Differential effects of ketamine and MK-801 on the induction of long-term potentiation. Academic Article

abstract

• Ketamine and MK-801 are phencyclidine (PCP)-like noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor that produce a use-dependent blockade of the NMDA receptor-coupled channel. Recent studies have suggested that the binding properties of these drugs to the NMDA receptor in-vitro are different. In the present study, the effects of ketamine and MK-801 on the induction of long-term potentiation (LTP) were compared at perforant path--granule cell synapses in anaesthetized rats. LTP was observed in animals treated with either saline or MK-801, but not in those treated with ketamine. These results reveal that ketamine and MK-801 differentially modulate the induction of LTP, and we propose that this differential modulation may be related to the different binding properties of the drugs.

authors

• Maren, Stephen

published proceedings

• Neuroreport

author list (cited authors)

• Maren, S., Baudry, M., & Thompson, R. F.

citation count

• 16

complete list of authors

• Maren, S||Baudry, M||Thompson, RF

publication date

• May 1991

publisher

• Wolters Kluwer  Publisher

published in

• NeuroReport  Journal

keywords

• Animals
• Dizocilpine Maleate
• Electrophysiology
• Evoked Potentials
• Ketamine
• Male
• Rats
• Receptors, N-Methyl-D-Aspartate
• Synapses

PubMed Central ID

• 1832985

Digital Object Identifier (DOI)

• 10.1097/00001756-199105000-00006

start page

• 239

end page

• 242

volume

• 2

issue

• 5

URL

• http://dx.doi.org/10.1097/00001756-199105000-00006