Effects of 7-nitroindazole, a neuronal nitric oxide synthase (nNOS) inhibitor, on locomotor activity and contextual fear conditioning in rats. Academic Article

abstract

• The effect of 7-nitroindazole (7-NI), a selective neuronal nitric oxide synthase (nNOS) inhibitor, on contextual fear conditioning in rats was examined. Systemic administration of 7-NI did not affect the acquisition of contextual fear (measured as freezing), but it did reduce locomotor activity and cause a corresponding increase in the expression of contextual freezing. It is concluded that nNOS activity is not required for either the acquisition or expression of contextual fear conditioning.

authors

• Maren, Stephen

published proceedings

• Brain Res

author list (cited authors)

• Maren, S.

citation count

• 36

complete list of authors

• Maren, S

publication date

• August 1998

publisher

• Elsevier  Publisher

published in

• BRAIN RESEARCH  Journal

keywords

• Animals
• Conditioning, Classical
• Enzyme Inhibitors
• Fear
• Indazoles
• Male
• Motor Activity
• Nitric Oxide Synthase
• Nitric Oxide Synthase Type I
• Rats
• Rats, Inbred Strains

PubMed Central ID

• 9729355

Digital Object Identifier (DOI)

• 10.1016/s0006-8993(98)00668-4

start page

• 155

end page

• 158

volume

• 804

issue

• 1

URL

• http://dx.doi.org/10.1016/s0006-8993(98)00668-4