HR job title
- Retired Professor
- Contact Info
- 1 979 845 6981
Zhu, Guan Professor
Positions
Our laboratory conducts translational research with an ultimate goal to discover new anti-parasitic therapeutics by targeting metabolic enzymes and other molecules critical or essential to the parasite infection, survival and development, such as those involved in the lipid and energy metabolisms and interacting with host cells in Cryptosporidium and other protozoan parasites. Other research areas include functional genomics and molecular evolution of apicomplexan parasites, and parasitic diseases important to the conservation of wild animals.
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Overview
Publications
selected publications
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academic article
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Ma, J., Guo, F., Jin, Z. i., Geng, M., Ju, M., Ravichandran, A., ... Zhang, H.
(2020).
Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin. Antimicrobial Agents and Chemotherapy.
64(8), e00244-e00220.
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Zhu, G., & Liu, M.
(2020).
An old drug as a promising new cure for the hard-to-treat echinococcosis. EBioMedicine.
55, 102749-102749.
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Yu, X., Guo, F., Mouneimne, R. B., & Zhu, G.
(2020).
Cryptosporidium parvum Elongation Factor 1 Participates in the Formation of Base Structure at the Infection Site During Invasion. Journal of Infectious Diseases.
221(11), 1816-1825.
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Eltahan, R., Guo, F., Zhang, H., & Zhu, G.
(2019).
The Action of the Hexokinase Inhibitor 2-deoxy-d-glucose on Cryptosporidium parvum and the Discovery of Activities against the Parasite Hexokinase from Marketed Drugs. Journal of Eukaryotic Microbiology.
66(3), 460-468.
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Yu, X., Hoyle, R. L., Guo, F., Ratliff, C. M., Cantu, V., Crow, J., ... Zhu, G.
(2019).
A Vavraia-like microsporidium as the cause of deadly infection in threatened and endangered Eurycea salamanders in the United States. Parasites and Vectors.
12(1), 108.
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Jin, Z. i., Ma, J., Zhu, G., & Zhang, H.
(2019).
Discovery of Novel Anti-cryptosporidial Activities From Natural Products by in vitro High-Throughput Phenotypic Screening. Frontiers in Microbiology.
10(AUG), 1999.
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Guo, F., Zhang, H., Eltahan, R., & Zhu, G.
(2019).
Molecular and Biochemical Characterization of a Type II Thioesterase From the Zoonotic Protozoan Parasite Cryptosporidium parvum. Frontiers in Cellular and Infection Microbiology.
9(JUN), 199.
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Abraham, A., Brasov, I., Thekkiniath, J., Kilian, N., Lawres, L., Gao, R., ... Ben Mamoun, C.
(2018).
Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies. 293(52), 19974-19981.
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Schlemmer, S. N., Scott, E. M., Vallone, L. V., Johnson, M. C., Guo, F., & Zhu, G.
(2018).
What is your diagnosis? Corneal scrape from a dog. Veterinary Clinical Pathology.
47(2), 315-316.
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Eltahan, R., Guo, F., Zhang, H., Xiang, L., & Zhu, G.
(2018).
Discovery of ebselen as an inhibitor of Cryptosporidium parvum glucose-6-phosphate isomerase (CpGPI) by high-throughput screening of existing drugs. International Journal for Parasitology: Drugs and Drug Resistance.
8(1), 43-49.
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Yu, Z., Ruan, Y., Zhou, M., Chen, S., Zhang, Y., Wang, L., Zhu, G., & Yu, Y.
(2018).
Prevalence of intestinal parasites in companion dogs with diarrhea in Beijing, China, and genetic characteristics of Giardia and Cryptosporidium species. Parasitology Research.
117(1), 35-43.
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Guo, F., Zhang, H., McNair, N. N., Mead, J. R., & Zhu, G.
(2018).
The Existing Drug Vorinostat as a New Lead Against Cryptosporidiosis by Targeting the Parasite Histone Deacetylases. Journal of Infectious Diseases.
217(7), 1110-1117.
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He, L., He, P., Luo, X., Li, M., Yu, L., Guo, J., ... Zhao, J.
(2018).
The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development. Parasites and Vectors.
11(1), 452.
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Yu, X., Zhang, H., & Zhu, G.
(2017).
Characterization of Host Cell Mutants Significantly Resistant to Cryptosporidium parvum Infection. Journal of Eukaryotic Microbiology.
64(6), 843-849.
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Sun, C., Dong, W., Shao, T., Li, J., Zhao, J., Nie, L. i., ... Shao, J.
(2017).
Peroxiredoxin 1 (Prx1) is a dual-function enzyme by possessing Cys-independent catalase-like activity. 474(8), 1373-1394.
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Guo, F., Forde, M. S., Werre, S. R., Krecek, R. C., & Zhu, G.
(2017).
Seroprevalence of five parasitic pathogens in pregnant women in ten Caribbean countries. Parasitology Research.
116(1), 347-358.
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Xiang, L., Guo, F., Yu, Y., Parson, L. S., LaCoste, L., Gibson, A., ... Zhu, G.
(2017).
Multiyear Survey of Coccidia, Cryptosporidia, Microsporidia, Histomona, and Hematozoa in Wild Quail in the Rolling Plains Ecoregion of Texas and Oklahoma, USA. Journal of Eukaryotic Microbiology.
64(1), 4-17.
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Ifeonu, O. O., Chibucos, M. C., Orvis, J., Su, Q. i., Elwin, K., Guo, F., ... Silva, J. C.
(2016).
Annotated draft genome sequences of three species of Cryptosporidium: Cryptosporidium meleagridis isolate UKMEL1, C. baileyi isolate TAMU-09Q1 and C. hominis isolates TU502_2012 and UKH1. Pathogens and Disease.
74(7), ftw080-ftw080.
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Guo, F., Zhang, H., Payne, H. R., & Zhu, G.
(2016).
Differential Gene Expression and Protein Localization of Cryptosporidium parvum Fatty Acyl-CoA Synthetase Isoforms. 63(2), 233-246.
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Wang, S., Wang, S., Luo, Y., Xiao, L., Luo, X., Gao, S., ... Cai, X.
(2016).
Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host. Nature Communications.
7(1), 12845.
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Sun, M., Liao, S., Zhang, L., Wu, C., Qi, N., Lv, M., ... Cai, J.
(2016).
Molecular and biochemical characterization of Eimeria tenella hexokinase. Parasitology Research.
115(9), 3425-3433.
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He, K., Wu, Z., Wen, J., Xu, B. o., Shao, Y., Qian, J., Zhu, G., & Yao, Q.
(2016).
Silk Fibroin Scaffolds Facilitating the Repair of Rat Abdominal Wall Defect. Journal of Biomaterials and Tissue Engineering.
6(8), 665-671.
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Sun, C., Dong, W., Zhao, J., Nie, L. i., Xiang, L., Zhu, G., & Shao, J.
(2015).
Cysteine-independent catalase-like activity of vertebrate peroxiredoxin 1 (Prx1). Journal of Biological Chemistry.
290(45), 27013-27013.
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Zhang, H., Guo, F., & Zhu, G.
(2015).
Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics. PLOS Pathogens.
11(11), e1005250-e1005250.
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Guo, F., Forde, M. S., Werre, S. R., Zhu, G., & Krecek, R. C.
(2015).
SEROPREVALENCE OF FIVE PARASITIC PATHOGENS IN PREGNANT WOMEN FROM 10 CARIBBEAN COUNTRIES. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE.
93(4), 347-348.
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Sun, C., Dong, W., Zhao, J., Nie, L. i., Xiang, L., Zhu, G., & Shao, J.
(2015).
Cysteine-independent Catalase-like Activity of Vertebrate Peroxiredoxin 1 (Prx1). 290(32), 19942-19954.
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Checkley, W., White, A. C., Jaganath, D., Arrowood, M. J., Chalmers, R. M., Chen, X., ... Houpt, E. R.
(2015).
A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium. 15(1), 85-94.
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Guo, F., Ortega-Pierres, G., Argello-Garca, R., Zhang, H., & Zhu, G.
(2015).
Giardia fatty acyl-CoA synthetases as potential drug targets. 6(JUL), 753.
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Zhang, H., & Zhu, G.
(2015).
Quantitative RT-PCR assay for high-throughput screening (HTS) of drugs against the growth of Cryptosporidium parvum in vitro. 6(SEP), 991.
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Guo, F., Zhang, H., Fritzler, J. M., Rider, S. D., Xiang, L., McNair, N. N., Mead, J. R., & Zhu, G.
(2014).
Amelioration of Cryptosporidium parvum infection in vitro and in vivo by targeting parasite fatty acyl-coenzyme A synthetases. Journal of Infectious Diseases.
209(8), 1279-1287.
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Yu, Y., Zhang, H., Guo, F., Sun, M., & Zhu, G.
(2014).
A unique hexokinase in Cryptosporidium parvum, an apicomplexan pathogen lacking the Krebs cycle and oxidative phosphorylation. Protist.
165(5), 701-714.
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Yu, X., Yu, H., Kong, L., Guo, F., Zhu, G., & Li, Q. i.
(2014).
Molecular cloning and differential expression in tissues of a tyrosinase gene in the Pacific oyster Crassostrea gigas. Molecular Biology Reports.
41(8), 5403-5411.
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Dong, W., Sun, C., Zhu, G., Hu, S., Xiang, L., & Shao, J.
(2014).
New function for Escherichia coli xanthosine phophorylase (xapA): genetic and biochemical evidences on its participation in NAD(+) salvage from nicotinamide. BMC Microbiology.
14(1), 29.
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Cao, Y., Shi, Y., Qiao, H., Yang, Y., Liu, J., Shi, Y., ... Jin, Y.
(2014).
Distribution of lethal giant larvae (Lgl) protein in the tegument and negative impact of siRNA-based gene silencing on worm surface structure and egg hatching in Schistosoma japonicum. Parasitology Research.
113(1), 1-9.
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Guo, A., Cai, J., Gong, W., Yan, H., Luo, X., Tian, G., ... Cai, X.
(2013).
Transcriptome analysis in chicken cecal epithelia upon infection by Eimeria tenella in vivo. PLoS ONE.
8(5), e64236-e64236.
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Hu, G., Gong, A., Roth, A. L., Huang, B. Q., Ward, H. D., Zhu, G., ... Chen, X.
(2013).
Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense. PLOS Pathogens.
9(4), e1003261-e1003261.
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Zhang, M., Yan, L., Zhu, G., Holifield, M., Todd, D., & Zhang, S.
(2013).
Streptococcus troglodytidis sp. nov., isolated from a foot abscess of a chimpanzee (Pan troglodytes). International Journal of Systematic and Evolutionary Microbiology.
63(Pt 2), 449-453.
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Zhu, L., Nie, L. i., Zhu, G., Xiang, L., & Shao, J.
(2013).
Advances in research of fish immune-relevant genes: a comparative overview of innate and adaptive immunity in teleosts. 39(1-2), 39-62.
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Xiang, L., Guo, F., Zhang, H., LaCoste, L., Rollins, D., Bruno, A., Fedynich, A. M., & Zhu, G.
(2013).
Gene discovery, evolutionary affinity and molecular detection of Oxyspirura petrowi, an eye worm parasite of game birds. BMC Microbiology.
13(1), 233-233.
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Zhang, H., Guo, F., & Zhu, G.
(2012).
Involvement of host cell integrin 2 in Cryptosporidium parvum infection. 80(5), 1753-1758.
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Fritzler, J. M., & Zhu, G.
(2012).
Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP). Journal of Antimicrobial Chemotherapy.
67(3), 609-617.
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Sun, M., Zhu, G., Qin, Z., Wu, C., Lv, M., Liao, S., ... Cai, J.
(2012).
Functional characterizations of malonyl-CoA:acyl carrier protein transacylase (MCAT) in Eimeria tenella. Molecular and Biochemical Parasitology.
184(1), 20-28.
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Guo, F., & Zhu, G.
(2012).
Presence and removal of a contaminating NADH oxidation activity in recombinant maltose-binding protein fusion proteins expressed in Escherichia coli. BioTechniques.
52(4), 247-253.
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Zhang, H., Guo, F., Zhou, H., & Zhu, G.
(2012).
Transcriptome analysis reveals unique metabolic features in the Cryptosporidium parvum Oocysts associated with environmental survival and stresses. BMC GENOMICS.
13(1), 647.
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Fritzler, J. M., Craig, T. M., Elgayar, A., Plummer, C., Wilson, R. S., Peterson, M. J., & Zhu, G.
(2011).
A new eimeriid (Apicomplexa) species from endangered Attwater's prairie chickens (Tympanuchus cupido attwateri) in Texas. Journal of Parasitology.
97(4), 671-675.
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Lei, C., Rider, S. D., Wang, C., Zhang, H., Tan, X., & Zhu, G.
(2010).
The apicomplexan Cryptosporidium parvum possesses a single mitochondrial-type ferredoxin and ferredoxin:NADP+ reductase system. Protein Science.
19(11), 2073-2084.
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Yu, Y., Zhang, H., & Zhu, G.
(2010).
Plant-type trehalose synthetic pathway in cryptosporidium and some other apicomplexans. PLoS ONE.
5(9), e12593-e12593.
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Templeton, T. J., Enomoto, S., Chen, W., Huang, C., Lancto, C. A., Abrahamsen, M. S., & Zhu, G.
(2010).
A genome-sequence survey for Ascogregarina taiwanensis supports evolutionary affiliation but metabolic diversity between a Gregarine and Cryptosporidium. Molecular Biology and Evolution (MBE).
27(2), 235-248.
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Ctrnct, V., Fritzler, J. M., Surinov, M., Hrd, I., Zhu, G., & Stejskal, F.
(2010).
Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro. Experimental Parasitology.
126(2), 113-116.
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Zhu, G., Shi, X., & Cai, X.
(2010).
The reductase domain in a Type I fatty acid synthase from the apicomplexan Cryptosporidium parvum: restricted substrate preference towards very long chain fatty acyl thioesters. BMC Biochemistry.
11(1), 46-46.
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Rider, S. D., & Zhu, G.
(2010).
Cryptosporidium: genomic and biochemical features. Experimental Parasitology.
124(1), 2-9.
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Rider, S. D., & Zhu, G.
(2009).
An apicomplexan ankyrin-repeat histone deacetylase with relatives in photosynthetic eukaryotes. INTERNATIONAL JOURNAL FOR PARASITOLOGY.
39(7), 747-754.
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Rider, S. D., & Zhu, G.
(2008).
Differential expression of the two distinct replication protein A subunits from Cryptosporidium parvum. Journal of Cellular Biochemistry.
104(6), 2207-2216.
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Hostetler, H. A., Syler, L. R., Hall, L. N., Zhu, G., Schroeder, F., & Kier, A. B.
(2008).
A novel high-throughput screening assay for putative antidiabetic agents through PPARalpha interactions. Journal of Biomolecular Screening.
13(9), 855-861.
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Fritzler, J. M., Millership, J. J., & Zhu, G.
(2007).
Cryptosporidium parvum long-chain fatty acid elongase. Clinical and Vaccine Immunology.
6(11), 2018-2028.
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Cai, X., Lorraine Fuller, A., McDougald, L. R., Tan, X., Cai, J., Wang, F., Sacchettini, J. C., & Zhu, G.
(2007).
Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa). FEMS Microbiology Letters.
272(2), 238-244.
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Cook, T., Roos, D., Morada, M., Zhu, G., Keithly, J. S., Feagin, J. E., Wu, G., & Yarlett, N.
(2007).
Divergent polyamine metabolism in the Apicomplexa. Microbiology (United Kingdom).
153(Pt 4), 1123-1130.
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Fritzler, J. M., & Zhu, G.
(2007).
Functional characterization of the acyl-[acyl carrier protein] ligase in the Cryptosporidium parvum giant polyketide synthase. INTERNATIONAL JOURNAL FOR PARASITOLOGY.
37(3-4), 307-316.
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Zeng, B., Cai, X., & Zhu, G.
(2006).
Functional characterization of a fatty acyl-CoA-binding protein (ACBP) from the apicomplexan Cryptosporidium parvum. Microbiology (United Kingdom).
152(Pt 8), 2355-2363.
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Zeng, B., & Zhu, G.
(2006).
Two distinct oxysterol binding protein-related proteins in the parasitic protist Cryptosporidium parvum (Apicomplexa). Biochemical and Biophysical Research Communications.
346(2), 591-599.
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Cai, X., Woods, K. M., Upton, S. J., & Zhu, G.
(2005).
Application of quantitative real-time reverse transcription-PCR in assessing drug efficacy against the intracellular pathogen Cryptosporidium parvum in vitro. 49(11), 4437-4442.
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Thompson, R., Olson, M. E., Zhu, G., Enomoto, S., Abrahamsen, M. S., & Hijjawi, N. S.
(2005).
Cryptosporidium and cryptosporidiosis. 59, 77-158.
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Rider, S. D., Cai, X., Sullivan, W. J., Smith, A. T., Radke, J., White, M., & Zhu, G.
(2005).
The protozoan parasite Cryptosporidium parvum possesses two functionally and evolutionarily divergent replication protein A large subunits. 280(36), 31460-31469.
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Cai, X., Herschap, D., & Zhu, G.
(2005).
Functional characterization of an evolutionarily distinct phosphopantetheinyl transferase in the apicomplexan Cryptosporidium parvum. 4(7), 1211-1220.
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Senkovich, O., Speed, H., Grigorian, A., Bradley, K., Ramarao, C. S., Lane, B., Zhu, G., & Chattopadhyay, D.
(2005).
Crystallization of three key glycolytic enzymes of the opportunistic pathogen Cryptosporidium parvum. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
1750(2), 166-172.
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Chen, X., O'Hara, S. P., Huang, B. Q., Nelson, J. B., Lin, J., Zhu, G., Ward, H. D., & LaRusso, N. F.
(2004).
Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion. 72(12), 6806-6816.
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Zhu, G.
(2004).
Current progress in the fatty acid metabolism in Cryptosporidium parvum. Journal of Eukaryotic Microbiology.
51(4), 381-388.
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Millership, J. J., Waghela, P., Cai, X., Cockerham, A., & Zhu, G.
(2004).
Differential expression and interaction of transcription co-activator MBF1 with TATA-binding protein (TBP) in the apicomplexan Cryptosporidium parvum. Microbiology (United Kingdom).
150(Pt 5), 1207-1213.
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Millership, J. J., Cai, X., & Zhu, G.
(2004).
Functional characterization of replication protein A2 (RPA2) from Cryptosporidium parvum. Microbiology (United Kingdom).
150(Pt 5), 1197-1205.
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Cai, X., Lancto, C. A., Abrahamsen, M. S., & Zhu, G.
(2004).
Intron-containing beta-tubulin transcripts in Cryptosporidium parvum cultured in vitro. Microbiology (United Kingdom).
150(Pt 5), 1191-1195.
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Zhu, G., & Chen, H.
(2004).
Monophyletic relationship between severe acute respiratory syndrome coronavirus and group 2 coronaviruses. Journal of Infectious Diseases.
189(9), 1676-1678.
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Abrahamsen, M. S., Templeton, T. J., Enomoto, S., Abrahante, J. E., Zhu, G., Lancto, C. A., ... Kapur, V.
(2004).
Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science.
304(5669), 441-445.
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Madern, D., Cai, X., Abrahamsen, M. S., & Zhu, G.
(2004).
Evolution of Cryptosporidium parvum lactate dehydrogenase from malate dehydrogenase by a very recent event of gene duplication. Molecular Biology and Evolution (MBE).
21(3), 489-497.
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Weaver, E. A., Collisson, E. W., Slater, M., & Zhu, G.
(2004).
Phylogenetic analyses of Texas isolates indicate an evolving subtype of the clade B feline immunodeficiency viruses. Journal of Virology.
78(4), 2158-2163.
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Zhu, G., Li, Y., Cai, X., Millership, J. J., Marchewka, M. J., & Keithly, J. S.
(2004).
Expression and functional characterization of a giant Type I fatty acid synthase (CpFAS1) gene from Cryptosporidium parvum. Molecular and Biochemical Parasitology.
134(1), 127-135.
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Cai, X., Fuller, A. L., McDougald, L. R., & Zhu, G.
(2003).
Apicoplast genome of the coccidian Eimeria tenella. Gene.
321(1-2), 39-46.
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Chen, X., Huang, B. Q., Splinter, P. L., Cao, H., Zhu, G., McNiven, M. A., & LaRusso, N. F.
(2003).
Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src. Gastroenterology.
125(1), 216-228.
-
Zhu, G., & Keithly, J. S.
(2002).
Alpha-proteobacterial relationship of apicomplexan lactate and malate dehydrogenases. Journal of Eukaryotic Microbiology.
49(3), 255-261.
-
LaGier, M. J., Keithly, J. S., & Zhu, G.
(2002).
Characterisation of a novel transporter from Cryptosporidium parvum. INTERNATIONAL JOURNAL FOR PARASITOLOGY.
32(7), 877-887.
-
Zhu, G., LaGier, M. J., Stejskal, F., Millership, J. J., Cai, X., & Keithly, J. S.
(2002).
Cryptosporidium parvum: the first protist known to encode a putative polyketide synthase. Gene.
298(1), 79-89.
-
Millership, J. J., & Zhu, G.
(2002).
Heterogeneous expression and functional analysis of two distinct replication protein A large subunits from Cryptosporidium parvum. INTERNATIONAL JOURNAL FOR PARASITOLOGY.
32(12), 1477-1485.
-
Rotte, C., Stejskal, F., Zhu, G., Keithly, J. S., & Martin, W.
(2001).
Pyruvate : NADP+ oxidoreductase from the mitochondrion of Euglena gracilis and from the apicomplexan Cryptosporidium parvum: a biochemical relic linking pyruvate metabolism in mitochondriate and amitochondriate protists. Molecular Biology and Evolution (MBE).
18(5), 710-720.
-
LaGier, M. J., Zhu, G., & Keithly, J. S.
(2001).
Characterization of a heavy metal ATPase from the apicomplexan Cryptosporidium parvum. Gene.
266(1-2), 25-34.
-
Chaturvedi, S., Hamilton, A. J., Hobby, P., Zhu, G., Lowry, C. V., & Chaturvedi, V.
(2001).
Molecular cloning, phylogenetic analysis and three-dimensional modeling of Cu,Zn superoxide dismutase (CnSOD1) from three varieties of Cryptococcus neoformans. Gene.
268(1-2), 41-51.
-
Zhu, G., Keithly, J. S., & Philippe, H.
(2000).
What is the phylogenetic position of Cryptosporidium?. International Journal of Systematic and Evolutionary Microbiology.
50 Pt 4(4), 1673-1681.
-
Zhu, G., Marchewka, M. J., & Keithly, J. S.
(2000).
Cryptosporidium parvum appears to lack a plastid genome. Microbiology (United Kingdom).
146 ( Pt 2)(2), 315-321.
-
Zhu, G., LaGier, M. J., Hirose, S., & Keithly, J. S.
(2000).
Cryptosporidium parvum: functional complementation of a parasite transcriptional coactivator CpMBF1 in yeast. Experimental Parasitology.
96(4), 195-201.
-
Zhu, G., Marchewka, M. J., Woods, K. M., Upton, S. J., & Keithly, J. S.
(2000).
Molecular analysis of a Type I fatty acid synthase in Cryptosporidium parvum. Molecular and Biochemical Parasitology.
105(2), 253-260.
-
Zhu, G., Marchewka, M. J., & Keithly, J. S.
(1999).
Cryptosporidium parvum possesses a short-type replication protein A large subunit that differs from its host. FEMS Microbiology Letters.
176(2), 367-372.
-
Klein, R. D., Geary, T. G., Gibson, A. S., Favreau, M. A., Winterrowd, C. A., Upton, S. J., ... Yarlett, N.
(1999).
Reconstitution of a bacterial/plant polyamine biosynthesis pathway in Saccharomyces cerevisiae. Microbiology (United Kingdom).
145 ( Pt 2)(2), 301-307.
-
Zhu, G., Marchewka, M. J., Ennis, J. G., & Keithly, J. S.
(1998).
Direct isolation of DNA from patient stools for polymerase chain reaction detection of Cryptosporidium parvum. Journal of Infectious Diseases.
177(5), 1443-1446.
-
Fang, G., Zhu, G., Burger, H., Keithly, J. S., & Weiser, B.
(1998).
Minimizing DNA recombination during long RT-PCR. Journal of Virological Methods.
76(1-2), 139-148.
-
Chen, H., & Zhu, G.
(1997).
Computer program for calculating the melting temperature of degenerate oligonucleotides used in PCR or hybridization. BioTechniques.
22(6), 1158-1160.
-
Zhu, G., & Keithly, J. S.
(1997).
Molecular analysis of a P-type ATPase from Cryptosporidium parvum. Molecular and Biochemical Parasitology.
90(1), 307-316.
-
Keithly, J. S., Zhu, G., Upton, S. J., Woods, K. M., Martinez, M. P., & Yarlett, N.
(1997).
Polyamine biosynthesis in Cryptosporidium parvum and its implications for chemotherapy. Molecular and Biochemical Parasitology.
88(1-2), 35-42.
-
Zhu, G., & Keithly, J. S.
(1996).
The beta tubulin gene of Eimeria tenella. Molecular and Biochemical Parasitology.
76(1-2), 315-319.
-
ZHU, G., & MCDOUGALD, L. R.
(1995).
CONFOCAL LASER-SCANNING MICROSCOPY OF BETA-TUBULIN AND ALPHA-ACTININ IN ASEXUAL STAGES OF EIMERIA-TENELLA (APICOMPLEXA, EIMERIIDAE) IN CELL-CULTURE. Archiv für Protistenkunde.
145(1-2), 112-118.
-
Zhu, G., Johnson, J. K., & McDougald, L. R.
(1994).
Peptides associated with monensin resistance in sporozoites of Eimeria tenella (Coccidia). Journal of Parasitology.
80(2), 284-287.
-
Zhu, G., Johnson, J., & McDougald, L. R.
(1994).
Amplification of ionophore resistance in a field strain of Eimeria tenella by treating free sporozoites with monensin in vitro. Veterinary Parasitology.
51(3-4), 211-217.
-
Zhu, G., & McDougald, L. R.
(1993).
Variant proteins associated with ionophore resistance in sporozoites of Eimeria tenella (Coccidia). Parasitology Research.
79(6), 480-484.
-
Zhu, G., & McDougald, L. R.
(1992).
Characterization in vitro and in vivo of resistance to ionophores in a strain of Eimeria tenella. Journal of Parasitology.
78(6), 1067-1073.
-
McDougald, L. R., Gilbert, J. M., Fuller, L., Rotibi, A., Xie, M., & Zhu, G.
(1992).
How Much Does Roxarsone Contribute to Coccidiosis Control in Broilers when Used in Combination with Ionophores?. Journal of Applied Poultry Research.
1(2), 172-179.
-
Ma, J., Guo, F., Jin, Z. i., Geng, M., Ju, M., Ravichandran, A., ... Zhang, H.
(2020).
Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin. Antimicrobial Agents and Chemotherapy.
64(8), e00244-e00220.
-
chapter
-
Zhang, H., & Zhu, G.
(2020).
High-Throughput Screening of Drugs Against the Growth of Cryptosporidium parvum In Vitro by qRT-PCR. Methods in molecular biology (Clifton, N.J.).
CRYPTOSPORIDIUM: METHODS AND PROTOCOLS.
(pp. 319-334).
Springer Nature.
-
Zhu, G., & Guo, F.
(2014).
Cryptosporidium Metabolism. Cryptosporidium: parasite and disease.
(pp. 361-379).
Springer Nature.
-
Zhu, G.
(2009).
Energy Metabolism and Carbon Flow in Cryptosporidium parvum. GIARDIA AND CRYPTOSPORIDIUM: FROM MOLECULES TO DISEASE.
(pp. 360-368).
CABI Publishing.
-
Zhang, H., & Zhu, G.
(2020).
High-Throughput Screening of Drugs Against the Growth of Cryptosporidium parvum In Vitro by qRT-PCR. Methods in molecular biology (Clifton, N.J.).
CRYPTOSPORIDIUM: METHODS AND PROTOCOLS.
(pp. 319-334).
Springer Nature.
-
conference paper
-
Stejskal, F., Surinova, M., Hrdy, I., Fritzler, J. M., Zhu, G., & Korenkova, V.
(2009).
Inhibition of the Cryptosporidium parvum S-adenosylhomocysteine hydrolase with purine nucleoside analogues. Tropical Medicine and International Health.
220-220.
-
Rider, S. D., & Zhu, G.
(2008).
An improved histone deacetylase (HDAC) assay and its application for high-throughput screening of inhibitors against Cryptosporidium parvum enzymes. The FASEB Journal.
-
Chen, X., Ohara, S. P., Huang, B. Q., Nelson, J. B., Lin, J., Zhu, G., Ward, H. D., & LaRusso, N. F.
(2004).
Apical organelle discharge by Cryptosporidium parvum is temperature-, cytoskeleton- and intracellular calcium-dependent and required for host cell invasion. Molecular Biology of the Cell.
466A-467A.
-
Yarlett, N., Martinez, M. P., Zhu, G., Keithly, J. S., Woods, K., & Upton, S. J.
(1996).
Cryptosporidium parvum: polyamine biosynthesis from agmatine. Journal of Eukaryotic Microbiology.
73S-S73.
-
Stejskal, F., Surinova, M., Hrdy, I., Fritzler, J. M., Zhu, G., & Korenkova, V.
(2009).
Inhibition of the Cryptosporidium parvum S-adenosylhomocysteine hydrolase with purine nucleoside analogues. Tropical Medicine and International Health.
220-220.
Research
principal investigator on
- Discovery of inhibitors against cryptosporidial fatty acyl-CoA synthetase awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2021
- Discovery Of Host Cell Candidate Proteins Critical To The Attachment By Cryptosporidium Sporozoites awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2020
- Biochemistry of Protozoan parasites in animals and humans awarded by National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States) 2014 - 2019
- Developing Therapeutics against Giardia and Other Anaerobic Protozoa by Targeting Parasite Fatty Acyl-CoA Synthetase (ACS) awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2015 - 2018
- Bacterial-type hexokinase (HK) in the opportunistic parasite Cryptosporidium parvum awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2014 - 2017
- Evaluation of Marketed Drugs for Rapid Development As Anti- Cryptosporidial Agents awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2012 - 2015
co-principal investigator on
Teaching
teaching activities
- VPAR605 Mlclr & Immun Parastlgy Instructor
- VPAT685 Directed Studies Instructor
- VPAT691 Research Instructor
- VTMI685 Directed Studies Instructor
- VTMI691 Research Instructor
- VTPB285 Directed Studies Instructor
Background
education and training
- Ph.D. in Poultry/Parasitology, University of Georgia - (Athens, Georgia, United States) 1993
- M.S. in Zoology/Parasitology, Zhejiang University - (Hangzhou, Zhejiang, China) 1986
- B.S. in Biology, Zhejiang University - (Hangzhou, Zhejiang, China) 1983
- Wadsworth Center - (Albany, New York, United States) , Postdoctoral Training 1996
Contact
first name
- Guan
has last name
- Zhu
mailing address
-
Texas A&M University
Vet Med Pathobiology
4467 TAMU
College Station, TX 77843-4467
USA
Other
- gzhu@tamu.edu