HR job title
- Professor
- Contact Info
- 1 979 458 7960
- Websites
- ORCiD
- 0000-0002-9342-7411
Maren, Stephen University Distinguished Professor
My research focuses on the neural mechanisms underlying emotional learning and memory in animals and the relevance of these mechanisms to clinical disorders of fear and anxiety, including post-traumatic stress disorder (PTSD).
Research Areas
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Overview
Publications
selected publications
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academic article
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Binette, A. N., Liu, J., Bayer, H., Crayton, K. L., Melissari, L., Sweck, S. O., & Maren, S.
(2023).
Parvalbumin-Positive Interneurons in the Medial Prefrontal Cortex Regulate Stress-Induced Fear Extinction Impairments in Male and Female Rats. The Journal of Neuroscience.
43(22), 4162-4173.
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Crimmins, B. E., Lingawi, N. W., Chieng, B. C., Leung, B. K., Maren, S., & Laurent, V.
(2023).
Basal forebrain cholinergic signaling in the basolateral amygdala promotes strength and durability of fear memories. Neuropsychopharmacology.
48(4), 605-614.
-
Vasudevan, K., Ramanathan, K. R., Vierkant, V., & Maren, S.
(2022).
Nucleus reuniens inactivation does not impair consolidation or reconsolidation of fear extinction. Learning and Memory.
29(8), 216-222.
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Liu, J., Totty, M. S., Melissari, L., Bayer, H., & Maren, S.
(2022).
Convergent Coding of Recent and Remote Fear Memory in the Basolateral Amygdala. BIOLOGICAL PSYCHIATRY.
91(9), 832-840.
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Wilson, K., MacDonald, S., Bauer, E., Zhang, Y., Maren, S., & MacNamara, A.
(2022).
P109. Backward Conditioning Indirectly Retrieves Threat Memories: Implications for Internalizing Psychopathology. BIOLOGICAL PSYCHIATRY.
91(9), s131-S131.
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Blair, R. S., Acca, G. M., Tsao, B., Stevens, N., Maren, S., & Nagaya, N.
(2022).
Estrous cycle contributes to state-dependent contextual fear in female rats. Psychoneuroendocrinology.
141, 105776-105776.
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Totty, M. S., & Maren, S.
(2022).
Neural Oscillations in Aversively Motivated Behavior. Frontiers in Behavioral Neuroscience.
16, 936036.
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Binette, A. N., Totty, M. S., & Maren, S.
(2022).
Sex differences in the immediate extinction deficit and renewal of extinguished fear in rats. PLoS One.
17(6), e0264797-e0264797.
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Maren, S.
(2022).
Unrelenting Fear Under Stress: Neural Circuits and Mechanisms for the Immediate Extinction Deficit. Frontiers in Systems Neuroscience.
16, 888461.
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Oleksiak, C. R., Ramanathan, K. R., Miles, O. W., Perry, S. J., Maren, S., & Moscarello, J. M.
(2021).
Ventral hippocampus mediates the context-dependence of two-way signaled avoidance in male rats. 183, 107458-107458.
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Ressler, R. L., Goode, T. D., Kim, S., Ramanathan, K. R., & Maren, S.
(2021).
Covert capture and attenuation of a hippocampus-dependent fear memory. Nature Neuroscience.
24(5), 677-684.
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Bouton, M. E., Maren, S., & McNally, G. P.
(2021).
BEHAVIORAL AND NEUROBIOLOGICAL MECHANISMS OF PAVLOVIAN AND INSTRUMENTAL EXTINCTION LEARNING. Physiological Reviews.
101(2), 611-681.
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Totty, M. S., Warren, N., Huddleston, I., Ramanathan, K. R., Ressler, R. L., Oleksiak, C. R., & Maren, S.
(2021).
Behavioral and brain mechanisms mediating conditioned flight behavior in rats. Scientific Reports.
11(1), 8215.
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Totty, M. S., Warren, N., Huddleston, I., Ramanathan, K. R., Ressler, R. L., Oleksiak, C. R., & Maren, S.
(2021).
Behavioral and brain mechanisms mediating conditioned flight behavior in rats. 2021.01.29.428848.
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Ressler, R. L., Goode, T. D., Evemy, C., & Maren, S.
(2020).
NMDA receptors in the CeA and BNST differentially regulate fear conditioning to predictable and unpredictable threats. Neurobiology of Learning and Memory.
174, 107281-107281.
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Giustino, T. F., Ramanathan, K. R., Totty, M. S., Miles, O. W., & Maren, S.
(2020).
Locus Coeruleus Norepinephrine Drives Stress-Induced Increases in Basolateral Amygdala Firing and Impairs Extinction Learning. The Journal of Neuroscience.
40(4), 907-916.
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Goode, T. D., Acca, G. M., & Maren, S.
(2020).
Threat imminence dictates the role of the bed nucleus of the stria terminalis in contextual fear. Neurobiology of Learning and Memory.
167, 107116-107116.
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Haaker, J., Maren, S., Andreatta, M., Merz, C. J., Richter, J., Richter, S. H., ... Lonsdorf, T. B.
(2019).
Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning. Neuroscience and Biobehavioral Reviews.
107, 329-345.
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Ramanathan, K. R., & Maren, S.
(2019).
Nucleus reuniens mediates the extinction of contextual fear conditioning. Behavioural Brain Research.
374, 112114-112114.
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Totty, M. S., Payne, M. R., & Maren, S.
(2019).
Event boundaries do not cause the immediate extinction deficit after Pavlovian fear conditioning in rats. Scientific Reports.
9(1), 9459.
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Goode, T. D., Acca, G. M., & Maren, S.
(2019).
Threat imminence dictates the role of the bed nucleus of the stria terminalis in contextual fear. 696112.
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Goode, T. D., Ressler, R. L., Acca, G. M., Miles, O. W., & Maren, S.
(2019).
Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals. eLife.
8, e46525.
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Giustino, T. F., Fitzgerald, P. J., Ressler, R. L., & Maren, S.
(2019).
Locus coeruleus toggles reciprocal prefrontal firing to reinstate fear. Proceedings of the National Academy of Sciences of USA.
116(17), 8570-8575.
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Miles, O. W., & Maren, S.
(2019).
Role of the Bed Nucleus of the Stria Terminalis in PTSD: Insights From Preclinical Models. Frontiers in Behavioral Neuroscience.
13, 68.
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Ressler, R. L., & Maren, S.
(2019).
Synaptic encoding of fear memories in the amygdala. Current Opinion in Neurobiology.
54, 54-59.
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Goode, T. D., & Maren, S.
(2019).
Common neurocircuitry mediating drug and fear relapse in preclinical models. Psychopharmacology.
236(1), 415-437.
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Ramanathan, K. R., Ressler, R. L., Jin, J., & Maren, S.
(2018).
Nucleus Reuniens Is Required for Encoding and Retrieving Precise, Hippocampal-Dependent Contextual Fear Memories in Rats. The Journal of Neuroscience.
38(46), 9925-9933.
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Ramanathan, K. R., Jin, J., Giustino, T. F., Payne, M. R., & Maren, S.
(2018).
Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction. Nature Communications.
9(1), 4527.
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Marek, R., Jin, J., Goode, T. D., Giustino, T. F., Wang, Q., Acca, G. M., ... Sah, P.
(2018).
Author Correction: Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear. Nature Neuroscience.
21(9), 1291-1291.
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Goode, T. D., Ressler, R. L., Acca, G. M., Miles, O. W., & Maren, S.
(2018).
Bed nucleus of the stria terminalis regulates fear to ambiguous threat signals. 376228.
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Ramanathan, K. R., Ressler, R. L., Jin, J., & Maren, S.
(2018).
Nucleus reuniens is required for encoding and retrieving precise, hippocampal-dependent contextual fear memories in rats. 340190.
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Marek, R., Jin, J., Goode, T. D., Giustino, T. F., Wang, Q., Acca, G. M., ... Sah, P.
(2018).
Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear. Nature Neuroscience.
21(3), 384-392.
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Giustino, T. F., & Maren, S.
(2018).
Noradrenergic Modulation of Fear Conditioning and Extinction. Frontiers in Behavioral Neuroscience.
12, 43.
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Moscarello, J. M., & Maren, S.
(2018).
Flexibility in the face of fear: Hippocampal-prefrontal regulation of fear and avoidance. Current opinion in behavioral sciences.
19, 44-49.
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Giustino, T. F., Seemann, J. R., Acca, G. M., Goode, T. D., Fitzgerald, P. J., & Maren, S.
(2017).
-Adrenoceptor Blockade in the Basolateral Amygdala, But Not the Medial Prefrontal Cortex, Rescues the Immediate Extinction Deficit. Neuropsychopharmacology.
42(13), 2537-2544.
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Giustino, T. F., & Maren, S.
(2017).
Chandelier Cells Illuminate Inhibitory Control of Prefrontal-Amygdala Outputs. Trends in Neurosciences.
40(11), 640-642.
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Goode, T. D., & Maren, S.
(2017).
Role of the bed nucleus of the stria terminalis in aversive learning and memory. Learning and Memory.
24(9), 480-491.
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Maren, S.
(2017).
Synapse-Specific Encoding of Fear Memory in the Amygdala. Neuron.
95(5), 988-990.
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Goode, T. D., Holloway-Erickson, C. M., & Maren, S.
(2017).
Extinction after fear memory reactivation fails to eliminate renewal in rats. Neurobiology of Learning and Memory.
142(Pt A), 41-47.
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Prater, K. E., Aurbach, E. L., Larcinese, H. K., Smith, T. N., Turner, C. A., Blandino, P., ... Akil, H.
(2017).
Selectively Bred Rats Provide a Unique Model of Vulnerability to PTSD-Like Behavior and Respond Differentially to FGF2 Augmentation Early in Life. Neuropsychopharmacology.
42(8), 1706-1714.
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Acca, G. M., Mathew, A. S., Jin, J., Maren, S., & Nagaya, N.
(2017).
Allopregnanolone induces state-dependent fear via the bed nucleus of the stria terminalis. Hormones and Behaviour.
89, 137-144.
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Goode, T. D., Holloway-Erickson, C. M., & Maren, S.
(2017).
Extinction after fear memory reactivation fails to eliminate renewal in rats. Neurobiology of Learning and Memory.
142, 41-47.
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Giustino, T. F., Fitzgerald, P. J., & Maren, S.
(2016).
Fear Expression Suppresses Medial Prefrontal Cortical Firing in Rats. PLoS One.
11(10), e0165256-e0165256.
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Wang, Q., Jin, J., & Maren, S.
(2016).
Renewal of extinguished fear activates ventral hippocampal neurons projecting to the prelimbic and infralimbic cortices in rats. Neurobiology of Learning and Memory.
134 Pt A(Pt A), 38-43.
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Goode, T. D., Leong, K., Goodman, J., Maren, S., & Packard, M. G.
(2016).
Enhancement of striatum-dependent memory by conditioned fear is mediated by beta-adrenergic receptors in the basolateral amygdala. Neurobiology of Stress.
3, 74-82.
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Maren, S.
(2016).
Parsing Reward and Aversion in the Amygdala. Neuron.
90(2), 209-211.
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Giustino, T. F., Fitzgerald, P. J., & Maren, S.
(2016).
Revisiting propranolol and PTSD: Memory erasure or extinction enhancement?. Neurobiology of Learning and Memory.
130, 26-33.
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Maren, S., & Holmes, A.
(2016).
Stress and Fear Extinction. Neuropsychopharmacology.
41(1), 58-79.
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Jin, J., & Maren, S.
(2015).
Prefrontal-Hippocampal Interactions in Memory and Emotion. Frontiers in Systems Neuroscience.
9(DEC), 170.
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Giustino, T. F., & Maren, S.
(2015).
The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear. Frontiers in Behavioral Neuroscience.
9(NOVEMBER), 298.
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Maren, S.
(2015).
Out with the old and in with the new: Synaptic mechanisms of extinction in the amygdala. BRAIN RESEARCH.
1621, 231-238.
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Nagaya, N., Acca, G. M., & Maren, S.
(2015).
Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats. Frontiers in Behavioral Neuroscience.
9(AUGUST), 205.
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Nagaya, N., & Maren, S.
(2015).
Sex, steroids, and fear. BIOLOGICAL PSYCHIATRY.
78(3), 152-153.
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Maren, S.
(2015).
Anxious Using the Brain to Understand and Treat Fear and Anxiety. Science.
349(6243), 39-39.
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Fitzgerald, P. J., Giustino, T. F., Seemann, J. R., & Maren, S.
(2015).
Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress. Proceedings of the National Academy of Sciences of USA.
112(28), E3729-E3737.
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Goode, T. D., Kim, J. J., & Maren, S.
(2015).
Reversible Inactivation of the Bed Nucleus of the Stria Terminalis Prevents Reinstatement But Not Renewal of Extinguished Fear. eNeuro.
2(3), eneuro.0037-eneu15.2015.
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Goode, T. D., Kim, J. J., & Maren, S.
(2015).
Relapse of extinguished fear after exposure to a dangerous context is mitigated by testing in a safe context. Learning and Memory.
22(3), 170-178.
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Jin, J., & Maren, S.
(2015).
Fear renewal preferentially activates ventral hippocampal neurons projecting to both amygdala and prefrontal cortex in rats. Scientific Reports.
5(1), 8388.
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Morrow, J. D., Saunders, B. T., Maren, S., & Robinson, T. E.
(2015).
Sign-tracking to an appetitive cue predicts incubation of conditioned fear in rats. Behavioural Brain Research.
276, 59-66.
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Maren, S.
(2014).
Nature and causes of the immediate extinction deficit: a brief review. Neurobiology of Learning and Memory.
113, 19-24.
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Fitzgerald, P. J., Seemann, J. R., & Maren, S.
(2014).
Can fear extinction be enhanced? A review of pharmacological and behavioral findings. Brain Research Bulletin.
105, 46-60.
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Maren, S.
(2014).
Fear of the unexpected: hippocampus mediates novelty-induced return of extinguished fear in rats. Neurobiology of Learning and Memory.
108, 88-95.
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Goode, T. D., & Maren, S.
(2014).
Animal models of fear relapse. Institute for Laboratory Animal Research (ILAR) Journal.
55(2), 246-258.
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Orsini, C. A., Yan, C., & Maren, S.
(2013).
Ensemble coding of context-dependent fear memory in the amygdala. Frontiers in Behavioral Neuroscience.
7(DEC), 199.
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Maren, S.
(2013).
Putting the brakes on fear. Neuron.
80(4), 837-838.
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Maren, S., Phan, K. L., & Liberzon, I.
(2013).
The contextual brain: implications for fear conditioning, extinction and psychopathology. Nature Reviews Neuroscience.
14(6), 417-428.
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Badrinarayan, A., Wescott, S. A., Vander Weele, C. M., Saunders, B. T., Couturier, B. E., Maren, S., & Aragona, B. J.
(2012).
Aversive stimuli differentially modulate real-time dopamine transmission dynamics within the nucleus accumbens core and shell. 32(45), 15779-15790.
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Knapska, E., Macias, M., Mikosz, M., Nowak, A., Owczarek, D., Wawrzyniak, M., ... Kaczmarek, L.
(2012).
Functional anatomy of neural circuits regulating fear and extinction. Proceedings of the National Academy of Sciences of USA.
109(42), 17093-17098.
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Orsini, C. A., & Maren, S.
(2012).
Neural and cellular mechanisms of fear and extinction memory formation. Neuroscience and Biobehavioral Reviews.
36(7), 1773-1802.
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Knox, D., George, S. A., Fitzpatrick, C. J., Rabinak, C. A., Maren, S., & Liberzon, I.
(2012).
Single prolonged stress disrupts retention of extinguished fear in rats. Learning and Memory.
19(2), 43-49.
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Orsini, C. A., Kim, J. H., Knapska, E., & Maren, S.
(2011).
Hippocampal and prefrontal projections to the basal amygdala mediate contextual regulation of fear after extinction. 31(47), 17269-17277.
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Morrow, J. D., Maren, S., & Robinson, T. E.
(2011).
Individual variation in the propensity to attribute incentive salience to an appetitive cue predicts the propensity to attribute motivational salience to an aversive cue. Behavioural Brain Research.
220(1), 238-243.
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Maren, S.
(2011).
Seeking a spotless mind: extinction, deconsolidation, and erasure of fear memory. Neuron.
70(5), 830-845.
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Chang, C., & Maren, S.
(2011).
Medial prefrontal cortex activation facilitates re-extinction of fear in rats. 18(4), 221-225.
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Zimmerman, J. M., & Maren, S.
(2011).
The bed nucleus of the stria terminalis is required for the expression of contextual but not auditory freezing in rats with basolateral amygdala lesions. Neurobiology of Learning and Memory.
95(2), 199-205.
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Chang, C., Berke, J. D., & Maren, S.
(2010).
Single-unit activity in the medial prefrontal cortex during immediate and delayed extinction of fear in rats. PLoS One.
5(8), e11971-e11971.
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Maren, S.
(2010).
Breaking down fear memory (commentary on Meins et al.). European Journal of Neuroscience.
31(11), 2032-2032.
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Chang, C., & Maren, S.
(2010).
Strain difference in the effect of infralimbic cortex lesions on fear extinction in rats. BEHAVIORAL NEUROSCIENCE.
124(3), 391-397.
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Zimmerman, J. M., & Maren, S.
(2010).
NMDA receptor antagonism in the basolateral but not central amygdala blocks the extinction of Pavlovian fear conditioning in rats. European Journal of Neuroscience.
31(9), 1664-1670.
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Knapska, E., Mikosz, M., Werka, T., & Maren, S.
(2010).
Social modulation of learning in rats. Learning & memory (Cold Spring Harbor, N.Y.).
17(1), 35-42.
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Knapska, E., Mikosz, M., Werka, T., & Maren, S.
(2010).
Social modulation of learning in rats. Learning and Memory.
17(1), 35-42.
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Jimenez, S. A., & Maren, S.
(2009).
Nuclear disconnection within the amygdala reveals a direct pathway to fear. Learning and Memory.
16(12), 766-768.
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Maren, S.
(2009).
An acid-sensing channel sows fear and panic. Cell.
139(5), 867-869.
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Orsini, C. A., & Maren, S.
(2009).
Glutamate receptors in the medial geniculate nucleus are necessary for expression and extinction of conditioned fear in rats. Neurobiology of Learning and Memory.
92(4), 581-589.
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Rabinak, C. A., Orsini, C. A., Zimmerman, J. M., & Maren, S.
(2009).
The amygdala is not necessary for unconditioned stimulus inflation after Pavlovian fear conditioning in rats. Learning and Memory.
16(10), 645-654.
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Knapska, E., & Maren, S.
(2009).
Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear. Learning and Memory.
16(8), 486-493.
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Chang, C., Knapska, E., Orsini, C. A., Rabinak, C. A., Zimmerman, J. M., & Maren, S.
(2009).
Fear extinction in rodents. Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.].
Chapter 8(1), Unit8.23-8.23.17.
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Chang, C., & Maren, S.
(2009).
Early extinction after fear conditioning yields a context-independent and short-term suppression of conditional freezing in rats. Learning and Memory.
16(1), 62-68.
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Rabinak, C. A., & Maren, S.
(2008).
Associative structure of fear memory after basolateral amygdala lesions in rats. BEHAVIORAL NEUROSCIENCE.
122(6), 1284-1294.
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Ji, J., & Maren, S.
(2008).
Lesions of the entorhinal cortex or fornix disrupt the context-dependence of fear extinction in rats. Behavioural Brain Research.
194(2), 201-206.
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Serrano, P., Friedman, E. L., Kenney, J., Taubenfeld, S. M., Zimmerman, J. M., Hanna, J., ... Fenton, A. A.
(2008).
PKMzeta maintains spatial, instrumental, and classically conditioned long-term memories. PLOS Biology.
6(12), 2698-2706.
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Maren, S.
(2008).
Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats. European Journal of Neuroscience.
28(8), 1661-1666.
-
Ji, J., & Maren, S.
(2008).
Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear. Learning and Memory.
15(4), 244-251.
-
Ji, J., & Maren, S.
(2007).
Hippocampal involvement in contextual modulation of fear extinction. The Hippocampus.
17(9), 749-758.
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Zimmerman, J. M., Rabinak, C. A., McLachlan, I. G., & Maren, S.
(2007).
The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining. Learning and Memory.
14(9), 634-644.
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Maren, S.
(2007).
Neuroscience. The threatened brain. Science.
317(5841), 1043-1044.
-
Maren, S., & Hobin, J. A.
(2007).
Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala. Learning and Memory.
14(4), 318-324.
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Merino, S. M., & Maren, S.
(2007).
Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long-term fear memory (vol 23, pg 196, 2006). European Journal of Neuroscience.
25(5), 1616-1616.
-
Nagaya, H., Maren, S., & Nagaya, N.
(2006).
Allergy immunotherapy as an early intervention in patients with child-onset atopic asthma. 139(1), 9-15.
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Maren, S., & Chang, C.
(2006).
Recent fear is resistant to extinction. Proceedings of the National Academy of Sciences of USA.
103(47), 18020-18025.
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Venton, B. J., Robinson, T. E., Kennedy, R. T., & Maren, S.
(2006).
Dynamic amino acid increases in the basolateral amygdala during acquisition and expression of conditioned fear. European Journal of Neuroscience.
23(12), 3391-3398.
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Hobin, J. A., Ji, J., & Maren, S.
(2006).
Ventral hippocampal muscimol disrupts context-specific fear memory retrieval after extinction in rats. The Hippocampus.
16(2), 174-182.
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Garcia, R., Chang, C., & Maren, S.
(2006).
Electrolytic lesions of the medial prefrontal cortex do not interfere with long-term memory of extinction of conditioned fear. Learning and Memory.
13(1), 14-17.
-
Merino, S. M., & Maren, S.
(2006).
Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long-term fear memory. European Journal of Neuroscience.
23(1), 196-204.
-
Briand, L. A., Robinson, T. E., & Maren, S.
(2005).
Enhancement of auditory fear conditioning after housing in a complex environment is attenuated by prior treatment with amphetamine. Learning and Memory.
12(6), 553-556.
-
Maren, S.
(2005).
Central and basolateral amygdala neurons crash the aversive conditioning party: Theoretical comment on Rorick-Kehn and Steinmetz (2005). BEHAVIORAL NEUROSCIENCE.
119(5), 1406-1410.
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Corcoran, K. A., Desmond, T. J., Frey, K. A., & Maren, S.
(2005).
Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction (vol 25, pg 8978, 2005). The Journal of Neuroscience.
25(42), 9821-9821.
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Corcoran, K. A., Desmond, T. J., Frey, K. A., & Maren, S.
(2005).
Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction. 25(39), 8978-8987.
-
Maren, S.
(2005).
Synaptic mechanisms of associative memory in the amygdala. Neuron.
47(6), 783-786.
-
Ji, J., & Maren, S.
(2005).
Electrolytic lesions of the dorsal hippocampus disrupt renewal of conditional fear after extinction. Learning and Memory.
12(3), 270-276.
-
Maren, S.
(2005).
Building and burying fear memories in the brain. The Neuroscientist: reviews at the interface of basic and clinical neurosciences.
11(1), 89-99.
-
Maren, S., & Quirk, G. J.
(2004).
Neuronal signalling of fear memory. Nature Reviews Neuroscience.
5(11), 844-852.
-
Corcoran, K. A., & Maren, S.
(2004).
Factors regulating the effects of hippocampal inactivation on renewal of conditional fear after extinction. Learning and Memory.
11(5), 598-603.
-
Goosens, K. A., & Maren, S.
(2004).
NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala. European Journal of Neuroscience.
20(2), 537-548.
-
Bhatnagar, S., Sun, L. M., Raber, J., Maren, S., Julius, D., & Dallman, M. F.
(2004).
Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptor. Physiology and Behavior.
81(4), 545-555.
-
Maren, S., & Holt, W. G.
(2004).
Hippocampus and Pavlovian fear conditioning in rats: muscimol infusions into the ventral, but not dorsal, hippocampus impair the acquisition of conditional freezing to an auditory conditional stimulus. BEHAVIORAL NEUROSCIENCE.
118(1), 97-110.
-
Goosens, K. A., Hobin, J. A., & Maren, S.
(2003).
Auditory-evoked spike firing in the lateral amygdala and Pavlovian fear conditioning: mnemonic code or fear bias?. Neuron.
40(5), 1013-1022.
-
Maren, S., Ferrario, C. R., Corcoran, K. A., Desmond, T. J., & Frey, K. A.
(2003).
Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats. European Journal of Neuroscience.
18(11), 3080-3088.
-
Hobin, J. A., Goosens, K. A., & Maren, S.
(2003).
Context-dependent neuronal activity in the lateral amygdala represents fear memories after extinction. 23(23), 8410-8416.
-
Maren, S.
(2003).
What the amygdala does and doesn't do in aversive learning. Learning and Memory.
10(5), 306-308.
-
Goosens, K. A., & Maren, S.
(2003).
Pretraining NMDA receptor blockade in the basolateral complex, but not the central nucleus, of the amygdala prevents savings of conditional fear. BEHAVIORAL NEUROSCIENCE.
117(4), 738-750.
-
Goosens, K. A., & Maren, S.
(2002).
Long-term potentiation as a substrate for memory: evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning. The Hippocampus.
12(5), 592-599.
-
Corcoran, K. A., Lu, Y. e., Turner, R. S., & Maren, S.
(2002).
Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease. Learning and Memory.
9(5), 243-252.
-
Jones, D. M., Esmaeil, N., Maren, S., & Macdonald, R. L.
(2002).
Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. Epilepsy Research.
50(3), 301-312.
-
Ye, L., Corcoran, K., King, G., Furay, A., Margolis, B., Albin, R., ... Turner, R. S.
(2002).
In vivo modulation of APP catabolism in brain and enhanced learning and memory in human Xl1 alpha/mint-1 transgenic mice. Neurobiology of Aging.
23(1), S240-S240.
-
Maren, S.
(2001).
Is there savings for pavlovian fear conditioning after neurotoxic basolateral amygdala lesions in rats?. Neurobiology of Learning and Memory.
76(3), 268-283.
-
indicated, N. A.
(2001).
Stephen A. Maren. Award for Distinguished Scientific Early Career Contributions to Psychology. American Psychologist.
56(11), 899-901.
-
Goosens, K. A., & Maren, S.
(2001).
Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats. Learning and Memory.
8(3), 148-155.
-
Maren, S., Yap, S. A., & Goosens, K. A.
(2001).
The amygdala is essential for the development of neuronal plasticity in the medial geniculate nucleus during auditory fear conditioning in rats. 21(6), RC135-rc135.
-
Corcoran, K. A., & Maren, S.
(2001).
Hippocampal inactivation disrupts contextual retrieval of fear memory after extinction. 21(5), 1720-1726.
-
Maren, S.
(2001).
Neurobiology of Pavlovian fear conditioning. Annual Review of Neuroscience.
24(1), 897-931.
-
Gupta, R. R., Sen, S., Diepenhorst, L. L., Rudick, C. N., & Maren, S.
(2001).
Estrogen modulates sexually dimorphic contextual fear conditioning and hippocampal long-term potentiation (LTP) in rats(1). BRAIN RESEARCH.
888(2), 356-365.
-
Maren, S.
(2000).
Auditory fear conditioning increases CS-elicited spike firing in lateral amygdala neurons even after extensive overtraining. European Journal of Neuroscience.
12(11), 4047-4054.
-
Crombag, H. S., Badiani, A., Maren, S., & Robinson, T. E.
(2000).
The role of contextual versus discrete drug-associated cues in promoting the induction of psychomotor sensitization to intravenous amphetamine. Behavioural Brain Research.
116(1), 1-22.
-
Goosens, K. A., Holt, W., & Maren, S.
(2000).
A role for amygdaloid PKA and PKC in the acquisition of long-term conditional fear memories in rats. Behavioural Brain Research.
114(1-2), 145-152.
-
Vazdarjanova, A.
(2000).
Does the basolateral amygdala store memories for emotional events?. Trends in Neurosciences.
23(8), 345-346.
-
Maren, S.
(2000).
Reply to vazdarjanova. Trends in Neurosciences.
23(8), 345-346.
-
Maren, S.
(1999).
Long-term potentiation in the amygdala: a mechanism for emotional learning and memory. Trends in Neurosciences.
22(12), 561-567.
-
Anagnostaras, S. G., Maren, S., Sage, J. R., Goodrich, S., & Fanselow, M. S.
(1999).
Scopolamine and Pavlovian fear conditioning in rats: dose-effect analysis. 21(6), 731-744.
-
Holt, W., & Maren, S.
(1999).
Muscimol inactivation of the dorsal hippocampus impairs contextual retrieval of fear memory. 19(20), 9054-9062.
-
Maren, S.
(1999).
Neurotoxic basolateral amygdala lesions impair learning and memory but not the performance of conditional fear in rats. 19(19), 8696-8703.
-
Maren, S.
(1999).
Neurotoxic or electrolytic lesions of the ventral subiculum produce deficits in the acquisition and expression of Pavlovian fear conditioning in rats. 113(2), 283-290.
-
Anagnostaras, S. G., Maren, S., & Fanselow, M. S.
(1999).
Temporally graded retrograde amnesia of contextual fear after hippocampal damage in rats: within-subjects examination. 19(3), 1106-1114.
-
Maren, S., & Holt, W. G.
(1999).
The hippocampus and contextual memory retrieval in Pavlovian fear conditioning. Integrative Psychological and Behavioral Science.
34(2), 123-124.
-
Maren, S.
(1998).
Effects of 7-nitroindazole, a neuronal nitric oxide synthase (nNOS) inhibitor, on locomotor activity and contextual fear conditioning in rats. BRAIN RESEARCH.
804(1), 155-158.
-
Maren, S., & Fanselow, M. S.
(1998).
Appetitive motivational states differ in their ability to augment aversive fear conditioning in rats (Rattus norvegicus). 24(3), 369-373.
-
Rosen, J. B., Fanselow, M. S., Young, S. L., Sitcoske, M., & Maren, S.
(1998).
Immediate-early gene expression in the amygdala following footshock stress and contextual fear conditioning. BRAIN RESEARCH.
796(1-2), 132-142.
-
De Oca, B. M., DeCola, J. P., Maren, S., & Fanselow, M. S.
(1998).
Distinct regions of the periaqueductal gray are involved in the acquisition and expression of defensive responses. 18(9), 3426-3432.
-
Maren, S.
(1998).
Overtraining does not mitigate contextual fear conditioning deficits produced by neurotoxic lesions of the basolateral amygdala. 18(8), 3088-3097.
-
Anagnostaras, S. G., Maren, S., DeCola, J. P., Lane, N. I., Gale, G. D., Schlinger, B. A., & Fanselow, M. S.
(1998).
Testicular hormones do not regulate sexually dimorphic Pavlovian fear conditioning or perforant-path long-term potentiation in adult male rats. Behavioural Brain Research.
92(1), 1-9.
-
Maren, S., Anagnostaras, S. G., & Fanselow, M. S.
(1998).
The startled seahorse: is the hippocampus necessary for contextual fear conditioning?. Trends in Cognitive Sciences.
2(2), 39-42.
-
Maren, S.
(1997).
Arousing the LTP and learning debate. 20(4), 622-+.
-
Maren, S., Aharonov, G., & Fanselow, M. S.
(1997).
Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behavioural Brain Research.
88(2), 261-274.
-
Kim, J. J., Shih, J. C., Chen, K., Chen, L., Bao, S., Maren, S., ... Thompson, R. F.
(1997).
Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice. Proceedings of the National Academy of Sciences of USA.
94(11), 5929-5933.
-
Maren, S., & Fanselow, M. S.
(1997).
Electrolytic lesions of the fimbria/fornix, dorsal hippocampus, or entorhinal cortex produce anterograde deficits in contextual fear conditioning in rats. Neurobiology of Learning and Memory.
67(2), 142-149.
-
Maren, S., Aharonov, G., Stote, D. L., & Fanselow, M. S.
(1996).
N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats. 110(6), 1365-1374.
-
Maren, S., Aharonov, G., & Fanselow, M. S.
(1996).
Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: absence of a temporal gradient. 110(4), 718-726.
-
Maren, S.
(1996).
Synaptic transmission and plasticity in the amygdala. An emerging physiology of fear conditioning circuits. 13(1), 1-22.
-
Maren, S., & Fanselow, M. S.
(1996).
The amygdala and fear conditioning: has the nut been cracked?. Neuron.
16(2), 237-240.
-
Anagnostaras, S. G., Maren, S., & Fanselow, M. S.
(1995).
Scopolamine selectively disrupts the acquisition of contextual fear conditioning in rats. Neurobiology of Learning and Memory.
64(3), 191-194.
-
Maren, S., & Fanselow, M. S.
(1995).
Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. 15(11), 7548-7564.
-
Maren, S.
(1995).
Sexually dimorphic perforant path long-term potentiation (LTP) in urethane-anesthetized rats. NEUROSCIENCE LETTERS.
196(3), 177-180.
-
Maren, S., & Baudry, M.
(1995).
Properties and mechanisms of long-term synaptic plasticity in the mammalian brain: relationships to learning and memory. Neurobiology of Learning and Memory.
63(1), 1-18.
-
Maren, S., De Oca, B., & Fanselow, M. S.
(1994).
Sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats: positive correlation between LTP and contextual learning. BRAIN RESEARCH.
661(1-2), 25-34.
-
Maren, S., Tocco, G., Chavanne, F., Baudry, M., Thompson, R. F., & Mitchell, D.
(1994).
Emergence neophobia correlates with hippocampal and cortical glutamate receptor binding in rats. Behavioral and Neural Biology.
62(1), 68-72.
-
Maren, S., DeCola, J. P., & Fanselow, M. S.
(1994).
Water deprivation enhances fear conditioning to contextual, but not discrete, conditional stimuli in rats. 108(3), 645-649.
-
Maren, S., DeCola, J. P., Swain, R. A., Fanselow, M. S., & Thompson, R. F.
(1994).
Parallel augmentation of hippocampal long-term potentiation, theta rhythm, and contextual fear conditioning in water-deprived rats. 108(1), 44-56.
-
Maren, S., Tocco, G., Standley, S., Baudry, M., & Thompson, R. F.
(1993).
Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo. Proceedings of the National Academy of Sciences of USA.
90(20), 9654-9658.
-
MITCHELL, D., MAREN, S., & HWANG, R.
(1993).
THE EFFECTS OF HIPPOCAMPAL-LESIONS ON 2 NEOTIC CHOICE TASKS. PSYCHOBIOLOGY.
21(3), 193-202.
-
MAREN, S., PATEL, K., THOMPSON, R. F., & MITCHELL, D.
(1993).
INDIVIDUAL-DIFFERENCES IN EMERGENCE NEOPHOBIA PREDICT MAGNITUDE OF PERFORANT-PATH LONG-TERM POTENTIATION (LTP) AND PLASMA-CORTICOSTERONE LEVELS IN RATS. PSYCHOBIOLOGY.
21(1), 2-10.
-
Maren, S., Baudry, M., & Thompson, R. F.
(1992).
Effects of the novel NMDA receptor antagonist, CGP 39551, on field potentials and the induction and expression of LTP in the dentate gyrus in vivo. Synapse (New York).
11(3), 221-228.
-
Tocco, G., Maren, S., Shors, T. J., Baudry, M., & Thompson, R. F.
(1992).
Long-term potentiation is associated with increased [3H]AMPA binding in rat hippocampus. BRAIN RESEARCH.
573(2), 228-234.
-
Schreiber, S. S., Maren, S., Tocco, G., Shors, T. J., & Thompson, R. F.
(1991).
A negative correlation between the induction of long-term potentiation and activation of immediate early genes. 11(1), 89-91.
-
Maren, S., Poremba, A., & Gabriel, M.
(1991).
Basolateral amygdaloid multi-unit neuronal correlates of discriminative avoidance learning in rabbits. BRAIN RESEARCH.
549(2), 311-316.
-
Maren, S., Baudry, M., & Thompson, R. F.
(1991).
Differential effects of ketamine and MK-801 on the induction of long-term potentiation. NeuroReport.
2(5), 239-242.
-
Binette, A. N., Liu, J., Bayer, H., Crayton, K. L., Melissari, L., Sweck, S. O., & Maren, S.
(2023).
Parvalbumin-Positive Interneurons in the Medial Prefrontal Cortex Regulate Stress-Induced Fear Extinction Impairments in Male and Female Rats. The Journal of Neuroscience.
43(22), 4162-4173.
-
chapter
-
Goode, T. D., Jin, J., & Maren, S.
(2018).
10 Neural Circuits for Fear Relapse. Neurobiology of Abnormal Emotion and Motivated Behaviors.
(pp. 182-202).
Elsevier.
-
Goode, T. D., Jin, J., & Maren, S.
(2018).
Neural Circuits for Fear Relapse. NEUROBIOLOGY OF ABNORMAL EMOTION AND MOTIVATED BEHAVIORS: INTEGRATING ANIMAL AND HUMAN RESEARCH.
(pp. 183-202).
Elsevier.
-
Maren, S.
(2017).
Emotional Learning: Animals. Learning and Memory: A Comprehensive Reference.
(pp. 391-410).
Elsevier.
-
Maren, S.
(2014).
Amygdala: Contributions to Fear. Reference Module in Biomedical Sciences.
Elsevier.
-
Rabinak, C. A., & Maren, S.
(2010).
Amygdala. The Corsini Encyclopedia of Psychology.
(pp. 1-2).
Wiley.
-
Maren, S.
(2009).
Amygdala: Contributions to Fear. Encyclopedia of Neuroscience.
(pp. 335-340).
Elsevier.
-
Maren, S.
(2008).
3.24 Emotional Learning: Animals. Learning and Memory: A Comprehensive Reference.
(pp. 475-502).
Elsevier.
-
Maren, S.
(2000).
Multiple Roles for Synoptic Plasticity in Pavlovian Fear Conditioning. Hölscher, C. (Eds.),
Neuronal Mechanisms of Memory Formation.
(pp. 77-99).
Cambridge University Press (CUP).
-
Goode, T. D., Jin, J., & Maren, S.
(2018).
10 Neural Circuits for Fear Relapse. Neurobiology of Abnormal Emotion and Motivated Behaviors.
(pp. 182-202).
Elsevier.
-
conference paper
-
MacNamara, A., Cheng, Y., Zhang, Y., Wilson, K., Bauer, E., Jackson, B., Maren, S., & MacDonald, S.
(2022).
MODELING ANXIETY AND ITS TREATMENT IN THE LAB: A NOVEL MEANS OF ELICITING CONTEXT AND MODULATION OF THREAT EXTINCTION BY WORKING MEMORY LOAD. PSYCHOPHYSIOLOGY.
S34-S34.
-
Maren, S.
(2022).
Sex-Dependent Role for Prefrontal Cortical Inhibitory Interneurons in the Regulation of Stress-Induced Impairments in Fear Extinction in Rats. Neuropsychopharmacology.
36-36.
-
Maren, S.
(2022).
Sex-Dependent Role for Prefrontal Cortical Inhibitory Interneurons in the Regulation of Stress-Induced Impairments in Fear Extinction in Rats. Neuropsychopharmacology.
36-36.
-
Wilson, K., MacDonald, S. E., Bauer, E., Zhang, Y., Maren, S., & MacNamara, A.
(2021).
BACKWARDS CONDITIONING AND INTOLERANCE OF UNCERTAINTY: AN ERP AND SCR INVESTIGATION. PSYCHOPHYSIOLOGY.
S41-S41.
-
Hammoud, M., Gorka, S., Rabinak, C., Liberzon, I., Maren, S., Phan, K. L., & Milad, M.
(2018).
Influence of Delta 9-Tetrahydrocannabinol (THC) on Fear Extinction Learning and Spontaneous Recovery. BIOLOGICAL PSYCHIATRY.
S348-S348.
-
Gorka, S., Rabinak, C., Milad, M., Liberzon, I., Maren, S., & Phan, K. L.
(2015).
Effects Delta 9-Tetrahydrocannabinol (THC) on Brain and Behavior During Fear Extinction Learning in Humans: A Combined Psychophysiological-fMRI Study. Neuropsychopharmacology.
S447-S447.
-
George, S. A., Knox, D., Khan, S., Maren, S., & Liberzon, I.
(2010).
The Effect of Single Prolonged Stress, a Rodent Model of Post Traumatic Stress Disorder, on Fear Conditioning, Extinction and Extinction Recall. BIOLOGICAL PSYCHIATRY.
30S-30S.
-
Bouton, M. E., Westbrook, R. F., Corcoran, K. A., & Maren, S.
(2006).
Contextual and temporal modulation of extinction: behavioral and biological mechanisms. BIOLOGICAL PSYCHIATRY.
352-360.
-
Lichtenwalner, R. J., Velander, A. J., Rabinak, C. A., Zhang, H., Fuller, C. L., Burant, C. F., Maren, S., & Parent, J. M.
(2006).
Genetic ablation of neurogenesis in adult mouse forebrain. ANNALS OF NEUROLOGY.
S49-S49.
-
Maren, S.
(2003).
The amygdala, synaptic plasticity, and fear memory. Annals of the New York Academy of Sciences.
106-113.
-
Maren, S., & Holt, W.
(2000).
The hippocampus and contextual memory retrieval in Pavlovian conditioning. Behavioural Brain Research.
97-108.
-
Wilson, K., MacDonald, S., Bauer, E., Zhang, Y., Maren, S., & MacNamara, A.
Backward Conditioning Indirectly Retrieves Threat Memories: Implications for Internalizing Psychopathology. BIOLOGICAL PSYCHIATRY.
S131-S131.
-
MacNamara, A., Cheng, Y., Zhang, Y., Wilson, K., Bauer, E., Jackson, B., Maren, S., & MacDonald, S.
(2022).
MODELING ANXIETY AND ITS TREATMENT IN THE LAB: A NOVEL MEANS OF ELICITING CONTEXT AND MODULATION OF THREAT EXTINCTION BY WORKING MEMORY LOAD. PSYCHOPHYSIOLOGY.
S34-S34.
-
institutional repository document
-
Totty, M. S., Ramanathan, K. R., Jin, J., Peters, S. E., & Maren, S.
(2022).
Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear
-
Binette, A. N., Totty, M. S., & Maren, S.
(2022).
Sex differences in the immediate extinction deficit and renewal of extinguished fear in rats
-
Liu, J., Totty, M. S., Melissari, L., Bayer, H., & Maren, S.
(2021).
Convergent coding of recent and remote fear memory in the basolateral amygdala
-
Totty, M. S., Ramanathan, K. R., Jin, J., Peters, S. E., & Maren, S.
(2022).
Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear
Research
principal investigator on
- Neural circuits for stress-impaired extinction learning awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023
- Neural Substrates of Contextual Memory In Fear Extinction awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2012 - 2021
- Noradrenergic modulation of stress-induced deficits in fear extinction awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2019
- Neural Circuits for Reinstatement of Fear awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2016 - 2018
investigator on
Teaching
teaching activities
- NRSC332 Neurosci Learn Memory Instructor
- NRSC335 Physiological Psych Instructor
- NRSC336 Drugs & Behavior Instructor
- NRSC485 Directed Studies Instructor
- NRSC491 Hnr-research Instructor
- NRSC649 Sem In Behav Neurosci Instructor
- NRSC691 Research Instructor
- PBSI484 Field Experiences Instructor
- PBSI485 Directed Studies Instructor
- PBSI491 Hnr-research Instructor
- PBSI649 Sem In Behav Neurosci Instructor
- PBSI685 Directed Studies Instructor
- PBSI691 Research Instructor
- PSYC332 Neurosci Learn Memory Instructor
- PSYC335 Physiological Psych Instructor
- PSYC336 Drugs & Behavior Instructor
- PSYC484 Field Experiences Instructor
- PSYC485 Directed Studies Instructor
- PSYC491 Hnr-research Instructor
- PSYC649 Sem In Behav Neurosci Instructor
- PSYC685 Directed Studies Instructor
- PSYC691 Research Instructor
Works By Students
chaired theses and dissertations
-
Jin, Jingji (2017-12). Neural Circuits Underlying Context-Dependent Fear Memory Retrieval.
-
Kim, Janice J (2014-12). Reversible Inactivation of the Bed Nucleus of the Stria Terminalis Blocks Reinstatement But Not Renewal of Extinguished Fear.
Background
education and training
- Ph.D. in Biological Sciences, University of Southern California - (Los Angeles, California, United States) 1993
- M.S. in Biological Sciences, University of Southern California - (Los Angeles, California, United States) 1991
- B.S. in Psychology, University of Illinois at Urbana Champaign - (Urbana, Illinois, United States) 1989
awards and honors
- Association of Former Students University-Level Distinguished Achievement Award, The, conferred by Texas A&M University - (College Station, Texas, United States), 2023
- Memory and Cognitive Disorders Award, conferred by McKnight Foundation - (Minneapolis, Minnesota, United States), 2015
- Fellow, conferred by Association for Psychological Science - (Washington D.C., District of Columbia, United States), 2009
- Faculty Recognition Award, conferred by University of Michigan Medical School - (Ann Arbor, Michigan, United States), 2005
- Distinguished Scientific Awards for an Early Career Contribution to Psychology, conferred by American Psychological Association - (Washington D.C., District of Columbia, United States), 2001
Contact
first name
- Stephen
has last name
- Maren
mailing address
-
Texas A&M University
Psychology
4235 TAMU
College Station, TX 77843-4235
USA
Other
In the News
- Groundbreaking Research at Texas A&M May Help Millions With PTSD Conquer Their Fear News Release
- President's Excellence Fund Hosts Virtual Symposium News Release
- Tiny things, big impact! News Release
- Will We Ever Be Able to Edit or Delete Memories? News Release
- maren@tamu.edu