Nature and causes of the immediate extinction deficit: a brief review. Academic Article

abstract

• Recent data in both rodents and humans suggests that the timing of extinction trials after conditioning influences the magnitude and duration of extinction. For example, administering extinction trials soon after Pavlovian fear conditioning in rats, mice, and humans results in minimal fear suppression - the so-called immediate extinction deficit. Here I review recent work examining the behavioral and neural substrates of the immediate extinction deficit. I suggest that extinction is most effective at some delay after conditioning, because brain systems involved in encoding and retrieving extinction memories function sub-optimally under stress.

authors

• Maren, Stephen

published proceedings

• Neurobiol Learn Mem

altmetric score

• 0.5

author list (cited authors)

• Maren, S.

citation count

• 72

complete list of authors

• Maren, Stephen

publication date

• September 2014

publisher

• Elsevier  Publisher

published in

• Neurobiology of Learning and Memory  Journal

keywords

• Animals
• Conditioning, Classical
• Extinction
• Extinction, Psychological
• Fear
• Fear Conditioning
• Freezing
• Human
• Humans
• Prefrontal Cortex
• Rat
• Spontaneous Recovery
• Time

PubMed Central ID

• 24176924

Digital Object Identifier (DOI)

• 10.1016/j.nlm.2013.10.012

start page

• 19

end page

• 24

volume

• 113

URL

• http://dx.doi.org/10.1016/j.nlm.2013.10.012