Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin. Academic Article

abstract

• Novel antiparasitic activity was observed for the antifungal occidiofungin. It efficaciously and irreversibly inhibited the zoonotic enteric parasite Cryptosporidium parvumin vitro with limited cytotoxicity (50% effective concentration [EC50] = 120nM versus 50% cytotoxic concentration [TC50] = 988nM), and its application disrupted the parasite morphology. This study expands the spectrum of activity of a glycolipopeptide named occidiofungin. Occidiofungin has poor gastrointestinal tract absorption properties, supporting future investigations into its potential activities on other enteric parasites.

authors

• Smith, James
• Zhu, Guan

published proceedings

• Antimicrob Agents Chemother

altmetric score

• 1

author list (cited authors)

• Ma, J., Guo, F., Jin, Z. i., Geng, M., Ju, M., Ravichandran, A., ... Zhang, H.

citation count

• 10

complete list of authors

• Ma, Jingbo||Guo, Fengguang||Jin, Zi||Geng, Mengxin||Ju, Min||Ravichandran, Akshaya||Orugunty, Ravi||Smith, Leif||Zhu, Guan||Zhang, Haili

publication date

• July 2020

publisher

• American Society for Microbiology  Publisher

published in

• Antimicrobial Agents and Chemotherapy  Journal

keywords

• Antifungal Agents
• Antiparasitic Agents
• Cryptosporidiosis
• Cryptosporidium
• Cryptosporidium Parvum
• Cytotoxicity
• Efficacy
• Glycopeptides
• Humans
• In Vitro
• Occidiofungin
• Peptides, Cyclic
• Protozoan Parasite

PubMed Central ID

• 32457108

Digital Object Identifier (DOI)

• 10.1128/AAC.00244-20

start page

• e00244

end page

• e00220

volume

• 64

issue

• 8

URL

• http://dx.doi.org/10.1128/aac.00244-20