HR job title
- Professor
- Contact Info
- 1 979 458 7960
- Websites
- ORCiD
- 0000-0002-9342-7411
Maren, Stephen University Distinguished Professor
Positions
My research focuses on the neural mechanisms underlying emotional learning and memory in animals and the relevance of these mechanisms to clinical disorders of fear and anxiety, including post-traumatic stress disorder.
Research Areas
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- Research
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Overview
Publications
selected publications
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academic article
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Totty, M. S., Warren, N., Huddleston, I., Ramanathan, K. R., Ressler, R. L., Oleksiak, C. R., & Maren, S.
(2021).
Behavioral and brain mechanisms mediating conditioned flight behavior in rats. SCIENTIFIC REPORTS.
11(1), 8215.
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Totty, M. S., Warren, N., Huddleston, I., Ramanathan, K. R., Ressler, R. L., Oleksiak, C. R., & Maren, S.
(2021).
Behavioral and brain mechanisms mediating conditioned flight behavior in rats. 2021.01.29.428848.
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Ressler, R. L., Goode, T. D., Kim, S., Ramanathan, K. R., & Maren, S.
(2021).
Covert capture and attenuation of a hippocampus-dependent fear memory. Nature Neuroscience.
24(5), 677-684.
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Oleksiak, C. R., Ramanathan, K. R., Miles, O. W., Perry, S. J., Maren, S., & Moscarello, J. M.
(2021).
Ventral hippocampus mediates the context-dependence of two-way signaled avoidance in male rats. 2021.02.04.429792.
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Oleksiak, C. R., Ramanathan, K. R., Miles, O. W., Perry, S. J., Maren, S., & Moscarello, J. M.
(2021).
Ventral hippocampus mediates the context-dependence of two-way signaled avoidance in male rats. NEUROBIOLOGY OF LEARNING AND MEMORY.
183, 107458-107458.
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Ressler, R. L., Goode, T. D., Evemy, C., & Maren, S.
(2020).
NMDA receptors in the CeA and BNST differentially regulate fear conditioning to predictable and unpredictable threats. NEUROBIOLOGY OF LEARNING AND MEMORY.
174, 107281-107281.
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Bouton, M. E., Maren, S., & McNally, G. P.
(2020).
Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning. Physiological Reviews.
101(2), 611-681.
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Giustino, T. F., Ramanathan, K. R., Totty, M. S., Miles, O. W., & Maren, S.
(2020).
Locus coeruleus norepinephrine drives stress-induced increases in basolateral amygdala firing and impairs extinction learning. JOURNAL OF NEUROSCIENCE.
40(4), 1092-1019.
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Goode, T. D., Acca, G. M., & Maren, S.
(2020).
Threat imminence dictates the role of the bed nucleus of the stria terminalis in contextual fear. NEUROBIOLOGY OF LEARNING AND MEMORY.
167, 107116-107116.
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Totty, M. S., Payne, M. R., & Maren, S.
(2019).
Event boundaries do not cause the immediate extinction deficit after Pavlovian fear conditioning in rats. SCIENTIFIC REPORTS.
9(1), 9459.
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Haaker, J., Maren, S., Andreatta, M., Merz, C. J., Richter, J., Richter, S. H., ... Lonsdorf, T. B.
(2019).
Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning. Neuroscience & Biobehavioral Reviews.
107, 329-345.
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Ramanathan, K. R., & Maren, S.
(2019).
Nucleus reuniens mediates the extinction of contextual fear conditioning. Behavioural Brain Research.
374, 112114-112114.
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Goode, T. D., Ressler, R. L., Acca, G. M., Miles, O. W., & Maren, S.
(2019).
Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals. Elife.
8, e46525.
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Miles, O. W., & Maren, S.
(2019).
Role of the Bed Nucleus of the Stria Terminalis in PTSD: Insights From Preclinical Models. Frontiers in Behavioral Neuroscience.
13, 68.
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Ressler, R. L., & Maren, S.
(2019).
Synaptic encoding of fear memories in the amygdala. Current Opinion in Neurobiology.
54, 54-59.
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Giustino, T. F., Fitzgerald, P. J., Ressler, R. L., & Maren, S.
(2019).
Locus coeruleus toggles reciprocal prefrontal firing to reinstate fear. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
116(17), 8570-8575.
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Goode, T. D., Acca, G. M., & Maren, S.
(2019).
Threat imminence dictates the role of the bed nucleus of the stria terminalis in contextual fear. 696112.
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Goode, T. D., & Maren, S.
(2019).
Common neurocircuitry mediating drug and fear relapse in preclinical models. Psychopharmacology.
236(1), 415-437.
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Ramanathan, K. R., Jin, J., Giustino, T. F., Payne, M. R., & Maren, S.
(2018).
Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction. NATURE COMMUNICATIONS.
9(1), 4527.
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Ramanathan, K. R., Ressler, R. L., Jin, J., & Maren, S.
(2018).
Nucleus Reuniens Is Required for Encoding and Retrieving Precise, Hippocampal-Dependent Contextual Fear Memories in Rats. JOURNAL OF NEUROSCIENCE.
38(46), 9925-9933.
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Marek, R., Jin, J., Goode, T. D., Giustino, T. F., Wang, Q., Acca, G. M., ... Sah, P.
(2018).
Author Correction: Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear. Nature Neuroscience.
21(9), 1291-1291.
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Giustino, T. F., & Maren, S.
(2018).
Noradrenergic Modulation of Fear Conditioning and Extinction. Frontiers in Behavioral Neuroscience.
12, 43.
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Moscarello, J. M., & Maren, S.
(2018).
Flexibility in the face of fear: hippocampal–prefrontal regulation of fear and avoidance. Current Opinion in Behavioral Sciences.
19, 44-49.
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Marek, R., Jin, J., Goode, T. D., Giustino, T. F., Wang, Q., Acca, G. M., ... Sah, P.
(2018).
Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear. Nature Neuroscience.
21(3), 384-392.
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Goode, T. D., Ressler, R. L., Acca, G. M., Miles, O. W., & Maren, S.
(2018).
Bed nucleus of the stria terminalis regulates fear to ambiguous threat signals. 376228.
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Ramanathan, K. R., Ressler, R. L., Jin, J., & Maren, S.
(2018).
Nucleus reuniens is required for encoding and retrieving precise, hippocampal-dependent contextual fear memories in rats. 340190.
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Giustino, T. F., Seemann, J. R., Acca, G. M., Goode, T. D., Fitzgerald, P. J., & Maren, S.
(2017).
β-Adrenoceptor Blockade in the Basolateral Amygdala, But Not the Medial Prefrontal Cortex, Rescues the Immediate Extinction Deficit. NEUROPSYCHOPHARMACOLOGY.
42(13), 2537-2544.
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Giustino, T. F., & Maren, S.
(2017).
Chandelier Cells Illuminate Inhibitory Control of Prefrontal–Amygdala Outputs. TRENDS IN NEUROSCIENCES.
40(11), 640-642.
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Goode, T. D., & Maren, S.
(2017).
Role of the bed nucleus of the stria terminalis in aversive learning and memory. Learning & Memory.
24(9), 480-491.
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Maren, S.
(2017).
Synapse-Specific Encoding of Fear Memory in the Amygdala. Neuron.
95(5), 988-990.
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Goode, T. D., Holloway-Erickson, C. M., & Maren, S.
(2017).
Extinction after fear memory reactivation fails to eliminate renewal in rats. NEUROBIOLOGY OF LEARNING AND MEMORY.
142(Pt A), 41-47.
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Goode, T. D., Holloway-Erickson, C. M., & Maren, S.
(2017).
Extinction after fear memory reactivation fails to eliminate renewal in rats. NEUROBIOLOGY OF LEARNING AND MEMORY.
142, 41-47.
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Prater, K. E., Aurbach, E. L., Larcinese, H. K., Smith, T. N., Turner, C. A., Blandino, P., ... Akil, H.
(2017).
Selectively Bred Rats Provide a Unique Model of Vulnerability to PTSD-Like Behavior and Respond Differentially to FGF2 Augmentation Early in Life. NEUROPSYCHOPHARMACOLOGY.
42(8), 1706-1714.
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Acca, G. M., Mathew, A. S., Jin, J., Maren, S., & Nagaya, N.
(2017).
Allopregnanolone induces state-dependent fear via the bed nucleus of the stria terminalis. HORMONES AND BEHAVIOR.
89, 137-144.
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Giustino, T. F., Fitzgerald, P. J., & Maren, S.
(2016).
Fear Expression Suppresses Medial Prefrontal Cortical Firing in Rats. PLOS ONE.
11(10), e0165256-e0165256.
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Maren, S.
(2016).
Parsing Reward and Aversion in the Amygdala. Neuron.
90(2), 209-211.
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Wang, Q., Jin, J., & Maren, S.
(2016).
Renewal of extinguished fear activates ventral hippocampal neurons projecting to the prelimbic and infralimbic cortices in rats. NEUROBIOLOGY OF LEARNING AND MEMORY.
134, 38-43.
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Giustino, T. F., Fitzgerald, P. J., & Maren, S.
(2016).
Revisiting propranolol and PTSD: Memory erasure or extinction enhancement?. NEUROBIOLOGY OF LEARNING AND MEMORY.
130, 26-33.
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Goode, T. D., Leong, K., Goodman, J., Maren, S., & Packard, M. G.
(2016).
Enhancement of striatum-dependent memory by conditioned fear is mediated by beta-adrenergic receptors in the basolateral amygdala. Neurobiology of Stress.
3, 74-82.
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Maren, S., & Holmes, A.
(2016).
Stress and Fear Extinction. NEUROPSYCHOPHARMACOLOGY.
41(1), 58-79.
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Giustino, T. F., & Maren, S.
(2015).
The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear. Frontiers in Behavioral Neuroscience.
9(NOVEMBER), 298.
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Maren, S.
(2015).
Out with the old and in with the new: Synaptic mechanisms of extinction in the amygdala. Brain Research.
1621, 231-238.
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Nagaya, N., & Maren, S.
(2015).
Sex, Steroids, and Fear. BIOLOGICAL PSYCHIATRY.
78(3), 152-153.
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Maren, S.
(2015).
Facing our fears. SCIENCE.
349(6243), 39-39.
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Jin, J., & Maren, S.
(2015).
Fear renewal preferentially activates ventral hippocampal neurons projecting to both amygdala and prefrontal cortex in rats. SCIENTIFIC REPORTS.
5(1), 8388.
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Fitzgerald, P. J., Giustino, T. F., Seemann, J. R., & Maren, S.
(2015).
Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
112(28), e3729-e3737.
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Goode, T. D., Kim, J. J., & Maren, S.
(2015).
Relapse of extinguished fear after exposure to a dangerous context is mitigated by testing in a safe context. Learning & Memory.
22(3), 170-178.
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Nagaya, N., Acca, G. M., & Maren, S.
(2015).
Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats. Frontiers in Behavioral Neuroscience.
9(AUGUST), 205.
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Jin, J., & Maren, S.
(2015).
Prefrontal-Hippocampal Interactions in Memory and Emotion. Frontiers in Systems Neuroscience.
9(DEC), 170.
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Goode, T. D., Kim, J. J., & Maren, S.
(2015).
Reversible Inactivation of the Bed Nucleus of the Stria Terminalis Prevents Reinstatement But Not Renewal of Extinguished Fear1,2,3. ENEURO.
2(3), eneuro.0037-eneu15.2015.
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Morrow, J. D., Saunders, B. T., Maren, S., & Robinson, T. E.
(2015).
Sign-tracking to an appetitive cue predicts incubation of conditioned fear in rats. Behavioural Brain Research.
276, 59-66.
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Fitzgerald, P. J., Seemann, J. R., & Maren, S.
(2014).
Can fear extinction be enhanced? A review of pharmacological and behavioral findings. Brain Research Bulletin.
105, 46-60.
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Maren, S.
(2014).
Fear of the unexpected: Hippocampus mediates novelty-induced return of extinguished fear in rats. NEUROBIOLOGY OF LEARNING AND MEMORY.
108, 88-95.
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Goode, T. D., & Maren, S.
(2014).
Animal Models of Fear Relapse. ILAR Journal.
55(2), 246-258.
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Maren, S.
(2013).
Putting the Brakes on Fear. Neuron.
80(4), 837-838.
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Maren, S., Phan, K. L., & Liberzon, I.
(2013).
The contextual brain: implications for fear conditioning, extinction and psychopathology. Nature Reviews Neuroscience.
14(6), 417-428.
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Maren, S.
(2013).
Nature and causes of the immediate extinction deficit: a brief review. NEUROBIOLOGY OF LEARNING AND MEMORY.
113, 19-24.
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Orsini, C. A., Yan, C., & Maren, S.
(2013).
Ensemble coding of context-dependent fear memory in the amygdala. Frontiers in Behavioral Neuroscience.
7(DEC), 199.
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Badrinarayan, A., Wescott, S. A., Weele, C., Saunders, B. T., Couturier, B. E., Maren, S., & Aragona, B. J.
(2012).
Aversive Stimuli Differentially Modulate Real-Time Dopamine Transmission Dynamics within the Nucleus Accumbens Core and Shell. JOURNAL OF NEUROSCIENCE.
32(45), 15779-15790.
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Knapska, E., Macias, M., Mikosz, M., Nowak, A., Owczarek, D., Wawrzyniak, M., ... Kaczmarek, L.
(2012).
Functional anatomy of neural circuits regulating fear and extinction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
109(42), 17093-17098.
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Orsini, C. A., & Maren, S.
(2012).
Neural and cellular mechanisms of fear and extinction memory formation. Neuroscience & Biobehavioral Reviews.
36(7), 1773-1802.
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Knox, D., George, S. A., Fitzpatrick, C. J., Rabinak, C. A., Maren, S., & Liberzon, I.
(2012).
Single prolonged stress disrupts retention of extinguished fear in rats. Learning & Memory.
19(2), 43-49.
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Orsini, C. A., Kim, J. H., Knapska, E., & Maren, S.
(2011).
Hippocampal and Prefrontal Projections to the Basal Amygdala Mediate Contextual Regulation of Fear after Extinction. JOURNAL OF NEUROSCIENCE.
31(47), 17269-17277.
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Morrow, J. D., Maren, S., & Robinson, T. E.
(2011).
Individual variation in the propensity to attribute incentive salience to an appetitive cue predicts the propensity to attribute motivational salience to an aversive cue. Behavioural Brain Research.
220(1), 238-243.
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Maren, S.
(2011).
Seeking a Spotless Mind: Extinction, Deconsolidation, and Erasure of Fear Memory. Neuron.
70(5), 830-845.
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Chang, C., & Maren, S.
(2011).
Medial prefrontal cortex activation facilitates re-extinction of fear in rats. Learning & Memory.
18(4), 221-225.
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Zimmerman, J. M., & Maren, S.
(2011).
The bed nucleus of the stria terminalis is required for the expression of contextual but not auditory freezing in rats with basolateral amygdala lesions. NEUROBIOLOGY OF LEARNING AND MEMORY.
95(2), 199-205.
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Chang, C., Berke, J. D., & Maren, S.
(2010).
Single-Unit Activity in the Medial Prefrontal Cortex during Immediate and Delayed Extinction of Fear in Rats. PLOS ONE.
5(8), e11971-e11971.
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Maren, S.
(2010).
COMMENTARY: Breaking down fear memory (Commentary on Meins et al.). EUROPEAN JOURNAL OF NEUROSCIENCE.
31(11), 2032-2032.
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Chang, C., & Maren, S.
(2010).
Strain Difference in the Effect of Infralimbic Cortex Lesions on Fear Extinction in Rats. BEHAVIORAL NEUROSCIENCE.
124(3), 391-397.
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Zimmerman, J. M., & Maren, S.
(2010).
NMDA receptor antagonism in the basolateral but not central amygdala blocks the extinction of Pavlovian fear conditioning in rats. EUROPEAN JOURNAL OF NEUROSCIENCE.
31(9), 1664-1670.
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Knapska, E., Mikosz, M., Werka, T., & Maren, S.
(2010).
Social modulation of learning in rats. Learning & Memory.
17(1), 35-42.
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Knapska, E., Mikosz, M., Werka, T., & Maren, S.
(2010).
Social modulation of learning in rats. Learning & memory (Cold Spring Harbor, N.Y.).
17(1), 35-42.
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Maren, S.
(2009).
An Acid-Sensing Channel Sows Fear and Panic. CELL.
139(5), 867-869.
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Orsini, C. A., & Maren, S.
(2009).
Glutamate receptors in the medial geniculate nucleus are necessary for expression and extinction of conditioned fear in rats. NEUROBIOLOGY OF LEARNING AND MEMORY.
92(4), 581-589.
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Jimenez, S. A., & Maren, S.
(2009).
Nuclear disconnection within the amygdala reveals a direct pathway to fear. Learning & Memory.
16(12), 766-768.
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Rabinak, C. A., Orsini, C. A., Zimmerman, J. M., & Maren, S.
(2009).
The amygdala is not necessary for unconditioned stimulus inflation after Pavlovian fear conditioning in rats. Learning & Memory.
16(10), 645-654.
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Knapska, E., & Maren, S.
(2009).
Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear. Learning & Memory.
16(8), 486-493.
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Chang, C., Knapska, E., Orsini, C. A., Rabinak, C. A., Zimmerman, J. M., & Maren, S.
(2009).
Fear Extinction in Rodents. Current Protocols in Neuroscience.
47(1), 8.23.1-8.23.17.
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Chang, C., & Maren, S.
(2009).
Early extinction after fear conditioning yields a context-independent and short-term suppression of conditional freezing in rats. Learning & Memory.
16(1), 62-68.
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Rabinak, C. A., & Maren, S.
(2008).
Associative Structure of Fear Memory After Basolateral Amygdala Lesions in Rats. BEHAVIORAL NEUROSCIENCE.
122(6), 1284-1294.
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Ji, J., & Maren, S.
(2008).
Lesions of the entorhinal cortex or fornix disrupt the context-dependence of fear extinction in rats. Behavioural Brain Research.
194(2), 201-206.
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Serrano, P., Friedman, E. L., Kenney, J., Taubenfeld, S. M., Zimmerman, J. M., Hanna, J., ... Fenton, A. A.
(2008).
PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories. PLOS Biology.
6(12), e318-2706.
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Maren, S.
(2008).
Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats. EUROPEAN JOURNAL OF NEUROSCIENCE.
28(8), 1661-1666.
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Ji, J., & Maren, S.
(2008).
Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear. Learning & Memory.
15(4), 244-251.
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Ji, J., & Maren, S.
(2007).
Hippocampal involvement in contextual modulation of fear extinction. Hippocampus.
17(9), 749-758.
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Zimmerman, J. M., Rabinak, C. A., McLachlan, I. G., & Maren, S.
(2007).
The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining. Learning & Memory.
14(9), 634-644.
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Maren, S.
(2007).
The Threatened Brain. SCIENCE.
317(5841), 1043-1044.
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Merino, S. M., & Maren, S.
(2007).
CORRIGENDUM: Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long‐term fear memory. EUROPEAN JOURNAL OF NEUROSCIENCE.
25(5), 1616-1616.
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Maren, S., & Hobin, J. A.
(2007).
Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala. Learning & Memory.
14(4), 318-324.
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Maren, S., & Chang, C.
(2006).
Recent fear is resistant to extinction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
103(47), 18020-18025.
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Venton, B. J., Robinson, T. E., Kennedy, R. T., & Maren, S.
(2006).
Dynamic amino acid increases in the basolateral amygdala during acquisition and expression of conditioned fear. EUROPEAN JOURNAL OF NEUROSCIENCE.
23(12), 3391-3398.
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Hobin, J. A., Ji, J., & Maren, S.
(2006).
Ventral hippocampal muscimol disrupts context‐specific fear memory retrieval after extinction in rats. Hippocampus.
16(2), 174-182.
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Nagaya, H., Maren, S., & Nagaya, N.
(2006).
Allergy Immunotherapy as an Early Intervention in Patients with Child-Onset Atopic Asthma. International Archives of Allergy and Immunology.
139(1), 9-15.
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Garcia, R., Chang, C., & Maren, S.
(2006).
Electrolytic lesions of the medial prefrontal cortex do not interfere with long-term memory of extinction of conditioned fear. Learning & Memory.
13(1), 14-17.
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Merino, S. M., & Maren, S.
(2006).
Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long‐term fear memory. EUROPEAN JOURNAL OF NEUROSCIENCE.
23(1), 196-204.
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Briand, L. A., Robinson, T. E., & Maren, S.
(2005).
Enhancement of auditory fear conditioning after housing in a complex environment is attenuated by prior treatment with amphetamine. Learning & Memory.
12(6), 553-556.
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Maren, S.
(2005).
Central and Basolateral Amygdala Neurons Crash the Aversive Conditioning Party: Theoretical Comment on Rorick-Kehn and Steinmetz (2005). BEHAVIORAL NEUROSCIENCE.
119(5), 1406-1410.
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Corcoran, K. A., Desmond, T. J., Frey, K. A., & Maren, S.
(2005).
Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction (vol 25, pg 8978, 2005). JOURNAL OF NEUROSCIENCE.
25(42), 9821-9821.
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Corcoran, K. A., Desmond, T. J., Frey, K. A., & Maren, S.
(2005).
Hippocampal Inactivation Disrupts the Acquisition and Contextual Encoding of Fear Extinction. JOURNAL OF NEUROSCIENCE.
25(39), 8978-8987.
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Maren, S.
(2005).
Synaptic Mechanisms of Associative Memory in the Amygdala. Neuron.
47(6), 783-786.
-
Ji, J., & Maren, S.
(2005).
Electrolytic lesions of the dorsal hippocampus disrupt renewal of conditional fear after extinction. Learning & Memory.
12(3), 270-276.
-
Maren, S.
(2005).
Building and Burying Fear Memories in the Brain. The Neuroscientist.
11(1), 89-99.
-
Maren, S., & Quirk, G. J.
(2004).
Neuronal signalling of fear memory. Nature Reviews Neuroscience.
5(11), 844-852.
-
Corcoran, K. A., & Maren, S.
(2004).
Factors Regulating the Effects of Hippocampal Inactivation on Renewal of Conditional Fear After Extinction. Learning & Memory.
11(5), 598-603.
-
Goosens, K. A., & Maren, S.
(2004).
NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala. EUROPEAN JOURNAL OF NEUROSCIENCE.
20(2), 537-548.
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Bhatnagar, S., Sun, L. M., Raber, J., Maren, S., Julius, D., & Dallman, M. F.
(2004).
Changes in anxiety-related behaviors and hypothalamic–pituitary–adrenal activity in mice lacking the 5-HT-3A receptor. Physiology & Behavior.
81(4), 545-555.
-
Maren, S., & Holt, W. G.
(2004).
Hippocampus and Pavlovian Fear Conditioning in Rats: Muscimol Infusions Into the Ventral, but Not Dorsal, Hippocampus Impair the Acquisition of Conditional Freezing to an Auditory Conditional Stimulus. BEHAVIORAL NEUROSCIENCE.
118(1), 97-110.
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Goosens, K. A., Hobin, J. A., & Maren, S.
(2003).
Auditory-Evoked Spike Firing in the Lateral Amygdala and Pavlovian Fear Conditioning Mnemonic Code or Fear Bias?. Neuron.
40(5), 1013-1022.
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Maren, S., Ferrario, C. R., Corcoran, K. A., Desmond, T. J., & Frey, K. A.
(2003).
Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats. EUROPEAN JOURNAL OF NEUROSCIENCE.
18(11), 3080-3088.
-
Hobin, J. A., Goosens, K. A., & Maren, S.
(2003).
Context-Dependent Neuronal Activity in the Lateral Amygdala Represents Fear Memories after Extinction. JOURNAL OF NEUROSCIENCE.
23(23), 8410-8416.
-
Maren, S.
(2003).
What the Amygdala Does and Doesn't Do in Aversive Learning. Learning & Memory.
10(5), 306-308.
-
Goosens, K. A., & Maren, S.
(2003).
Pretraining NMDA Receptor Blockade in the Basolateral Complex, but Not the Central Nucleus, of the Amygdala Prevents Savings of Conditional Fear. BEHAVIORAL NEUROSCIENCE.
117(4), 738-750.
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Goosens, K. A., & Maren, S.
(2002).
Long‐term potentiation as a substrate for memory: Evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning. Hippocampus.
12(5), 592-599.
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Corcoran, K. A., Lu, Y. e., Turner, R. S., & Maren, S.
(2002).
Overexpression of hAPPswe Impairs Rewarded Alternation and Contextual Fear Conditioning in a Transgenic Mouse Model of Alzheimer's Disease. Learning & Memory.
9(5), 243-252.
-
Jones, D. M., Esmaeil, N., Maren, S., & Macdonald, R. L.
(2002).
Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. Epilepsy Research.
50(3), 301-312.
-
Ye, L., Corcoran, K., King, G., Furay, A., Margolis, B., Albin, R., ... Turner, R. S.
(2002).
In vivo modulation of APP catabolism in brain and enhanced learning and memory in human Xl1 alpha/mint-1 transgenic mice. NEUROBIOLOGY OF AGING.
23(1), S240-S240.
-
indicated, N. A.
(2001).
Award for Distinguished Scientific Early Career Contributions to Psychology: Stephen A. Maren. AMERICAN PSYCHOLOGIST.
56(11), 899-901.
-
Maren, S.
(2001).
Is There Savings for Pavlovian Fear Conditioning after Neurotoxic Basolateral Amygdala Lesions in Rats?. NEUROBIOLOGY OF LEARNING AND MEMORY.
76(3), 268-283.
-
Goosens, K. A., & Maren, S.
(2001).
Contextual and Auditory Fear Conditioning are Mediated by the Lateral, Basal, and Central Amygdaloid Nuclei in Rats. Learning & Memory.
8(3), 148-155.
-
Corcoran, K. A., & Maren, S.
(2001).
Hippocampal Inactivation Disrupts Contextual Retrieval of Fear Memory after Extinction. JOURNAL OF NEUROSCIENCE.
21(5), 1720-1726.
-
Maren, S.
(2001).
NEUROBIOLOGY OF PAVLOVIAN FEAR CONDITIONING. Annual Review of Neuroscience.
24(1), 897-931.
-
Maren, S., Yap, S. A., & Goosens, K. A.
(2001).
The Amygdala Is Essential for the Development of Neuronal Plasticity in the Medial Geniculate Nucleus during Auditory Fear Conditioning in Rats. JOURNAL OF NEUROSCIENCE.
21(6), rc135-rc135.
-
Gupta, R. R., Sen, S., Diepenhorst, L. L., Rudick, C. N., & Maren, S.
(2001).
Estrogen modulates sexually dimorphic contextual fear conditioning and hippocampal long-term potentiation (LTP) in rats11Published on the World Wide Web on 1 December 2000. Brain Research.
888(2), 356-365.
-
Maren, S.
(2000).
Auditory fear conditioning increases CS‐elicited spike firing in lateral amygdala neurons even after extensive overtraining. EUROPEAN JOURNAL OF NEUROSCIENCE.
12(11), 4047-4054.
-
Crombag, H. S., Badiani, A., Maren, S., & Robinson, T. E.
(2000).
The role of contextual versus discrete drug-associated cues in promoting the induction of psychomotor sensitization to intravenous amphetamine. Behavioural Brain Research.
116(1), 1-22.
-
Goosens, K. A., Holt, W., & Maren, S.
(2000).
A role for amygdaloid PKA and PKC in the acquisition of long-term conditional fear memories in rats. Behavioural Brain Research.
114(1-2), 145-152.
-
Maren, S.
(2000).
Reply to Vazdarjanova. TRENDS IN NEUROSCIENCES.
23(8), 345-346.
-
Maren, S.
(2000).
Reply to vazdarjanova. TRENDS IN NEUROSCIENCES.
23(8), 345-346.
-
Maren, S.
(1999).
Long-term potentiation in the amygdala: a mechanism for emotional learning and memory. TRENDS IN NEUROSCIENCES.
22(12), 561-567.
-
Anagnostaras, S. G., Maren, S., Sage, J. R., Goodrich, S., & Fanselow, M. S.
(1999).
Scopolamine and Pavlovian Fear Conditioning in Rats: Dose-Effect Analysis. NEUROPSYCHOPHARMACOLOGY.
21(6), 731-744.
-
Holt, W., & Maren, S.
(1999).
Muscimol Inactivation of the Dorsal Hippocampus Impairs Contextual Retrieval of Fear Memory. JOURNAL OF NEUROSCIENCE.
19(20), 9054-9062.
-
Maren, S.
(1999).
Neurotoxic Basolateral Amygdala Lesions Impair Learning and Memory But Not the Performance of Conditional Fear in Rats. JOURNAL OF NEUROSCIENCE.
19(19), 8696-8703.
-
Maren, S.
(1999).
Neurotoxic or Electrolytic Lesions of the Ventral Subiculum Produce Deficits in the Acquisition and Expression of Pavlovian Fear Conditioning in Rats. BEHAVIORAL NEUROSCIENCE.
113(2), 283-290.
-
Anagnostaras, S. G., Maren, S., & Fanselow, M. S.
(1999).
Temporally Graded Retrograde Amnesia of Contextual Fear after Hippocampal Damage in Rats: Within-Subjects Examination. JOURNAL OF NEUROSCIENCE.
19(3), 1106-1114.
-
Maren, S., & Holt, W. G.
(1999).
The hippocampus and contextual memory retrieval in Pavlovian fear conditioning. INTEGRATIVE PHYSIOLOGICAL AND BEHAVIORAL SCIENCE.
34(2), 123-124.
-
Maren, S.
(1998).
Effects of 7-nitroindazole, a neuronal nitric oxide synthase (nNOS) inhibitor, on locomotor activity and contextual fear conditioning in rats1Published on the World Wide Web on 24 July 1998.1. Brain Research.
804(1), 155-158.
-
Maren, S., & Fanselow, M. S.
(1998).
Appetitive Motivational States Differ in Their Ability to Augment Aversive Fear Conditioning in Rats (Rattus norvegicus ). Journal of Experimental Psychology Animal Learning and Cognition.
24(3), 369-373.
-
Rosen, J. B., Fanselow, M. S., Young, S. L., Sitcoske, M., & Maren, S.
(1998).
Immediate-early gene expression in the amygdala following footshock stress and contextual fear conditioning. Brain Research.
796(1-2), 132-142.
-
De Oca, B. M., DeCola, J. P., Maren, S., & Fanselow, M. S.
(1998).
Distinct Regions of the Periaqueductal Gray Are Involved in the Acquisition and Expression of Defensive Responses. JOURNAL OF NEUROSCIENCE.
18(9), 3426-3432.
-
Maren, S.
(1998).
Overtraining Does Not Mitigate Contextual Fear Conditioning Deficits Produced by Neurotoxic Lesions of the Basolateral Amygdala. JOURNAL OF NEUROSCIENCE.
18(8), 3088-3097.
-
Anagnostaras, S. G., Maren, S., DeCola, J. P., Lane, N. I., Gale, G. D., Schlinger, B. A., & Fanselow, M. S.
(1998).
Testicular hormones do not regulate sexually dimorphic Pavlovian fear conditioning or perforant-path long-term potentiation in adult male rats. Behavioural Brain Research.
92(1), 1-9.
-
Maren, S., Anagnostaras, S. G., & Fanselow, M. S.
(1998).
The startled seahorse: is the hippocampus necessary for contextual fear conditioning?. Trends in Cognitive Sciences.
2(2), 39-42.
-
Maren, S.
(1997).
Arousing the LTP and learning debate. Behavioral and Brain Sciences.
20(4), 622-623.
-
Maren, S., Aharonov, G., & Fanselow, M. S.
(1997).
Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behavioural Brain Research.
88(2), 261-274.
-
Kim, J. J., Shih, J. C., Chen, K., Chen, L. u., Bao, S., Maren, S., ... Thompson, R. F.
(1997).
Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
94(11), 5929-5933.
-
Maren, S., & Fanselow, M. S.
(1997).
Electrolytic Lesions of the Fimbria/Fornix, Dorsal Hippocampus, or Entorhinal Cortex Produce Anterograde Deficits in Contextual Fear Conditioning in Rats. NEUROBIOLOGY OF LEARNING AND MEMORY.
67(2), 142-149.
-
Maren, S., Aharonov, G., Stote, D. L., & Fanselow, M. S.
(1996).
N-Methyl-D-Aspartate Receptors in the Basolateral Amygdala Are Required for Both Acquisition and Expression of Conditional Fear in Rats. BEHAVIORAL NEUROSCIENCE.
110(6), 1365-1374.
-
Maren, S., Aharonov, G., & Fanselow, M. S.
(1996).
Retrograde Abolition of Conditional Fear After Excitotoxic Lesions in the Basolateral Amygdala of Rats: Absence of a Temporal Gradient. BEHAVIORAL NEUROSCIENCE.
110(4), 718-726.
-
Maren, S.
(1996).
Synaptic transmission and plasticity in the amygdala. Molecular Neurobiology.
13(1), 1-22.
-
Maren, S., & Fanselow, M. S.
(1996).
The Amygdala and Fear Conditioning: Has the Nut Been Cracked?. Neuron.
16(2), 237-240.
-
ANAGNOSTARAS, S. G., MAREN, S., & FANSELOW, M. S.
(1995).
Scopolamine Selectively Disrupts the Acquisition of Contextual Fear Conditioning in Rats. NEUROBIOLOGY OF LEARNING AND MEMORY.
64(3), 191-194.
-
Maren, S., & Fanselow, ..
(1995).
Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. JOURNAL OF NEUROSCIENCE.
15(11), 7548-7564.
-
Maren, S.
(1995).
Sexually dimorphic perforant path long-term potentiation (LTP) in urethane-anesthetized rats. NEUROSCIENCE LETTERS.
196(2), 177-180.
-
Maren, S., & Baudry, M.
(1995).
Properties and Mechanisms of Long-Term Synaptic Plasticity in the Mammalian Brain: Relationships to Learning and Memory. NEUROBIOLOGY OF LEARNING AND MEMORY.
63(1), 1-18.
-
Maren, S., De Oca, B., & Fanselow, M. S.
(1994).
Sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats: positive correlation between LTP and contextual learning. Brain Research.
661(1-2), 25-34.
-
Maren, S., Tocco, G., Chavanne, F., Baudry, M., Thompson, R. F., & Mitchell, D.
(1994).
Emergence neophobia correlates with hippocampal and cortical glutamate receptor binding in rats. Behavioral and Neural Biology.
62(1), 68-72.
-
Maren, S., DeCola, J. P., & Fanselow, M. S.
(1994).
Water Deprivation Enhances Fear Conditioning to Contextual, but Not Discrete, Conditional Stimuli in Rats. BEHAVIORAL NEUROSCIENCE.
108(3), 645-649.
-
Maren, S., DeCola, J. P., Swain, R. A., Fanselow, M. S., & Thompson, R. F.
(1994).
Parallel Augmentation of Hippocampal Long-Term Potentiation, Theta Rhythm, and Contextual Fear Conditioning in Water-Deprived Rats. BEHAVIORAL NEUROSCIENCE.
108(1), 44-56.
-
Maren, S., Tocco, G., Standley, S., Baudry, M., & Thompson, R. F.
(1993).
Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
90(20), 9654-9658.
-
Mitchell, D., Maren, S., & Hwang, R.
(1993).
The effects of hippocampal lesions on two neotic choice tasks. Cognitive, Affective, & Behavioral Neuroscience.
21(3), 193-202.
-
Maren, S., Patel, K., Thompson, R. F., & Mitchell, D.
(1993).
Individual differences in emergence neophobia predict magnitude of perforant-path long-term potentiation (LTP) and plasma corticosterone levels in rats. Cognitive, Affective, & Behavioral Neuroscience.
21(1), 2-10.
-
Maren, S., Baudry, M., & Thompson, R. F.
(1992).
Effects of the novel NMDA receptor antagonist, CGP 39551, on field potentials and the induction and expression of LTP in the dentate gyrus in vivo. Synapse.
11(3), 221-228.
-
Tocco, G., Maren, S., Shors, T. J., Baudry, M., & Thompson, R. F.
(1992).
Long-term potentiation is associated with increased [3H]AMPA binding in rat hippocampus. Brain Research.
573(2), 228-234.
-
Schreiber, S. S., Maren, S., Tocco, G., Shors, T. J., & Thompson, R. F.
(1991).
A negative correlation between the induction of long-term potentiation and activation of immediate early genes. Brain Research.
11(1), 89-91.
-
Maren, S., Poremba, A., & Gabriel, M.
(1991).
Basolateral amygdaloid multi-unit neuronal correlates of discriminative avoidance learning in rabbits. Brain Research.
549(2), 311-316.
-
Maren, S., Baudry, M., & Thompson, R. F.
(1991).
Differential effects of ketamine and MK-801 on the induction of long-term potentiation. NEUROREPORT.
2(5), 239-242.
-
Totty, M. S., Warren, N., Huddleston, I., Ramanathan, K. R., Ressler, R. L., Oleksiak, C. R., & Maren, S.
(2021).
Behavioral and brain mechanisms mediating conditioned flight behavior in rats. SCIENTIFIC REPORTS.
11(1), 8215.
-
chapter
-
Maren, S.
(2017).
Emotional Learning: Animals☆. Learning and Memory: A Comprehensive Reference.
(pp. 391-410).
Elsevier.
-
Maren, S.
(2009).
Amygdala: Contributions to Fear. Encyclopedia of Neuroscience.
(pp. 335-340).
Elsevier.
-
Maren, S.
(2000).
Multiple Roles for Synoptic Plasticity in Pavlovian Fear Conditioning. Hölscher, C. (Eds.),
Neuronal Mechanisms of Memory Formation.
(pp. 77-99).
Cambridge University Press.
-
Maren, S.
(2017).
Emotional Learning: Animals☆. Learning and Memory: A Comprehensive Reference.
(pp. 391-410).
Elsevier.
-
conference paper
-
Hammoud, M., Gorka, S., Rabinak, C., Liberzon, I., Maren, S., Phan, K. L., & Milad, M.
(2018).
S4. Influence of Δ9-Tetrahydrocannabinol (THC) on Fear Extinction Learning and Spontaneous Recovery. BIOLOGICAL PSYCHIATRY.
s348-S348.
-
Gorka, S., Rabinak, C., Milad, M., Liberzon, I., Maren, S., & Phan, K. L.
(2015).
Effects Delta 9-Tetrahydrocannabinol (THC) on Brain and Behavior During Fear Extinction Learning in Humans: A Combined Psychophysiological-fMRI Study. NEUROPSYCHOPHARMACOLOGY.
S447-S447.
-
George, S. A., Knox, D., Khan, S., Maren, S., & Liberzon, I.
(2010).
The Effect of Single Prolonged Stress, a Rodent Model of Post Traumatic Stress Disorder, on Fear Conditioning, Extinction and Extinction Recall. BIOLOGICAL PSYCHIATRY.
30S-30S.
-
Bouton, M. E., Westbrook, R. F., Corcoran, K. A., & Maren, S.
(2006).
Contextual and Temporal Modulation of Extinction: Behavioral and Biological Mechanisms. BIOLOGICAL PSYCHIATRY.
352-360.
-
Lichtenwalner, R. J., Velander, A. J., Rabinak, C. A., Zhang, H., Fuller, C. L., Burant, C. F., Maren, S., & Parent, J. M.
(2006).
Genetic ablation of neurogenesis in adult mouse forebrain. ANNALS OF NEUROLOGY.
S49-S49.
-
MAREN, S.
(2003).
The Amygdala, Synaptic Plasticity, and Fear Memory. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES.
106-113.
-
Maren, S., & Holt, W.
(2000).
The hippocampus and contextual memory retrieval in Pavlovian conditioning. Behavioural Brain Research.
97-108.
-
Hammoud, M., Gorka, S., Rabinak, C., Liberzon, I., Maren, S., Phan, K. L., & Milad, M.
(2018).
S4. Influence of Δ9-Tetrahydrocannabinol (THC) on Fear Extinction Learning and Spontaneous Recovery. BIOLOGICAL PSYCHIATRY.
s348-S348.
Research
principal investigator on
- Neural circuits for stress-impaired extinction learning awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023
- Neural Substrates of Contextual Memory In Fear Extinction awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2012 - 2021
- Noradrenergic modulation of stress-induced deficits in fear extinction awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2019
- Neural Circuits for Reinstatement of Fear awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2016 - 2018
investigator on
awards and honors
- Memory and Cognitive Disorders Award, conferred by McKnight Foundation - (Minneapolis, Minnesota, United States), 2015
- Fellow, conferred by Association for Psychological Science - (Washington D.C., District of Columbia, United States), 2009
- Faculty Recognition Award, conferred by University of Michigan Medical School - (Ann Arbor, Michigan, United States), 2005
- Distinguished Scientific Awards for an Early Career Contribution to Psychology, conferred by American Psychological Association - (Washington D.C., District of Columbia, United States), 2001
Teaching
teaching activities
- NRSC332 Neurosci Learn Memory Instructor
- NRSC335 Physiological Psych Instructor
- NRSC336 Drugs & Behavior Instructor
- NRSC485 Directed Studies Instructor
- NRSC491 Hnr-research Instructor
- NRSC649 Sem In Behav Neurosci Instructor
- NRSC691 Research Instructor
- PSYC332 Neurosci Learn Memory Instructor
- PSYC335 Physiological Psych Instructor
- PSYC336 Drugs & Behavior Instructor
- PSYC484 Field Experiences Instructor
- PSYC485 Directed Studies Instructor
- PSYC491 Hnr-research Instructor
- PSYC649 Sem In Behav Neurosci Instructor
- PSYC685 Directed Studies Instructor
- PSYC691 Research Instructor
Works By Students
chaired theses and dissertations
-
Jin, Jingji (2017-12). Neural Circuits Underlying Context-Dependent Fear Memory Retrieval.
-
Kim, Janice J (2014-12). Reversible Inactivation of the Bed Nucleus of the Stria Terminalis Blocks Reinstatement But Not Renewal of Extinguished Fear.
Background
education and training
- Ph.D. in Biological Sciences, University of Southern California - (Los Angeles, California, United States) 1993
- M.S. in Biological Sciences, University of Southern California - (Los Angeles, California, United States) 1991
- B.S. in Psychology, University of Illinois at Urbana Champaign - (Urbana, Illinois, United States) 1989
Contact
first name
- Stephen
has last name
- Maren
mailing address
-
Texas A&M University
Psychology
4235 TAMU
College Station, TX 77843-4235
USA
Other
- maren@tamu.edu