Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin. Academic Article uri icon

abstract

  • Novel antiparasitic activity was observed for the antifungal occidiofungin. It efficaciously and irreversibly inhibited the zoonotic enteric parasite Cryptosporidium parvum in vitro with limited cytotoxicity (50% effective concentration [EC50] = 120nM versus 50% cytotoxic concentration [TC50] = 988nM), and its application disrupted the parasite morphology. This study expands the spectrum of activity of a glycolipopeptide named occidiofungin. Occidiofungin has poor gastrointestinal tract absorption properties, supporting future investigations into its potential activities on other enteric parasites.

published proceedings

  • Antimicrob Agents Chemother

altmetric score

  • 1

author list (cited authors)

  • Ma, J., Guo, F., Jin, Z. i., Geng, M., Ju, M., Ravichandran, A., ... Zhang, H.

citation count

  • 7

complete list of authors

  • Ma, Jingbo||Guo, Fengguang||Jin, Zi||Geng, Mengxin||Ju, Min||Ravichandran, Akshaya||Orugunty, Ravi||Smith, Leif||Zhu, Guan||Zhang, Haili

publication date

  • July 2020