Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin. Academic Article uri icon

abstract

  • Novel antiparasitic activity was observed for the antifungal occidiofungin. It efficaciously and irreversibly inhibited the zoonotic enteric parasite Cryptosporidium parvum in vitro with limited cytotoxicity (50% effective concentration [EC50] = 120 nM versus 50% cytotoxic concentration [TC50] = 988 nM), and its application disrupted the parasite morphology. This study expands the spectrum of activity of a glycolipopeptide named occidiofungin. Occidiofungin has poor gastrointestinal tract absorption properties, supporting future investigations into its potential activities on other enteric parasites.

author list (cited authors)

  • Ma, J., Guo, F., Jin, Z. i., Geng, M., Ju, M., Ravichandran, A., ... Zhang, H.

publication date

  • January 1, 2020 11:11 AM