Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro. Academic Article

abstract

• D-eritadenine and (S)-DHPA are aliphatic adenosine analogues known to target S-adenosylhomocysteine hydrolase (SAHH) and potent antiviral compounds. In the present study, we demonstrate that these two compounds also display efficacy against recombinant SAHH enzyme of the protozoan parasite Cryptosporidium parvum, as well as inhibition of parasite growth in vitro. Our data confirm that SAHH could serve as a rational drug target in cryptosporidial infection and antiviral adenosine analogues are potential candidates for drug development against cryptosporidiosis.

authors

• Zhu, Guan

published proceedings

• Exp Parasitol

altmetric score

• 3

author list (cited authors)

• Ctrnct, V., Fritzler, J. M., Surinov, M., Hrd, I., Zhu, G., & Stejskal, F.

citation count

• 14

complete list of authors

• Ctrnáctá, Vlasta||Fritzler, Jason M||Surinová, Mária||Hrdý, Ivan||Zhu, Guan||Stejskal, Frantisek

publication date

• January 2010

publisher

• Elsevier  Publisher

published in

• Experimental Parasitology  Journal

keywords

• Adenine
• Adenosylhomocysteinase
• Cryptosporidium Parvum
• Dose-Response Relationship, Drug
• Enzyme Inhibitors
• RNA, Protozoan
• Recombinant Proteins
• Regression Analysis
• Reverse Transcriptase Polymerase Chain Reaction

Digital Object Identifier (DOI)

• 10.1016/j.exppara.2010.04.007

start page

• 113

end page

• 116

volume

• 126

issue

• 2

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2Fj.exppara.2010.04.007