MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1. Academic Article uri icon


  • Our previous microarray data showed that microRNA-224 (miR-224) was downregulated in human prostate cancer (PCa) tissues compared with adjacent benign tissues. However, the underlying mechanisms by which miR-224 is involved in PCa remain unclear. In this study, we identified TRIB1 as a target gene of miR-224. Forced expression of miR-224 suppressed PCa cell proliferation, invasion and migration, and promoted cell apoptosis by downregulating TRIB1. Moreover, the expression level of miR-224 in PCa tissues was negatively correlated with that of TRIB1. miR-224 downregulation was frequently found in PCa tissues with metastasis, higher PSA level and clinical stage, whereas TRIB1 upregulation was significantly associated with metastasis. Both miR-224 downregulation and TRIB1 upregulation were significantly associated with poor biochemical recurrence-free survival of patients with PCa. In conclusion, these findings reveal that the aberrant expression of miR-224 and TRIB1 may promote PCa progression and have potentials to serve as novel biomarkers for PCa prognosis.

published proceedings

  • Int J Cancer

altmetric score

  • 6.5

author list (cited authors)

  • Lin, Z., Huang, Y., Zhang, Y., Han, Z., He, H., Ling, X., ... Wu, C.

citation count

  • 84

complete list of authors

  • Lin, Zhuo-Yuan||Huang, Ya-Qiang||Zhang, Yan-Qiong||Han, Zhao-Dong||He, Hui-Chan||Ling, Xiao-Hui||Fu, Xin||Dai, Qi-Shan||Cai, Chao||Chen, Jia-Hong||Liang, Yu-Xiang||Jiang, Fu-Neng||Zhong, Wei-De||Wang, Fen||Wu, Chin-Lee

publication date

  • August 2014