Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning Academic Article uri icon

abstract

  • Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.

altmetric score

  • 15.35

author list (cited authors)

  • Haaker, J., Maren, S., Andreatta, M., Merz, C. J., Richter, J., Richter, S. H., ... Lonsdorf, T. B.

citation count

  • 23

publication date

  • December 2019