Association of histopathologic grading and contrast-enhanced ultrasound in hepatocellular carcinoma
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Objective: To explore the correlation between contrast-enhanced ultrasound (CEUS) and the histopathological grading of hepatocellular carcinoma (HCC). Methods: Forty-seven patients with HCC underwent examination of CEUS performed with Sono Vue. The results of the CEUS were compared with histopathological grand and tumor differentiation. Results: Nine (100%) well differentiated HCCs TIC showed "quick-up and slow-down"; 15 of 24 (20.80%) moderately differentiated HCC's TIC showed "quick-up and slow-down"; 19 of 24 (79.20%) moderately differentiated HCC's TIC showed "quick-up and quick-down"; 8 of 14 (57.10%) poorly differentiated HCC's TIC showed "quick-up and slow-down", while 6 of 14 (42.9%) poorly differentiated HCC's TIC showed "quick-up and quick-down". Pathologic grading of HCC was correlated to washing-out time (P<0.05), but was not correlated to the arrival time, enhancement time or peak intensity (P>0.05). Conclusion: The type of TIC and acoustic quantified parameters of CEUS are useful for the diagnosis and histological differentiation of HCC.