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n27222a3e Assistant Professor

Positions

Assistant Professor, Biomedical Engineering, College of Engineering

Dr. Mabbott's research focuses on the development of metallic nanoparticles for use in biomedical devices and healthcare settings. Applications include: integration into point of care devices for sensitive detection of disease relevant biomolecules such as circulating miRNA; controlling the nanoparticles light-to-heat conversion (photothermal) efficiency for destruction of diseased tissues (eg. Tumors); localized delivery of miRNA for gene therapy; increasing the therapeutic effect of drugs; biological and chemical signal amplification.

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selected publications

academic article
- Clevenger, A. J., Crawford, L. Z., Noltensmeyer, D., Babaei, H., Mabbott, S. B., Avazmohammadi, R., & Raghavan, S. (2023). Rapid Prototypable Biomimetic Peristalsis Bioreactor Capable of Concurrent Shear and Multi-Axial Strain. Cells, Tissues, Organs: in vivo, in vitro. 212(1), 96-110.
- Soliman, C., Tu, D., Mabbott, S., Cot, G., & Maitland, K. (2022). Portable, multi-modal Raman and fluorescence spectroscopic platform for point-of-care applications. Journal of Biomedical Optics. 27(9), 095006-095006.
- Chavva, S. R., Bhat, N., San Juan, A., Jaitpal, S., & Mabbott, S. (2022). Simultaneous Thermal and Spectroscopic Screening of Morphologically Complex Theranostic Gold Nanoparticles. 3(2), 102-116.
- Tu, D., Holderby, A., Guo, H., Mabbott, S., Tian, L., & Cot, G. L. (2022). Spectrally multiplexed assay using gap enhanced nanoparticle for detection of a myocardial infarction biomarker panel. Analytica Chimica Acta. 1198, 339562-339562.
- Jaitpal, S., Chavva, S. R., & Mabbott, S. (2022). 3D Printed SERS-Active Thin-Film Substrates Used to Quantify Levels of the Genotoxic Isothiazolinone. ACS Omega. 7(3), 2850-2860.
- San Juan, A., Chavva, S. R., Tu, D., Tircuit, M., Cot, G., & Mabbott, S. (2021). Synthesis of SERS-active core-satellite nanoparticles using heterobifunctional PEG linkers. NANOSCALE ADVANCES. 4(1), 258-267.
- Tu, D., Holderby, A., Dean, J., Mabbott, S., & Cot, G. L. (2021). Paper Microfluidic Device with a Horizontal Motion Valve and a Localized Delay for Automatic Control of a Multistep Assay. Analytical Chemistry. 93(10), 4497-4505.
- Girard, A., Cooper, A., Mabbott, S., Bradley, B., Asiala, S., Jamieson, L., ... Graham, D. (2021). Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis. PLOS Pathogens. 17(11), e1010060-e1010060.
- Mabbott, S., Fernandes, S. C., Schechinger, M., Cote, G. L., Faulds, K., Mace, C. R., & Graham, D. (2020). Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering. The Analyst. 145(3), 983-991.
- Schechinger, M., Marks, H., Mabbott, S., Choudhury, M., & Cote', G. (2019). A SERS approach for rapid detection of microRNA-17 in the picomolar range. 144(13), 4033-4044.
- McConnell, G., Mabbott, S., Kanibolotsky, A. L., Skabara, P. J., Graham, D., Burley, G. A., & Laurand, N (2018). Organic Semiconductor Laser Platform for the Detection of DNA by AgNP Plasmonic Enhancement. Langmuir: the ACS journal of surfaces and colloids. 34(49), 14766-14773.
- Nicolson, F., Jamieson, L. E., Mabbott, S., Plakas, K., Shand, N. C., Detty, M. R., Graham, D., & Faulds, K (2018). Surface enhanced resonance Raman spectroscopy (SERRS) for probing through plastic and tissue barriers using a handheld spectrometer. The Analyst. 143(24), 5965-5973.
- Nicolson, F., Jamieson, L. E., Mabbott, S., Plakas, K., Shand, N. C., Detty, M. R., Graham, D., & Faulds, K (2018). Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo. The Analyst. 143(22), 5358-5363.
- Nicolson, F., Jamieson, L. E., Mabbott, S., Plakas, K., Shand, N. C., Detty, M. R., Graham, D., & Faulds, K (2018). Multiplex imaging of live breast cancer tumour models through tissue using handheld surface enhanced spatially offset resonance Raman spectroscopy (SESORRS). Chemical Communications. 54(61), 8530-8533.
- Nicolson, F., Jamieson, L. E., Mabbott, S., Plakas, K., Shand, N. C., Detty, M. R., Graham, D., & Faulds, K (2018). Through tissue imaging of a live breast cancer tumour model using handheld surface enhanced spatially offset resonance Raman spectroscopy (SESORRS). Chemical Science. 9(15), 3788-3792.
- Pala, L., Mabbott, S., Faulds, K., Bedics, M. A., Detty, M. R., & Graham, D. (2018). Introducing 12 new dyes for use with oligonucleotide functionalised silver nanoparticles for DNA detection with SERS. RSC Advances: an international journal to further the chemical sciences. 8(32), 17685-17693.
- Mabbott, S., Xu, Y., & Goodacre, R. (2017). Objective assessment of SERS thin films: comparison of silver on copper via galvanic displacement with commercially available fabricated substrates. Analytical Methods: advancing methods and applications. 9(33), 4783-4789.
- Laing, S., Suriano, R., Lamprou, D. A., Smith, C., Dalby, M. J., Mabbott, S., Faulds, K., & Graham, D (2017). Correction to Thermoresponsive Polymer Micropatterns Fabricated by Dip-Pen Nanolithography for a Highly Controllable Substrate with Potential Cellular Applications. ACS Applied Materials and Interfaces. 9(9), 8432-8432.
- Nicolson, F., Jamieson, L. E., Mabbott, S., Shand, N. C., Graham, D., & Faulds, K. (2017). Through barrier detection of ethanol using handheld Raman spectroscopyConventional Raman versus spatially offset Raman spectroscopy (SORS). Journal of Raman Spectroscopy. 48(12), 1828-1838.
- Marks, H., Huang, P., Mabbott, S., Graham, D., Kameoka, J., & Cot, G. (2016). Ferric plasmonic nanoparticles, aptamers, and magnetofluidic chips: toward the development of diagnostic surface-enhanced Raman spectroscopy assays. Journal of Biomedical Optics. 21(12), 127005-127005.
- Mackanic, D. G., Mabbott, S., Faulds, K., & Graham, D. (2016). Analysis of Photothermal Release of Oligonucleotides from Hollow Gold Nanospheres by Surface-Enhanced Raman Scattering. The Journal of Physical Chemistry C: Energy Conversion and Storage, Optical and Electronic Devices, Interfaces, Nanomaterials, and Hard Matter. 120(37), 20677-20683.
- Laing, S., Suriano, R., Lamprou, D. A., Smith, C., Dalby, M. J., Mabbott, S., Faulds, K., & Graham, D (2016). Thermoresponsive Polymer Micropatterns Fabricated by Dip-Pen Nanolithography for a Highly Controllable Substrate with Potential Cellular Applications. ACS Applied Materials and Interfaces. 8(37), 24844-24852.
- Mabbott, S., Thompson, D., Sirimuthu, N., McNay, G., Faulds, K., & Graham, D (2016). From synthetic DNA to PCR product: detection of fungal infections using SERS. Faraday Discussions. 187, 461-472.
- Docherty, J., Mabbott, S., Smith, E., Faulds, K., Davidson, C., Reglinski, J., & Graham, D. (2016). Detection of potentially toxic metals by SERS using salen complexes. The Analyst. 141(20), 5857-5863.
- Docherty, J., Mabbott, S., Smith, W. E., Reglinski, J., Faulds, K., Davidson, C., & Graham, D (2015). Determination of metal ion concentrations by SERS using 2,2'-bipyridyl complexes. The Analyst. 140(19), 6538-6543.
- Kashmery, H. A., Thompson, D. G., Dondi, R., Mabbott, S., Graham, D., Clark, A. W., & Burley, G. A (2015). SERS enhancement of silver nanoparticles prepared by a template-directed triazole ligand strategy. Chemical Communications. 51(65), 13028-13031.
- Bedics, M. A., Kearns, H., Cox, J. M., Mabbott, S., Ali, F., Shand, N. C., ... Detty, M. R (2015). Extreme red shifted SERS nanotags. Chemical Science. 6(4), 2302-2306.
- Mabbott, S., Alharbi, O., Groves, K., & Goodacre, R. (2015). Application of surface enhanced Raman scattering to the solution based detection of a popular legal high, 5,6-methylenedioxy-2-aminoindane (MDAI). The Analyst. 140(13), 4399-4406.
- Gracie, K., Correa, E., Mabbott, S., Dougan, J. A., Graham, D., Goodacre, R., & Faulds, K. (2014). Simultaneous detection and quantification of three bacterial meningitis pathogens by SERS. Chemical Science. 5(3), 1030-1040.
- Mabbott, S., Correa, E., Cowcher, D. P., Allwood, J. W., & Goodacre, R. (2013). Optimization of parameters for the quantitative surface-enhanced Raman scattering detection of mephedrone using a fractional factorial design and a portable Raman spectrometer. Analytical Chemistry. 85(2), 923-931.
- Mabbott, S., Eckmann, A., Casiraghi, C., & Goodacre, R (2013). 2p or not 2p: tuppence-based SERS for the detection of illicit materials. The Analyst. 138(1), 118-122.
- Mabbott, S., Larmour, I. A., Vishnyakov, V., Xu, Y., Graham, D., & Goodacre, R. (2012). The optimisation of facile substrates for surface enhanced Raman scattering through galvanic replacement of silver onto copper. The Analyst. 137(12), 2791-2798.
chapter
- Asiala, S., Barrett, L., Mabbott, S., & Graham, D. (2016). Advances in Biofunctional SERS-Active Nanoparticles for Future Clinical Diagnostics and Therapeutics. ACS Symposium Series. FRONTIERS OF PLASMON ENHANCED SPECTROSCOPY, VOL 1. (pp. 131-161). American Chemical Society (ACS).
conference paper
- Chaturvedi, N., Arias, R., Tu, D., Mabbott, S., & Cote, G. L. (2022). A low-cost, paper fluidic platform to detect B-type Natriuretic Peptide (BNP) for Congestive Heart Failure (CHF). Proceedings of SPIE. 1196805-1196805-7.
- Jaitpal, S., Chavva, S., & Mabbott, S. (2021). Towards point-of-care detection of microRNAs using paper-based microfluidics. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 116510c-116510c-6.
- Sengupta, S., Bedics, M., Plakas, K., Bromley, L., Kearns, H., Mabbott, S., ... Velarde, L (2016). Orientation and binding of near infrared absorbing dyes at a gold surface. ACS National Meeting Book of Abstracts.
- Heydari, E., Mabbott, S., Thompson, D., Graham, D., Cooper, J. M., & Clark, A. W. (2016). Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering. Proceedings of SPIE. 972105-972105-6.
- Hayes, M., Graham, D., & Mabbott, S (2016). Investigation of surface enhanced Raman scattering activity in silver-coated magnetic nanoparticles. ACS National Meeting Book of Abstracts.
- Hayes, M., Graham, D., & Mabbott, S (2016). Undergraduate research in Glasgow, Scotland: A study on magnetic nanoparticles and life beyond the United States. ACS National Meeting Book of Abstracts.
- Marks, H., Mabbott, S., Huang, P., Jackson, G. W., Kameoka, J., Graham, D., & Cote, G. L. (2016). Comparison of Fe2O3 and Fe2CoO4 core-shell plasmonic nanoparticles for aptamer mediated SERS assays. Proceedings of SPIE. 97220n-97220n-8.
- Mackanic, D., Mabbott, S., & Graham, D (2015). Summer research in the UK: Unique chemistry in a unique environment. ACS National Meeting Book of Abstracts.
- Marks, H., Mabbott, S., Jackson, G. W., Graham, D., & Cote, G. L. (2015). SERS active colloidal nanoparticles for the detection of small blood biomarkers using aptamers. Proceedings of SPIE. 93381c-93381c-5.