A negative correlation between the induction of long-term potentiation and activation of immediate early genes. Academic Article

abstract

• In the present study we examined the relationship between the induction of long-term potentiation (LTP) in the dentate gyrus of anesthetized rats and activation of immediate early genes (IEGs; c-fos and zif/268) using several different high-frequency stimulation paradigms. Stimulation parameters that effectively induced LTP were not associated with IEG activation. Conversely, stimulation parameters that failed to induce LTP consistently resulted in IEG activation. These results suggest that there is a negative correlation between IEG activation and LTP, and that activation of IEGs is neither necessary nor sufficient for the induction of LTP.

authors

• Maren, Stephen

published proceedings

• Brain Res Mol Brain Res

author list (cited authors)

• Schreiber, S. S., Maren, S., Tocco, G., Shors, T. J., & Thompson, R. F.

citation count

• 35

complete list of authors

• Schreiber, SS||Maren, S||Tocco, G||Shors, TJ||Thompson, RF

publication date

• August 1991

publisher

• Elsevier  Publisher

published in

• n0169-328XISSN  Journal

keywords

• Animals
• Electric Stimulation
• Evoked Potentials
• Gene Expression Regulation
• Genes, Fos
• Hippocampus
• Rats
• Synapses
• Time Factors

PubMed Central ID

• 1662748

Digital Object Identifier (DOI)

• 10.1016/0169-328x(91)90025-s

start page

• 89

end page

• 91

volume

• 11

issue

• 1

URL

• http://dx.doi.org/10.1016/0169-328x(91)90025-s