., ... Cai, H.
(2018).
Pharmacologically targeting the myristoylation of the scaffold protein FRS2 inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression. 293(17), 6434-6448.
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Collins, T. N., Mao, Y., Li, H., Bouaziz, M., Hong, A., Feng, G., ... Zhang, X.
(2018).
Crk proteins transduce FGF signaling to promote lens fiber cell elongation. eLife.
7, e32586.
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Xu, S., Zhou, Z., Li, H., Liu, Z., Pan, X., Wang, F., ... Li, D.
(2018).
BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis. Journal of Cell Science.
131(3), jcs211151.
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Garg, A., Bansal, M., Gotoh, N., Feng, G., Zhong, J., Wang, F., ... Zhang, X.
(2017).
Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis. PLOS Genetics.
13(10), e1007047-e1007047.
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Nandi, S., Gutin, G., Blackwood, C. A., Kamatkar, N. G., Lee, K. W., Fishell, G., ... Hbert, J. M.
(2017).
FGF-Dependent, Context-Driven Role for FRS Adapters in the Early Telencephalon. Journal of Neuroscience.
37(23), 5690-5698.
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Lin, H., Fang, Z., Su, Y., Li, P., Wang, J., Liao, H., ... Zhang, Z.
(2017).
DHX32 Promotes Angiogenesis in Colorectal Cancer Through Augmenting β-catenin Signaling to Induce Expression of VEGFA. EBioMedicine.
18, 62-72.
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Fang, Y., Lin, H., Wang, J., Su, X., Wang, F., You, P., Niu, J., & Zhang, Z.
(2017).
Association between H63D polymorphism and alcoholic liver disease risk: a meta-analysis. International Journal of Clinical and Experimental Medicine.
10(1), 69-78.
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Mathew, G., Hannan, A., Hertzler-Schaefer, K., Wang, F., Feng, G., Zhong, J., ... Zhang, X.
(2016).
Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor. Proceedings of the National Academy of Sciences of the United States of America.
113(46), 13156-13161.
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Xiao, L., Feng, Q., Zhang, Z., Wang, F., Lydon, J. P., Ittmann, M. M., ... He, B.
(2016).
The essential role of GATA transcription factors in adult murine prostate. Oncotarget.
7(30), 47891-47903.
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Li, W., Zou, J., Yue, F., Song, K., Chen, Q. i., McKeehan, W. L., ... Liu, L.
(2016).
Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed. Aging Cell.
15(2), 370-379.
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Shi, M., Zhang, Y., Liu, L., Zhang, T., Han, F., Cleveland, J., ... Zhang, D.
(2016).
MAP1S Protein Regulates the Phagocytosis of Bacteria and Toll-like Receptor (TLR) Signaling. 291(3), 1243-1250.
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Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Arozena, A. A., ... Bagniewska-Zadworna, A.
(2016).
Erratum. Autophagy.
12(2), 443-443.
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Li, X., Wang, C., Xiao, J., McKeehan, W. L., & Wang, F.
(2016).
Fibroblast growth factors, old kids on the new block. Seminars in Cell and Developmental Biology.
53, 155-167.
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Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., ... Zughaier, S. M.
(2016).
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy.
12(1), 1-222.
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Liu, J., You, P., Chen, G., Fu, X., Zeng, X., Wang, C., ... Wang, F.
(2016).
Hyperactivated FRS2-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients. Oncogene.
35(14), 1750-1759.
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Atala, A.
(2016).
Re: Autophagy Defects Suggested by Low Levels of Autophagy Activator MAP1S and High Levels of Autophagy Inhibitor LRPPRC Predict Poor Prognosis of Prostate Cancer Patients. Investigative urology.
195(6), 1948-1949.
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Lin, L., Fang, Z., Lin, H., You, H., Wang, J., Su, Y., Wang, F., & Zhang, Z.
(2016).
Depletion of Cks1 and Cks2 expression compromises cell proliferation and enhance chemotherapy-induced apoptosis in HepG2 cells. Oncology Reports.
35(1), 26-32.
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Jiang, X., Zhong, W., Huang, H., He, H., Jiang, F., Chen, Y., ... Liu, L.
(2015).
Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patients. Molecular Carcinogenesis.
54(10), 1194-1204.
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Yue, F., Li, W., Zou, J., Chen, Q. i., Xu, G., Huang, H., ... Liu, L.
(2015).
Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin. Aging.
7(10), 839-853.
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Huang, Y., Hamana, T., Liu, J., Wang, C., An, L., You, P., ... Wang, F.
(2015).
Prostate Sphere-forming Stem Cells Are Derived from the P63-expressing Basal Compartment. 290(29), 17745-17752.
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Huang, Y., Hamana, T., Liu, J., Wang, C., An, L., You, P., ... Wang, F.
(2015).
Type 2 Fibroblast Growth Factor Receptor Signaling Preserves Stemness and Prevents Differentiation of Prostate Stem Cells from the Basal Compartment. 290(29), 17753-17761.
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Ye, W., Wang, J., Song, Y., Yu, D., Sun, C., Liu, C., ... Chen, Y.
(2015).
A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node. Development.
142(14), 2521-2532.
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Phillips, T. D., Richardson, M., Cheng, Y., He, L., McDonald, T. J., Cizmas, L. H., ... Zhou, G.
(2015).
Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Archives of Toxicology.
89(6), 967-977.
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Huang, Y., Jin, C., Hamana, T., Liu, J., Wang, C., An, L., McKeehan, W. L., & Wang, F.
(2015).
Overexpression of FGF9 in prostate epithelial cells augments reactive stroma formation and promotes prostate cancer progression. International Journal of Biological Sciences.
11(8), 948-960.
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Wan, X., Corn, P. G., Yang, J., Palanisamy, N., Starbuck, M. W., Efstathiou, E., ... Navone, N. M.
(2015).
Erratum: Erratum: Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases (Science Translational Medicine (2015) 7 (287er3)). Science Translational Medicine.
7(287),
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Xu, C., Li, W., Qiu, P., Xia, Y., Du, X., Wang, F., ... Li, X.
(2015).
The therapeutic potential of a novel non-ATP-competitive fibroblast growth factor receptor 1 inhibitor on gastric cancer. 26(4), 379-387.
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Lin, H., Liu, W., Fang, Z., Liang, X., Li, J., Bai, Y., ... Zhang, Z.
(2015).
Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer. Scientific Reports.
5(1), 9247.
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Fang, Z., Tang, J., Bai, Y., Lin, H., You, H., Jin, H., ... Zhang, Z.
(2015).
Plasma levels of microRNA-24, microRNA-320a, and microRNA-423-5p are potential biomarkers for colorectal carcinoma. 34(1), 86.
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Ho, T. H., Liu, X., Huang, Y., Warneke, C. L., Johnson, M. M., Hoang, A., ... Jonasch, E.
(2015).
The impact of FGFR1 and FRS2 expression on sorafenib treatment in metastatic renal cell carcinoma. BMC Cancer.
15(1), 304.
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Tien, J., Liao, L., Liu, Y., Liu, Z., Lee, D., Wang, F., & Xu, J.
(2014).
The steroid receptor coactivator-3 is required for developing neuroendocrine tumor in the mouse prostate. International Journal of Biological Sciences.
10(10), 1116-1127.
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Wan, X., Corn, P. G., Yang, J., Palanisamy, N., Starbuck, M. W., Efstathiou, E., ... Navone, N. M.
(2014).
Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases. Science Translational Medicine.
6(252), 252ra122.
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Lee, D., Liu, Y., Liao, L., Wang, F., & Xu, J.
(2014).
The prostate basal cell (BC) heterogeneity and the p63-positive BC differentiation spectrum in mice. International Journal of Biological Sciences.
10(9), 1007-1017.
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Wang, C., Yang, C., Chang, J. Y., You, P., Li, Y., Jin, C., ... Wang, F.
(2014).
Hepatocyte FRS2 is essential for the endocrine fibroblast growth factor to limit the amplitude of bile acid production induced by prandial activity. Current Molecular Medicine.
14(6), 703-711.
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Lin, Z., Huang, Y., Zhang, Y., Han, Z., He, H., Ling, X., ... Wu, C.
(2014).
MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1. International Journal of Cancer.
135(3), 541-550.
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Jiang, X., Li, X., Huang, H., Jiang, F., Lin, Z., He, H., ... Liu, L.
(2014).
Elevated levels of mitochondrion-associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer. 120(8), 1228-1236.
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Li, H., Tao, C., Cai, Z., Hertzler-Schaefer, K., Collins, T. N., Wang, F., ... Zhang, X.
(2014).
Frs2 and Shp2 signal independently of Gab to mediate FGF signaling in lens development. Journal of Cell Science.
127(Pt 3), 571-582.
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Zhao, S., Zhang, Y., Zhang, Q., Wang, F., & Zhang, D.
(2014).
Toll-like receptors and prostate cancer. Frontiers in Immunology.
5(JUL), 352.
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Yang, Z., Hai, B. o., Qin, L., Ti, X., Shangguan, L., Zhao, Y., ... Liu, F.
(2013).
Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a -catenin-dependent manner. Molecular and Cellular Biology.
33(23), 4732-4744.
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Corn, P. G., Wang, F., McKeehan, W. L., & Navone, N.
(2013).
Targeting fibroblast growth factor pathways in prostate cancer. CLINICAL CANCER RESEARCH.
19(21), 5856-5866.
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Chang, J., Wang, C., Liu, J., Huang, Y., Jin, C., Yang, C., ... Wang, F.
(2013).
Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells. Journal of Biological Chemistry.
288(40), 28952-28961.
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Wang, C., Chang, J., Yang, C., Huang, Y., Liu, J., You, P., ... Li, X.
(2013).
Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis. 288(30), 22174-22183.
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Cai, Z., Tao, C., Li, H., Ladher, R., Gotoh, N., Feng, G., Wang, F., & Zhang, X.
(2013).
Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development.
140(13), 2711-2723.
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Tien, J., Liu, Z., Liao, L., Wang, F., Xu, Y., Wu, Y., ... Xu, J.
(2013).
The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer. 73(13), 3997-4008.
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Yang, F., Zhang, Y., Ressler, S. J., Ittmann, M. M., Ayala, G. E., Dang, T. D., Wang, F., & Rowley, D. R.
(2013).
FGFR1 is essential for prostate cancer progression and metastasis. Cancer Research.
73(12), 3716-3724.
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Yang, C., Lu, W., Lin, T., You, P., Ye, M., Huang, Y., ... Luo, Y.
(2013).
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. 13(1), 67.
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Zhang, T., Liu, J., Zhang, J., Thekkethottiyil, E. B., Macatee, T. L., Ismat, F. A., Wang, F., & Stoller, J. Z.
(2013).
Jun is required in Isl1-expressing progenitor cells for cardiovascular development. PLoS ONE.
8(2), e57032-e57032.
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Guan, J., Simon, A. K., Prescott, M., Menendez, J. A., Liu, F., Wang, F., ... Zhang, J.
(2013).
Autophagy in stem cells. Autophagy.
9(6), 830-849.
-
Wang, J., Fang, Z., Ye, H., You, P., Cai, M., Duan, H., Wang, F., & Zhang, Z.
(2013).
Clinical significance of overexpressed cyclin‐dependent kinase subunits 1 and 2 in esophageal carcinoma. Diseases of the Esophagus.
26(7), 729-736.
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Gay, D., Kwon, O., Zhang, Z., Spata, M., Plikus, M. V., Holler, P. D., ... Cotsarelis, G.
(2013).
Fgf9 from dermal T cells induces hair follicle neogenesis after wounding. Nature Medicine.
19(7), 916-923.
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Chang, J., Wang, C., Jin, C., Yang, C., Huang, Y., Liu, J., ... Wang, F.
(2013).
Self-renewal and multilineage differentiation of mouse dental epithelial stem cells. Stem Cell Research.
11(3), 990-1002.
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Shi, Z., Cai, Z., Yu, J., Zhang, T., Zhao, S., Smeds, E., ... Zhang, D.
(2012).
Toll-like receptor 11 (TLR11) prevents Salmonella penetration into the murine Peyer patches. Journal of Biological Chemistry.
287(52), 43417-43423.
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Madakashira, B. P., Kobrinski, D. A., Hancher, A. D., Arneman, E. C., Wagner, B. D., Wang, F., ... Robinson, M. L.
(2012).
Frs2 enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development.
139(24), 4601-4612.
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Foltz, I. N., Hu, S., King, C., Wu, X., Yang, C., Wang, W., ... Li, Y.
(2012).
Treating diabetes and obesity with an FGF21-mimetic antibody activating the Klotho/FGFR1c receptor complex. Science Translational Medicine.
4(162), 162ra153.
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Zhou, J., Qin, L. i., Tien, J., Gao, L. i., Chen, X., Wang, F., Hsieh, J., & Xu, J.
(2012).
Nkx3.1 functions as para-transcription factor to regulate gene expression and cell proliferation in non-cell autonomous manner. 287(21), 17248-17256.
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Yang, X., Li, Q. i., Lin, X. i., Ma, Y., Yue, X., Tao, Z., ... Chang, J.
(2012).
Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1. The FASEB Journal.
26(5), 2105-2116.
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Yang, C., Jin, C., Li, X., Wang, F., McKeehan, W. L., & Luo, Y.
(2012).
Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PLoS ONE.
7(3), e33870-e33870.
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Zhang, J., Liu, J., Huang, Y., Chang, J., Liu, L., McKeehan, W. L., Martin, J. F., & Wang, F.
(2012).
FRS2-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. 110(4), e29-e39.
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Yang, C., Wang, C., Ye, M., Jin, C., He, W., Wang, F., McKeehan, W. L., & Luo, Y.
(2012).
Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress. Nutrition and Metabolism.
9(1), 94.
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Chen, P., Qin, L., Barnes, C., Charisse, K., Yi, T., Zhang, X., ... Simons, M.
(2012).
FGF regulates TGF- signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Reports.
2(6), 1684-1696.
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Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., ... Zuckerbraun, B.
(2012).
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy.
8(4), 445-544.
-
Liu, L., McKeehan, W. L., Wang, F., & Xie, R.
(2012).
MAP1S enhances autophagy to suppress tumorigenesis. Autophagy.
8(2), 278-280.
-
Zhang, J., Liu, J., Liu, L., McKeehan, W. L., & Wang, F.
(2012).
The fibroblast growth factor signaling axis controls cardiac stem cell differentiation through regulating autophagy. Autophagy.
8(4), 690-691.
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Xie, R., Wang, F., McKeehan, W. L., & Liu, L.
(2011).
Autophagy enhanced by microtubule- and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis. Cancer Research.
71(24), 7537-7546.
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Zhou, G., Zhu, H., Phillips, T. D., Wang, J., Wang, S., Wang, F., ... Moorthy, B.
(2011).
Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. PLoS ONE.
6(10), e26589-e26589.
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Kobayashi, M., Huang, Y., Jin, C., Luo, Y., Okamoto, T., Wang, F., & McKeehan, W. L.
(2011).
FGFR1 abrogates inhibitory effect of androgen receptor concurrent with induction of androgen-receptor variants in androgen receptor-negative prostate tumor epithelial cells. The Prostate.
71(15), 1691-1700.
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Yin, Y., Wang, F., & Ornitz, D. M.
(2011).
Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development. Development.
138(15), 3169-3177.
-
Valiyeva, F., Jiang, F., Elmaadawi, A., Moussa, M., Yee, S., Raptis, L., ... Xuan, J. W.
(2011).
Characterization of the oncogenic activity of the novel TRIM59 gene in mouse cancer models. MOLECULAR CANCER THERAPEUTICS.
10(7), 1229-1240.
-
Sims-Lucas, S., Cusack, B., Eswarakumar, V. P., Zhang, J., Wang, F., & Bates, C. M.
(2011).
Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium. Development.
138(7), 1275-1280.
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Xie, R., Nguyen, S., McKeehan, K., Wang, F., McKeehan, W. L., & Liu, L.
(2011).
Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation. 286(12), 10367-10377.
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Jin, C., Yang, C., Wu, X., Wang, F., & McKeehan, W. L.
(2011).
FGFR3-expressing smooth muscle-like stromal cells differentiate in response to FGFR2IIIb-expressing prostate tumor cells and delay tumor progression. In Vitro Cellular and Developmental Biology - Animal.
47(7), 500-505.
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Lin, X., Zhang, Y., Liu, L., McKeehan, W. L., Shen, Y., Song, S., & Wang, F.
(2011).
FRS2 is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts. 7(8), 1114-1121.
-
Wang, F.
(2011).
Modeling human prostate cancer in genetically engineered mice. Progress in Molecular Biology and Translational Science.
100, 1-49.
-
Zhang, J., Chang, J., Huang, Y., Lin, X., Luo, Y., Schwartz, R. J., Martin, J. F., & Wang, F.
(2010).
The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation. 107(10), 1209-1219.
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Luo, Y., Yang, C., Lu, W., Xie, R., Jin, C., Huang, P., Wang, F., & McKeehan, W. L.
(2010).
Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation. 285(39), 30069-30078.
-
Gao, S., Wu, H., Wang, F., & Wang, Z.
(2010).
Altered differentiation and proliferation of prostate epithelium in mice lacking the androgen receptor cofactor p44/WDR77. ENDOCRINOLOGY.
151(8), 3941-3953.
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Zhang, L. i., Zhang, B., Valdez, J. M., Wang, F., Ittmann, M., & Xin, L. i.
(2010).
Dicer ablation impairs prostate stem cell activity and causes prostate atrophy. Stem Cells.
28(7), 1260-1269.
-
Lin, Y., & Wang, F.
(2010).
FGF signalling in prostate development, tissue homoeostasis and tumorigenesis. Bioscience Reports: molecular and cellular biology of the cell surface.
30(5), 285-291.
-
Haling, J. R., Wang, F., & Ginsberg, M. H.
(2010).
Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha. Molecular Biology of the Cell.
21(4), 664-673.
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Wang, J., Greene, S. B., Bonilla-Claudio, M., Tao, Y. e., Zhang, J., Bai, Y., ... Martin, J. F.
(2010).
Bmp Signaling Regulates Myocardial Differentiation from Cardiac Progenitors Through a MicroRNA-Mediated Mechanism. Developmental Cell.
19(6), 903-912.
-
Zhou, G., Richardson, M., Fazili, I. S., Wang, J., Donnelly, K. C., Wang, F., Amendt, B., & Moorthy, B.
(2010).
Role of retinoic acid in the modulation of benzo(a)pyrene-DNA adducts in human hepatoma cells: Implications for cancer prevention. TOXICOLOGY AND APPLIED PHARMACOLOGY.
249(3), 224-230.
-
Shen, D., Fang, Z., You, P., Liu, P., Wang, F., Huang, C., ... Zhang, Z.
(2010).
Clinical significance and expression of cyclin kinase subunits 1 and 2 in hepatocellular carcinoma. Liver International.
30(1), 119-125.
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Cai, Z., Shi, Z., Sanchez, A., Zhang, T., Liu, M., Yang, J., Wang, F., & Zhang, D.
(2009).
Transcriptional regulation of Tlr11 gene expression in epithelial cells. Journal of Biological Chemistry.
284(48), 33088-33096.
-
Xuan, J. W., Bygrave, M., Valiyeva, F., Moussa, M., Izawa, J. I., Bauman, G. S., ... Fenster, A.
(2009).
Molecular targeted enhanced ultrasound imaging of flk1 reveals diagnosis and prognosis potential in a genetically engineered mouse prostate cancer model. Molecular Imaging.
8(4), 209-220.
-
Huang, X., Yang, C., Jin, C., Luo, Y., Wang, F., & McKeehan, W. L.
(2009).
Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis. Molecular Carcinogenesis.
48(6), 553-562.
-
Wang, F., Li, K. Y., Deng, Y., Xu, F., Luo, H. C., Chen, Y. C., & Hong, K.
(2009).
Contrast-enhanced ultrasound in the diagnosis of small hepatic lesions. Chinese Journal of Interventional Imaging and Therapy.
6(3), 199-202.
-
Deng, Y., Li, K. Y., Xu, F., Wang, F., Hu, L. J., Luo, H. C., & Chen, Y. C.
(2009).
Association of histopathologic grading and contrast-enhanced ultrasound in hepatocellular carcinoma. Chinese Journal of Interventional Imaging and Therapy.
6(2), 120-123.
-
Lin, Y., Cheng, Y., Qin, C., Lin, C., D'Souza, R., & Wang, F.
(2009).
FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors. Developmental Dynamics.
238(2), 324-330.
-
Sims-Lucas, S., Cullen-McEwen, L., Eswarakumar, V. P., Hains, D., Kish, K., Becknell, B., ... Bates, C. M.
(2009).
Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia. American Journal of Physiology: Renal Physiology.
297(5), F1208-F1219.
-
Lin, Y., Chen, L., Lin, C., Luo, Y., Tsai, R., & Wang, F.
(2009).
Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum. Developmental Biology.
329(1), 44-54.
-
Luo, Y., Yang, C., Jin, C., Xie, R., Wang, F., & McKeehan, W. L.
(2009).
Novel phosphotyrosine targets of FGFR2IIIb signaling. Cellular Signalling.
21(9), 1370-1378.
-
Zhang, J., Lin, Y., Zhang, Y., Lan, Y., Lin, C., Moon, A. M., ... Wang, F.
(2008).
Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development.
135(21), 3611-3622.
-
Lan, Y., Zhang, Y., Wang, J., Lin, C., Ittmann, M. M., & Wang, F.
(2008).
Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. International Journal of Cancer.
123(3), 543-551.
-
Sutherland, B. W., Knoblaugh, S. E., Kaplan-Lefko, P. J., Wang, F., Holzenberger, M., & Greenberg, N. M.
(2008).
Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium. 68(9), 3495-3504.
-
Zhang, Y., Zhang, J., Lin, Y., Lan, Y., Lin, C., Xuan, J. W., ... Wang, F.
(2008).
Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis. Development.
135(4), 775-784.
-
Zhang, Y., McKeehan, K., Lin, Y., Zhang, J., & Wang, F.
(2008).
Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor. Molecular Endocrinology.
22(1), 167-175.
-
Huang, X., Yang, C., Luo, Y., Jin, C., Wang, F., & McKeehan, W. L.
(2007).
FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes.
56(10), 2501-2510.
-
Lin, Y., Zhang, J., Zhang, Y., & Wang, F.
(2007).
Generation of an Frs2alpha conditional null allele. Genesis.
45(9), 554-559.
-
Lin, Y., Liu, G., Zhang, Y., Hu, Y., Yu, K., Lin, C., ... Wang, F.
(2007).
Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Development.
134(4), 723-734.
-
Acevedo, V. D., Gangula, R. D., Freeman, K. W., Li, R., Zhang, Y., Wang, F., ... Spencer, D. M.
(2007).
Inducible FGFR-1 Activation Leads to Irreversible Prostate Adenocarcinoma and an Epithelial-to-Mesenchymal Transition. Cancer Cell.
12(6), 559-571.
-
Guo, C., Wu, G., Chin, J. L., Bauman, G., Moussa, M., Wang, F., ... Xuan, J. W.
(2006).
Bub1 up-regulation and hyperphosphorylation promote malignant transformation in SV40 tag-induced transgenic mouse models. 4(12), 957-969.
-
Huang, X., Yu, C., Jin, C., Yang, C., Xie, R., Cao, D., Wang, F., & McKeehan, W. L.
(2006).
Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis. Molecular Carcinogenesis.
45(12), 934-942.
-
Lin, Y., Liu, G., & Wang, F.
(2006).
Generation of an Fgf9 conditional null allele. Genesis.
44(3), 150-154.
-
Weng, J., Wang, J., Hu, X., Wang, F., Ittmann, M., & Liu, M.
(2006).
PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer. International Journal of Cancer.
118(6), 1471-1480.
-
Huang, X., Yu, C., Jin, C., Kobayashi, M., Bowles, C. A., Wang, F., & McKeehan, W. L.
(2006).
Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis. Cancer Research.
66(3), 1481-1490.
-
Ma, W., Xia, X., Stafford, L. J., Yu, C., Wang, F., LeSage, G., & Liu, M.
(2006).
Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis. Oncogene.
25(30), 4207-4216.
-
Yu, C., Wang, F., Jin, C., Huang, X., & McKeehan, W. L.
(2005).
Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids. 280(18), 17707-17714.
-
Zhang, Y., Lin, Y., Bowles, C., & Wang, F.
(2004).
Direct cell cycle regulation by the fibroblast growth factor receptor (FGFR) kinase through phosphorylation-dependent release of Cks1 from FGFR substrate 2. Journal of Biological Chemistry.
279(53), 55348-55354.
-
Jin, C., Wang, F., Wu, X., Yu, C., Luo, Y., & McKeehan, W. L.
(2004).
Directionally specific paracrine communication mediated by epithelial FGF9 to stromal FGFR3 in two-compartment premalignant prostate tumors. 64(13), 4555-4562.
-
Wang, F., McKeehan, K., Yu, C., Ittmann, M., & McKeehan, W. L.
(2004).
Chronic activity of ectopic type 1 fibroblast growth factor receptor tyrosine kinase in prostate epithelium results in hyperplasia accompanied by intraepithelial neoplasia. The Prostate.
58(1), 1-12.
-
Jin, C., McKeehan, K., Guo, W., Jauma, S., Ittmann, M. M., Foster, B., ... Wang, F.
(2003).
Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate. Cancer Research.
63(24), 8784-8790.
-
Yu, C., Wang, F., Jin, C., Huang, X., Miller, D. L., Basilico, C., & McKeehan, W. L.
(2003).
Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis. 163(4), 1653-1662.
-
Jin, C., McKeehan, K., & Wang, F.
(2003).
Transgenic mouse with high Cre recombinase activity in all prostate lobes, seminal vesicle, and ductus deferens. The Prostate.
57(2), 160-164.
-
Wu, X., Jin, C., Wang, F., Yu, C., & McKeehan, W. L.
(2003).
Stromal cell heterogeneity in fibroblast growth factor-mediated stromal-epithelial cell cross-talk in premalignant prostate tumors. Cancer Research.
63(16), 4936-4944.
-
Yu, C., Wang, F., Jin, C., Wu, X., Chan, W., & McKeehan, W. L.
(2002).
Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice. 161(6), 2003-2010.
-
Jin, C. L., McKeehan, K., Lambert, D., & Wang, F.
(2002).
The intracellular microenvironment in host cell-specific phosphorylation of SNT1 by the FGFR1 tyrosine kinase. Shi yan sheng wu xue bao.
35(3), 184-190.
-
Wang, F.
(2002).
Cell- and receptor isotype-specific phosphorylation of SNT1 by fibroblast growth factor receptor tyrosine kinases. 38(3), 178-183.
-
Wang, F., McKeehan, K., Yu, C., & McKeehan, W. L.
(2002).
Fibroblast growth factor receptor 1 phosphotyrosine 766: molecular target for prevention of progression of prostate tumors to malignancy. Cancer Research.
62(6), 1898-1903.
-
Kan, M., Uematsu, F., Wu, X., & Wang, F.
(2001).
Directional specificity of prostate stromal to epithelial cell communication via FGF7/FGFR2 is set by cell- and FGFR2 isoform-specific heparan sulfate. 37(9), 575-577.
-
Wu, X., Kan, M., Wang, F., Jin, C., Yu, C., & McKeehan, W. L.
(2001).
A rare premalignant prostate tumor epithelial cell syndecan-1 forms a fibroblast growth factor-binding complex with progression-promoting ectopic fibroblast growth factor receptor 1. Cancer Research.
61(13), 5295-5302.
-
Jones, R. B., Wang, F., Luo, Y., Yu, C., Jin, C., Suzuki, T., Kan, M., & McKeehan, W. L.
(2001).
The nonsense-mediated decay pathway and mutually exclusive expression of alternatively spliced FGFR2IIIb and -IIIc mRNAs. 276(6), 4158-4167.
-
Uematsu, F., Jang, J. H., Kan, M., Wang, F., Luo, Y., & McKeehan, W. L.
(2001).
Evidence that the intracellular domain of FGF receptor 2IIIb affects contact of the ectodomain with two FGF7 ligands. Biochemical and Biophysical Research Communications.
283(4), 791-797.
-
Xia, C., Ma, W., Wang, F., Hua Sb, .., & Liu, M.
(2001).
Identification of a prostate-specific G-protein coupled receptor in prostate cancer. Oncogene.
20(41), 5903-5907.
-
Yu, C., Wang, F., Kan, M., Jin, C., Jones, R. B., Weinstein, M., Deng, C. X., & McKeehan, W. L.
(2000).
Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. Journal of Biological Chemistry.
275(20), 15482-15489.
-
Wang, F.
(2000).
Epitope swapping to distinguish transgenic from endogenous fibroblast growth factor receptor type 1. BioTechniques.
28(5), 834-838.
-
Uematsu, F., Kan, M., Wang, F., Jang, J. H., Luo, Y., & McKeehan, W. L.
(2000).
Ligand binding properties of binary complexes of heparin and immunoglobulin-like modules of FGF receptor 2. Biochemical and Biophysical Research Communications.
272(3), 830-836.
-
Kan, M., Wu, X., Wang, F., & McKeehan, W. L.
(1999).
Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase. Journal of Biological Chemistry.
274(22), 15947-15952.
-
Wang, F., Lu, W., McKeehan, K., Mohamedali, K., Gabriel, J. L., Kan, M., & McKeehan, W. L.
(1999).
Common and specific determinants for fibroblast growth factors in the ectodomain of the receptor kinase complex. Biochemistry.
38(1), 160-171.
-
McKeehan, W. L., Wang, F., & Kan, M.
(1998).
The heparan sulfate-fibroblast growth factor family: diversity of structure and function. Progress in Molecular Biology and Translational Science.
59(C), 135-176.
-
Feng, S., Wang, F., Matsubara, A., Kan, M., & McKeehan, W. L.
(1997).
Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cells. Cancer Research.
57(23), 5369-5378.
-
Wang, F., Kan, M., McKeehan, K., Jang, J. H., Feng, S., & McKeehan, W. L.
(1997).
A homeo-interaction sequence in the ectodomain of the fibroblast growth factor receptor. Journal of Biological Chemistry.
272(38), 23887-23895.
-
Jang, J. H., Wang, F., & Kan, M.
(1997).
Heparan sulfate is required for interaction and activation of the epithelial cell fibroblast growth factor receptor-2IIIb with stromal-derived fibroblast growth factor-7. In Vitro Cellular and Developmental Biology - Animal.
33(10), 819-824.
-
Wang, F., & McKeehan, W. L.
(1996).
Insulin-like growth factor-1 messenger RNA isoforms in rat prostate and prostate tumors. In Vitro Cellular and Developmental Biology - Animal.
32(5), 265-268.
-
Kan, M., Wang, F., To, B., Gabriel, J. L., & McKeehan, W. L.
(1996).
Divalent cations and heparin/heparan sulfate cooperate to control assembly and activity of the fibroblast growth factor receptor complex. Journal of Biological Chemistry.
271(42), 26143-26148.
-
Luo, Y., Gabriel, J. L., Wang, F., Zhan, X., Maciag, T., Kan, M., & McKeehan, W. L.
(1996).
Molecular modeling and deletion mutagenesis implicate the nuclear translocation sequence in structural integrity of fibroblast growth factor-1. Journal of Biological Chemistry.
271(43), 26876-26883.
-
Feng, S., Xu, J., Wang, F., Kan, M., & McKeehan, W. L.
(1996).
Nuclear localization of a complex of fibroblast growth factor(FGF)-1 and an NH2-terminal fragment of FGF receptor isoforms R4 and R1alpha in human liver cells. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
1310(1), 67-73.
-
Wang, F., Kan, M., & McKeehan, W. L.
(1995).
Multiple mutant cDNAs from one reaction mixture using asymmetric primers in PCR. BioTechniques.
19(4), 556-559.
-
Wang, F., Kan, M., Yan, G., Xu, J., & McKeehan, W. L.
(1995).
Alternately spliced NH2-terminal immunoglobulin-like Loop I in the ectodomain of the fibroblast growth factor (FGF) receptor 1 lowers affinity for both heparin and FGF-1. Journal of Biological Chemistry.
270(17), 10231-10235.
-
Wang, F., Kan, M., Xu, J., Yan, G., & McKeehan, W. L.
(1995).
Ligand-specific structural domains in the fibroblast growth factor receptor. Journal of Biological Chemistry.
270(17), 10222-10230.
-
Hou, J., Wang, F., & McKeehan, W. L.
(1994).
Molecular cloning and expression of the gene for a major leucine-rich protein from human hepatoblastoma cells (HepG2). 30A(2), 111-114.
-
Shi, E., Kan, M., Xu, J., Wang, F., Hou, J., & McKeehan, W. L.
(1993).
Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants. 13(7), 3907-3918.
-
Kan, M., Wang, F., Xu, J., Crabb, J. W., Hou, J., & McKeehan, W. L.
(1993).
An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science.
259(5103), 1918-1921.
-
Matsuzaki, K., Xu, J., Wang, F., McKeehan, W. L., Krummen, L., & Kan, M.
(1993).
A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor. Journal of Biological Chemistry.
268(17), 12719-12723.
-
Yan, G., Fukabori, Y., Nikolaropoulos, S., Wang, F., & McKeehan, W. L.
(1992).
Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin. Molecular Endocrinology.
6(12), 2123-2128.
-
Yan, G., Wang, F., Fukabori, Y., Sussman, D., Hou, J., & McKeehan, W. L.
(1992).
Expression and transforming activity of a variant of the heparin-binding fibroblast growth factor receptor (flg) gene resulting from splicing of the alpha exon at an alternate 3'-acceptor site. Biochemical and Biophysical Research Communications.
183(2), 423-430.
-
Hou, J., Kan, M., Wang, F., Xu, J. M., Nakahara, M., McBride, G., McKeehan, K., & McKeehan, W. L.
(1992).
Substitution of putative half-cystine residues in heparin-binding fibroblast growth factor receptors. Loss of binding activity in both two and three loop isoforms. Journal of Biological Chemistry.
267(25), 17804-17808.
-
Yan, G. C., Nikolaropoulos, S., Wang, F., & McKeehan, W. L.
(1991).
Sequence of rat keratinocyte growth factor (heparin-binding growth factor type 7). 27A(6), 437-438.
-
Liu, S., Lai, J., Feng, Y., Zhuo, Y., Zhang, H., Chen, Y., ... Zhong, W.
(2023).
Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial -oxidation in castration-resistant prostate cancer cells. Journal of Biological Chemistry.
299(1), 102720-102720.
-
chapter
-
Wang, F., Luo, Y., & McKeehan, W. L.
(2014).
The FGF signaling axis in prostate tumorigenesis. MOLECULAR ONCOLOGY: CAUSES OF CANCER AND TARGETS FOR TREATMENT.
(pp. 190-203).
Cambridge University Press (CUP).
-
Wang, F., McKeehan, W. L., Shen, M. M., & Abate-Shen, C.
(2011).
GENETICALLY ENGINEERED MOUSE MODELS IN PROSTATE CANCER RESEARCH. Recent Advances in Prostate Cancer.
(pp. 219-282).
World Scientific Publishing.
-
McKeehan, W. L., Wang, F., & Luo, Y.
(2010).
The Fibroblast Growth Factor (FGF) Signaling Complex. Handbook of Cell Signaling.
(pp. 253-259).
Elsevier.
-
Wang, F., & McKeehan, W. L.
(2003).
The Fibroblast Growth Factor (FGF) Signaling Complex. Handbook of Cell Signaling.
(pp. 265-270).
Elsevier.
-
Wang, F., Luo, Y., & McKeehan, W. L.
(2014).
The FGF signaling axis in prostate tumorigenesis. MOLECULAR ONCOLOGY: CAUSES OF CANCER AND TARGETS FOR TREATMENT.
(pp. 190-203).
Cambridge University Press (CUP).
-
conference paper
-
Li, X., Nairn, A., Nagy, T., Wang, F., Yamaguchi, Y. u., Moremen, K., & Wang, L.
(2013).
Heparan Sulfate Is Required For Prostate Cancer Initiation And Progression. GLYCOBIOLOGY.
1345-1345.
-
Thai, H. H., Warneke, C. L., Anh, H., Tamboli, P., Wang, F., & Jonasch, E.
(2013).
The role of FGF signaling in VEGF-pathway targeted therapy resistance: Data from patients and model systems. Journal of Clinical Oncology.
386-386.
-
Tien, J. C., Liu, Z., Gao, L. i., Wang, F., & Xu, J.
(2012).
SRC-3 is a critical mediator in the development of castration-resistant prostate cancer. Cancer Research.
3296-3296.
-
Ho, T. H., Wang, F., Hoang, A., Tamboli, P., & Jonasch, E.
(2011).
Fibroblast growth factor receptor 1 (FGFR1) expression and activation in clear cell renal cell carcinoma (ccRCC). Journal of Clinical Oncology.
e15015-e15015.
-
Kwon, O., Ito, M., Yang, Z., Wang, F., Ornitz, D. M., & Cotsarelis, G.
(2009).
Fibroblast growth factor 9 from dendritic epidermal T cells promotes hair follicle neogenesis after wounding in adult skin. Journal of Investigative Dermatology.
S104-S104.
-
Guo, C., Wu, G., Chin, J. L., Bauman, G., Moussa, M., Wang, F., ... Xuan, J. W.
(2006).
Bub1 up-regulation and hyper-phosphorylation are major features promoting malignant transformation in SV40 Tag -induced transgenic mouse models. Cancer Research.
-
Wang, F., Lu, W., McKeehan, K., Mohamedali, K., Gabriel, J. L., Kan, M., & McKeehan, W. L.
(1998).
Common and specific determinants for fibroblast growth factors (FGF) in the kinase ectodomain of the receptor complex. Molecular Biology of the Cell.
235A-235A.
-
Kan, M., Jang, J. H., Wu, X., Kan, M., Tran, T., Wang, F., & McKeehan, W. L.
(1997).
Heparan sulfate proteoglycan (HSPG) confers specificity of FGFR4 for FGF-1 in liver cells: Restriction of FGF-1 binding by soluble heparin and HSPG. Molecular Biology of the Cell.
1398-1398.
-
Kan, M., Wang, F., Kan, M., To, B., Gabriel, J. L., & McKeehan, W. L.
(1996).
Divalent cations cooperate with heparin or heparan sulfate to regulate assembly of the fibroblast growth factor receptor complex. Molecular Biology of the Cell.
1074-1074.
-
Jang, J. H., Kan, M., Wang, F., & McKeehan, W. L.
(1996).
Heparan sulfate is required for interaction and activation of the epithelial cell fibroblast growth factor receptor-2IIIB with stromal-derived fibroblast growth factor 7. Molecular Biology of the Cell.
1075-1075.
-
WANG, F., KAN, M., MCKEEHAN, K., & MCKEEHAN, W. L.
(1995).
HETERODIMERIZATION AMONG THE FIBROBLAST GROWTH-FACTOR RECEPTOR ISOFORMS. Molecular Biology of the Cell.
713-713.
-
McKeehan, W. L., Hou, J., Adams, P., Wang, F., Yan, G. C., & Kan, M.
(1993).
Heparin-binding fibroblast growth factors and prostate cancer. Advances in Experimental Medicine and Biology.
203-213.
-
Li, X., Nairn, A., Nagy, T., Wang, F., Yamaguchi, Y. u., Moremen, K., & Wang, L.
(2013).
Heparan Sulfate Is Required For Prostate Cancer Initiation And Progression. GLYCOBIOLOGY.
1345-1345.
Research
principal investigator on
investigator on
Teaching
teaching activities
- IBST691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Biochemistry, Clarkson University - (Potsdam, New York, United States) 1994
- M.S. in Cell Biology, Xiamen University - (Amoy, Fujian, China) 1985
- B.S. in Microbiology, Xiamen University - (Amoy, Fujian, China) 1982
- Texas A&M University - (College Station, Texas, United States) , Postdoctoral Training 1996
Contact
first name
- Fen
has last name
- Wang
mailing address
-
2121 w holcombe blvd
Ibt Center For Translational Cancer Research
houston
houston, Texas 77030
USA
Other
- fwang@tamhsc.edu