Nuclear disconnection within the amygdala reveals a direct pathway to fear. Academic Article uri icon

abstract

  • It is widely believed that a descending serial circuit consisting of neural projections from the basolateral complex (BLA) to the central nucleus (CEA) of the amygdala mediates fear expression. Here we directly test this hypothesis and show that disconnecting the BLA and CEA with asymmetric neurotoxic lesions after Pavlovian fear conditioning in rats completely abolishes the expression of conditional freezing. These results demonstrate that neural projections from the BLA to CEA are essential for the expression of learned fear responses.

published proceedings

  • Learn Mem

altmetric score

  • 3

author list (cited authors)

  • Jimenez, S. A., & Maren, S

citation count

  • 32

complete list of authors

  • Jimenez, Stephanie A||Maren, Stephen

publication date

  • December 2009