Heparin-binding fibroblast growth factors and prostate cancer. Conference Paper uri icon


  • Studies of model rat prostate tissue and derived cells indicate the insulin-like (IGF), epidermal growth factor (EGF), transforming growth factor beta (TGF-beta) and heparin-binding fibroblast growth factor (HBGF) families and their receptors may play important roles in regulation of normal prostate cell growth. Tumor cells at different levels in the progression from slow-growing, hormone-dependence to fast-growing, hormone-independence exhibit distinct alterations in expression of specific growth factors and their receptor phenotype. Distinct IGF-I and HBGF mRNAs are constitutively expressed in the mesenchymal cells of slow-tumors, but alteration in HBGF receptor phenotype occurs in the epithelial cells. Fast-tumors exhibit even higher constitutive expression of multiple HBGFs. Splice variants in cDNA for the HBGF receptor in fast-tumors suggest constitutive expression of an intracellular receptor, that together with intracellular HBGFs, may constitute an intracellular autocrine system that is independent of exogenous hormones and growth factors.

published proceedings

  • Adv Exp Med Biol

author list (cited authors)

  • McKeehan, W. L., Hou, J., Adams, P., Wang, F., Yan, G. C., & Kan, M.

citation count

  • 7

complete list of authors

  • McKeehan, WL||Hou, J||Adams, P||Wang, F||Yan, GC||Kan, M

publication date

  • January 1993