Altered differentiation and proliferation of prostate epithelium in mice lacking the androgen receptor cofactor p44/WDR77. Academic Article

abstract

• Although it has been observed that various cofactors modulate activity of the androgen receptor (AR), the specific relationship between AR cofactors and prostate development and functions has not been well studied. To determine whether AR cofactor p44/WDR77 is important in prostate growth and development, we examined prostate architecture in p44/WDR77-null mice and wild-type (WT) littermates. Prostate glands from p44/WDR77-deficient animals were not only smaller than those from WT mice but also had fewer branches and terminal duct tips and were deficient in production of secretory proteins. The p44/WDR77-null prostate tissue was less differentiated and hyperproliferative relative to WT littermates. In addition, the altered expression of androgen-regulated genes was observed in the p44/WDR77-null prostate. Thus, these results suggest that the AR cofactor p44/WDR77 plays important roles in prostate growth and differentiation by modulating AR-target gene expression.

authors

• Wang, Fen

published proceedings

• Endocrinology

author list (cited authors)

• Gao, S., Wu, H., Wang, F., & Wang, Z.

citation count

• 19

complete list of authors

• Gao, Shen||Wu, Hong||Wang, Fen||Wang, Zhengxin

publication date

• August 2010

publisher

• The Endocrine Society  Publisher

published in

• ENDOCRINOLOGY  Journal

keywords

• Animals
• Cell Differentiation
• Cell Proliferation
• Cells, Cultured
• Embryo, Mammalian
• Epithelium
• Female
• Gene Expression Profiling
• Gene Expression Regulation, Developmental
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Organ Specificity
• Pregnancy
• Prostate
• Prostatic Hyperplasia
• Receptors, Androgen
• Transcription Factors

PubMed Central ID

• 20519372

Digital Object Identifier (DOI)

• 10.1210/en.2009-1080

start page

• 3941

end page

• 3953

volume

• 151

issue

• 8

URL

• http://dx.doi.org/10.1210/en.2009-1080